Entity

Time filter

Source Type

Guangzhou, China

Hu X.H.,Jinling Institute of Technology | Li D.,Grandhope Biotech Co.
Materials Technology | Year: 2013

Hydrogel contact lenses are ideal carriers for ophthalmic drug delivery. Conventional poly(hydroxyethyl methacrylate) hydrogel contact lenses have restricted applications in ophthalmic drug delivery due to low oxygen transmissibility. Water and hydrophilic monomer N-vinyl-2-pyrrolidone are introduced in polymerisation to enhance the properties of hydrogel such as gelation time, transparency, structure, swelling and water retention properties in this work. Norfloxacin as a drug model could be loaded into hydrogels by soaking repeatedly. The sustained drug release in a given period is dependent on the characteristics of solution and loading time. © 2013 W. S. Maney & Son Ltd.


Hu X.,Jinling Institute of Technology | Li D.,Grandhope Biotech Co. | Tan H.,Nanjing University of Science and Technology | Pan C.,Jinling Institute of Technology | Chen X.,Jinling Institute of Technology
Journal of Macromolecular Science, Part A: Pure and Applied Chemistry | Year: 2014

Injectable hydrogels have attracted a lot of attention in drug delivery, however, their capacity to deliver water-insoluble or hydrophobic anti-cancer drugs is limited. Here, we developed injectable graphene oxide/graphene composite supramolecular hydrogels to deliver anti-cancer drugs. Pluronic F-127 was used to stabilize graphene oxide (GO) and reduced graphene oxide (RGO) in solution, which was mixed with α-cyclodextrin (α-CD) solution to form hydrogels. Native hydrogel was used as control. GO or RGO slightly shortened gelation time. The storage and loss moduli of the hydrogels were tracked by dynamic force measurement. The storage modulus of GO or RGO composite hydrogels was larger than that of the native hydrogel. Hydrogels were unstable in solution and eroded gradually. GO or RGO in Pluronic F-127 solution could potentially improve the solubility of the water-insoluble anti-cancer drug camptothecin (CPT), especially with large drug-loaded CPT amount. Drug release behaviors from solutions and hydrogels were characterized. The nanocomponents (GO or RGO) were able to bind more drug molecules either for CPT or for doxorubicin hydrochloride (DXR) in solution. Therefore, GO or RGO composite hydrogel could potentially enable better controlled and gentler drug release (for both CPT and DXR) than native hydrogel. © 2014 Copyright Taylor & Francis Group, LLC.


Hu X.,Jinling Institute of Technology | Chen X.,Jinling Institute of Technology | Tan H.,Nanjing University of Science and Technology | Li D.,Grandhope Biotech Co. | And 2 more authors.
Journal of Macromolecular Science, Part A: Pure and Applied Chemistry | Year: 2013

Considering that conventional hydrogels showed limited capabilities of controlling hydrophobic drug loading and releasing and graphene materials had interactions with hydrophobic drugs, we designed a graphene oxide (GO) composite hydrogel for drug delivery. But GO could not disperse well in monomer solution and agglomerated badly. Thus, water-soluble GO (GO-tripolymer) was first prepared under the stabilization of amphiphilic polymer, Pluronic F-127. The GO-tripolymer showed good solubility in PBS with the increase of polymer concentration. All GO-tripolymer solutions had the same UV absorption peaks as GO. Then, GO composite hydrogels (HNG hydrogels) were formed by the polymerization of hydroxyethyl methacrylate (HEMA), N-Vinyl pyrrolidone (NVP) and GO-tripolymer mixture. The introduction of GO-tripolymer had little effect on the gelation time and equilibrium swelling ratio of hydrogel. The freeze-drying hydrogel showed porous structure. The pore size decreased and the rough surface was detected with the increase of GO concentration. HNG hydrogel could load more puerarin and norfloxacin than conventional hydrogel (HN hydrogel). Moreover, HNG hydrogel could control puerarin and norfloxacin release more steadily than HN hydrogel. HNG exhibited low cytotoxicity. © 2013 Copyright Taylor and Francis Group, LLC.


Hu X.,Jinling Institute of Technology | Qiu J.,Jinling Institute of Technology | Tan H.,Nanjing University of Science and Technology | Li D.,Grandhope Biotech Co. | Ma X.,Jinling Institute of Technology
Journal of Macromolecular Science, Part A: Pure and Applied Chemistry | Year: 2013

Hydrogel contact lenses are ideal drug carriers for ophthalmic drugs delivery. However, some drawbacks of traditional hydrogel restricted their application in the drug delivery field. Herein, we introduced chitosan and β-cyclodextrin (β-CD) into traditional hydrogel in order to improve the properties and control drug release. β-CD functionized and crosslinkable chitosan derivative (CCH) was synthesized and introduced into HEMA/NVP monomers to form HNC tripolymer hydrogel. The introduction of CCH accelerated the polymerization of monomers. Other properties such as equilibrium swelling ratio and oxygen transmissibility of HNC hydrogel were superior to that of HN hydrogel. The capacity of HNC hydrogel to resist the protein absorption was also superior to that of HN hydrogel. Hydrogels exhibited different capacity of drug loading and releasing for different drug. © 2013 Copyright Taylor and Francis Group, LLC.


Hu X.H.,Jinling Institute of Technology | Tan H.P.,Nanjing University of Science and Technology | Li D.,Grandhope Biotech Co. | Gu M.Y.,Jinling Institute of Technology
Materials Technology | Year: 2014

Soft contact lenses are very popular for vision correction and cosmetic alterations since 1960. However, wearing soft contact lenses induced many healthy problems, which are often related to the surface properties of contact lenses such as low wettability and protein deposition. Chitosan (CS)/Hyaluronic acid (HA) multilayer was assembled on the surface of contact lenses by layer-bylayer (LbL) technique to improve the surface properties of low wettability and protein deposition in the research. Surface modification improved the hydrophilic, reduced protein adsorption, enhanced water retention and increased the surface roughness length. Since LbL self-assembled multilayer films were proved to deliver drug effectively, norfloxacin and timolol as model drugs were loaded into CS/HA multilayer during LbL process. The contact lens with CS/HA multilayer could control norfloxacin steadily release in 1 h, timolol steadily release in half an hour. The novel aspect of the research is the construction of CS/HA multilayer on the surface of contact lenses for improving their surface properties and drug delivery. The impact of the research concerns the applications of multilayer and LBL technique, which opens up a useful way to decrease the problem of wearing hydrogel contact lenses and increase the possibility of hydrogel contact lenses as drug carrier. © 2014 W. S. Maney & Son Ltd.

Discover hidden collaborations