Government Victoria College

Palakkad, India

Government Victoria College

Palakkad, India
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Natarajan R.,Cochin University of Science and Technology | Unnikrishnan P.A.,Cochin University of Science and Technology | Radhamani S.,N S S College | Rappai J.P.,Government Victoria College | Prathapan S.,Cochin University of Science and Technology
Tetrahedron Letters | Year: 2016

Starting from easily accessible nitrones and acetylenes, a simple, metal free synthesis of substituted quinolines under mild conditions with high atom efficiency has been developed. Our method is flexible enough to introduce substituents regiospecifically at the 2,3,4,6,8-positions of the quinoline product. © 2016 Elsevier Ltd. All rights reserved.


Vinayasree S.,Cochin University of Science and Technology | Vinayasree S.,Government Victoria College | Soloman M.A.,St Alberts College | Sunny V.,P.A. College | And 3 more authors.
Composites Science and Technology | Year: 2013

Flexible and thin single layer microwave absorbers based on strontium ferrite-carbon black-nitrile rubber composites have been fabricated employing a specific recipe and their reflection loss characteristics were studied in the S (2-4. GHz) and X-bands (8-12. GHz). The incorporation of carbon black not only reinforces the rubber by improving the mechanical properties of the composite but also modifies the dielectric permittivity of the composite. Strontium ferrite when impregnated into a rubber matrix imparts the required magnetic permeability to the composite. The combination of strontium ferrite and carbon black can then be employed to tune the microwave absorption characteristics of the resulting composite. The complex dielectric permittivity and permeability were measured by employing a cavity perturbation technique. The microwave absorption characteristics of composites were modelled in that an electromagnetic wave incident normally on the metal terminated single layer absorber. The influence of filler volume fraction, frequency, absorber thickness on the bandwidth of absorption are discussed and correlated. © 2013 Elsevier Ltd.


Reena Mary A.P.,Cochin University of Science and Technology | Reena Mary A.P.,Government Victoria College | Suchand Sandeep C.S.,Raman Research Institute | Narayanan T.N.,Rice University | And 4 more authors.
Nanotechnology | Year: 2011

Oxide free stable metallic nanofluids have the potential for various applications such as in thermal management and inkjet printing apart from being a candidate system for fundamental studies. A stable suspension of nickel nanoparticles of ∼ 5nm size has been realized by a modified two-step synthesis route. Structural characterization by x-ray diffraction and transmission electron microscopy shows that the nanoparticles are metallic and are phase pure. The nanoparticles exhibited superparamagnetic properties. The magneto-optical transmission properties of the nickel nanofluid (Ni-F) were investigated by linear optical dichroism measurements. The magnetic field dependent light transmission studies exhibited a polarization dependent optical absorption, known as optical dichroism, indicating that the nanoparticles suspended in the fluid are non-interacting and superparamagnetic in nature. The nonlinear optical limiting properties of Ni-F under high input optical fluence were then analyzed by an open aperture z-scan technique. The Ni-F exhibits a saturable absorption at moderate laser intensities while effective two-photon absorption is evident at higher intensities. The Ni-F appears to be a unique material for various optical devices such as field modulated gratings and optical switches which can be controlled by an external magnetic field. © 2011 IOP Publishing Ltd.


Joseph T.,Indian National Institute for Interdisciplinary Science and Technology | Joseph T.,Government Victoria College | Uma S.,Cochin University of Science and Technology | Philip J.,Cochin University of Science and Technology | Sebastian M.T.,Indian National Institute for Interdisciplinary Science and Technology
Journal of Materials Science: Materials in Electronics | Year: 2012

Polymer/Sr 2ZnSi 2O 7 (SZS) ceramic composites suitable for substrate applications have been developed using the polymers polystyrene (PS), high density polyethylene (HDPE) and Di-Glycidyl Ether of Bisphenol A(DGEBA). The dielectric, thermal and mechanical properties of the composites are investigated as a function of various concentrations of the ceramic filler. The obtained values of relative permittivity, dielectric loss tangent, thermal conductivity and coefficient of thermal expansion of the composites are compared with the corresponding theoretical predictions. The relative permittivity of the polymer/ceramic composites increases with filler loading. The dielectric loss tangent also shows the same trend except for DGEBA/SZS composites. The major advantages of the ceramic loading are improvement in thermal conductivity and a decrease in the coefficient of thermal expansion. The tensile strength of the composites decreases with increase in filler content, whereas an improvement is observed in microhardness. The variation of relative permittivity (at 1 MHz) of the composites is also studied as afunction of temperature. © 2011 Springer Science+Business Media, LLC.


Radhamani S.,Cochin University of Science and Technology | Natarajan R.,Cochin University of Science and Technology | Unnikrishnan P.A.,Cochin University of Science and Technology | Prathapan S.,Cochin University of Science and Technology | Rappai J.P.,Government Victoria College
New Journal of Chemistry | Year: 2015

Depending on the nature of N- and C-substituents, nitrones exhibit diverse reactivity towards electron deficient acetylenes. Observed reactions include formal 1,3-dipolar cycloaddition and nucleophilic addition reactions. Possible involvement of zwitterionic intermediates and an unusual 1-aza-Cope rearrangement account for the generation of unexpected 1:1 adducts in the reaction of N-arylnitrones. © 2015 The Royal Society of Chemistry and the Centre National de la Recherche Scientifique.


Natarajan R.,Cochin University of Science and Technology | Rappai J.P.,Government Victoria College | Unnikrishnan P.A.,Cochin University of Science and Technology | Radhamani S.,N S S College | Prathapan S.,Cochin University of Science and Technology
Synlett | Year: 2015

Starting from readily accessible nitrones and electron-deficient acetylenes, a highly efficient and versatile synthetic protocol for 3-substituted indoles has been developed. Copyright © 2015, Georg Thieme Verlag. All rights reserved.


Rappai J.P.,Cochin University of Science and Technology | Rappai J.P.,Government Victoria College | Karthikeyan J.,Cochin University of Science and Technology | Prathapan S.,Cochin University of Science and Technology | Unnikrishnan P.A.,Cochin University of Science and Technology
Synthetic Communications | Year: 2011

The dehydration of aldoximes and amides, and oxidation of benzoin are accomplished in one-pot using in situ-generated Burgess-type reagent. © Taylor & Francis Group, LLC.


Suresh V.,Rajiv Gandhi Center for Biotechnology | Suresh V.,Government Victoria College | Sojan J.,Government Victoria College | Krishna Radhika N.,Central Tuber Crops Research Institute ICAR | Asha V.V.,Rajiv Gandhi Center for Biotechnology
Journal of Ethnopharmacology | Year: 2014

Ethnopharmacological relevance: Phyllanthus rheedei Wight is a plant used by Muthuvan tribes of Kerala for treating liver related diseases. Materials and methods: The different extracts of Phyllanthus rheedei were analysed on cell lines were viz, PLC/PRF, Hep3B, FLCII10 and HepG2215 for its anti-HBV property. The analysis was done through ELISA, SQRT-PCR and immuno blotting. The most active extract was then divided in to fractions using HPTLC and the most active fraction was further identified. Results: From the screening experiments it was shown that the ethanol extract of this plant has the maximum activity in lowering the viral markers like HBsAg, HBV Core and HBV X protein and whole virions with comparatively lesser cytotoxicity. The dose responses of this particular extract were further established. Conclusions: This study concluded that the ethanol extract of Phyllanthus rheedei is very much effective in preventing the multiplication of HBV at the cellular level. This study scientifically validated the tribal claim of the use of this plant for severe liver disorders. © 2014 Elsevier Ireland Ltd. All rights reserved.


Suresh V.,Government Victoria College | Krishnakumar K.A.,Maharajas College | Asha V.V.,Rajiv Gandhi Center for Biotechnology
Biomedicine and Pharmacotherapy | Year: 2015

The existing screening systems for anti-hepatitis B virus (anti-HBV) drug discovery is time-consuming mainly due to the laborious detection system it is using. A new fluorescence based screening system for high throughput anti-HBV drug discovery was created by tagging hepatitis B surface antigen (HBsAg) with monomeric red fluorescent protein and hepatitis B virus (HBV) core protein with enhanced green fluorescent protein. The two constructs were co-transfected on to Hep3B cells and the transfection was stabilized by fluorescent activated cell sorter (FACS). The fusion proteins expressed through the secretory protein pathway as evidenced by localization with ER-Tracker and tubulin tracker. The new system has given analogues results like that of conventional enzyme-linked immunosorbent assay (ELISA). Hence it can be of very high potential for large scale drug screening systems. © 2015 Elsevier Masson SAS.


PubMed | Maharajas College, Rajiv Gandhi Center for Biotechnology and Government Victoria College
Type: | Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie | Year: 2015

The existing screening systems for anti-hepatitis B virus (anti-HBV) drug discovery is time-consuming mainly due to the laborious detection system it is using. A new fluorescence based screening system for high throughput anti-HBV drug discovery was created by tagging hepatitis B surface antigen (HBsAg) with monomeric red fluorescent protein and hepatitis B virus (HBV) core protein with enhanced green fluorescent protein. The two constructs were co-transfected on to Hep3B cells and the transfection was stabilized by fluorescent activated cell sorter (FACS). The fusion proteins expressed through the secretory protein pathway as evidenced by localization with ER-Tracker and tubulin tracker. The new system has given analogues results like that of conventional enzyme-linked immunosorbent assay (ELISA). Hence it can be of very high potential for large scale drug screening systems.

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