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Anju,Chaudhary Devi Lal University | Agarwal A.,Guru Jambheshwar University of Science and Technology | Aghamkar P.,Chaudhary Devi Lal University | Lal B.,Government Polytechnic for Women | Singh V.,Sudan University of Science and Technology
Ceramics International | Year: 2017

The effect of Ti4+ substitution on the crystal structure and magnetic properties of the Bi0.8Ba0.2FeO3 ceramic nanoparticles was investigated. Bi0.8Ba0.2Fe1−xTixO3 (x=0, 0.05, 0.10, 0.15 and 0.20) ceramics have been prepared by tartaric acid modified sol-gel method. Rietveld refinement of the XRD profile pattern of Bi0.8Ba0.2FeO3 ceramic revealed the formation of pseudo-cubic (Pm3m) phase and confirms structural distortion on incorporation of Ti4+ ions, which consequently transform pseudo-cubic (Pm3m) structure to tetragonal (P4mm) structure. The saturation magnetization increases appreciably on Ti4+ ions substitution in Bi0.8Ba0.2FeO3 and is found to be 0.57 emu/g for Bi0.8Ba0.2Fe0.95Ti0.05O3 ceramic. The increase in the magnetization by the substitution of non-magnetic Ti4+ ions has been ascribed to crystal structure modification made by the Ti4+ ions. However, a sudden decrease in the magnetization has been observed for Bi0.8Ba0.2Fe0.8Ti0.2O3 ceramic nanoparticles. The prominent Ti (3d) – O (2p) hybridization would stabilize the ferroelectric distortion and consequently reduce the magnetization. Scanning Electron Microscope (SEM) image of Bi0.8Ba0.2Fe0.8Ti0.2O3 ceramic sample revealed the formation of dense microstructure with uniform grains size. © 2017 Elsevier Ltd and Techna Group S.r.l.

Singh V.,Guru Jambheshwar University of Science and Technology | Aghamkar P.,Guru Jambheshwar University of Science and Technology | Aghamkar P.,Chaudhary Devi Lal University | Lald B.,Government Polytechnic for Women
Acta Physica Polonica A | Year: 2013

Using chemical route a 2,3-butanedione dihydrazone (BDDH) compound was prepared. The third-order non- linear optical properties of BDDH were investigated by using single beam z-scan technique with Q-switched, frequency doubled Nd:YAG laser (= 532 nm) at 5 ns pulse. Efiect of excitation intensity on nonlinear optical properties has been studied and found that experimental and computed values are well in agreement. Also, we found the measured nonlinear optical coeficients are nearly ten times larger than the reported. The excited state absorption cross-section of BDDH was found to be larger than that of the ground state absorption cross-section, indicating the reverse saturable absorption.

Siva Sankar A.,Government Polytechnic for Women
International Journal of Applied Engineering Research | Year: 2014

Cuckoo Search (CS) algorithm is one of the modern metaheuristic algorithms found to be efficient for solving global optimization problems. The optimal location and size of FACTS devices in an interconnected power system is a complex task. For this purpose, a modified cuckoo search (MCS) algorithm is proposed in this paper. It is the hybridization of genetic algorithm (GA) with the cuckoo search (CS) algorithm. Here, the random walk by a cuckoo in the conventional CS algorithm is completely replaced by GA for its fast convergence. Here the considered FACTS device is Unified Power Flow Controller (UPFC). The optimal location of UPFC is computed based on the voltage deviation and power loss of the system. Then, the optimal size of the FACTS device is determined by optimizing the power model parameters. Here, the Newton-Raphson load flow study is used for analyzing the power flow of the transmission system. The proposed technique is implemented in MATLAB platform and its performance is evaluated by using IEEE 30-bus test system. The results have also been compared with existing standard CS algorithm. It has been shown that the new algorithm is more effective and efficient. © Research India Publications.

Sasikala C.,Jawaharlal Nehru Technological University Kakinada | Sudhakar Y.,Government Polytechnic for Women
Asian Journal of Pharmaceutical and Clinical Research | Year: 2014

This study evaluated methanolic extract of Ventilago maderaspatana (MVM) on reducing hyperglycemia and hyperlipidemia in streptozotocin (STZ) - induced diabetic rats. MVM was orally administered once a day after 3 days of STZ - induction at 100, 200 and 400 mg/kg for 45 day and the results showed that serum fasting blood glucose, glucose-6-phosphotase, fructose 1, 6-phosphotase in hepatic tissues, total cholesterol, free fatty acids, and triglyceride in serum, hemoglobin A1c (HbA1c) in blood levels were significantly decreased, whereas Hb in blood and serum high density lipoprotein, glucokinase, glucose-6-phosphate dehydrogenase in hepatic tissues and liver and muscle glycogen level were increased. The dosage of 400 mg/kg is more effective than that of 100, 200 mg/kg. These results suggest that the MVM possesses antidiabetic and hypolipidemic effects in STZ - induced diabetic rats. © 2014 Asian Journal of Pharmaceutical and Clinical Research. All rights reserved.

Kumar G.N.H.,Government Polytechnic for Women | Parthasarathy G.,National Geophysical Research Institute | Rao J.L.,Sri Venkateswara University
American Mineralogist | Year: 2011

We report here for the first time low-temperature (123-295 K) electron paramagnetic resonance (EPR) spectroscopic data on naturally occurring calumetite [Cu(OH,Cl2)-2H2O] from the Khetri copper complex, Jhunjhunu district, Rajasthan, India. The sample was characterized by X-ray powder diffraction (XRD), differential thermal analysis (DTA), and thermogravimetric (TG) analysis techniques. DTA scans show two endothermic reactions at about 378 and 598 K, which are attributed to dehydration of the sample. TG data indicate weight loss of up to 24 wt% in the temperature region between 600 and 700 K. The room-temperature EPR spectrum exhibits parallel and perpendicular components centered at g∥ = 2.26 and g = 2.10, respectively. The evaluated spin-Hamiltonian parameters indicate that these resonance signals are characteristic of Cu2+ ions in distorted octahedral symmetry. The population difference (N) between the Zeeman levels has been evaluated and is found to increase with decreasing temperature.

Santhrani T.,Sri Padmavati University | Nirmaladevis P.,Government Polytechnic for Women
International Journal of Pharmacy and Technology | Year: 2011

Epilepsy is a characteristic neurological disorder of recurrent seizures of cerebral origin. In female epileptic patients, seizure frequency doubles at the time of menstruation which is often called as Catamenial Epilepsy. The cyclic changes of menstrual cycle alter the pharmacokinetics of the anti-epileptic drugs. In the present study, the Phenytoin levels in the salivary samples of female epileptic patients are estimated by HPLC method. In order to study the alterations in the pharmacokinetics of phenytoin, various pharmacokinetic parameters like AUC, Cmax, Elimination Half life, volume of distribution, mean clearance can be determined. The results of the study shows mean salivary levels of phenytoin were lower in follicular phase compared to ovulatory phase could be the reason for precipitating seizures during menses in catamenial epileptic patients. Hence dosage adjustments may be made for better management of disease. At the same time, the levels being monitored cautiously because of its narrow therapeutic index and enzyme saturation kinetics.

Santhrani T.,Sri Padmavati University | Nirmaladevi P.,Government Polytechnic for Women
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2011

The level of female Hormones is phase specific and the Pharmacokinetic parameters of drugs are altered by the cyclic changes in menstrual cycle. The luteal phase has high levels of progesterone levels and follicular phase has higher circulating α-1 acid glycoprotein which alters absorption and distribution respectively. The objective of the present research work is to study the influence of menstrual cycle (i.e., follicular phase, ovulatory phase and luteal phase) on pharmacokinetic parameters of most commonly prescribed antibiotic, Ofloxacin. Salivary levels of Ofloxacin in healthy volunteers were estimated during three phases of menstrual cycle for the evaluation of various pharmacokinetic parameters. 20 female healthy volunteers of 20 to 50 years age with regular menstrual cycle, were participated in the study, received 400 mg of Ofloxacin tablet at 9 am along with a glass of water 1 hr after breakfast on 3 rd, 13 th and 23 rd day of menstrual cycle. Salivary samples (2ml) were obtained at 1, 2, 4, 6, 8, 12 & 24 hrs after dosing, were estimated for drug concentration by HPLC method. All the results were expressed as Mean ± S.D, data was analyzed using one way ANOVA, followed by Newman-Keuls multiple comparision test. A value of P < 0.05 was considered to be statistically significant. The mean salivary concentrations of Ofloxacin were decreased in ovulatory and luteal phases than follicular phase due to which bacteria may develop resistance in several infections and the diseases may not cured in these phases of menstrual cycle and may require dosage adjustments.

Kashyap M.K.,Kurukshetra University | Lal B.,Government Polytechnic for Women
AIP Conference Proceedings | Year: 2011

We present investigation on the magneto-optical (MO) properties of RAl 2 (R=Ce and Pr; a rare earth compound) compounds including the spin-orbit coupling using full potential Linear Augmented Plane Wave (FPLAPW) method which is based on precise first principle density functional theory (DFT). We have adopted Coulomb corrected local spin density approximation (LDA+U) as the exchange correlation functional in the calculations. The MO Kerr rotation is larger in PrAl2 than that in CeAl2 which can be attributed to an increase in the valence f-electrons of rare earth element from Ce to Pr. The Kerr spectrum is analyzed to ascertain the origin of the various peaks in terms of optical transitions. © 2011 American Institute of Physics.

Anupama B.,Rbvrr Womens College | Sunita M.,Government Polytechnic for Women | Shiva Leela D.,Osmania University | Ushaiah B.,Osmania University | Gyana Kumari C.,Osmania University
Journal of Fluorescence | Year: 2014

A series of transition metal complexes of Co(II), Ni(II), Zn(II), Fe(III) and VO(IV) have been synthesized involving the Schiff base, 2,3-dimethyl-1- phenyl-4-(2-hydroxy-3-methoxy benzylideneamino)-pyrazol-5-one(L), obtained by condensation of 4-aminoantipyrine with 3-methoxy salicylaldehyde. Structural features were obtained from their FT-IR, UV-vis, NMR, ESI Mass, elemental analysis, magnetic moments, molar conductivity and thermal analysis studies. The Schiff base acts as a monovalent bidentate ligand, coordinating through the azomethine nitrogen and phenolic oxygen atom. Based on elemental and spectral studies six coordinated geometry is assigned to Co(II), Ni(II), Fe(III) and VO(IV) complexes and four coordinated geometry is assigned to Zn(II) complex. The interaction of metal complexes with Calf thymus DNA were carried out by UV-VIS titrations, fluorescence spectroscopy and viscosity measurements. The binding constants (Kb) of the complexes were determined as 5 × 105 M-1 for Co(II) complex, 1.33 × 104 M-1 for Ni(II) complex, 3.33 × 105 M-1 for Zn(II) complex, 1.25 × 105 M-1 for Fe(III) complex and 8 × 105 M-1 for VO(IV) complex. Quenching studies of the complexes indicate that these complexes strongly bind to DNA. Viscosity measurements indicate the binding mode of complexes with CT DNA by intercalation through groove. The ligand and it's metal complexes were screened for their antimicrobial activity against bacteria. The results showed the metal complexes to be biologically active, while the ligand to be inactive. © 2014 Springer Science+Business Media New York.

PubMed | Government Polytechnic for Women, Alliance Institute of Advanced Pharmaceutical & Health science and Adept Pharma and Bioscience Excellence Private Ltd
Type: Journal Article | Journal: Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society | Year: 2015

A solid self-nanoemulsifying drug-delivery system (solid SNEDDS) has been explored to improve the solubility and dissolution profile of glipizide. SNEDDS preconcentrate was systematically optimized using a circumscribed central composite design by varying Captex 355 (Oil), Solutol HS15 (Surfactant) and Imwitor 988 (Co-surfactant). The optimized SNEDDS preconcentrate consisted of Captex 355 (30%w/w), Solutol HS15 (45%w/w) and Imwitor 988 (25%w/w). The saturation solubility (SS) of glipizide in optimized SNEDDS preconcentrate was found to be 45.121.36mg/ml, indicating an improvement (1367 times) of glipizide solubility as compared to its aqueous solubility (0.0330.0021mg/ml). At 90% SS, glipizide was loaded to the optimized SNEDDS. In-vitro dilution of liquid SNEDDS resulted in a nanoemulsion with a mean droplet size of 29.4nm. TEM studies of diluted liquid SNEDDS confirmed the uniform shape and size of the globules. The liquid SNEDDS was adsorbed onto calcium carbonate and talc to form solid SNEDDS. PXRD, DSC, and SEM results indicated that, the presence of glipizide as an amorphous and as a molecular dispersion state within solid SNEDDS. Glipizide dissolution improved significantly (p<0.001) from the solid SNEDDS (100% in 15min) as compared to the pure drug (18.37%) and commercial product (65.82) respectively.

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