Barral M.,Groupe Henri Mondor Albert Chenevier |
Soyer P.,Hopital Lariboisiere |
Soyer P.,University Paris Diderot |
Ben Hassen W.,Groupe Henri Mondor Albert Chenevier |
And 11 more authors.
Diagnostic and Interventional Imaging | Year: 2013
Purpose: To evaluate reproducibility and variations in apparent diffusion coefficient (ADC) measurement in normal pancreatic parenchyma at 1.5-and 3.0-Tesla and determine if differences may exist between the four pancreatic segments. Materials and methods: Diffusion-weighted MR imaging of the pancreas was performed at 1.5-Tesla in 20 patients and at 3.0-Tesla in other 20 patients strictly matched for gender and age using the same b values (0, 400 and 800 s/mm2). Two independent observers placed regions of interest within the four pancreatic segments to measure ADC at both fields. Intra-and inter-observer agreement in ADC measurement was assessed using Bland-Altman analysis and comparison between ADC values obtained at both fields using non-parametrical tests. Results: There were no significant differences in ADC between repeated measurements and between ADC obtained at 1.5-Tesla and those at 3.0-Tesla. The 95% limits of intra-observer agreement between ADC were 2.3%-22.7% at 1.5-Tesla and 1%-24.2% at 3.0-Tesla and those for inter-observer agreement between 1.9%-14% at 1.5-Tesla and 8%-25% at 3.0-Tesla. ADC values were similar in all pancreatic segments at 3.0-T whereas the tail had lower ADC at 1.5-Tesla. Conclusion: ADC measurement conveys high degrees of intra-and inter-observer reproducibility. ADC have homogeneous distribution among the four pancreatic segments at 3.0-Tesla. © 2013 Éditions françaises de radiologie.
PubMed | Hopital Necker, Nuclear Medicine, Institute Paoli Calmettes, Groupe hospitalier lArchet and 6 more.
Type: Journal Article | Journal: Annals of oncology : official journal of the European Society for Medical Oncology | Year: 2016
Most peripheral T-cell lymphoma (PTCL) patients have a poor outcome and the identification of prognostic factors at diagnosis is needed.The prognostic impact of total metabolic tumor volume (TMTV0), measured on baseline [(18)F]2-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography, was evaluated in a retrospective study including 108 PTCL patients (27 PTCL not otherwise specified, 43 angioimmunoblastic T-cell lymphomas and 38 anaplastic large-cell lymphomas). All received anthracycline-based chemotherapy. TMTV0 was computed with the 41% maximum standardized uptake value threshold method and an optimal cut-off point for binary outcomes was determined and compared with others prognostic factors.With a median follow-up of 23 months, 2-year progression-free survival (PFS) was 49% and 2-year overall survival (OS) was 67%. High TMTV0 was significantly associated with a worse prognosis. At 2 years, PFS was 26% in patients with a high TMTV0 (>230 cm(3), n = 53) versus 71% for those with a low TMTV0, [P < 0.0001, hazard ratio (HR) = 4], whereas OS was 50% versus 80%, respectively, (P = 0.0005, HR = 3.1). In multivariate analysis, TMTV0 was the only significant independent parameter for both PFS and OS. TMTV0, combined with PIT, discriminated even better than TMTV0 alone, patients with an adverse outcome (TMTV0 >230 cm(3) and PIT >1, n = 33,) from those with good prognosis (TMTV0 230 cm(3) and PIT 1, n = 40): 19% versus 73% 2-year PFS (P < 0.0001) and 43% versus 81% 2-year OS, respectively (P = 0.0002). Thirty-one patients (other TMTV0-PIT combinations) had an intermediate outcome, 50% 2-year PFS and 68% 2-year OS.TMTV0 appears as an independent predictor of PTCL outcome. Combined with PIT, it could identify different risk categories at diagnosis and warrants further validation as a prognostic marker.
Hoertel N.,Service de Psychiatrie |
Hoertel N.,University of Paris Descartes |
Hoertel N.,French Institute of Health and Medical Research |
De Maricourt P.,University of Paris Descartes |
And 11 more authors.
Journal of Clinical Psychopharmacology | Year: 2014
Background: The present study sought to quantify the generalizability of clinical trial results in individualswith a Diagnostic and StatisticalManual of Mental Disorders, Fourth Edition, diagnosis of social anxiety disorder (SAD) to a large representative community sample. Methods: Data were derived from the 2004-2005 National Epidemiologic Survey on Alcohol and Related Conditions, a large nationally representative sample of 34,653 adults from the US population. We applied a standard set of exclusion criteria representative of pharmacological and psychotherapy clinical trials to all adults with a Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, diagnosis of SAD (n = 965) in the past 12months and then to a subsample of participants seeking treatment (n = 363). Our aim was to assess how many participants with SAD would fulfill typical eligibility criteria. Results: We found that more than 7 of 10 respondents from the overall SAD sample in a typical pharmacological efficacy trial and more than 6 of 10 participants in a typical psychotherapy efficacy trialwould have been excluded by at least 1 criterion. In addition, more than 8 of 10 respondents seeking treatment for SAD would have been excluded fromparticipation in a typical pharmacological or psychotherapy efficacy trial. Having a current major depression explained a large proportion of ineligibility. Conclusions: Clinical trials should carefully consider the impact of exclusion criteria on the generalizability of their results and explain the rationale for their use. For SAD treatment trials to adequately inform clinical practice, the eligibility rate must be increased through a general relaxation of overly stringent eligibility criteria. Copyright © 2014 Lippincott Williams & Wilkins.
Lin C.,Chang Gung University |
Luciani A.,Groupe Henri Mondor Albert Chenevier |
Itti E.,Groupe Henri Mondor Albert Chenevier |
Haioun C.,Groupe Henri Mondor Albert Chenevier |
And 3 more authors.
Cancer Imaging | Year: 2012
The current evidence regarding the usefulness of whole-body diffusion-weighted magnetic resonance imaging (diffusion MRI) in the assessment of lymphoma is reviewed. Diffusion MRI combining both anatomical and biophysiological information is currently under investigation as a valuable tool in the oncology field including lymphoma, not only for staging but also for the assessment of response. Representative images for each purpose are shown. Diffusion MRI requires no administration of contrast medium and does not use ionizing radiation, which could be particularly advantageous for repeat follow-up surveillance in lymphoma patients. Diffusion MRI may prove to be a useful biomarker in clinical decision making for patients with lymphoma. Large-scale prospective studies are warranted to further establish its complementary value to the current standard of care, [18F] fluorodeoxyglucose positron emission tomography/computed tomography. © 2012 International Cancer Imaging Society.
Legou F.,Groupe Henri Mondor Albert Chenevier |
Legou F.,University Paris Est Creteil |
Chiaradia M.,Groupe Henri Mondor Albert Chenevier |
Chiaradia M.,University Paris Est Creteil |
And 14 more authors.
Diagnostic and Interventional Imaging | Year: 2014
The management of colorectal intrahepatic metastases before resection is multidisciplinary and radiologists and nuclear medicine specialists play a major role. In accordance with the French National Guide for appropriate use of diagnostic imaging, the approach should be multimodal: a chest-abdomen and pelvic (CAP) CT scan and hepatic MRI are mandatory while PET-CT provides important additional information, in particular on intra-abdominal extrahepatic metastases. This multimodal approach emphasizes the importance of early and appropriate use of imaging in these patients, as well as the central role of multidisciplinary meetings in oncology. © 2014 Éditions françaises de radiologie.
Bessede E.,French Institute of Health and Medical Research |
Bessede E.,University of Bordeaux 1 |
Copie-Bergman C.,Groupe Henri Mondor Albert Chenevier |
Copie-Bergman C.,University Paris Est Creteil |
And 15 more authors.
Antioxidants and Redox Signaling | Year: 2012
Helicobacter pylori infection plays a crucial role in the pathogenesis of gastric extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT). However, the host response to this infection is also important in the development of the disease. In particular, NADPH oxidases (NOXs) which generate reactive oxygen species are known to induce cell damage possibly leading to carcinogenesis. We analyze for the first time NOX expression in a series of well characterized gastric MALT lymphoma (GML) patients in comparison with controls. Our observation leads to the hypothesis that NOX2 expression is significantly associated with GML. © 2012 Mary Ann Liebert, Inc.
Gilardin L.,Hopital Saint Louis |
Gilardin L.,University Pierre and Marie Curie |
Copie-Bergman C.,Groupe Henri Mondor Albert Chenevier |
Copie-Bergman C.,University Paris Est Creteil |
And 16 more authors.
British Journal of Haematology | Year: 2013
Most cases of human immunodeficiency virus (HIV)-associated non-Hodgkin Lymphoma (NHL) are of B-cell origin; T-cell NHLs are rarely reported. Within a single centre prospective cohort of 370 HIV-NHL, 17 (5%) were of T-cell origin (82% male; median age, 39 years). Median CD4+ cell count was 0·194 × 109/l and 41% had undetectable plasma HIV-RNA at lymphoma diagnosis. All patients received combination antiretroviral therapy during chemotherapy. All histological samples were centrally reviewed. The distribution of the histological subtypes differed from the general population with absence of angioimmunoblastic subtype. Lymphoma was disseminated in 14 patients, and seven patients had performance status >2. All patients received full-dose chemotherapy: eight standard and nine intensive regimens. Two patients who received intensive chemotherapy died during therapy. The complete remission rate was 53%; 62·5% with standard therapy and 44% with intensive therapy. After a median follow-up of 7·2 years, the median overall survival was 9·4 months. Most deaths (85%) occurred within the first year following diagnosis, as a consequence of lymphoma progression in 10/13 cases. In this rare but severe complication of HIV infection the use of intensive chemotherapy does not appear to be beneficial for response, with increased toxicity. © 2013 John Wiley & Sons Ltd.
Meunier J.,Mapi Patient Centered Outcomes |
Fautrel B.,University Pierre and Marie Curie |
Roquelaure Y.,University of Angers |
Claudepierre P.,Groupe Henri Mondor Albert Chenevier |
Claudepierre P.,University Paris Est Creteil
Occupational Medicine | Year: 2016
Background Rheumatoid arthritis (RA) causes significant impairment of physical function, and thus adversely affects patients' ability to work. Aims To document how often work limitations are discussed by rheumatologists and RA patients during consultations. Methods We conducted an observational study in a sample of French rheumatologists and in a parallel sample of patients recruited by pharmacists. We asked all rheumatologists in France practising in private practice or mixed practice (private practice and hospital) to participate in a telephone survey about their most recent consultation with an RA patient. Randomly selected pharmacists recruited RA patients to complete a questionnaire about their most recent consultation with their rheumatologist. We included patients aged 20-59, with a paid job or unemployed. We calculated the proportion of consultations including work-related discussions in both samples. Results Of the 1737 rheumatologists contacted, 153 (9%) described consultations with eligible patients. Of the 1200 pharmacists contacted, 39 (3%) recruited 81 RA patients. The proportion of consultations including work-related discussions was 50% [95% confidence interval (CI) 42-58%] in the rheumatologist sample and 52% (95% CI 41-63%) in the patient sample. The most frequent subject of discussion (88%) was physical problems related to work in both samples. Conclusions This is the first study to document the proportion of consultations where rheumatologists and their RA patients discuss work. Both specialists and patients reported that work was discussed in one in every two consultations. © The Author 2016. Published by Oxford University Press on behalf of the Society of Occupational Medicine.
Bossard C.,University of Nantes |
Dobay M.P.,Swiss Institute of Bioinformatics |
Parrens M.,Departement de Pathologie |
Lamant L.,Hopital Purpan |
And 12 more authors.
Blood | Year: 2014
The extended use of brentuximab-vedotin was reported for CD30+ nonanaplastic peripheralT-celllymphomas(PTCLs)with promising efficacy. CD30 status assessmentis thus a critical factor for therapeutic decision, but the reliability of immunohistochemistry (IHC) in evaluating its expression remains to be defined. This prompted us to investigate the correlation between semiquantitative CD30 protein assessment by IHC andmessengerRNA(mRNA) assessment by micro arraysinacohortof376 noncutaneous PTCLs representative of the main entities. By IHC, CD30 expression was heterogeneous across and within entities and significantly associated with large tumor cell size. In additionto100% anaplastic large-cell lymphomas, 57%ofother PTCL entities were CD30-positive at a 5% threshold. CD30 protein expression was highly correlated to mRNA levels. mRNA levels were bimodal, separating high from low CD30-expressing PTCL cases. Weconclude that IHC is a valuable tool in clinical practice to assess CD30 expression in PTCLs. © 2014 by The American Society of Hematology.
PubMed | Philips, Groupe Henri Mondor Albert Chenevier and University Paris Est Creteil
Type: Case Reports | Journal: Journal of vascular and interventional radiology : JVIR | Year: 2015
The purpose of this study was to evaluate the automatic three-dimensional detection of prostatic arteries (PAs) with the use of dual-phase cone-beam computed tomography (CT) imaging and vessel-tracking software during prostatic artery (PA) embolization (PAE). In six patients, six right PAs and five left PAs were detected by using the software (sensitivity, 92%). The false-positive arteries (right side, 14%; left side, 25%) were deleted after cone-beam CT review. Automatic software detection of PAs from cone-beam CT may permit identification of the PA during PAE.