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Salt Lake City, UT, United States

Lancaster N.,Desert Research Institute | McCarley-Holder G.,Great Basin
Geomorphology | Year: 2013

Aerial photographs and satellite images have been used to document the evolution of a small (<1km2) dunefield over the past 60-70years. Over this period, the dunefield has undergone significant changes, including development of well defined linear and crescentic dunes from an initial small area of partially vegetated dunes, resulting in an increase in the area of the dunes by a factor of 3 since 1944. The dune field continues to expand toward the southeast but its upwind margins are now experiencing significant erosion because the sand supply is now cut off by dust control measures in the source area and transport pathway. This study provides some information on the timescales of dune development in a high-energy aeolian environment, which formerly experienced an abundant supply of sand, with rapid development of crescentic dunes over a period of 20years. The complexity of dunefield development is also highlighted, even on decadal timescales, and the important role of episodic sediment supply in forming new generations of dunes. Periods of rapid dunefield change involving lagged input of additional sand from external sources appear to be linked to episodes of high flows in the Owens River, which is the main sediment source for the Keeler Dunes. © 2012 Elsevier B.V. Source


Patent
Great Basin | Date: 2015-11-23

Methods and materials are disclosed relating to an improved method for amplifying a signal in a diagnostic assay for a nucleic acid, comprising the steps of providing an amplification polymer bound to a nucleic acid analyte, wherein the amplification polymer comprises a plurality of amine groups; binding amine groups on the amplification polymer with a detectable label complex; and reacting under high salt conditions an acetylating compound with amine groups not bound with a detectable label complex.


Composition and methods for amplifying and detecting solution-state polynucleotide targets in a single device are described. In one aspect, a method for a coupled isothermal amplification and detection process utilizes a coated solid support, including a solid substrate, a cationic layer, and a plurality of target-specific probes attached to the coated solid support. Polynucleotide targets in the sample are amplified by an isothermal amplification process involving in situ hybridization onto the coated solid support. The entire process can be carried out with a high degree of specificity under low salt conditions in less than one hour. Further aspects of the present invention include methods for coupled hybridization/detection of polynucleotide targets, coated silicon biosensors optimized for use with the coupled detection systems to provide visual detection of polynucleotide targets under visible light conditions, and kits for practicing in the above described methods.


Patent
Great Basin | Date: 2013-06-03

Methods for rapidly detecting clinically relevant mutations in the infectious genome of an agent are disclosed. The methods include use of a novel target and temperature dependent RNase H mediated cleavage of blocked DNA primers to initiate isothermal helicase-dependent amplification of a target sequence such as a sequence in the rpoB gene.


An in vitro diagnostics analyzer and assay cartridge for carrying out biochemical assays is disclosed. The analyzer includes a tilted clamp assembly for holding an assay cartridge, upper and lower motor assemblies for manipulating the assay cartridge, and an optical reader. The cartridge includes an injection port for receiving a biological sample, a central channel through which the sample passes, one or more processing chambers, one or more reagent containers, a detection chamber, and optionally a waste chamber. The analyzer and cartridge may be used for detection of a variety of analytes, including pathogens for medical diagnostics.

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