Cmr Group Of Institutions

Hyderabad, India

Cmr Group Of Institutions

Hyderabad, India

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Garige B.S.R.,Anurag Group of Institutions | Srisailam K.,Anurag Group of Institutions | Srisailam K.,Satavahana University | Vattikuti U.M.R.,Cmr Group Of Institutions
Asian Journal of Chemistry | Year: 2016

This study assesses the central nervous system depressant effects and muscle relaxant activity of methanolic extract of Galphimia gracilis leaf in Swiss albino mice employing models like open field test, hole-board test, sodium pentobarbital-induced sleep test, pentylenetetrazole induced convulsions, picrotoxin-induced convulsions, rota rod test and grip strengthening test. The LD50 results of the extract was found to be > 2000 mg/kg. The extract exhibited significant (P = 0.001) effects in both the open field test and hole-board test. The extract at 100, 200 and 400 mg/kg doses extended the duration of sleep induced by sodium pentobarbital (40 mg/kg) and also delayed the onset of seizures induced by pentylenetetrazole (90 mg/kg) and picrotoxin (10 mg/kg) respectively. The extract also exhibited significant (P = .001) effects in Grip strengthening test and Rota rod test. The study concludes that the methanolic extract of Galphimia gracilis leaf has significant depressant activity and muscle relaxant effects.


Rao Garige B.S.,Anurag Group of Institutions | Keshetti S.,Satavahana University | Rao Vattikuti U.M.,Cmr Group Of Institutions
Asian Journal of Chemistry | Year: 2016

This study assesses the analgesic and anti-inflammatory properties of methanolic extract of Galphimia glauca leaf using in vivo models. The dose range of 100, 200 and 400 mg/kg b.w was administered orally for assessing analgesic and anti-inflammatory activity respectively. Further studies were conducted for determining the involvement of central and peripheral receptor actions in the analgesic activity of the extract by pre-challenging it with naloxone and acetic acid respectively. The LD50 of the extract was found to be > 2000 mg/kg b.w. The leaf extract at 400 mg/kg dose exhibited significant (P ≤ 0.001) and dose-dependent analgesic activity. It also exhibited central and peripheral analgesic actions when treated with naloxone and acetic acid respectively. However, the extract of leaf has shown anti-inflammatory activity, which is not comparable to that of standard drug. The results revealed that the methanolic extract of Galphimia glauca leaf has potential in terms of analgesic properties. © 2016, Chemical Publishing Co. All rights reserved.

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