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Padavi, Sri Lanka

Ozkaya E.,Bezmialem Foundation University | Akduman H.,Government Hospital | Erenberk U.,Bezmialem Foundation University | Demir A.,Bezmialem Foundation University | Dundaroz M.R.,Bezmialem Foundation University
American Journal of Rhinology and Allergy | Year: 2013

Background: Oxidative stress may play a role in the pathophysiology of several diseases including allergic rhinitis (AR). In children with AR an antioxidant enzyme paraoxonase (PON1) has not been previously investigated. The aim of this study was to investigate plasma PON1 activity and plasma total oxidant status (TOS), which are in the form of plasma reactive oxidants, and their association with severity of disease in house-mite-sensitive children with AR. Methods: This study included 66 children with persistent AR and 40 healthy controls aged between 7 and 12 years old. Plasma PON1, TOS, and total serum immunoglobulin E (IgE) were measured. The nasal symptom scores and body mass index were evaluated at the time of blood collection. Results: Mean serum PON1 levels were significantly lower and, TOS levels were higher in the patient group than in the control group (p ≤ 0.001 and p ≤ 0.002, respectively). A significant negative correlation was observed between serum levels of PON1 and nasal symptom scores. However, serum levels of TOS were correlated with nasal symptom scores positively. There were no correlations between levels of total IgE and levels of PON1 and TOS levels. Conclusion: Plasma PON1 and TOS levels may serve as predictors of disease severity in children with AR and both of them appear to be attractive candidates for modulating inflammation in AR. Copyright © 2013, OceanSide Publications, Inc., U.S.A.

Kumar R.V.,Government Hospital | Neki N.S.,Government of Punjab | Mani T.,Government of Punjab
Journal International Medical Sciences Academy | Year: 2015

Cavernous angioma is a cerebral vascular malformation which commonly presents with seizures, hemorrhage, focal neurological signs and headache. However the affected persons may be entirely asymptomatic. Cerebral cavernous malformations are angiographically occult and usually detected by Magnetic resonance (MRI) imaging of the brain. We encountered a 65 years old male who presented with recurrent hemorrhagic stroke whose initial investigations like Computerized Tomography (CT) scan brain, MRI brain and CT Angiogram failed to detect cerebral cavernous malformations. On clinical suspicion we did Gradient echo MRI imaging of the brain which helped us clinch the diagnosis of cavernous angioma brain. © 2015, International Medical Sciences Academy. All rights reserved.

Baskaran R.,St. Josephs College | Antoinette B.,Government Hospital
Asian Journal of Pharmaceutical and Clinical Research | Year: 2012

Steriotactic body radiation therapy is a newly emerging radiotherapy treatment method to deliver a high dose of radiation to the target in a single dose or number of fractions. The features of SBRT patients both normal and abnormal tissue are defined with CT, MRI, or angiography or any other image studies that may be useful in localizing the target volumes. It is a non-surgical procedure that uses highly focused X rays beams to treat lung cancer. Unlike surgery SBRS is painless and patients can continue routine life style activities without any difficulty. Rapid arc radiotherapy represents a new revolution in cancer care. Cancers including head and neck malignancies, brain tumors, thoracic tumors, abdominal tumors, pelvic tumors have been treated with this technology.

Sahin M.,Government Hospital | Sahin Z.A.,Kafkas University
International Journal of Diabetes in Developing Countries | Year: 2015

In women, it is clinically difficult to measure the sexual functions. Partner’s sexual performance, quality of the relationship, cultural-ethnic, educational and socio-economic status of the patient, psychological changes, chronic diseases such as diabetes and its complications affect the sexual functions. This study was conducted in order to determine the sexual dysfunction (SD) and sexual quality of life of women with type 2 diabetes. This cross-sectional and descriptive study was conducted at nine family health centers located in the city center of Kars. We used a questionnaire for data collection, and the Sexual Quality of Life Questionnaire-Female (SQLQ-F) and Female Sexual Function Index (FSFI) were used as the data collection tool. Sexual dysfunction and sexual quality of life of women with type 2 diabetes. The mean total FSFI was 67.36 ± 10.25 and the mean score for sexual desire was 3.28 ± 2.58, arousal 8.42 ± 4.33, lubrication 12.57 ± 4.89, orgasm 7.25 ± 3.52, satisfaction 9.06 ± 2.18, and pain 9.28 ± 4.45. The most common problem was sexual desire (3.28 ± 2.58), while the least common one was lubrication (12.57 ± 4.89). The mean total SQLQ-F score was 38.56 ± 10.89 which is considered to indicate low. Results showed that as the level of sexual quality of life increased, the sexual desire, arousal, lubrication, orgasm, satisfaction and total FSFI increased and a statistically positive significant difference between SD. Sexual quality of life level and pain, increased, indicating a statistically negative significant difference between SD and sexual quality of life level. © 2015, Research Society for Study of Diabetes in India.

Objective: To investigate the efficacy of ethanolic extract of nilavembu kudineer choornam (EENKC) in inflammation, pain and fever using animal models to support its actions. Methods: Acute toxicity study of EENKC was performed in mice to fix the effective dose. The antipyretic, anti-inflammatory and analgesic activity of EENKC was evaluated in brewer's yeast induced pyrexia in rats, carrageenan-induced inflammation in rats and acetic-acid induced writhing in mice model. Results: Acute toxicity revealed that EENKC didn't show death and toxic signs up to 2 000 mg/kg. In brewer's yeast induced pyrexia and carrageenan-induced inflammation EENKC at the doses of 200 and 400 mg/kg inhibited fever and inflammation significantly (P<0.01 and <0.05) compared to control animals. In mice, the number of writhing induced by acetic-acid was significantly (P<0.01) reduced after treatment with both the dose of EENKC than control animals. EENKC 200 mg/kg inhibits inflammation higher level in carrageenan-induced paw edema, but there is no significant difference when compared to indomethacin 10 mg/kg. Conclusions: The present findings revealed that EENKC possesses antipyretic, anti-inflammatory and analgesic activity which supports nilavembu kudineer choornam efficacy in chikungunya fever. © 2011 Hainan Medical College.

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