Bhubaneshwar, India
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Mallik B.K.,Government of Odisha | Panda T.,Kalahandi Institute for Tribology and Ethnobiology | Padhy R.N.,B J B Autonomous College
Asian Pacific Journal of Tropical Biomedicine | Year: 2012

Objective: To record ethnobotanical information from a hill-dwelling aboriginal tribe of Odisha. Methods: Gathering information on medicinal uses of plants by moving door to door for conducting personal interviews with socio-economically backward tribals (aborigine people) of Niyamagiri hill area of Kalahandi district, Odisha state, India and recording the accumulated knowledge with the snowball technique. Plants were identified by the users on forest floor and were botanically classified. Results: This communication consists of uses of parts of 111 plant species belonging to 105 genera of 59 plant families, against 68 human ailments, diarrhoea, dysentery, scabies, intestinal worms, gastrointestinal disorders, venereal disease, gynecological disorders, gingivitis, rheumatism, joint pains, wounds, cut injuries, mouth troubles, ear diseases, acute eye infections, foot inflammation, foot crack and eczema, particularly. These plants are used as herbal healing sources, as a part of cultural practice of aborigines down the ages. Among these plants, many are specific to the climate identified zone of the hilly forest patches of the district. Conclusions: The present record of ethnomedicinal data indicated that the backward local ethnic people use plants from their surroundings, as healing sources for all possible ailments. © 2012 Asian Pacific Tropical Biomedical Magazine.


Kumar C.S.,Government of Odisha | Turvey C.G.,Cornell University | Kropp J.D.,University of Florida
Applied Economic Perspectives and Policy | Year: 2013

India and China have the largest farm-household populations in the world-populations that are also among the poorest. Among the many factors that affect farm livelihoods, access to credit has been identified as a significant barrier preventing the escape from poverty. While there has been significant research on credit constraints in developing countries, there is surprisingly little information pertaining to the actual impacts of credit constraints on household well-being. The objective of this paper is to investigate the impacts of credit constraints on various factors affecting farm households, such as physical and human capital formation, agricultural inputs applications, consumption smoothing, and wage-seeking behavior using direct elicitation. This paper contributes to the literature and policy debates by comparing the effects of credit constraints in China and India as surveyed in 2008-2009. The analytical results and data demonstrate that binding credit constraints adversely affect a broad range of production and livelihood choices. We empirically show that credit constraints negatively affect food consumption, farm input applications, and health and educational attainments. © The Author(s) 2013.Published by Oxford University Press, on behalf of Agricultural and Applied Economics Association. All rights reserved.


Das A.,The World Bank | Gupta R.D.,Ministry of Health and Family Welfare | Friedman J.,The World Bank | Pradhan M.M.,Government of Odisha | And 2 more authors.
Malaria Journal | Year: 2013

Background: The focus of India's National Malaria Programme witnessed a paradigm shift recently from health facility to community-based approaches. The current thrust is on diagnosing and treating malaria by community health workers and prevention through free provision of long-lasting insecticidal nets. However, appropriate community awareness and practice are inevitable for the effectiveness of such efforts. In this context, the study assessed community perceptions and practice on malaria and similar febrile illnesses. This evidence base is intended to direct the roll-out of the new strategies and improve community acceptance and utilization of services. Methods. A qualitative study involving 26 focus group discussions and 40 key informant interviews was conducted in two districts of Odisha State in India. The key points of discussion were centred on community perceptions and practice regarding malaria prevention and treatment. Thematic analysis of data was performed. Results: The 272 respondents consisted of 50% females, three-quarter scheduled tribe community and 30% students. A half of them were literates. Malaria was reported to be the most common disease in their settings with multiple modes of transmission by the FGD participants. Adoption of prevention methods was seasonal with perceived mosquito density. The reported use of bed nets was low and the utilization was determined by seasonality, affordability, intoxication and alternate uses of nets. Although respondents were aware of malaria-related symptoms, care-seeking from traditional healers and unqualified providers was prevalent. The respondents expressed lack of trust in the community health workers due to frequent drug stock-outs. The major determinants of health care seeking were socio-cultural beliefs, age, gender, faith in the service provider, proximity, poverty, and perceived effectiveness of available services. Conclusion: Apart from the socio-cultural and behavioural factors, the availability of acceptable care can modulate the community perceptions and practices on malaria management. The current community awareness on symptoms of malaria and prevention is fair, yet the prevention and treatment practices are not optimal. Promoting active community involvement and ownership in malaria control and management through strengthening community based organizations would be relevant. Further, timely availability of drugs and commodities at the community level can improve their confidence in the public health system. © 2013 Das et al.; licensee BioMed Central Ltd.


Sengupta D.,Government of Odisha | Bhargava D.K.,Government of Odisha | Dixit A.,Government of Odisha | Sahoo B.S.,Government of Odisha | And 3 more authors.
British journal of cancer | Year: 2014

The overexpression of oestrogen-related receptor-β (ERRβ) in breast cancer patients is correlated with improved prognosis and longer relapse-free survival, and the level of ERRβ mRNA is inversely correlated with the S-phase fraction of cells from breast cancer patients. Chromatin immunoprecipitation (ChIP) cloning of ERRβ transcriptional targets and gel supershift assays identified breast cancer amplified sequence 2 (BCAS2) and Follistatin (FST) as two important downstream genes that help to regulate tumourigenesis. Confocal microscopy, co-immunoprecipitation (CoIP), western blotting and quantitative real-time PCR confirmed the involvement of ERRβ in oestrogen signalling. Overexpressed ERRβ induced FST-mediated apoptosis in breast cancer cells, and E-cadherin expression was also enhanced through upregulation of FST. However, this anti-proliferative signalling function was challenged by ERRβ-mediated BCAS2 upregulation, which inhibited FST transcription through the downregulation of β-catenin/TCF4 recruitment to the FST promoter. Interestingly, ERRβ-mediated upregulation of BCAS2 downregulated the major G1-S transition marker cyclin D1, despite the predictable oncogenic properties of BCAS2. Our study provides the first evidence that ERRβ, which is a coregulator of ERα also acts as a potential tumour-suppressor molecule in breast cancer. Our current report also provides novel insights into the entire cascade of ERRβ signalling events, which may lead to BCAS2-mediated blockage of the G1/S transition and inhibition of the epithelial to mesenchymal transition through FST-mediated regulation of E-cadherin. Importantly, matrix metalloprotease 7, which is a classical mediator of metastasis and E-cadherin cleavage, was also restricted as a result of ERRβ-mediated FST overexpression.


Patro S.,Government of Odisha | Maiti I.B.,University of Kentucky | Dey N.,Government of Odisha
Journal of Biotechnology | Year: 2013

We have developed a novel bi-directional promoter (FsFfCBD) by placing two heterogeneous core-promoters from the Figwort mosaic virus sub-genomic transcript promoter (FsCP, -69 to +31) and Cauliflower mosaic virus 35S promoter (CCP, -89 to +1) respectively on upstream (5') and downstream (3') ends of a tri-hybrid enhancer (FsEFfECE), in reverse orientation. The FsEFfECE domain encompasses three heterologous enhancer fragments from Figwort mosaic virus sub-genomic transcript promoter (FsE, 101. bp, -70 to -170), Figwort mosaic virus full-length transcript promoter (FfE, 196. bp, -249 to -54) and Cauliflower mosaic virus 35S promoter (CE, 254. bp, -343 to -90). The bi-directional nature of the FsFfCBD promoter (coupled to GFP and GUS) was established both in transient systems (onion epidermal cells and tobacco protoplasts) and transgenic plant (Nicotiana tabacum samsun NN) by monitoring the simultaneous expression of GFP and GUS employing fluorescence (for GFP) and biochemical (for GUS) based assays. In transgenic plants, the FsFfCBD promoter was found to be 6.8 and 2.5 times stronger than two parent promoters; Fs and FfC respectively. The bi-directional compound promoter FsFfCBD, composed of three heterologous enhancers with enhanced activity could become a valuable additional tool for efficient plant metabolic engineering and molecular pharming. © 2012 Elsevier B.V.


In the present study, we developed a set of three chimeric/hybrid promoters namely FSgt-PFlt, PFlt-UAS-2X and MSgt-PFlt incorporating different important domains of Figwort Mosaic Virus sub-genomic transcript promoter (FSgt, -270 to -60), Mirabilis Mosaic Virus sub-genomic transcript promoter (MSgt, -306 to -125) and Peanut Chlorotic Streak Caulimovirus full-length transcript promoter (PFlt-, -353 to +24 and PFlt-UAS, -353 to -49). We demonstrated that these chimeric/hybrid promoters can drive the expression of reporter genes in different plant species including tobacco, Arabidopsis, petunia, tomato and spinach. FSgt-PFlt, PFlt-UAS-2X and MSgt-PFlt promoters showed 4.2, 1.5 and 1.2 times stronger GUS activities compared to the activity of the CaMV35S promoter, respectively, in tobacco protoplasts. Protoplast-derived recombinant promoter driven GFP showed enhanced accumulation compared to that obtained under the CaMV35S promoter. FSgt-PFlt, PFlt-UAS-2X and MSgt-PFlt promoters showed 3.0, 1.3 and 1.0 times stronger activities than the activity of the CaMV35S2 (a modified version of the CaMV35S promoter with double enhancer domain) promoter, respectively, in tobacco (Nicotiana tabacum, var. Samsun NN). Alongside, we observed a fair correlation between recombinant promoter-driven GUS accumulation with the corresponding uidA-mRNA level in transgenic tobacco. Histochemical (X-gluc) staining of whole transgenic seedlings and fluorescence images of ImaGene Green™ treated floral parts expressing the GUS under the control of recombinant promoters also support above findings. Furthermore, we confirmed that these chimeric promoters are inducible in the presence of 150 μM salicylic acid (SA) and abscisic acid (ABA). Taken altogether, we propose that SA/ABA inducible chimeric/recombinant promoters could be used for strong expression of gene(s) of interest in crop plants.


Tripathy S.K.,Government of Odisha
International Journal of Theoretical Physics | Year: 2013

Anisotropic Locally Rotationally Symmetric Bianchi-I (LRSBI) cosmological model is investigated with variable gravitational and cosmological constants in the framework of Einstein's general relativity. The shear scalar is considered to be proportional to the expansion scalar. The dynamics of the anisotropic universe with variable G and Λ are discussed. Our calculations for the Supernova constraints concerning the luminosity distance provide reasonable results. © 2013 Springer Science+Business Media New York.


Maiti S.,Government of Odisha | Patro S.,Government of Odisha | Purohit S.,Government of Odisha | Jain S.,Government of Odisha | And 2 more authors.
Antimicrobial Agents and Chemotherapy | Year: 2014

We successfully produced two human β-defensins (hBD-1 and hBD-2) in bacteria as functional peptides and tested their antibacterial activities against Salmonella enterica serovar Typhi, Escherichia coli, and Staphylococcus aureus employing both spectroscopic and viable CFU count methods. Purified peptides showed approximately 50% inhibition of the bacterial population when used individually and up to 90% when used in combination. The 50% lethal doses (LD50) of hBD-1 against S. Typhi, E. coli, and S. aureus were 0.36, 0.40, and 0.69 μg/μl, respectively, while those for hBD-2 against the same bacteria were 0.38, 0.36, and 0.66 μg/μl, respectively. Moreover, we observed that bacterium-derived antimicrobial peptides were also effective in increasing survival time and decreasing bacterial loads in the peritoneal fluid, liver, and spleen of a mouse intraperitoneally infected with S. Typhi. The 1:1 hBD-1/hBD-2 combination showed maximum effectiveness in challenging the Salmonella infection in vitro and in vivo. We also observed less tissue damage and sepsis formation in the livers of infected mice after treatment with hBD-1 and hBD-2 peptides individually or in combination. Based on these findings, we conclude that bacterium-derived recombinant β-defensins (hBD-1 and hBD-2) are promising antimicrobial peptide (AMP)-based substances for the development of new therapeutics against typhoid fever. © 2014, American Society for Microbiology. All Rights Reserved.


Sahu B.K.,Government of Odisha
Indian Journal of Environmental Protection | Year: 2015

Intensive agriculture has been practiced in some pockets of Angul-Talcher industrial region of Odisha. Though pesticides are indispensible for intensive agriculture, their indiscriminate use invites water quality problems. Pesticides contamination of ground water is a matter of great concern as ground water is used for drinking by rural agricultural households. Residues of some organochlorine pesticides, namely BHC, lindane, DDT, endosulphan, heptachlor, aldrin and dialdrin were monitored in ground water samples collected from 5 dug wells located near the agricultural fields in the study area. In spite of ban on use of most of the organochlorine pesticides, it is found from the study that the residues of some of these pesticides in dug well water are still higher than their maximum residue limit (MRL) recommended for drinking water. © 2015 - Kalpana Corporation.


Tripathy S.K.,Government of Odisha
Astrophysics and Space Science | Year: 2014

We study cosmological models with anisotropy in expansion rates in the context of the recent observations predicting an accelerating universe. In the absence of any anisotropy in the cosmic fluid, it is shown that the role of skewness in directional Hubble rates is crucial in deciding the behavior of the model. We find that incorporation of skewness leads to a more evolving effective equation of state parameter. © 2013 Springer Science+Business Media Dordrecht.

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