Government of Puducherry
Government of Puducherry
Shakila G.,Government of Puducherry |
Periandy S.,Tagore Arts College |
Ramalingam S.,Avc College
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy | Year: 2012
The FT-IR and FT-Raman spectra of the compound 1,2-dibromobenzene have been recorded in the region 4000-100 cm -1. The vibrational analysis has been made using HF and DFT (B3LYP and LSDA) level of theory by employing 6-31 +G (d, p) and 6-311 ++G (d, p) basis sets. Optimized geometrical parameters have been calculated, interpreted and compared with the reported experimental values of some halogen-substituted benzene. The experimental geometrical parameters show satisfactory agreement with the theoretical prediction of HF and DFT. The geometrical structure of the compound is fractured by the substitutions of couple of Br in the ring. From the vibrational assignments it is observed that, the vibrational pattern of the fundamental modes is realigned slightly with respect to the substitutions. The simulated FT-IR and FT-Raman spectra of the compound for different methods are compared with the experimental spectra. The impact of Br in the vibrational assignments of the molecule is also investigated. © 2011 Elsevier B.V. All rights reserved.
Hemalatha K.,Government of Puducherry |
Girija K.,Government of Puducherry
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2011
A series of some novel 2, 3-disubstituted quinazolinone derivatives were synthesized by condensing 2-methyl/ 2-phenyl/6-bromo-2-methyl/6-bromo-2-phenyl/6, 8-dibromo-2-methyl/ 6, 8-dibromo-2-phenyl benzoxazines with compounds containing amino group. All the newly synthesized compounds chemical structures were confirmed by IR, 1H-NMR, 13C-NMR and Mass spectral data. All the synthesized compounds have been tested for their analgesic and anti-inflammatory activities.
Vadivelou G.,Government of Puducherry
Proceedings of the International Conference on Inventive Computation Technologies, ICICT 2016 | Year: 2016
To select the best service meeting their requirements, service users prefer to personalize their non-functional attributes, such as reliability and price. But, that creates challenges as service providers have to consider contradictory non-functional attributes in the service selection process for service users. Present memory-based collaborative filtering (CF) service recommendation methods employs this recommendation technique using non-functional attribute values obtained at service invocation in order to calculate the similarity between users or items, and also to predict missing non-functional attributes. However, this approach is not sufficient as the nonfunctional attribute values of invoked services may not necessarily satisfy their individual preferences. In this paper, a CF-based service recommendation method using users' individual preference on non-functional attributes is proposed.
Hemalatha K.,Government of Puducherry |
Girija K.,Government of Puducherry
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2012
A series of some novel 2, 3-disubstituted quinazolinone derivatives were synthesized by condensing 2-methyl/ 2-phenyl/6-bromo-2-methyl/6- bromo-2-phenyl/6, 8-dibromo-2-methyl/ 6,8-dibromo-2-phenyl benzoxazines with compounds containing amino group. The chemical structures of the newly synthesized compounds were confirmed by IR, 1H-NMR, 13C-NMR, Mass spectral data and elemental analysis. Title compounds were subjected to preliminary QSAR study using Mol inspiration software. All the synthesized compounds were screened for their invitro anti-oxidant activity by 1, 1-diphenyl-2, 2-picryl hydrazyl free radical (DPPH) method.
Ganesan P.,Government of Puducherry |
Soundararajan R.,Government of Puducherry |
Shanmugam U.,Government of Puducherry |
Ramu V.,Government of Puducherry
Asian Journal of Pharmaceutical Sciences | Year: 2015
The poor dissolution characteristics of water-insoluble drugs are a major challenge for pharmaceutical scientists. Reduction of the particle size/increase in the surface area of the drug is a widely used and relatively simple method for increasing dissolution rates. The objective of this study was to improve solubility, release and comparability of dissolution of a poorly soluble drug using two different types of formulations (solid dispersions and microspheres). Hydrochlorothiazide was used as a model drug. The solid dispersions and microspheres were prepared by solvent evaporation method using ethyl cellulose, hydroxypropyl methylcellulose in different drug-to-carrier ratios (1:1, 1:2 w:w). The prepared formulations were evaluated for interaction study by Fourier transform infrared spectroscopy, differential scanning calorimetry. , percentage of practical yield, drug loading, surface morphology by scanning electron microscopy, optical microscopy and in-vitro release studies. The results showed no interaction between the drug and polymer, amorphous state of solid dispersions and microspheres, percentage yield of 42.53% to 78.10%, drug content of 99.60 % to 99.64%, good spherical appearance in formulation VI and significant increase in the dissolution rate. © 2015 The Authors.
Usharani B.,University of Madras |
Muthuraj M.,Government of Puducherry
African Journal of Microbiology Research | Year: 2010
Production and partial purification of protease enzyme by Bacillus laterosporus was the aim of this study. B. laterosporus was allowed to grow in shake flask broth culture for purpose of inducing protease enzyme. The protease enzyme was purified by ammonium sulfate precipitation followed by dialysis and further concentrated by Amicon tubes. After concentration, the protein was subjected to 12% Zymogram gel with gelatin and the molecular weight of the protease enzyme was 15 kDa. The protease activity increased as there was increase in enzyme concentration; optimum substrate concentration (starch) was 1.0% (w/v); an optimum incubation temperature was 40°C. Purified protease enzyme had a maximum activity at pH 7.0 of phosphate buffer and the optimum incubation time was 24 h. The protease isolated from B. latrosporus is a mesophilic protease. It is stable at pH 7, at 40°C temperature, and this enzyme can be exploited commercially. ©2010 Academic Journals.
Thirunavukarasu S.,Government of Puducherry
Journal of Clinical Imaging Science | Year: 2011
Bilateral temporal and frontal lobe involvement is a common characteristic of herpes simplex encephalitis (HSE). Clinical sequelae of herpes simplex encephalitis may manifest sometimes as Kluver Bucy syndrome (KBS). In herpes simplex encephalitis, apart from frontal lobe, extra temporal involvement is rare and uncommon. We report a case of HSE manifesting clinically as KBS with a rare radiological finding of temporal and extratemporal involvement of pons.
Venkatachalapathy T.S.,Government of Puducherry
Indian Journal of Surgery | Year: 2014
Following reports of heparin use in burn treatment, an ethics-committee-approved prospective randomized study with controls compared results obtained using traditional usual burn treatment without heparin with results in similar patients similarly treated with heparin added topically. The subjects were 100 consecutive burn patients (age <15 years) with second-degree superficial and deep burns of 5–45 % total body surface area size. Two largely similar cohort groups—a control group (C) and a heparin group (H) with 50 subjects per group—were randomly treated. The 50 control group patients received traditional routine treatment, including topical antimicrobial cream, debridement, and, when needed, skin grafts in the early postburn period. The 50 heparin group patients, without topical cream, were additionally treated, starting on day 1 postburn, with 200 IU/ml sodium aqueous heparin solution USP (heparin) dripped on the burn surfaces and inserted into the blisters two to four times a day for 1–2 days, and then only on burn surfaces for a total of 5–7 days, before skin grafting, when needed. Thereafter, control and heparin group treatment was similar. It was found that the heparin patients complained of less pain and received less pain medicine than the control patients. The heparin group needed fewer dressings and oral antibiotics than the control group. The 50 heparin group patients had 4 skin graftings (8 %), while the 50 control group patients had 10 (20 %). Five control group patients died (mortality 10 %). No heparin group patients died. The number of days in hospital for the heparin group versus control group was significantly less (overall P < 0.0001): 58 % of heparin group patients were discharged within 10 days versus 6 % of control group patients; 82 % of heparin group patients were out in 20 days versus 14 % of control group patients; 98 % of the heparin group versus 44 % of the control group were out in 30 days; and while 100 % of heparin group patients were discharged by day 40, 56 % of the control group required up to another 10 days. Burns in heparin group patients healed on average in 15 days (maximum period 37 days) versus an average of 25 days (maximum >48 days) in control group patients (P < 0.0006). Procedures and costs in the heparin group were much reduced compared with the control group. Differences between the heparin and control groups are presented for the sake of comparison. It was concluded that heparin applied topically for 5–7 days improved burn treatment: it reduced pain, pain medicine, dressings, and use of antibiotics; it significantly reduced IV fluids (P < 0.04), days in hospital (P < 0.0001), and healing time (P < 0.0006); and it reduced skin grafts, mortality, and costs. © 2012, Association of Surgeons of India.
Prabhu M.,Health Science University |
Radha R.,Government of Puducherry
Asian Journal of Pharmaceutical and Clinical Research | Year: 2012
A series of some novel aryl imidazole derivatives were prepared by the condensation of compounds containing primary aromatic amine and aryl aldehydes to give respective Schiff's bases, which was further reacted with ammonium acetate and isatin in the presence of glacial acetic acid. The synthesized compounds were characterized by using IR and screened for their invitro antibacterial and invitro antihelmintic activity. All the synthesized compounds showed moderate to good antibacterial activity against the tested bacteria Bacillus subtilis (Gram positive organism) and Klebsiella pneumonia (Gram negative organism) and moderate to good anthelmintic activity against Indian earthworm Pheretima posthuma.
Vishnupriya R.,Government of Puducherry |
Rajarajeswaram P.,Government of Puducherry
Journal of Obstetrics and Gynecology of India | Year: 2011
Objectives The purpose of this study is to analyze the potential benefits of aerobic exercises at different intensities in the management of pre menstrual syndrome. Methods The study design is quasi-experimental; sixty-one female subjects were randomly allocated into three groups, Group A (mild intensity), Group B (moderate intensity) and Group C (severe intensity) and the intervention were given for 6 weeks. The study setting was general community settings. The outcome measures were menstrual symptom questionnaire, VO2 max, forced vital capacity (FVC), maximum voluntary ventilation (MVV) and lipid profile (HDL, LDL, TGL). Results There is significant decrease in menstrual symptoms in both Groups B and C. However, Group C improved with increased rate of perceived exertion. LDL levels did not change significantly but HDL, TGL, VO2 max, FVC, and MVV improved significantly in Groups B and C, but remains significantly unchanged in Group A. Conclusions This study encourages the employment of regular, moderate intensity aerobic exercise as a potential intervention for pre menstrual syndrome. . © 2012 Federation of Obstetric & Gynecological Societies of India.