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Ghotkar N.S.,Rashtrasant Tukadoji Maharaj Nagpur University | Ghotkar N.S.,Government Vidharbha Institute of Science and Humanities | Berad B.N.,Rashtrasant Tukadoji Maharaj Nagpur University | Berad B.N.,Government Vidharbha Institute of Science and Humanities
Der Pharma Chemica | Year: 2015

Three component condendensation of B-keto ester, aldehyde and urea or thiourea catalyzed by layered double hydroxide (LDH) to give 3,4-dihydropyrimidin-2(1H)-one is described. Catalyst has high region specific and chemo selective activity as well as no toxicity. It is cheap eco-friendly and easily synthesized catalyst. The mild reaction conditions, easy isolation of the product and high yields are the important features of this protocol.


Tayade D.T.,Government Vidharbha Institute of Science and Humanities | Jadhao N.G.,Government Vidharbha Institute of Science and Humanities
Journal of Pure and Applied Microbiology | Year: 2012

Heteroacyclic and Heterocyclic nucleus containing drugs showed remarkable and noticeable drug absorption, transmission and drug activity and effects; hence they created their own status in chemical, pharmaceutical, medicinal, agricultural and drug sciences. Thioamido, benzaimido heterocycles showed an assortment of significances, applications and importances in industrial, pharmaceutical, medicinal and drug chemistry. Considering all these facts into consideration it was thought interesting to synthesize Substitutedthiocarbamides, 2-[(2,6-Disubstitutedthiocarbamidophenyl)amino] benzeneacetic acid by interacting 2-[(2,6-dichlorophenyl)amino]benzeneacetic acid,monosodium salt with various thiourea in isopropanol medium. The justification and identification of the structure of these newly synthesized compounds had been established on the basis of chemical characterization, elemental analysis, and through spectral data.

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