Palayamkottai, India
Palayamkottai, India

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Nandhagopal K.,Government Siddha Medical College | Kanniyakumari M.,Sri Santhigiri Siddha Medical College | Anbu J.,Vels University | Velpandian V.,Government Siddha Medical College
International Journal of Pharma and Bio Sciences | Year: 2013

Phoenix dactylifera linn (Arecaceae) commonly known as Date palm has been widely used in Siddha system of medicine for diabetes. The powder form of dried dates (Karchure chooranam) showed a significant inhibitory effect was screened at500mg/kg, for the in vivo anti-diabetic activity on alloxan induced diabetic rats. Glibenclamide (10mg/kg) used as reference standard. Single dose (500 mg/kg) treatment with the siddha drug Karchure chooranam produced 69.34% anti-hyperglycaemic effect (antidiabetic effect). The trial drug showed a significant anti-diabetic activity (P<0.01) and were comparable with that of standard thus validating the traditional claim of the plant.


Velpandian,Government Siddha Medical College | Anbu J.,Vels University | Prema S.,Tamil University
International Journal of Pharma and Bio Sciences | Year: 2013

The Kodi Pavala Chunnam (KPC) is traditionally used in Siddha system. The present investigation was evaluated the hepatoprotective activity KPC against carbon tetrachloride (CCl4) induced liver damage in wistar rats. The KPCwas used 100 mg/kg and 200 mg/kg administered orally to the animals. The Silymarin (100 mg/kg) was given as reference standard. The KPC was effective in protecting the liver against the injury as there was significant produced action in wetliver weight, Liver volume, Direct and total bilirubin, SGPT, SGOT, ALP, Total protein, Cholesterol, Triglyceride, CAT, SOD, LPO.


Sutha S.,Government Siddha Medical College | Mohan V.R.,Ethnopharmacology Unit | Kumaresan S.,Tamil University | Murugan C.,Botanical Survey of India | Athiperumalsami T.,Ethnopharmacology Unit
Indian Journal of Traditional Knowledge | Year: 2010

The study has been carried out in Kalakad-Mundanthurai Tiger Reserve of Western Ghats, Tirunelveli, Tamil Nadu. Kanikkar, the predominant tribal community has their settlements in different areas in the Reserve Forest. Fifty medicinal plants belonging to 36 families are identified which have been employed by the tribal community for the treatment of rheumatism. The plants have been enumerated with botanical names followed by family name, local (Kanikkar) name, plant parts used, mode of administration and uses.


Thomas W.,Government Siddha Medical College | Merish S.,Government Siddha Medical College | Tamizhamuthu M.,Government Siddha Medical College
International Journal of Pharmacognosy and Phytochemical Research | Year: 2014

'Food as Medicine' is one of the basic concepts of Traditional Siddha Indian Medicine. The household recipes containing greens are part of Tamil culture. Even today one can find preparations containing greens (Keerai in Tamil) in the regular diet of south Indians. This tradition is passed through generations because of the immense medicinal properties which the greens posses. Among the frequently consumed greens Ponnankanni (Sessile joyweed - Alternanthera sessilis) finds an important place in Traditional Siddha Medical literatures. The specialty begins with its Tamil name which indicates 'Ponnankanni - Pon aagum kaan nee' (Literally meaning - Your body will get golden luster). According to Traditional Siddha literatures, this herb contains gold and thereby comes under Kaya Kalpa (Panacea) category also. Besides it is also rich in anti-oxidants, Sterol compounds, gives cooling effect to eyes & body, relieves neuritis, treats 96 types of eye diseases and aids disease free healthier life. This review paper gives an overview of all aspects of Alternanthera sessilis including botanical, phyto-chemical, Pharmacognosy and medicinal uses with reference to Siddha Indian Medicine.


Sutha S.,Government Siddha Medical College | Kalpana Devi V.,Ethnopharmacology Unit | Mohan V.R.,Ethnopharmacology Unit
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2012

Alstonia venenata R.Br. (Apocynaceae) known to the Kanikkar as "Malaivaathamudakki" is an important medicinal plant. The Kanikkar tribe, inhabitants of KMTR, Western Ghats, Tamil Nadu use this plant to get relief from rheumatic pain. The present investigation deals with GC-MS analysis of ethanol extract of the above said plant. Twenty three compounds were identified.


Bharathkumar G.,Tamil University | Pitchiah Kumar M.,Government Siddha Medical College
Asian Journal of Pharmaceutical and Clinical Research | Year: 2014

In Siddha system of medicine drugs consist of polyherbal formulations, containing different plants, used for the treatment of various diseases. Karisalai Karpam chooranam is a polyherbal formulation consisting seven traditionally used herbs. Since there is no information about pharmaceutical activities of antioxidant and phytochemical evaluation, the present study focused on the in vitro antioxidant methods where different solvent extract of Karisalai Karpam chooranam screened for 2,2’-azino-bis-3-ethyl benzthiazoline-6-sulphonic acid free radical scavenging activity, lipid peroxidation assay, superoxide scavenging activity, metal chelating assay, nitric oxide scavenging activity, and antioxidant activity in hemoglobin-induced linoleic acid. The results revealed potent scavenging activity when compared with standard. The aqueous-methanol extract of Karisalai Karpam chooranam was screened for further phytochemicals which indicated the presence of alkaloids, flavonoids, tannin, saponin, tepenoids, polyphenols and absence of glycosides, anthocyanin. These metabolites profile was recorded with thin layer chromatography. The result indicated promising antioxidant activity of crude extract and needs further exploration for their effective use in both modern and traditional system of medicines. © 2014, Asian Journal of Pharmaceutical and Clinical Research. All rights reserved.


Alagammal M.,Government Siddha Medical College | Tresina Soris P.,Ethnopharmacology unit | Mohan V.R.,Ethnopharmacology unit
Journal of Applied Pharmaceutical Science | Year: 2012

This study was carried out to analyze the active constituents present in the whole plant of Polygala rosmarinifolia. Twelve compounds in ethanol extract were identified by Gas chromatography-Mass spectrometry (GC-MS) analysis. 1, 5-Anhydro-d-mannitol (73.35%) was the prevailing compound in ethanol extract, which is suggested to be an anticancer compound. This is the first report of identification of active constituents from whole plant of Polygala rosmarinifolia.


Alagammal M.,Government Siddha Medical College | Nishanthini A.,Ethnopharmacology Unit | Mohan V.R.,Ethnopharmacology Unit
Journal of Applied Pharmaceutical Science | Year: 2012

The ethanol extract of Polygala rosmarinifolia whole plant (Family: Polygalaceae) was investigated for its antihyperglycemic and antihyperlipidaemic effect in Wistar Albino rats. Diabetes was induced inAlbino rats by administration of alloxan monohydrate (150mg/kg, i.p).The ethanol extracts of Polygala rosmarinifolia at a dose of 100 and 200mg/kg of body weight were administered at single dose per day to diabetes induced rats for a period of 14 days. The effect of ethanol extract of Polygala rosmarinifolia whole plant extract on blood glucose, serum insulin, urea, creatinine, glycosylated haemoglobin, serum lipid profile [total cholesterol (TC), triglycerides (TG), low densitylipoprotein - cholesterol (LDL-C), very low density lipoprotein-cholester (VLDL-C), high density lipoprotein - cholesterol (HDL-C) and phospholipid (PL)] serum protein, albumin, globulin, serum enzymes [serum glutamate pyruvate transaminases (SGPT), serum glutamate oxaloacetate transaminases (SGOT), and alkaline phosphatase (ALP)], were measured in the diabetic rats. The ethanol extract of Polygala rosmarinifolia whole plant elicited significant reductions of blood glucose (P<0.05), lipid parameters except HDL-C, serum enzymes and significantly increased HDL-C. The extracts also caused significant increase in serum insulin (P<0.05) in the diabetic rats. From the above results, it is concluded that ethanol extract of Polygala rosmarinifolia possesses significant antihyperglycemic and antihyperlipidaemic effects in alloxan induced diabetic rats.


Alagammal M.,Government Siddha Medical College | Packialincy M.,Ethnopharmacology unit | Mohan V.R.,Ethnopharmacology unit
Journal of Applied Pharmaceutical Science | Year: 2012

The present study aims to evaluate the antitumor activity of ethanol extract of whole plant of Polygala rosmarinifolia on DAL model in Swiss Albino mice. Evaluation of the antitumor effect of ethanol extract of whole plant of Polygala rosmarinifolia on tumor growth and host survival time was made by the study of the following parameters: tumor volume, viable and non viable cell count and life span of host.The results showed decrease in tumor volume and cell viability. Hematological studies revealed that, the Hb count decreased in DAL treatedmice, whereas it was induced by the drug treated animals and showed an increase in Hb near to normal levels. The results suggested that the extracts of whole plant of Polygala rosmarinifolia exhibited significant antitumor activity on DAL bearing mice.


Thanigavelan V.,Sairam Advanced Center for Research | Lakshmanakumar V.,Sairam Advanced Center for Research | Kaliyamurthi V.,Sairam Advanced Center for Research | Pitchiah Kumar M.,Government Siddha Medical College | Victor Rajamanickam G.,Sairam Advanced Center for Research
Journal of Applied Pharmaceutical Science | Year: 2012

Sphaeranthus amaranthoides Burm belonging to the family Asteraceae is a rejuvenator herb of Siddha system having Tamil name 'Sivakaranthai'. The present studies deals with a detailed pharmacological including pharmacognostical study particularly on leaf and infloresence of Sphaeranthus amaranthoides. The morphological characters of leaf and inflorescence observed by double staining. It revealed the stomatal index of lower surface with 42-48 and upper su rface with 30-36/mm and presence of leaf resin canals. Inflorescences are cone shap ed and its axis is siphonate. Sivakaranthai leaf powder (SLP) subjected to quality control t est and by phytoconstituents estimation, appreciable presence of calcium, ferrous, tannin, proteins and phenols known. The results of elemental concentration level indicated the presence of toxic metals within the tolerance level. In vitro antibacterial activity evaluation confirmed the good anti-microbial activity at the dilution of 50 |il/disc against bacterial strain such as Streptococcus mutans, Staphylococcus aureus, Escherchia coli Klebsiella pneumonia, Pseudomonas aeruginosa. Rats found safe up to a maximum dose of 2000mg/kg body weight in acute toxicity study following OECD 423 guidelines. The analgesic and anti-inflammation activities evaluation were done by tail flick hot water immersion method and by C arrageenan induced acute hind paw oedema method on Wistar albino rats, respectively. Th e SLP has shown very weak analgesic and moderate anti-inflammatory action rather than standard Indomethacin and no adverse effects produced. In the light of above results, it concluded that Sphaeranthus amaranthoides might use in any suitable formulation in which anti-microbial property and micronutrients needed.

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