Singh K.,Government of Punjab
Indian Journal of Agricultural Economics | Year: 2011
Some concerted policy initiatives and capital investments need to be channeled judiciously, so that the mismanagement that had been depleting the underground water, which had accumulated over the centuries, can be curtailed. The depletion rate of groundwater resource from the central region of Punjab, where most of the rice is grown, and supplied to the food security of the country, is 4 ± 0.5 km 3 per year for the period June 1999-June 2005. The demand for water from the agriculture sector, which is the major claimant to produce food and fiber for the mankind, responds to a variety of factors, and can be efficiently managed to restore the water balance to a significant extent. An appropriate policy for groundwater use in the urban sector is needed, where there is uncontrolled criminal exploitation and wastage of groundwater. The utmost priority is to conserve the groundwater, whatever are the means, measures and policies necessary.
Sarkar S.,Indian Institute of Science |
Mandal C.,Indian Institute of Science |
Sangwan R.,Government of Punjab
Endocrine-Related Cancer | Year: 2014
β-catenin plays a pivotal role in organogenesis and oncogenesis. Alterations in β-catenin expression are common in pancreatic cancer,which is an extremely aggressive malignancywith a notably poor prognosis. In this report, we analyzed the apoptotic activity of withanolide-D (witha-D), a steroidal lactone that was purified from an Indian medicinal plant, Withania somnifera, and its underlying mechanism of action. Witha-D induced apoptosis in pancreatic ductal adenocarcinoma cells by prompting cell-cycle arrest at the G2/M phase. This lactone abrogated β-catenin signaling in these cells regardless of disease grade, mutational status, and gemcitabine sensitivity. Witha-D also upregulated E-cadherin inmost cells, thereby supporting the inversion of the epithelial-mesenchymal transition. Furthermore, the Akt/Gsk3β kinase cascade was identified as a critical mediator of G2/M regulation and β-catenin signaling. Witha-D deactivated Akt, which failed to promote Gsk3β deactivation phosphorylation. Consequently, activated Gsk3β facilitated β-catenin destruction in pancreatic carcinoma cells. The knockdown of Chk1 and Chk2 further activated Akt and reversed the molecular signal. Taken together, the results of the current study represent the first evidence of β-catenin signal crosstalk during the G2/M phase by functionally inactivating Akt via witha-D treatment in pancreatic cancer cells. In conclusion, this finding suggests the potential identification of a new lead molecule in the treatment of pancreatic adenocarcinoma. © 2014 Society for Endocrinology.
Sharma J.R.,Sant Longowal Institute of Engineering And Technology |
Gupta P.,Government of Punjab
Computers and Mathematics with Applications | Year: 2014
In this paper, we present a three-step iterative method of convergence order five for solving systems of nonlinear equations. The methodology is based on the two-step Homeier's method with cubic convergence (Homeier, 2004). Computational efficiency in its general form is discussed and a comparison between the efficiency of proposed technique and existing ones is made. The performance is tested through numerical examples. Moreover, theoretical results concerning order of convergence and computational efficiency are verified in the examples. It is shown that the present method has an edge over existing methods, particularly when applied to large systems of equations. © 2013 Elsevier Ltd. All rights reserved.
Genome-wide transcriptome study in wheat identified candidate genes related to processing quality, majority of them showing interaction (quality x development) and having temporal and spatial distributions.
Roy J.,Government of Punjab
BMC genomics | Year: 2014
The cultivated bread wheat (Triticum aestivum L.) possesses unique flour quality, which can be processed into many end-use food products such as bread, pasta, chapatti (unleavened flat bread), biscuit, etc. The present wheat varieties require improvement in processing quality to meet the increasing demand of better quality food products. However, processing quality is very complex and controlled by many genes, which have not been completely explored. To identify the candidate genes whose expressions changed due to variation in processing quality and interaction (quality x development), genome-wide transcriptome studies were performed in two sets of diverse Indian wheat varieties differing for chapatti quality. It is also important to understand the temporal and spatial distributions of their expressions for designing tissue and growth specific functional genomics experiments. Gene-specific two-way ANOVA analysis of expression of about 55 K transcripts in two diverse sets of Indian wheat varieties for chapatti quality at three seed developmental stages identified 236 differentially expressed probe sets (10-fold). Out of 236, 110 probe sets were identified for chapatti quality. Many processing quality related key genes such as glutenin and gliadins, puroindolines, grain softness protein, alpha and beta amylases, proteases, were identified, and many other candidate genes related to cellular and molecular functions were also identified. The ANOVA analysis revealed that the expression of 56 of 110 probe sets was involved in interaction (quality x development). Majority of the probe sets showed differential expression at early stage of seed development i.e. temporal expression. Meta-analysis revealed that the majority of the genes expressed in one or a few growth stages indicating spatial distribution of their expressions. The differential expressions of a few candidate genes such as pre-alpha/beta-gliadin and gamma gliadin were validated by RT-PCR. Therefore, this study identified several quality related key genes including many other genes, their interactions (quality x development) and temporal and spatial distributions. The candidate genes identified for processing quality and information on temporal and spatial distributions of their expressions would be useful for designing wheat improvement programs for processing quality either by changing their expression or development of single nucleotide polymorphisms (SNPs) markers.
Dahuja A.,Government of Punjab |
Dahuja G.,Government of Punjab |
Jaswal V.,Government of Punjab |
Sandhu K.,Government of Punjab
Journal of Arthroplasty | Year: 2014
Total knee arthroplasty(TKA) is associated with extensive postoperative blood loss. Despite various studies proving the efficacy of Tranexamic Acid (TEA) with single or multiple boluses of different sizes with or without subsequent infusions, no consensus has been reached on the dose of tranexamic acid to be administered or the duration of treatment. In this study, we have investigated in a homogenous healthy population undergoing total knee arthroplasty, if administration of a high dose of tranexamic acid has a blood sparing effect. They were found to be significant with high power concluding a decrease in total blood loss in patients who were administered Tranexamic Acid (TEA) during Total Knee Arthroplasty (TKA). A dose regimen of 15. mg/kg every 8. h for 24. h would seem appropriate as longer administration of TEA was not accompanied by further reduction in blood loss. © 2014 Elsevier Inc.
Agarwal A.,National Institute of Pharmaceutical Education and Research |
Banerjee A.,Government of Punjab |
Banerjee U.C.,National Institute of Pharmaceutical Education and Research
Critical Reviews in Biotechnology | Year: 2011
Xanthine oxidoreductase (XOR) is a ubiquitous complex cytosolic molybdoflavoprotein which controls the rate limiting step of purine catabolism by converting xanthine to uric acid. It is known that optimum concentrations of uric acid (UA) and reactive oxygen species (ROS) are necessary for normal functioning of the body. The ability of XOR to perform detoxification reactions, and to synthesize UA and reactive oxygen species (ROS) makes it a versatile intra-and extra-cellular protective "housekeeping enzyme". It is also an important component of the innate immune system. The enzyme is a target of drugs against gout and hyperuricemia and the protein is of major interest as it is associated with ischemia reperfusion (I/R) injury, vascular disorders in diabetes, cardiovascular disorders, adipogenesis, metabolic syndrome, cancer, and many other disease conditions. Xanthine oxidoreductase in conjugation with antibodies has been shown to have an anti-tumor effect due to its ability to produce ROS, which in turn reduces the growth of cancer tissues. Apart from this, XOR in association with nitric oxide synthase also participates in myocardial excitation-contraction coupling. Although XOR was discovered over 100 years ago, its physiological and pathophysiological roles are still not clearly elucidated. In this review, various physiological and pathophysiological functional aspects of XOR and its association with various forms of cancer are discussed in detail. © 2010 Informa Healthcare USA, Inc.
Kaplas M.,Government of Punjab
International Journal of Advanced Manufacturing Technology | Year: 2011
The aim of the present research was to compare the efficacy of two powder based 3D printing technologies for rapid casting of light alloys. The technologies of ZCast process and investment casting were employed to cast aluminium A356 alloy and zinc ZA-12 alloy. The split pattern shells were printed in ZCast501 powder and used directly as mould with outside sand support in case of ZCast process. Two commercially available powders starch-based ZP14 and plaster-based ZP100 were infiltrated with two infiltrants acrylate and wax resulting in four different material systems for making investment casting patterns. A standard method was premeditated by identifying and designing the benchmark component. The proposed concept was presented in physical form by fabricating prototypes to appraise the impact of technology used on dimensional accuracy. The dimensional accuracy was acceded by assigning tolerance grades as per UNI EN 20286-1 ISO. In addition, the working suitability of castings was analysed by comparing important mechanical properties, and further, the results were supported by radiography and microstructure analysis. The feasibility of decreasing shell wall thickness for ZCast process was also checked so as to make the process more economical and fast. © 2010 Springer-Verlag London Limited.
Upadhyay S.K.,Government of Punjab |
Kumar J.,Government of Punjab |
Alok A.,Government of Punjab |
Tuli R.,Government of Punjab
G3: Genes, Genomes, Genetics | Year: 2013
The clustered, regularly interspaced, short palindromic repeats (CRISPR) and CRISPR-associated protein (Cas) system has been used as an efficient tool for genome editing. We report the application of CRISPR-Cas-mediated genome editing to wheat (Triticum aestivum), the most important food crop plant with a very large and complex genome. The mutations were targeted in the inositol oxygenase (inox) and phytoene desaturase (pds) genes using cell suspension culture of wheat and in the pds gene in leaves of Nicotiana benthamiana. The expression of chimeric guide RNAs (cgRNA) targeting single and multiple sites resulted in indel mutations in all the tested samples. The expression of Cas9 or sgRNA alone did not cause any mutation. The expression of duplex cgRNA with Cas9 targeting two sites in the same gene resulted in deletion of DNA fragment between the targeted sequences. Multiplexing the cgRNA could target two genes at one time. Target specificity analysis of cgRNA showed that mismatches at the 39 end of the target site abolished the cleavage activity completely. The mismatches at the 59 end reduced cleavage, suggesting that the off target effects can be abolished in vivo by selecting target sites with unique sequences at 39 end. This approach provides a powerful method for genome engineering in plants. © 2013 S. Upadhyay et al.
Asrar-Ulhaq,Government of Punjab
Irrigation and Drainage | Year: 2010
This paper presents initial results of performance evaluation of farmers' organizations (FOs) in the Lower Chenab Canal (East) Pilot Area Water Board (AWB) of Pakistan's Punjab. It discusses the overall setting of the system, FOs' management regime and monitoring framework for assessing their performance. The paper also identifies major challenges confronting these young organizations and strategies for improving their performance, replication and sustainable growth. The internal and external performance evaluation of 84 FOs, conducted by the Punjab Irrigation and Drainage Authority (PIDA) and the Japan International Cooperation Agency (JICA) consultants, indicates that performance of about 20% FOs is good, 60-65% satisfactory, while the performance of 15-20% of FOs ranges from unsatisfactory to poor. This evaluation brings out the good performance of FOs in dispute resolution, improved equity and development of local capacity for irrigation management. The main FO issues include declining abiana collection, weaknesses in maintenance of accounts and increasing inequity in water distribution in some cases. Improvement strategies include continued capacity building and mainstreaming of FOs, avoiding institutional fatigue, closer coordination and support to FOs and improved monitoring systems for identification of FO problems and timely course correction. © 2010 John Wiley & Sons, Ltd.
News Article | February 28, 2017
•UAE participated as Focus Country for the second consecutive year •Ministers of Greece, Punjab, Indonesia and top diplomats from UAE, Turkey, Cyprus, Egypt, Malaysia attended the show •Bahrain, Cambodia, Cyprus, Greece, Ho Chi Minh City debuted at OTM 2017 •Over 10000 trade visitors attended the 3 day show Exhibitors from a record number of 60 countries showcased their destinations at OTM 2017 from February 21-23 at the Bombay Convention & Exhibition Centre. This was by far the largest number of countries participating in any trade show in the country. OTM is organised by Fairfest Media Ltd every year in the largest travel market in India – Mumbai. 1134 travel organisations from 60 Countries exhibited at OTM 2017 including National and State Tourism Organisations, Hotels, Airlines, Destination Marketing Companies and other suppliers serving leisure as well as business travel and MICE (Meetings, Incentives, Conventions, Events) markets. Over 10,000 travel trade visitors attended the show in addition to more than 500 buyers from travel trade and corporate sectors who had qualified for special hosting privileges. International buyers from countries like Kuwait, New Zealand, Philippines, Russia and Thailand were also extended similar hosting hospitality. Who’s who from the global travel industry assembled at OTM 2017. The dignitaries present at the inaugural session included Sohan Singh Thandal, Minister of Tourism, Government of Punjab; I Gde Pitana, Deputy Tourism Minister for Overseas Promotion of Indonesia; H.E. Mohammed K Al Mheiri, Undersecretary- Ministry of Economy and Adviser to the Minister for Tourism; H.E. Dr Ahmed Al Banna, UAE Ambassador to India; H.E. Demetrios A Theophylactou, High Commissioner, Cyprus High Commission; Dimitrios Tryfonopoulos, Secretary General, Greek National Tourism Organisation; Datuk Seri Mirza Mohammad Taiyab, Director General, Tourism Malaysia; H.E. Erdal Sabri Ergen, Consul General, Consulate General of Turkey in Mumbai; Ismail A Hamid, Egyptian Tourism Counsellor, Egyptian Tourism Office; Guldeep Singh Sahni, President, Outbound Tour Operators Association of India. The Tourism Minister of Greece, Elena Kountoura graced the show with her presence on second day. H.E. Panos Kalogeropoulos, Ambassador of Greece to India and the Tourism Minister took a tour of the show and interacted with various other participants. This was the first time that Greece Tourism participated at OTM 2017 with a large delegation including private sector operators. The UAE Ministry of Economy organised a national Visit UAE pavilion for the second year in a row, featuring various tourism departments and agencies from the UAE. The delegation was led by H.E. Mohammed K Al Mheiri who informed that the UAE has broadened its presence to include the various government bodies responsible for tourism in all the emirates as well as private sector representatives involved in tourism. Premium Partner Country of OTM 2017, Turkish Ministry of Culture and Tourism has been participating at OTM for the last seven years with a large number of tour operators. Gülara Alkaçır, Culture & Tourism Officer was extremely satisfied with the event turnout and expects many more tourists from India. Besides showcasing their myriad tourism attractions, Indonesia Tourism presented an array of cultural offerings during the show. Representatives from Indonesia’s travel and tourism industry under the umbrella of The Ministry of Tourism, Republic of Indonesia discussed their India-specific tourism promotion plans during OTM 2017. First-time participants at OTM like Bahrain, Cambodia, Cyprus, Greece, Ho Chi Minh City provided variety of experiences to the valued travel trade partners and Indian travellers. Mumbai is the largest source market for leisure and MICE travel in India. It accounts for some 60% of the outbound travel market in India, considering it is the most popular gateway for the entire West and South India. OTM provides the right platform for national and international tourism boards and private operators to tap this market in the most comprehensive and cost-effective way. A brand-new addition at OTM 2017 was the co-located BLTM- Business & Luxury Travel Mart, where qualified hosted buyers met the sellers by appointments. Indian citizens whether travelling abroad or within the country are much coveted and one of the fastest growing markets for leisure as well as business travel segments. According to the data published by India’s Ministry of Tourism, 20.38 million Indians took foreign trips out of India in 2015 (11.1% higher than 2014). The number of domestic trips within India was a whopping 1432 million (11.6% higher than in 2014). In contrast, the number of foreign tourist arrival was 8.03 million (4.05% higher than in 2014). OTM caters to all of these markets. UNWTO estimates the number of Indian outbound travellers will grow to approximately 50 million in 2020, contributing $28 billion in expenditure. To tap into this lucrative market, OTM 2017 has participants from 60 countries. These included NTOs from Abu Dhabi, Ajman, Bahrain, Bangladesh, Bhutan, Cambodia, China, Croatia, Cyprus, Dubai, Egypt, Fiji, Fujairah, Greece, India, Indonesia, Japan, Kenya, Macao, Malaysia, Maldives, Nepal, Philippines, Ras Al Khaimah, Romania, Rwanda, Seychelles, Sharjah, Sri Lanka, Taiwan, Thailand, Turkey, Vietnam and country representations from Argentina, Australia, Bolivia, Brazil, Bulgaria, Chile, Ecuador, France, Germany, Hong Kong, Ireland, Italy, Jordan, Kazakhstan, Kyrgyzstan, Lebanon, Mauritius, Mongolia, Morocco, Russia, Singapore, Slovenia, South Africa, Tanzania, United Kingdom, USA, etc. Participation from India was equally aggressive as their international counterparts. This included Tourism departments along with private operators from Andaman & Nicobar, Andhra Pradesh, Assam, Gujarat, Himachal Pradesh, Jammu & Kashmir, Jharkhand, Karnataka, Kerala, Madhya Pradesh, Maharashtra, Manipur, Odisha, Punjab, Sikkim, Uttar Pradesh, Uttarakhand, West Bengal and private sector participation from Daman & Diu, Delhi, Goa, Haryana, Puducherry, Rajasthan, Tamil Nadu, Telangana in a big way. The Ministry of Tourism, Government of India had a strong presence at the show. More than 100 corporate buyers from top companies like Canara HSBC, L'Oreal India Pvt Ltd, Capgemini, Reliance Infrastructure Ltd, Khaitan & Co, Hdfc Standard Life Insurance Company Ltd, Mahindra Finance, Godrej & Boyce Mfg Co Ltd, Larsen & Toubro, Deloitte Shared Services India Llp, Wockhardt Ltd, Ambuja Cements Ltd, Birla Sun Life Insurance Company Ltd, Rajkumar Hirani Films, Ericsson India Pvt Ltd, etc had pre-scheduled over 2000 appointments for meeting sellers of their choice at the show. OTM is the only big travel trade show in the country to have the participation of corporate buyers on this scale. The two Buyer-Seller Speed Networking sessions were a huge hit, designed to facilitate onsite meeting appointments with the buyers to visit the sellers. Visit UAE Lounge was made available for the speed networking sessions. In another first, the MICE Club was launched at OTM, with an objective to facilitate networking and education opportunities among the community of buyers and sellers from Business Travel and MICE segments. Globally, travel trade fairs are considered important annual opportunities for face-to-face meetings and networking among buyers and sellers. Traditionally, visitors at these fairs walk the show and meet the sellers of their interest. The advent of online technologies has not left this field untouched either. Increasingly, the buyers and sellers pre-schedule appointments online for meetings at the show. OTM 2017 had deployed a state-of-the-art online meeting diary system provided by EventsAir based in Australia. It is an advanced system that facilitated matchmaking and appointments between the Buyers and Sellers, and received over 5000 meeting requests prior to the show. OTM 2017 was supported by Pacific Asia Travel Association (PATA), Travel Agents Association of India (TAAI), Outbound Tour Operators Association of India (OTOAI), Indian Association of Tour Operators (IATO), Association of Domestic Tour Operators of India (ADTOI), Travel Agents Federation of India (TAFI), Network of Indian MICE Agents (NIMA), IATA Agents Association of India (IAAI), Maharashtra Tour Operators Association (MTOA), Travel Agents Association of Pune (TAAP), Travel Agents Association of Nashik (TAAN), South Gujarat Association of Travel Agents (SATA), SKAL International, Enterprising Travel Agent's Association (ETAA), etc. In addition to buying and selling opportunities on the show floor, exhibitors from various countries and states also made colourful cultural presentations. There was an equally interesting line up of workshops and presentations conducted on the sidelines of the mart. Featuring destinations through films has been a traditionally successful strategy for many destinations. Mumbai being one of the biggest hubs of film production in the world, OTM partnered with The Film and TV Producers Guild of India and Globe Hoppers to organise “Shoot-at-Site”, an exclusive workshop on the opening day of OTM focused on promoting tourism through films shoots, facilitating ease-of-doing business, and making film-shooting friendly policies by the government. The workshop was attended by international and state tourism boards and leading film production companies, and was also supported by the Motion Pictures Association of America - India office, and Ernst & Young. Destination Weddings is one of the fastest growing segments in tourism. A workshop on ‘Destination Indian Weddings’ was curated with the help of Globe Hoppers. Some of the leading Wedding Planners from Mumbai and Delhi attended the session along with the tourism boards. Travel Blogger Speed-Networking Session was conducted during the sidelines of OTM providing a chance to meet top 45 travel bloggers from the country and build on their prominent role in the travel marketing ecosystem. Fairfest was the first mover in India in the space of travel marts. It was established in 1989. Its OTM is now India’s largest travel trade show on the basis of countries represented, as well as the number of sellers and buyers. Sanjiv Agarwal, Chairman & CEO, Fairfest Media Ltd (organiser of OTM), said, “We are excited about the record number of 60 countries participating in OTM 2017, which is the largest ever in any trade show in India. We have seen growth and consolidation of our lead as the largest travel fair in every other parameter including area of exhibition halls rented, number of sellers and buyers. It also shows resilience of travel market despite slowdowns.” OTM 2018 will be held from January 23-25 at the Bombay Exhibition & Convention Centre. For more information on OTM 2017, visit http://otm.co.in/ OTM is organised by Fairfest Media Ltd, also the organisers of TTF and BLTM branded travel shows. It is India’s oldest and the largest travel trade show network for over 25 years, spanning 10 cities. Fairfest Media also publishes of the most widely distributed print and web editions of the B2B journal Travel News Digest (TND). It also organises Municipalika, an only of its kind annual event focused on urban solutions. Like us on Facebook @ https://www.facebook.com/OTMIndia/