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Sangeetha N.,Government Thanjavur Medical College | Sangeetha N.,Government Stanley Medical College | Palaniappan V.,Government Thanjavur Medical College | Hemavathy N.,Government Thanjavur Medical College | Subathra K.,Government Theni Medical college
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2014

To evaluate the incidence, age and sex distribution of salivary gland lesions and to analyse the histopathological type and Ki-67 immunohistochemistry expressions in salivary gland tumors. Surgical specimens were fixed in 10% neutral buffered formalin. Sections of 5μ thickness were cut and stained with Hematoxylin and Eosin stains. Immunohistochemistry of Ki-67 was done in salivary gland tumors. The mean age for benign tumors, malignant tumors and non neoplastic lesions were 39, 49.05 and 33.33 yrs respectively with female predominance. The average Ki-67 labeling indexes for benign tumors were 1% and for malignant tumors were 17%. Pleomorphic adenoma was the most common benign tumor and adenoid cystic carcinoma was the most common malignant tumor. There was significantly higher frequency of Ki-67 positive cells in malignant salivary gland tumors compared to benign tumors.

Raadhika K.,Government Theni Medical college | Shanthi M.,Institute of Pharmacology
International Journal of Pharma and Bio Sciences | Year: 2012

To compare the efficacy and tolerability of oral racemic salbutamol and levosalbutamol in patients with mild bronchial asthma. a single blind trial was designed to find out the usefulness of the tablet racemic salbutamol (2mg) and levosalbutamol (1mg) given independently to 25 matched mild bronchial asthma cases who satisfied a rigid inclusion and exclusion criteria at three times daily dosage over a period of 15 days. They were assessed objectively before and after by peak flow meter and serum potassium; and subjectively by palpitation, cough, breathlessness, and wheeze. Data were analysed statistically. The mean peak expiratory flow rate before and after therapy in racemic salbutamol group was 227.50 and 248ml respectively and in levosalbutamol group 231 and 282.5ml respectively with significant improvement in both but more in latter. No significant difference in serum potassium level either in intra or in inter group was noticed. Tachycardia, tremor, and muscular cramps were significantly low in levosalbutamol group. Levosalbutamol was found to be superior to salbutamol in terms of efficacy and tolerability in patients with mild bronchial asthma as evidenced by subjective and objective means.

Thilagam G.T.,Government Theni Medical College | Tamilarasi S.,Institute of Pharmacology | Parameswari R.,Institute of Pharmacology | Raadhika R.,Institute of Pharmacology | Mathivani M.,Government Theni Medical College
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2013

Diabetes mellitus is a significant, growing threat to global health. Indians have got high central adiposity and high percentage body fat in comparison with many other populations, which is responsible for insulin resistance. Pioglitazone by acting through the PPAR gamma receptor, effectively mobilises the visceral fat to subcutaneous areas, which highly correlates with insulin resistance. The aim and objective of this study was to evaluate the effect of Pioglitazone on abdominal fat distribution in type 2 diabetic patients. Type 2 diabetic patients with fasting plasma glucose 140 - 240 mg / dl and BMI < 35 kg / m2 were selected for the study.T.Pioglitazone 15-30 mg was administered depending upon the individual blood glucose levels. Plasma glucose - fasting, postprandial, lipid profile, visceral and subcutaneous fat levels, were measured both prior and after drug administration, by using CT scan. Visceral fat was found to be decreased and subcutaneous fat was increased, which was found to be statistically significant(P < 0.001).Also plasma glucose levels were found to be reduced significantly(p<0.001). Thus from this study it was observed, that pioglitazone reduced visceral fat level & improves insulin sensitivity, which was reflected through improvement in plasma glucose homeostasis and a favourable lipid profile, which is essential in the prevention of macrovascular(coronary, cerebral) complications in patients with type 2 diabetes mellitus.

Mathivani M.,Government Theni Medical College | Parameswari R.,Institute of Pharmacology | Sarojini R.,Government Theni Medical College | Geetha K.,Government Theni Medical College | Gowrithilagam T.,Government Theni Medical College
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2013

Snake bite is one of the major public health problems in India. Antisnake venom is the mile stone and the only mainstay therapy in the management of snake bite. In India polyvalent Antisnake venom is used. Antisnake venom is a double edged sword. It has got risks of anaphylactic reactions. It is also a scarce and costly commodity.It should be used cautiously with regard to its dose, cost, and adverse rections.So this study was done to evaluate the pattern of use and adverse reactions to Antisnake venom in haemotoxic snake bite in a tertiary care hospital. Institutional ethical committee clearance was obtained.About 212 snakebite vicims with haemotoxic envenomation were studied from the time of reporting to the hospital and followed up till their discharge.About 59.9% developed early adverse reactions. Itching and urticaria (40.94%) was most common followed by nausea,vomiting and abdominal pain(18.11%). The time of onset of reactions were between 5 and 60 minutes. The adverse reactions were simple to manage with available drugs. No death occurred due to acute anaphylactic reaction.Prophylaxis with Adrenaline significantly (p<0.05) reduced the incidence of reactions. The complications due to snake bite was minimum if Anti snake venom was administered within first 8 hours.

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