Singh V.,Guru Jambheshwar University of Science and Technology |
Aghamkar P.,Guru Jambheshwar University of Science and Technology |
Aghamkar P.,Chaudhary Devi Lal University |
Lald B.,Government Polytechnic for Women
Acta Physica Polonica A | Year: 2013
Using chemical route a 2,3-butanedione dihydrazone (BDDH) compound was prepared. The third-order non- linear optical properties of BDDH were investigated by using single beam z-scan technique with Q-switched, frequency doubled Nd:YAG laser (= 532 nm) at 5 ns pulse. Efiect of excitation intensity on nonlinear optical properties has been studied and found that experimental and computed values are well in agreement. Also, we found the measured nonlinear optical coeficients are nearly ten times larger than the reported. The excited state absorption cross-section of BDDH was found to be larger than that of the ground state absorption cross-section, indicating the reverse saturable absorption.
Santhrani T.,Sri Padmavati University |
Nirmaladevis P.,Government Polytechnic for Women
International Journal of Pharmacy and Technology | Year: 2011
Epilepsy is a characteristic neurological disorder of recurrent seizures of cerebral origin. In female epileptic patients, seizure frequency doubles at the time of menstruation which is often called as Catamenial Epilepsy. The cyclic changes of menstrual cycle alter the pharmacokinetics of the anti-epileptic drugs. In the present study, the Phenytoin levels in the salivary samples of female epileptic patients are estimated by HPLC method. In order to study the alterations in the pharmacokinetics of phenytoin, various pharmacokinetic parameters like AUC, Cmax, Elimination Half life, volume of distribution, mean clearance can be determined. The results of the study shows mean salivary levels of phenytoin were lower in follicular phase compared to ovulatory phase could be the reason for precipitating seizures during menses in catamenial epileptic patients. Hence dosage adjustments may be made for better management of disease. At the same time, the levels being monitored cautiously because of its narrow therapeutic index and enzyme saturation kinetics.
Santhrani T.,Sri Padmavati University |
Nirmaladevi P.,Government Polytechnic for Women
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2011
The level of female Hormones is phase specific and the Pharmacokinetic parameters of drugs are altered by the cyclic changes in menstrual cycle. The luteal phase has high levels of progesterone levels and follicular phase has higher circulating α-1 acid glycoprotein which alters absorption and distribution respectively. The objective of the present research work is to study the influence of menstrual cycle (i.e., follicular phase, ovulatory phase and luteal phase) on pharmacokinetic parameters of most commonly prescribed antibiotic, Ofloxacin. Salivary levels of Ofloxacin in healthy volunteers were estimated during three phases of menstrual cycle for the evaluation of various pharmacokinetic parameters. 20 female healthy volunteers of 20 to 50 years age with regular menstrual cycle, were participated in the study, received 400 mg of Ofloxacin tablet at 9 am along with a glass of water 1 hr after breakfast on 3 rd, 13 th and 23 rd day of menstrual cycle. Salivary samples (2ml) were obtained at 1, 2, 4, 6, 8, 12 & 24 hrs after dosing, were estimated for drug concentration by HPLC method. All the results were expressed as Mean ± S.D, data was analyzed using one way ANOVA, followed by Newman-Keuls multiple comparision test. A value of P < 0.05 was considered to be statistically significant. The mean salivary concentrations of Ofloxacin were decreased in ovulatory and luteal phases than follicular phase due to which bacteria may develop resistance in several infections and the diseases may not cured in these phases of menstrual cycle and may require dosage adjustments.
Siva Sankar A.,Government Polytechnic for Women
International Journal of Applied Engineering Research | Year: 2014
Cuckoo Search (CS) algorithm is one of the modern metaheuristic algorithms found to be efficient for solving global optimization problems. The optimal location and size of FACTS devices in an interconnected power system is a complex task. For this purpose, a modified cuckoo search (MCS) algorithm is proposed in this paper. It is the hybridization of genetic algorithm (GA) with the cuckoo search (CS) algorithm. Here, the random walk by a cuckoo in the conventional CS algorithm is completely replaced by GA for its fast convergence. Here the considered FACTS device is Unified Power Flow Controller (UPFC). The optimal location of UPFC is computed based on the voltage deviation and power loss of the system. Then, the optimal size of the FACTS device is determined by optimizing the power model parameters. Here, the Newton-Raphson load flow study is used for analyzing the power flow of the transmission system. The proposed technique is implemented in MATLAB platform and its performance is evaluated by using IEEE 30-bus test system. The results have also been compared with existing standard CS algorithm. It has been shown that the new algorithm is more effective and efficient. © Research India Publications.
Subbarao A.,National Institute of Technology Tiruchirappalli |
Raghavan S.,National Institute of Technology Tiruchirappalli |
Rao P.P.S.,Government Polytechnic for Women
2011 2nd International Conference on Wireless Communication, Vehicular Technology, Information Theory and Aerospace and Electronic Systems Technology, Wireless VITAE 2011 | Year: 2011
A novel compact Ultra wideband antenna fed by CPW is presented. The antenna has a size of 23 mm × 27 mm. It provides band width ranging from 2.7 GHz to 10.6 GHz. The antenna can be easily integrated with radio frequency circuit for low cost. Details of antenna are presented with parametric study. The bandwidth is varied by varying the intrusion depth L2 and distance 'g' between conducting plane and ground and thus ultra wideband with is obtained. The antenna is Omni directional in operating range and it has good radiation efficiency. The fundamental parameters return loss, VSWR, radiation pattern are obtained, which meet standard specifications. Method of moments based IE3D simulator is used to analyze antenna. © 2011 IEEE.