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Lakshmi T.,Saveetha Dental College and Hospital | Krishnan V.,SRM University | Rajendran R.,Green Chemical Herbal Extracts and Formulations | Madhusudhanan N.,Sathyabama Dental College
Pharmacognosy Reviews | Year: 2015

Azadirachta indica commonly known as Neem, is an evergreen tree. Since time immemorial it has been used by Indian people for treatment of various diseases due to its medicinal properties. It possesses anti-bacterial, anti-cariogenic, anti-helminthic, anti-diabetic, anti-oxidant, astringent, anti-viral, cytotoxic, and anti-inflammatory activity. Nimbidin, Azadirachtin and nimbinin are active compounds present in Neem which are responsible for antibacterial activity. Neem bark is used as an active ingredient in a number of toothpastes and toothpowders. Neem bark has anti-bacterial properties, it is quite useful in dentistry for curing gingival problems and maintaining oral health in a natural way. Neem twigs are used as oral deodorant, toothache reliever and for cleaning of teeth. The objective of this article is to focus on the various aspects of Azadirachta indica in dentistry in order to provide a tool for future research. © 2015, Medknow. All rights reserved.


PubMed | SRM University, Saveetha Dental College and Hospital, Green Chemical Herbal Extracts and Formulations and Sathyabama Dental College
Type: Journal Article | Journal: Pharmacognosy reviews | Year: 2015

Azadirachta indica commonly known as Neem, is an evergreen tree. Since time immemorial it has been used by Indian people for treatment of various diseases due to its medicinal properties. It possesses anti-bacterial, anti-cariogenic, anti-helminthic, anti-diabetic, anti-oxidant, astringent, anti-viral, cytotoxic, and anti-inflammatory activity. Nimbidin, Azadirachtin and nimbinin are active compounds present in Neem which are responsible for antibacterial activity. Neem bark is used as an active ingredient in a number of toothpastes and toothpowders. Neem bark has anti-bacterial properties, it is quite useful in dentistry for curing gingival problems and maintaining oral health in a natural way. Neem twigs are used as oral deodorant, toothache reliever and for cleaning of teeth. The objective of this article is to focus on the various aspects of Azadirachta indica in dentistry in order to provide a tool for future research.


Lakshmi T.,Saveetha Dental College and Hospitals | Madhusudhanan N.,Sathyabhama Dental College and Hospitals | Rajendran R.,Green Chemical Herbal Extracts and Formulations
Research Journal of Pharmacy and Technology | Year: 2013

Nymphaea alba commonly known as white water lily, an aquatic flowering plant. It contains the active alkaloids nupharine and nymphaeine, and flowers possess sedative and acts as an aphrodisiac. Roots and stalks are used in traditional herbal medicine along with the flower, the petals and other flower parts are the most widely used for medicinal purpose. In modern herbal practice it is used as a remedy for dysentery. The aim of the article is to update the pharmacological actions of the plant for the basis of future research. © RJPT.


Lakshmi T.,Saveetha Dental College and Hospitals | Rajendran R.,Green Chemical herbal extracts and formulations
International Journal of Pharma and Bio Sciences | Year: 2013

Hemidesmus indicus is widely used in Ayurveda for treatment of various disease conditions. It is used as a tonic, demulcent, diaphoretic, diuretic and blood purifier. The therapeutic action of the herb is due to presence of major chemical constituents like coumarinolignoids hemidesmine and hemidesmin. This herb is beneficial in skin disorders, urinary tract infections and to treat kidney failure. Based on the scientific research the article is reviewed to reveal the therapeutic aspects of the herbal extract for the beneficial of further research.


Lakshmi T.,Saveetha Dental College and Hospitals | Rajendran R.,Green Chemical herbal extracts and formulations
International Journal of ChemTech Research | Year: 2013

The present paper deals with the estimation of Boswellic acids and Gymnemic acids in Boswellia serrata & Gymnema sylvestre of therapeutic importance, which is an important medicinal plants. This study involves the quantitative determination of secondary metabolites. The amount of the Boswellic acid present in Boswellia serrata extract are reported (65%) and for Gymnemic acids in Gymnema sylvestre it is estimated as 27%.This data has provided the basis for its wide use as the therapeutic agent both in the traditional and folk medicines.


Lakshmi T.,Saveetha Dental College and Hospitals | Rajendran R.,Green Chemical Herbal extracts and Formulations
International Journal of Pharma and Bio Sciences | Year: 2012

Acacia catechu willd (Family: Fabaceae and subfamily: Mimosoideae) known as Black cutch has a diverse pharmacological and phytochemical importance. It is a potent medicinal plant in the traditional Indian medicinal systems. The leaves, bark, heartwood had many nutritional and medicinal uses .The aim of our present study is to investigate the Estimation of Bioflavonoid Quercetin in Acacia catechu Ethanolic Leaf extract by HPLC method.


Lakshmi T.,Saveetha Dental College and Hospitals | Rajendran R.,Green Chemical Herbal Extracts and Formulations | Raghavan V.,Green Chemical Herbal Extracts and Formulations | Silvester A.,Green Chemical Herbal Extracts and Formulations
Biosciences Biotechnology Research Asia | Year: 2014

To establish the fingerprint profile of total extract of Caralluma fimbriata using high performance thin layer chromatography (HPTLC) technique. HPTLC studies were carried out. CAMAG HPTLC system equipped with Linomat V applicator, TLC scanner 3, Reprostar 3 and WIN CATS-4 software were used. HPTLC finger printing of Caralluma fimbriata leaf extract revealed that the chromatogram obtained with the reference solution shows in the middle part a Dark blue zone [Slimalumaside A] at RF 0.33 and in the upper part a Blue zone [Slimalumaside B] at RF 0.94 was observed. It can be concluded that HPTLC fingerprint analysis of total extract of Caralluma fimbriata can be used as a diagnostic tool for the appropriate identification various extracts.


Sudhakara G.,Sri Krishnadevaraya University | Mallaiah P.,Sri Krishnadevaraya University | Sreenivasulu N.,Sri Krishnadevaraya University | Sasi Bhusana Rao B.,Sri Krishnadevaraya University | And 2 more authors.
Journal of Physiology and Biochemistry | Year: 2014

The main aim of this study was to investigate the beneficial effects of hydro-alcoholic extract of Caralluma fimbriata (CFE) on the effects of high-fat diet feeding on insulin resistance and oxidative stress in Wistar rats. High-fat diet (60% of fat) and CFE (200 mg/kg body weight/day) were given concurrently to the rats for a period of 90 days. Feeding with high-fat diet resulted in the development of hyperglycemia, hyperinsulinemia, hyperleptinemia, and hypertriglyceridemia and impaired insulin sensitivity ( P <0.05). Administration of CFE to high-fat diet-fed rats for 90 days resulted in a significant improvement in plasma glucose, insulin, leptin, and triglycerides. Regarding liver antioxidant status, high-fat fed rats showed higher levels of lipid peroxidation, protein oxidation and lower GSH levels and lower activities of enzymatic antioxidants, while CFE treatment prevented all these observed abnormalities. In conclusion, intake of CFE may be beneficial for the suppression of high-fat diet-induced insulin resistance and oxidative stress. © University of Navarra 2014.


PubMed | Green Chemical Herbal Extracts and Formulations and Sri Krishnadevaraya University
Type: | Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie | Year: 2016

The objective of the present study was to investigate the preventive effects of hydro-alcoholic extract of Caralluma fimbriata (CFE) and Metformin (Met) against high-fat diet (HF-diet) induced alterations in lipid metabolism in Wistar rats. The experimental animals were divided into five groups, two of which were fed with chow diet and the other three with HF- (60%) diet. CFE (200mg/kg body weight/day) was administered through oral route to each group of chow-fed rats, HF-fed rats and Met (20mg/kg body weight/day) to one of the HF-diet fed groups. At the end of 90days of experimental period, hypercholestermia, hypertriglycerdemia, with decreased HDL-cholesterol and increased LDL, VLDL-cholesterol and atherogenic index and elevated levels of serum and hepatic transaminases and hepatic lipids (p<0.05) and alterations in the activities of enzymes of lipid metabolism, and the liver showed mild to severe distortion of the normal architecture as well as prominence and widening of the liver sinusoids as observed in HF-fed rats, were prevented by CFE/Met treatment. The results showed that CFE/Met supplementation ameliorated significantly the disturbance in serum and hepatic transaminases, plasma and hepatic lipid profile and lipid metabolism under HF-fed conditions. It can be concluded from these results that CFE might be valuable in reducing the alterations related to lipid metabolism under high calorie diet consumption.

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