Grodno State Medical University

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Hrodna, Belarus

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Dzeshka M.S.,University of Birmingham | Dzeshka M.S.,Grodno State Medical University | Lip G.Y.H.,University of Birmingham | Lip G.Y.H.,University of Aalborg | And 2 more authors.
Journal of the American College of Cardiology | Year: 2015

Atrial fibrillation (AF) is associated with structural, electrical, and contractile remodeling of the atria. Development and progression of atrial fibrosis is the hallmark of structural remodeling in AF and is considered the substrate for AF perpetuation. In contrast, experimental and clinical data on the effect of ventricular fibrotic processes in the pathogenesis of AF and its complications are controversial. Ventricular fibrosis seems to contribute to abnormalities in cardiac relaxation and contractility and to the development of heart failure, a common finding in AF. Given that AF and heart failure frequently coexist and that both conditions affect patient prognosis, a better understanding of the mutual effect of fibrosis in AF and heart failure is of particular interest. In this review paper, we provide an overview of the general mechanisms of cardiac fibrosis in AF, differences between fibrotic processes in atria and ventricles, and the clinical and prognostic significance of cardiac fibrosis in AF. © 2015 American College of Cardiology Foundation.


In this paper we focused on methods of estimation of unrecorded alcohol consumption level. Present methods of estimation of unrevorded alcohol consumption allow only approximate estimation of unrecorded alcohol consumption level. Tacking into consideration the extreme importance of such kind of data, further investigation is necessary to improve the reliability of methods estimation of unrecorded alcohol consumption. © Center for Study and Control of Alcoholism and Other Addictions.


It has been repeatedly emphasized that alcohol provides the most plausible explanation for both the high rate of cardiovascular mortality rate and its dramatic fluctuations in Russia over recent decades, while other traditional risk factors identified in epidemiological studies have little predictive value. The aim of this study was to examine the relation between alcohol consumption and ischemic heart disease (IHD) mortality rates in Russia. A ge-standardized sex-specific male and female IHD mortality data for the period 1980-2005 and data on overall alcohol consumption were analyzed by means of ARIMA time series analysis. The results of the analysis showed that alcohol consumption was significantly associated with both male and female IHD mortality rates: a 1-liter increase in overall alcohol consumption would result in a 3.9% increase in the male IHD mortality rate and a 2.7% increase in the female IHD mortality rate. As a conclusion, the results of this study provide indirect support for the hypothesis that the drastic fluctuations in IHD mortality in Russia over recent decades are related to alcohol, as indicated by the close temporal association between number of deaths from IHD and overall alcohol consumption per capita.


Razvodovsky Y.E.,Grodno State Medical University
Journal of injury & violence research | Year: 2012

High accidental death rates in the former Soviet republics (FSR) and its profound fluctuation over the past decades have attracted considerable interest. The research evidences emphasize binge drinking pattern as a potentially important contributor to accident mortality crisis in FSR. In line with this evidence we assume that higher level of alcohol consumption in conjunction with binge drinking pattern results in close aggregate-level association between alcohol psychoses and accidental death rates in the former Soviet Slavic republic Belarus. Trends in alcohol psychoses rate (as a proxy for alcohol consumption) from 1979 to 2007 were analyzed employing a distributed lag analysis in order to asses bivariate relationship between the two time series. According to the Bureau of Forensic Medicine autopsy reports the number of deaths due to accidents and injuries increased by 52.5% (from 62.3 to 95.0 per 100.000 of residents), and fatal alcohol poisoning rate increased by 108.6% (from 12.8 to 26.7 per 100.000 of residents) in Belarus between 1979 and 2007. Alcohol in blood was found in 50.1% victims of deaths from accidents and injuries for the whole period, with the minimum figure 40% in 1986 and maximum 58.2% in 2005. The outcome of distributed lags analysis indicated statistically significant association between the number of alcohol psychoses cases and the number BAC-positive deaths from accidents at zero lag. The outcome of this study supports previous findings suggesting that alcohol and deaths from accidents are closely connected in a culture with prevailing intoxication-oriented drinking pattern, and add to growing body of evidence that a substantial proportion of accidental deaths in Belarus are due to effects of binge drinking.


Razvodovsky Y.E.,Grodno State Medical University
Alcohol and Alcoholism | Year: 2015

Aims: To test the hypothesis of beverage-specific effect in Russia on the incidence rate of alcoholic psychoses (a known indicator of a population's alcohol-related problems). Methods: Time series analytical modeling techniques (ARIMA) were used to examine the relation between the sales of different alcoholic beverages (vodka, wine, beer) and alcoholic psychoses incidence rate between 1970 and 2013. Results: The analysis suggests that of the three beverages vodka alone was associated with alcoholic psychoses incidence rate. The estimated effect of vodka sales on the alcohol psychoses rate is statistically significant: a 1 l per person per year increase in vodka sales would result in a 23.4% increase in the alcoholic psychoses incidence rate. Conclusion: The incidence of alcoholic psychoses is more responsive to changes in vodka sales per capita than wine or beer sales. © The Author 2015. Medical Council on Alcohol and Oxford University Press. All rights reserved.


Alcohol abuse has numerous adverse health and social consequences. The consumer response to changes in alcohol affordability is an important issue on alcohol policy debates. Studies from many countries have shown an inverse relationship between alcohol prices and alcohol consumption in the population. There are, however, suggestions that increasing the price of alcohol by rising taxes may have limited effect on alcohol-related problems, associated with long-term heavy drinking. The aim of the present study was to evaluate the relationship between alcohol affordability and alcohol-related mortality rates in post-Soviet Belarus. For this purpose trends in alcohol-related mortality rates (mortality from liver cirrhosis, pancreatitis, alcoholism and alcohol psychoses) and affordability of vodka between 1990 and 2010 were compared. The time series analysis revealed that 1% increase in vodka affordability is associated with an increase in liver cirrhosis mortality of 0,77%, an increase in pancreatitis mortality of 0.53%, an increase in mortality from alcoholism and alcohol psychoses of 0,70%. The major conclusion emerging from this study is that affordability of alcohol is one of the most important predictor of alcohol-related problems in a population. These findings provide additional evidence that decreasing in affordability of alcohol is an effective strategy for reducing alcohol consumption and alcohol-related harm.


Stroke is an international health problem with high associated human and economic costs. The mortality rate from stroke in Russia is one of the highest in the world. Risk factors identification is therefore a high priority from the public health perspective. Epidemiological evidence suggests that binge drinking is an important determinant of high stroke mortality rate in Russia. The aim of the present study was to estimate the premature stroke mortality attributable to alcohol abuse in Russia on the basis of aggregate-level data of stroke mortality and alcohol consumption. Age-standardized sex-specific male and female stroke mortality data for the period 1980-2005 and data on overall alcohol consumption were analyzed by means ARIMA time series analysis. The results of the analysis suggest that 26.8% of all male stroke deaths and 18.4% female stroke deaths in Russia could be attributed to alcohol. The estimated alcohol-attributable fraction for men ranged from 16.2% (75+ age group) to 57,5% (30-44 age group) and for women from 21.7% (60-74 age group) and 43.5% (30- 44 age group). The outcomes of this study provide support for the hypothesis that alcohol is an important contributor to the high stroke mortality rate in Russian Federation. Therefore prevention of alcoholattributable harm should be a major public health priority in Russia. Given the distribution of alcohol-related stroke deaths, interventions should be focused on the young and middle-aged men and women.


Razvodovsky Y.E.,Grodno State Medical University
Psychiatria Danubina | Year: 2011

Background: Research evidence has suggested that the consumption of different types of alcoholic beverage may have a differential effect on suicide rate. The aim of this study was to examine the relation between the consumption of different beverage types and suicide rates in Russia. Subjects and methods: Age-standardized sex- and age-specific suicide rate for the period 1980-2005 and data on beverage-specific alcohol sale were obtained from the Russian State Statistical Committee. Time-series analytical modeling techniques (ARIMA) were used to examine the relationship between the sale of different alcoholic beverages and suicide rates. Results: Vodka consumption as measured by sale was significantly associated with both male and female suicide rate. The consumption of beer and wine were not associated with suicide rate. The estimates of the age specific models for men were positive (except for the 75+ age group) and ranging from 0.069 (60-74 age group) to 0.123 (30-44 age group). The estimates for women were positive for the 15-29 age group (0.08), 30-44 age group (0.096) and 45-59 age group (0.057). Conclusions: These findings suggest that public health efforts should focus on both reducing overall consumption and changing beverage preference away from distilled spirits in order to reduce suicide rate in Russia. © Medicinska naklada.


Razvodovsky Y.E.,Grodno State Medical University
Adicciones | Year: 2010

Background: High violent mortality rate in Russia and its profound fluctuation over recent decades have attracted considerable interest. A mounting body of evidence points to the binge drinking pattern as a potentially important contributor to the violent mortality crisis in Russia. In line with this evidence, we assume that higher level of vodka consumption in conjunction with binge drinking pattern results in close aggregate-level association between vodka sales and violent mortality rates in Russia. Aims and Methods: To test this hypothesis, trends in beverage-specific alcohol sales per capita and mortality rates from external causes in Russia between 1980 and 2005 were analyzed by means of ARIMA time-series analysis. Results: Results of the analysis indicate that violent mortality rates tend to be more responsive to change in vodka sales per capita than to change in total level of alcohol sales. The analysis suggests that a 1-litre increase in vodka sales per capita would result in a 5% increase in violent mortality rate, an 11.3% increase in accidents and injuries mortality rate, a 9.2% increase in suicide rate, a 12.5% increase in homicide rate, and a 21.9% increase in fatal alcohol poisoning rate. Conclusion: The outcomes of this study provide support for the hypothesis that alcohol played a crucial role in the fluctuation in violent mortality rate in Russia in recent decades. Assuming that drinking vodka is usually associated with intoxication episodes, these findings provide additional evidence that the binge drinking pattern is an important determinant of the violent mortality crisis in Russia.


Accumulated research evidence suggests that alcohol is a major contributor to premature deaths toll in Russia. The aim of the present study was to estimate the premature adult mortality attributable to alcohol abuse in Russia on the basis of aggregate-level data of allcause mortality and alcohol consumption. With this purpose agestandardized sex-specific male and female all-cause mortality data for the period 1980-2005 and data on overall alcohol consumption were analyzed by means ARIMA time series analysis. As a result alcohol consumption was significantly associated with both male and female all-cause mortality rates: a 1 liter increase in overall alcohol consumption would result in a 3.9% increase in the male mortality rate and in 2.4% increase in female mortality rate. The results of the analysis also suggest that 41.1% of all male deaths and 27.8% female deaths in Russia could be attributed to alcohol. We can conclude that alcohol is a major contributor to the high mortality rate in Russian Federation. Therefore prevention of alcohol-attributable harm should be a major public health priority in Russia.

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