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Palayamkottai, India

Velpandian V.,Government Siddha Medical College | Anjana A.,Vels University | Anbu J.,Vels University | Prema S.,Tamil University
Asian Journal of Pharmaceutical and Clinical Research

Kodi Pavala Chunnam (KPC) a Siddha formulation which have so many pharmacological activities. The study was designed according to the OECD guidelines as per that the dose level used as 5, 50, 300, 2000, 4000 mg/kg. The aim of the present investigation was to evaluate acute and subacute toxicity of the KPC on wistar rats at the dose levels of 100, 200 and 400 mg/kg was fixed for study. The different sets of animal used for 28 days and results from the present study have elucidated that treatment of KPC exerts no significant signs of toxicity at any dose level used in the study. Physical, Biochemical, Hematological as well as histopathological parameters were unaltered throughout the study. The results of study have suggested there was no obvious toxicity observed with the treatment of KPC. Source

Velpandian,Government Siddha Medical College | Anbu J.,Vels University | Prema S.,Tamil University
International Journal of Pharma and Bio Sciences

The Kodi Pavala Chunnam (KPC) is traditionally used in Siddha system. The present investigation was evaluated the hepatoprotective activity KPC against carbon tetrachloride (CCl4) induced liver damage in wistar rats. The KPCwas used 100 mg/kg and 200 mg/kg administered orally to the animals. The Silymarin (100 mg/kg) was given as reference standard. The KPC was effective in protecting the liver against the injury as there was significant produced action in wetliver weight, Liver volume, Direct and total bilirubin, SGPT, SGOT, ALP, Total protein, Cholesterol, Triglyceride, CAT, SOD, LPO. Source

Sutha S.,Government Siddha Medical College | Mohan V.R.,Ethnopharmacology Unit | Kumaresan S.,Tamil University | Murugan C.,Botanical Survey of India | Athiperumalsami T.,Ethnopharmacology Unit
Indian Journal of Traditional Knowledge

The study has been carried out in Kalakad-Mundanthurai Tiger Reserve of Western Ghats, Tirunelveli, Tamil Nadu. Kanikkar, the predominant tribal community has their settlements in different areas in the Reserve Forest. Fifty medicinal plants belonging to 36 families are identified which have been employed by the tribal community for the treatment of rheumatism. The plants have been enumerated with botanical names followed by family name, local (Kanikkar) name, plant parts used, mode of administration and uses. Source

Sutha S.,Government Siddha Medical College | Kalpana Devi V.,Ethnopharmacology Unit | Mohan V.R.,Ethnopharmacology Unit
Research Journal of Pharmaceutical, Biological and Chemical Sciences

Alstonia venenata R.Br. (Apocynaceae) known to the Kanikkar as "Malaivaathamudakki" is an important medicinal plant. The Kanikkar tribe, inhabitants of KMTR, Western Ghats, Tamil Nadu use this plant to get relief from rheumatic pain. The present investigation deals with GC-MS analysis of ethanol extract of the above said plant. Twenty three compounds were identified. Source

Thanigavelan V.,Sairam Advanced Center for Research | Lakshmanakumar V.,Sairam Advanced Center for Research | Kaliyamurthi V.,Sairam Advanced Center for Research | Pitchiah Kumar M.,Government Siddha Medical College | Victor Rajamanickam G.,Sairam Advanced Center for Research
Journal of Applied Pharmaceutical Science

Sphaeranthus amaranthoides Burm belonging to the family Asteraceae is a rejuvenator herb of Siddha system having Tamil name 'Sivakaranthai'. The present studies deals with a detailed pharmacological including pharmacognostical study particularly on leaf and infloresence of Sphaeranthus amaranthoides. The morphological characters of leaf and inflorescence observed by double staining. It revealed the stomatal index of lower surface with 42-48 and upper su rface with 30-36/mm and presence of leaf resin canals. Inflorescences are cone shap ed and its axis is siphonate. Sivakaranthai leaf powder (SLP) subjected to quality control t est and by phytoconstituents estimation, appreciable presence of calcium, ferrous, tannin, proteins and phenols known. The results of elemental concentration level indicated the presence of toxic metals within the tolerance level. In vitro antibacterial activity evaluation confirmed the good anti-microbial activity at the dilution of 50 |il/disc against bacterial strain such as Streptococcus mutans, Staphylococcus aureus, Escherchia coli Klebsiella pneumonia, Pseudomonas aeruginosa. Rats found safe up to a maximum dose of 2000mg/kg body weight in acute toxicity study following OECD 423 guidelines. The analgesic and anti-inflammation activities evaluation were done by tail flick hot water immersion method and by C arrageenan induced acute hind paw oedema method on Wistar albino rats, respectively. Th e SLP has shown very weak analgesic and moderate anti-inflammatory action rather than standard Indomethacin and no adverse effects produced. In the light of above results, it concluded that Sphaeranthus amaranthoides might use in any suitable formulation in which anti-microbial property and micronutrients needed. Source

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