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Van Atteveldt N.,Group 47 | Van Atteveldt N.,VU University Amsterdam | Van Atteveldt N.,Maastricht University | Murray M.M.,University of Lausanne | And 4 more authors.
Neuron | Year: 2014

Research into the anatomical substrates and "principles" for integrating inputs from separate sensory surfaces has yielded divergent findings. This suggests that multisensory integration is flexible and context dependent and underlines the need for dynamically adaptive neuronal integration mechanisms. We propose that flexible multisensory integration can be explained by a combination of canonical, population-level integrative operations, such as oscillatory phase resetting and divisive normalization. These canonical operations subsume multisensory integration into a fundamental set of principles as to how the brain integrates all sorts of information, and they are being used proactively and adaptively. We illustrate this proposition by unifying recent findings from different research themes such as timing, behavioral goal, and experience-related differences in integration. van Atteveldt etal. discuss how the flexible, context-dependent manifestations of multisensory integration can be explained by adaptive and proactive interplay of canonical neural operations for cue integration, such as oscillatory phase resetting and divisive normalization. © 2014 Elsevier Inc.


Montalescot G.,Group 47 | Brieger D.,University of Sydney | Dalby A.J.,Milpark Hospital | Park S.-J.,University of Ulsan | Mehran R.,Mount Sinai School of Medicine
Journal of the American College of Cardiology | Year: 2015

The duration of dual antiplatelet therapy (DAPT) after coronary stenting has been evaluated in randomized studies with apparently conflicting results. Although longer exposure associates with more bleeding complications, late stent thrombosis (ST) and myocardial infarction are reduced. In addition, as new drug-eluting stents carry a lower risk of ST compared with the first-generation drug-eluting stents and possibly even bare-metal stents, a shift toward better protection from ST may have an effect on the duration and intensity of DAPT. Whether the duration of DAPT should be shorter or longer than the currently recommended 6 to 12 months is analyzed in this review, drawing on lessons from the most recent studies. © 2015 American College of Cardiology Foundation.


Population genetic studies focus on natural dispersal and isolation by landscape barriers as the main drivers of genetic population structure. However, anthropogenic factors such as reintroductions, translocations and wild x domestic hybridization may also have strong effects on genetic population structure. In this study we genotyped 351 Single Nucleotide Polymorphism markers evenly spread across the genome in 645 wild boar (Sus scrofa) from Northwest Europe to evaluate determinants of genetic population structure. We show that wild boar genetic population structure is influenced by historical reintroductions and by genetic introgression from domestic pigs. Six genetically distinct and geographically coherent wild boar clusters were identified in the Netherlands and Western Germany. The Dutch Veluwe cluster is known to be reintroduced, and three adjacent Dutch and German clusters are suspected to be a result of reintroduction, based on clustering results, low levels of heterozygosity and relatively high genetic distances to nearby populations. Recent wild x domestic hybrids were found geographically widespread across clusters and at low frequencies (average 3.9%). The relationship between pairwise kinship coefficients and geographic distance showed male-biased dispersal at the population genetic level. Our results demonstrate that wildlife and landscape management by humans are shaping the genetic diversity of an iconic wildlife species. Historical reintroductions, translocation and recent restocking activities with farmed wild boar have all influenced wild boar genetic population structure. The current trend of wild boar population growth and range expansion has recently led to a number of contact zones between clusters, and further admixture between the different wild boar clusters is to be expected.


Ahmadlou M.,Group 47 | Heimel J.A.,Group 47
Nature Communications | Year: 2015

The superior colliculus is a layered structure important for body- and gaze-orienting responses. Its superficial layer is, next to the lateral geniculate nucleus, the second major target of retinal ganglion axons and is retinotopically organized. Here we show that in the mouse there is also a precise organization of orientation preference. In columns perpendicular to the tectal surface, neurons respond to the same visual location and prefer gratings of the same orientation. Calcium imaging and extracellular recording revealed that the preferred grating varies with retinotopic location, and is oriented parallel to the concentric circle around the centre of vision through the receptive field. This implies that not all orientations are equally represented across the visual field. This makes the superior colliculus different from visual cortex and unsuitable for translation-invariant object recognition and suggests that visual stimuli might have different behavioural consequences depending on their retinotopic location. © 2015 Macmillan Publishers Limited. All rights reserved.


Patent
Group 47 | Date: 2015-10-21

Digital optical tape archival storage systems and methods are disclosed. A digital optical tape recorder may simultaneously write data and two or more guide tracks onto a digital optical tape recording medium. A digital optical taper reader may include a camera comprising an array of detectors to capture a two-dimensional image of the digital optical tape recording medium, and an image processor to extract the data from the two-dimensional image. The camera may capture the two-dimensional image of the digital optical tape recording medium without aligning individual data bits recorded on the digital optical tape recording medium to individual detectors within the camera.


Patent
Group 47 | Date: 2014-04-23

Digital optical tape archival storage systems and methods are disclosed. A digital optical tape recorder may simultaneously write data and two or more guide tracks onto a digital optical tape recording medium. A digital optical taper reader may include a camera to capture a two-dimensional image of the digital optical tape recording medium, and an image processor to extract the data from the two-dimensional image.


Patent
Group 47 | Date: 2014-04-10

Methods and apparatus for archival storage of an image are disclosed. The image may be separated into a plurality of bit plane images. The plurality of bit plane images may be written separately onto digital optical tape.


Patent
Group 47 | Date: 2016-09-20

Methods and apparatus for archival storage of an image are disclosed. The image is converted into one or more bit plane images. Fiducial markers are generated and written onto digital optical tape concurrent with writing the one or more bit plane images onto the digital optical tape.


Patent
Group 47 | Date: 2016-09-20

Digital optical tape archival storage systems and methods are disclosed. A digital optical tape recorder simultaneously writes data and two or more guide tracks onto an unformatted digital optical tape recording medium. A digital optical tape reader includes a camera and an image processor. The camera captures a two-dimensional image of the digital optical tape recording medium including the data and the two or more guide tracks. The image processor extracts the data from the two-dimensional image based, at least in part, on the guide tracks.


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