Government Medical College Nagpur

Nāgpur, India

Government Medical College Nagpur

Nāgpur, India
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Rahule A.S.,Government Medical College GMC Akola | Bashir M.S.M.,Rajiv Gandhi Institute of Medical science RIMS Adilabad andhra Pradesh | Meshram M.M.,Government Medical College Nagpur
Medico-Legal Update | Year: 2012

Background: Determination of sex from single formula is difficult for different zone. For this reason we planned the study on the population of Vidarbha using femur to know the status. Material and Methods: 140 femurs, (96 male, 44 females) were included in the study. Parameters used were diameters of head, weight and bicondylar angle. In head, recorded diameters were vertical, anteroposterior and mediolateral. By Demarking Points (DP), percentage of bones in males and females were calculated. Results: Using DP, with vertical diameter 41.66% right male and 68% of female and 66.66% male and 68% left female bones could be assigned sex. With anteroposterior diameter 73% male and 73% of female right and 75% of males and 54.54% female left could be identified. By mediolateral diameter 21% right males and 73% females and 6.25% of left male and 64% of left female bones could be sexed. With weight, 16.66% of right and 42.66% male and none of the female could be sexed. There was statistically significant difference in bicondylar angles of femur in males and females. Conclusion: We conclude that anteroposterior diameter of the head of femur is the best criteria for sexual dimorphism in the studied population. Vertical diameter, transverse diameter, bicondylar angle and weight of the femur are also discriminate parameters in order of their accuracy.


Chaudhari K.,Government Medical College Nagpur | Khanzode S.,Government Medical College Nagpur | Dakhale G.,Indira Gandhi Government Medical College | Saoji A.,Government Medical College Nagpur | Sarode S.,Government Medical College Nagpur
Indian Journal of Clinical Biochemistry | Year: 2010

Derangement of antioxidant levels in major depressive disorder had been correlated with oxidative damage. The effect of Selective Serotonin Re-Uptake Inhibitors on endogenous antioxidant uric acid levels in major depressive disorder has never been examined. This was a prospective; open labeled, parallel, 12 weeks study, in which serum uric acid levels and Hamilton Rating Scale for Depression score were estimated in age and sex matched thirty-six healthy and forty major depressive disorder subjects before and after fluoxetine and citalopram treatment. Significant decrease in serum uric acid (P<0.0001) was observed in newly diagnosed major depressive disorder subjects when compared to healthy subjects. The trend was reversed after 6 weeks more significantly after 12 weeks of treatment with improvement in Hamilton Rating Scale for Depression score. Also, Significant and negative correlation was found between Hamilton Rating Scale for Depression score and serum uric acid level (r= -0.864, P<0.001) after 12 weeks of treatment. Treatment with fluoxetine or citalopram reverses endogenous antioxidants like uric acid and improves Hamilton Rating Scale for Depression score in major depressive disorder.


Mahato L.O.,Government Medical College Nagpur | Rangari K.A.,Government Medical College Nagpur | Naidu S.S.,Government Medical College Nagpur | Rahule A.S.,Government Medical College Akola | Bashir M.S.M.,Rajiv Gandhi Institute of Medical science RIMS
Indian Journal of Public Health Research and Development | Year: 2014

Background: Dermatoglyphics is useful in the management of various genetic disorders. Thalassemia is a genetic disorder of early age which in sever forms needs blood transfusion. By dermatoglyphics which deals with epidermal ridges we can diagnose the cases of thalassemia. This study was conducted to find whether any specific pattern of palmer dermatoglyphics exist for thalassemic population of Vidarbha region of India. Materials and Method: 100 thalassemic cases with equal number of healthy volunteers were included in this prospective study. Palmer dermatoglyphic study was performed by using "Ink method" of Cummins. Results: Palmar patterns are significantly more in thalassemics mainly in hypothenar and thenar/ ID1areas than controls. Significant increase in number of palmar triradii is also seen. There is distal displacement of axial triradii is available in both male and female thalassemics. 'atd' angles and 'a-b' ridge count is also more in thalassemics than control cases. Conclusion: Vidarbha region have specific differences in patients of thalassemia as far as palmer dermatoglyphic patterns is concerned. The knowledge will be useful in the management of the disease. © 2014, Indian Journal of Public Health Research and Development. All rights reserved.


Turankar S.,Sir JJ Group of Hospitals | Sonone K.,Government Medical College Nagpur | Turankar A.,Sir JJ Group of Hospitals
Journal of Clinical and Diagnostic Research | Year: 2013

Aim and Objective: To study the serum prolactin levels and the serum TSH in primary infertile females. Material and Method: In this study, we investigated thirty women who were diagnosed cases of primary infertility, who attended the Biochemistry Department, Sir JJ Group of Hos-pitals, Mumbai, India, for hormonal evaluations. Thirty fertile women with similar ages were enrolled as the controls. The status of the thyroid dysfunction and the levels of serum pro-lactin were reviewed in infertile women and in the controls. The serum Prolactin and the thyroid stimulating hormone lev-els were measured by using Siemens kits in IMMULITE 1000 chemiluminescence immunoassays. Results: In our study, the serum prolactin levels in the infer-tile group were found to be high as compared to those in the control group and they were highly significant (p<0.0001). The serum TSH levels in the infertile group were found to be high, as compared to those of control group and they were highly significant (p<0.0001). Conclusion: There is a higher incidence of hyperprolactinae-mia in infertile patients. There is also a greater propensity for thyroid disorders in infertile women than in the fertile ones. The incidence of hypothyroidism in the hyperprolactinaemic sub-jects in the study population was found to be highly signifi-cant than the normal controls.


Lokhande Suryabhan L.,Seth Gs Medical College And Kem Hospital Mumbai | Iyer Chandrashekhar M.,Government Medical College Nagpur | Shinde Ratnendra R.,Seth Gs Medical College And Hospital | Nandedkar Prerna D.,Seth Gs Medical College And Kem Hospital Mumbai
Journal of Clinical and Diagnostic Research | Year: 2013

Background and Objectives: Type 2 Diabetes Mellitus (Type 2 DM), which is characterized by a relative insulin deficiency or insulin resistance is associated with a cluster of metabolic ab- normalities, which includes glucose intolerance, hypertension, a unique dyslipidaemia, a procoagulant state, and an increase in macrovascular diseases. The present study was conducted to assess the significance of postprandial dyslipidaemia with respect to fasting dyslipidaemia, in the pathogenesis of athero- sclerotic changes and possible cardiovascular diseases (CVD) and complications.Methods and Statistical Analysis: Fifty diagnosed cases of type 2 DM which were in the age group of 35-65 years, which had a duration of diabetes of more than five years, were in- cluded in the study and 50 age and sex matched healthy sub- jects were taken as the controls. In both the study groups, we measured the serum levels of fasting as well as the postpran- dial lipid profile, which was comprised of the total Cholesterol (TC), triglycerides (TGs), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and the waist-hip ratio (WHI) as the cardiovascular risk factors. Thestatistical analysis was done by using the Students unpaired't'-test.Results: The results of this study showed significantly in- creased levels of serum total cholesterol, TGs, LDL-C and VLDL-C in the postprandial state as compared to those in the fasting state (p<0.001) and as compared to those in the fast- ing and the postprandial states of the controls (p<0.001). The serum HDL-C level was significantly lower in the postprandial state as compared to that in the fasting state (p<0.001). Also, the postprandial and the fasting HDL-C levels were signifi- cantly lower as compared to the levels in their respective con- trol groups (p<0.001). Conclusion: The findings of the present study indicated that the lipid profile, as a cardiovascular risk factor, was significant- ly elevated in the postprandial state as compared to that in the fasting state and that it was significantly elevated in the post- prandial and the fasting states in the Type 2 DM patients as compared to the levels in their respective control groups. This signified a routine estimation of the postprandial lipid profile, rather than the fasting lipid parameters, in the cardiovascular risk assessment in Type 2 DM.


Tabhane M.K.,Salve Institute of Medical science and Research Center | Palikundwar K.G.,Government Medical College Nagpur | Ksheersagar D.D.,Salve Institute of Medical science and Research Center | Meshram M.M.,Government Medical College Nagpur | Rahule A.S.,Government Medical College Nagpur
Medico-Legal Update | Year: 2014

Background: Dermatoglyphics is the scientific study of epidermal ridges which can be used in predictions of genetic disorders since epidermal ridge patterns are under genetic influence. This study attempts to analyze whether any specific pattern exist for Vitiligo population of Vidarbha region of Maharashtra India or not. Materials and Method: A total of 200 cases, 100 each of Vitiligo and control were enrolled for the study. Dermatoglyphic prints were taken by "Ink method". Detailed dermatoglyphic analysis was done with the help of magnifying hand lens and ridge counting was done with the help of a sharp needle. Results: Vitiligo patients exhibited increase percentage of whorl pattern on first finger followed by second finger in both the sexes. Loops pattern is more common in females compared to males. Increased percentage of arches on first and third digits in males and fifth in females is also observed Conclusion: There are specific differences in the dermatoglyphic patterns in Vitiligo patients as compared with normal general population of the region.


PubMed | Government Medical College Nagpur
Type: Journal Article | Journal: Indian journal of clinical biochemistry : IJCB | Year: 2012

Derangement of antioxidant levels in major depressive disorder had been correlated with oxidative damage. The effect of Selective Serotonin Re-Uptake Inhibitors on endogenous antioxidant uric acid levels in major depressive disorder has never been examined. This was a prospective; open labeled, parallel, 12 weeks study, in which serum uric acid levels and Hamilton Rating Scale for Depression score were estimated in age and sex matched thirty-six healthy and forty major depressive disorder subjects before and after fluoxetine and citalopram treatment. Significant decrease in serum uric acid (P<0.0001) was observed in newly diagnosed major depressive disorder subjects when compared to healthy subjects. The trend was reversed after 6 weeks more significantly after 12 weeks of treatment with improvement in Hamilton Rating Scale for Depression score. Also, Significant and negative correlation was found between Hamilton Rating Scale for Depression score and serum uric acid level (r= -0.864, P<0.001) after 12 weeks of treatment. Treatment with fluoxetine or citalopram reverses endogenous antioxidants like uric acid and improves Hamilton Rating Scale for Depression score in major depressive disorder.


PubMed | Government Medical College Nagpur
Type: Journal Article | Journal: Indian journal of clinical biochemistry : IJCB | Year: 2012

The level of sialic acid in the obese polymorphonuclear leukocytes (PMNL) was found to be significantly reduced as compared to normal. Activity of sialic acid degrading enzyme, sialidase, was found to be increased in the obese state. Restoration in both sialic acid content and sialidase activity was also evidenced in the PMNL of treated obese patients.

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