Griffith University is a public research university in southeastern Queensland on the east coast of Australia. The university has five campuses located on the Gold Coast, Logan City and the Brisbane suburbs of Mount Gravatt, Nathan and South Bank. Current total enrolment is approximately 43,000 with 4,000 full-time equivalent staff. Griffith University offers undergraduate and postgraduate degrees across ten discipline areas including Arts, Education, Business, Health, Law, Engineering, Information Technology, Environment, Music and Visual Arts. Wikipedia.
Griffith University | Date: 2015-04-15
A method and composition for eliciting an immune response to group A streptococcal bacteria in a mammal is provided, which includes administering to the mammal an M protein fragment, variant or derivative thereof and a SpyCEP protein or peptide fragment, or an antibody to the SpyCEP protein or fragment to facilitate restoring or enhancing neutrophil activity. Also provided is an immunodominant peptide fragment of SpyCEP.
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2013.2.3.4-2 | Award Amount: 8.64M | Year: 2014
This proposal builds on the proven methodology developed in the SEtTReND FP7 project to develop inhibitors of schistosome HME as lead compounds for new drugs. We will employ a target-based strategy for the development of novel drug leads against schistosomiasis, leishmaniasis, Chagas disease and malaria by targeting histone modifying enzymes (HME), in particular those involved in acetylation/deacetylation and methylation/demethylation. The principal objectives of A-PARADDISE are: - The identification of HMEs from Leishmania sp. and Trypanosoma cruzi and the molecular characterization and functional characterization of selected potential targets, - Phenotypic screening of Leishmania, T. cruzi, S. mansoni and P. falciparum using HME class inhibitors, inhibitors developed specifically against S. mansoni and P. falciparum HMEs. This will permit us to obtain a comprehensive view of inhibitor classes and chemical scaffolds of interest, - Production of recombinant Leishmania and T. cruzi HME proteins, structural studies. Selected, validated target enzymes will be produced, crystallized and analysed by X-ray diffraction. Assays will be optimized to permit testing of inhibitors, - High-throughput and structure-based (in silico) screening of selected HMEs. Inhibitors selected will be further screened by phenotypic assays on the parasites in vitro, - Optimisation of inhibitor structures by chemical synthesis based on molecular modelling studies (inhibitors of all origins), - Transcriptomic analysis of drug-treated parasites to verify target specificity and mechanism of action (all parasites), - Pharmacological and toxicological studies (in vitro and in vivo) of selected inhibitors, in vivo testing of compounds in parasite-infected mice. The overall objective of the A-PARADDISE project is to develop optimized epigenetic inhibitors for further testing and optimisation as drug candidates against the four parasites studied.
Nimmo G.R.,Griffith University
Clinical Microbiology and Infection | Year: 2012
The epidemic of USA300-0114 methicillin-resistant Staphylococcus aureus (MRSA) in the USA has been remarkable for its virulence and for its ability to cause infections in both the community and healthcare settings. Although it has mainly been associated with skin and soft tissue infections, particularly furunculosis, it has also caused severe life-threatening conditions such as necrotizing pneumonia, osteomyelitis, and septic arthritis. This strain or a closely related Latin American variant has now spread to multiple countries on five continents, where associated clinical and epidemiological features have been in keeping with those seen in the USA. Furthermore, it has become the dominant community-associated MRSA strain in five countries. It is now a major international epidemic strain, but whether it will fant established community-associated strains in other countries remains to be seen. © 2012 The Author. Clinical Microbiology and Infection © 2012 European Society of Clinical Microbiology and Infectious Diseases.
Berners-Price S.J.,Griffith University
Angewandte Chemie - International Edition | Year: 2011
The next generation: Classical Pt II anticancer compounds contain cis diam(m)ine ligands and are activated by ligand-substitution reactions. Pt IV diam(m)ine diazido dihydroxo complexes are nontoxic to cells until activated by light. Replacement of the diam(m)ine ligands in a trans configuration by pyridine gives a complex that is potently cytotoxic when irradiated with visible light and which has potential as a photochemotherapeutic agent. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Prestridge S.,Griffith University
Computers and Education | Year: 2012
This paper explores teacher beliefs that influence the ways Information and Communications Technologies (ICT) are used in learning contexts. Much has been written about the impact of teachers' beliefs and attitudes to ICT as 'barriers' to ICT integration (Ertmer, Ottenbreit-Leftwich, & York, 2007; Higgins & Moseley, 2001; Loveless, 2003). This paper takes a closer look at the types of beliefs that influence ICT practices in classrooms and the alignment of these beliefs to current pedagogical reform in Australia. The paper draws on data collected through the initial phase of a research project that involved an Industry Collaborative of four Catholic primary schools (prep - grade 7). Data are drawn from teacher surveys, interviews and document analysis. The results present specific links between ICT beliefs that are informing teachers' practices. ICT beliefs and practices are aligned to reform agenda for digital pedagogies. The findings of this research inform teacher ICT practice and requirements for ICT professional development. © 2011 Elsevier Ltd. All rights reserved.
Good M.F.,Griffith University
Science | Year: 2013
McCallum H.,Griffith University
Philosophical Transactions of the Royal Society B: Biological Sciences | Year: 2012
Invading infectious diseases can, in theory, lead to the extinction of host populations, particularly if reservoir species are present or if disease transmission is frequency-dependent. The number of historic or prehistoric extinctions that can unequivocally be attributed to infectious disease is relatively small, but gathering firm evidence in retrospect is extremely difficult. Amphibian chytridiomycosis and Tasmanian devil facial tumour disease (DFTD) are two very different infectious diseases that are currently threatening to cause extinctions in Australia. These provide an unusual opportunity to investigate the processes of disease-induced extinction and possible management strategies. Both diseases are apparently recent in origin. Tasmanian DFTD is entirely host-specific but potentially able to cause extinction because transmission depends weakly, if at all, on host density. Amphibian chytridiomycosis has a broad host range but is highly pathogenic only to some populations of some species. At present, both diseases can only be managed by attempting to isolate individuals or populations from disease. Management options to accelerate the process of evolution of host resistance or tolerance are being investigated in both cases. Anthropogenic changes including movement of diseases and hosts, habitat destruction and fragmentation and climate change are likely to increase emerging disease threats to biodiversity and it is critical to further develop strategies to manage these threats. © 2012 The Royal Society.
Vivoda V.,Griffith University
Energy Policy | Year: 2012
If energy security is defined as the availability of energy at all times in various forms, in sufficient quantities and at affordable prices, without unacceptable or irreversible impact on the economy and the environment, Japan is facing an energy security predicament. For a country that was already uneasy about energy security, the March 11, 2011 earthquake and tsunami, which caused a nuclear catastrophe in TEPCO's Fukushima Daiichi nuclear power plant, turned this unease into outright anxiety. With the temporary and/or permanent closure of many nuclear reactors Japan has had to replace lost power. Tokyo has had no choice but to secure additional fossil fuels, a strategy that has negatively affected Japan's economy due to rising fuel costs. The increase in Japan's fossil fuel consumption has also caused a significant increase in greenhouse gas emissions, and affected Tokyo's commitment to Kyoto targets. This paper analyzes the consequences of the 2011 nuclear disaster for Japan's energy security. Recognizing that Japan's future energy policy choices are constrained and path dependent, the paper outlines energy policy recommendations for Japan's government. © 2012 Elsevier Ltd.
Fry B.,Griffith University
Marine Ecology Progress Series | Year: 2013
Statistical mixing models have been developed to help ecologists deal with isotope tracer data and to estimate source contributions in complex systems such as food webs and sediments. However, there are often too few tracer measurements and too many sources, so that unique solutions are not possible in underdetermined mixing models. This review highlights 3 approaches for solving otherwise underdetermined mixing models. The approaches include frequency-based statistics, calculations based on sectors measured in mixing polygons, and linear mixing between central and sidewall points in the mixing polygons. All approaches have some assumptions that allow extrapolation of mean solutions from measured data, with the simplest assumption being that any uncertainty in source contributions is divided in an even-handed manner among sources. A new graphical approach is proposed that allows scientists to critically recognize and separate datasupported aspects of solutions from any assumed aspects of solutions. The data-supported aspects of solutions can be tracked conservatively as the sum of the minimum source contributions, SMIN, and for the many cases where SMIN is low, additional ways to approach mixing problems are summarized from the published literature. Many underdetermined mixing problems do not have robust mean solutions with tracers employed thus far, so that there is a longerterm need for additional tracers and methodologies to really solve these complex ecological problems. This review concludes with several practical steps one can take to interpret isotope tracer information from underdetermined systems. © Inter-Research 2013.
Griffith University | Date: 2016-10-26
The present invention relates to a method for producing a sport beverage, comprising the steps of providing malt and/or unmalted grains, providing mashing liquor produced from spent grains, processing the malt and the mashing liquor to obtain a wort, fermenting the wort by using a yeast and optionally, blending with flavour(s) and/or vitamin(s); and/or adding of sugar(s). The present invention further relates to a sport beverage obtained by said method, wherein said sport beverage is non-alcoholic or has an alcohol content of less than about 1.2 vol-%, preferably less than about 0.5 vol-%. The present invention also relates to the use of the sport beverage before and/or after physical activities.