Aix-en-Provence, France
Aix-en-Provence, France
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Patent
Graftys Inc. | Date: 2017-10-11

The present invention relates to a bone cement paste containing a powder component comprising -tricalcium phosphate (-TCP) particles having an average size greater than or equal to 10 m and a liquid component comprising blood or a blood-derived product.


Verron E.,French Institute of Health and Medical Research | Verron E.,Graftys Inc. | Khairoun I.,French Institute of Health and Medical Research | Guicheux J.,French Institute of Health and Medical Research | Bouler J.-M.,French Institute of Health and Medical Research
Drug Discovery Today | Year: 2010

A short review is proposed on the existing literature for the research performed in calcium phosphate (CaP) biomaterials used as drug delivery systems. In the first part, a brief update is given on the performance of both CaP ceramics and CaP cements. Second, a review of the research and clinical situation is developed for CaP materials already used as drug delivery systems. Experimental works performed for local delivery are reported. In particular, a description is given of the in vitro and in vivo studies in which these materials are loaded with various proteins and drugs. © 2010 Elsevier Ltd.


Patent
Graftys Inc., University of Nantes and French National Center for Scientific Research | Date: 2010-03-03

The present invention relates to a galliated calcium-phosphate biomaterial comprising a gallium-doped phosphocalcic compound of formula (I): Ca(_(005-1 5X))Ga_(x)(POO_(4))7, wherein 0


Patent
Graftys Inc., University of Nantes and French National Center for Scientific Research | Date: 2014-11-14

The present invention relates to a macroporous, resorbable and injectable apatitic calcium-phosphate cement with a high compressive strength useful as bone cement and releasing a bone resorption inhibitor, preparation method and uses thereof.


Patent
Graftys Inc. and French National Center for Scientific Research | Date: 2010-09-15

The present invention relates to a gallium-doped phosphocalcic compound of formula (I):Ca_((10.5-1.5x))Ga_(x)(PO_(4))_(7)(I)wherein 0 < x < 1 and the salts, hydrates and mixtures thereof. The invention further relates to a solid state process and a process in solution for the manufacture of such compounds and the use thereof for the preparation of a biomaterial, in particular a self-setting calcium-phosphate cement (CPC).


Patent
Graftys Inc. and French National Center for Scientific Research | Date: 2010-09-15

The present invention relates to a galliated calcium-phosphate biomaterial comprising a gallium-doped phosphocalcic compound of formula (I):Ca_((10.5-1.5x))Ga_(x)(PO_(4))_(7)(I)wherein 0 < x < 1 and the salts, hydrates and mixtures thereof and/or a calcium deficient apatite structure with in particular a (Ca + Ga)/P molar ratio in the range of 1.3 to 1.67, and a gallium content up to 4.5 % by weight. It also relates to processes of preparation of such materials and uses thereof, in particular as dental or bony implants. It further relates to a kit comprising a galliated calcium-phosphate biomaterial in combination with a fluid component. It finally relates to methods of use of the galliated calcium-phosphate biomaterial, notably for III) ions increase radio-opacity after bone implantation and can be released for inhibiting bone resorption.


Zhang J.,University of Nantes | Liu W.,University of Nantes | Schnitzler V.,University of Nantes | Schnitzler V.,Graftys Inc. | And 2 more authors.
Acta Biomaterialia | Year: 2014

Since their initial formulation in the 1980s, calcium phosphate cements (CPCs) have been increasingly used as bone substitutes. This article provides an overview on the chemistry, kinetics of setting and handling properties (setting time, cohesion and injectability) of CPCs for bone substitution, with a focus on their mechanical properties. Many processing parameters, such as particle size, composition of cement reactants and additives, can be adjusted to control the setting process of CPCs, concomitantly influencing their handling and mechanical performance. Moreover, this review shows that, although the mechanical strength of CPCs is generally low, it is not a critical issue for their application for bone repair - an observation not often realized by researchers and clinicians. CPCs with compressive strengths comparable to those of cortical bones can be produced through densification and/or homogenization of the cement matrix. The real limitation for CPCs appears to be their low fracture toughness and poor mechanical reliability (Weibull modulus), which have so far been only rarely studied. © 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.


Patent
Graftys Inc., Ecole Nationale Veterinaire De Nantes and University of Nantes | Date: 2013-09-03

The present invention concerns a composition useful as bone substitute comprising one or more calcium-phosphate compounds in association with an analgesic. It also refers to a preparation process of said composition, a preparation process of a drug-combined device comprising said composition, the drug combined device thus obtained, a kit comprising said composition and the use of said composition for the preparation of a drug-combined device useful for filling a bony defect caused in the iliac crest by collection of auto-graft bone, as a scaffold for tissue engineering and to produce a dental or bony implant.


Patent
University of Nantes and Graftys Inc. | Date: 2010-03-03

The present invention relates to a gallium-doped phosphocalcic compound of formula (I): Ca_((10.5-1.5x))Ga_(x)(PO_(4))_(7), wherein 0


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