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Pantnagar, India

Govind Ballabh Pant University of Agriculture and Technology is the first agricultural university of India. It was inaugurated by Jawahar Lal Nehru on 17 November 1960 as the Uttar Pradesh Agricultural University . Later the name was changed to Govind Ballabh Pant University of Agriculture and Technology in 1972 in memory of the first Chief Minister of Uttar Pradesh and statesman Pandit Govind Ballabh Pant. The University was declared as the best among all the other State Universities in India, in 1997. The University lies in the campus-town of Pantnagar in the district of Udham Singh Nagar in the state of Uttarakhand. The university is regarded as the harbinger of Green Revolution in India. Wikipedia.

Pandey R.,Forest Health Services | Mishra A.,Govind Ballabh Pant University of Agriculture & Technology
Applied Biochemistry and Biotechnology | Year: 2010

The antibacterial activity of Aloe barbadensis was tested on clinically isolated bacterial pathogens i.e. Enterococcus bovis, Staphylococcus aureus, Escherichia coli, Proteus vulgaris, Proteus mirabilis, Pseudomonas aeruginosa, Morganella morganii, and Klebsiella pneumoniae causing infection in human being. Ethanolic and aqueous extracts were used for the antibacterial effect, which was measured by the appearance of zone of inhibition. Relatively higher MIC concentrations were obtained for gram negative bacteria E. coli and K. pneumoniae, with ethanol extract; however, no inhibitory effect was noted for aqueous extract. Ethanolic extract possesses great inhibitory activity for gram positive bacteria, E. bovis followed by S. aureus. Among gram negative bacteria, highest inhibitory effect was observed with P. aeruginosa, followed by M. morganii, P. mirabilis, and P. vulgaris, which was significant (p∈<∈0.01) than E. coli and K. pneumoniae. Antimicrobial activity tests of crude extract of A. barbadensis were carried out to validate the use of traditional medicinal herbal and results of this study tend to give credence to the common use of A. barbadensis gel and leaf. © 2009 Humana Press. Source

Parakh N.,Govind Ballabh Pant University of Agriculture & Technology | Bhargava B.,All India Institute of Medical Sciences
American Journal of Cardiovascular Drugs | Year: 2011

The importance of heart rate in human health and disease has been well known to clinicians for quite some time. Recent epidemiologic studies have further strengthened this concept. Modulation of heart rate by pharmacologic as well as non-pharmacologic means has affected cardiovascular mortality and morbidity in various trials and observational studies. Conventional rate-control agents, such as β-adrenoceptor antagonists (β-blockers), calcium channel blockers, and digoxin, have contributed greatly to the management of various diseases where heart-rate reduction is required; however, these agents have effects beyond rate control that may be unacceptable.Ivabradine has recently been recognized as a pure heart-rate-reducing agent and is being extensively studied. It is the latest addition to the class of drugs used to control angina. It is indicated in cases of β-blocker intolerance or when β-blockers fail to achieve a heart rate of <60 beats/min. The pure heart-rate-reducing effect of ivabradine has also been reported in smaller studies and anecdotal case reports. The theoretical possibilities of the utility of ivabradine are many and have opened up a whole new field of research for the future. The BEAUTIFUL trial enrolled approximately 10000 patients with coronary artery disease (CAD) and left ventricular dysfunction, with the aim of assessing the effect of ivabradine versus atenolol on various cardiovascular outcomes. Although ivabradine failed to achieve favorable results for primary endpoints, it appeared effective in achieving a favorable secondary endpoint in a subgroup of patients who had a heart rate of >70 beats/min. Other large trials are also underway to assess the effects of ivabradine on heart failure, acute coronary syndromes, CAD, and other cardiovascular disorders. In this review, we discuss the pharmacologic basis of the action of ivabradine and its role in angina control, as well as in other conditions being actively studied or in which a role for ivabradine has been hypothesized. © 2011 Adis Data Information BV. All rights reserved. Source

Marla S.S.,Govind Ballabh Pant University of Agriculture & Technology | Singh V.K.,Banaras Hindu University
Functional and Integrative Genomics | Year: 2012

Plant Lipoxygenases (LOX) are known to play major role in plant immunity by providing front-line defense against pathogen-induced injury. To verify this, we isolated a full-length OsLOX3 gene and also 12 OsLOX cDNA clones from Oryza sativa indica (cultivar Pusa Basmati 1). We have examined the role played by LOXs in plant development and during attack by blast pathogen Magnaporthe grisea. Gene expression, promoter region analysis, and biochemical and protein structure analysis of isolated OsLOX3 revealed significant homology with LOX super family. Protein sequence comparison of OsLOXs revealed high levels of homology when compared with japonica rice (up to100%) and Arabidopsis (up to 64%). Isolated LOX3 gene and 12 OsLOX cDNAs contained the catalytic LOX domains much required for oxygen binding and synthesis of oxylipins. Amino acid composition, protein secondary structure, and promoter region analysis (with abundance of motifs CGTCA and TGACG) support the role of OsLOX3 gene in providing resistance to diseases in rice plants. OsLOX3 gene expression analysis of root, shoot, flag leaf, and developing and mature seed revealed organ specific patterns during rice plant development and gave evidence to association between tissue location and physiological roles played by individual OsLOXs. Increased defense activity of oxylipins was observed as demonstrated by PCR amplification of OsLOX3 gene and upon inoculation with virulent strains of M. grisea and ectopic application of methyl jasmonate in the injured leaf tissue in adult rice plants. © Springer-Verlag 2012. Source

Datta S.N.,Govind Ballabh Pant University of Agriculture & Technology
Aquaculture | Year: 2011

Comparative study was conducted to examine growth rate, biomass production and proximate composition of six different Azolla species. Essential amino acids (EAA) of different Azolla species in linear growth phase also analysed. A feeding trial was conducted in the cemented tanks (8.0. m. ×. 1.25. m. ×. 1.0. m) to examine efficacy of dried Azolla mixture as a feed ingredient in the diet of Labeo rohita. Azolla mixture was incorporated in diet at 15%, 25% and 35% level. Highest weight gain was recorded with the diet containing 25% Azolla mixture with specific growth rate of 0.7468% / day. The experimental fish recorded the value of exponent 'b' in the range of 2.5155 to 2.7760. The condition factor 'K' of all experimental fish was above 1.0 (1.2237-1.2326) indicating good condition of experimented fish. Incorporation of Azolla in the fish diets reduced the fat content in muscle of fish. © 2010 Elsevier B.V. Source

Tandon S.,Govind Ballabh Pant University of Agriculture & Technology
Pestology | Year: 2012

Due to continuous use of single pesticides for controlling pests in rice and wheat, residue build up of these pesticides in environment and crop were observed. Residue analysis in grain, straw and soil treated with isoproturon and butachlor at recommended rate were done by HPLC in rice- wheat cropping system for continuous nine years at harvest time. Non detectable residue of both herbicides was found in soil, grain and straw samples at harvest every year. The limit of detection for both pesticides was 0.001 μg/g. Source

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