Government College for Girls

Chandigarh, India

Government College for Girls

Chandigarh, India

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Singh D.P.,Government of Punjab | Singh D.P.,Panjab University | Khare P.,Government of Punjab | Khare P.,Panjab University | And 7 more authors.
International Journal of Obesity | Year: 2016

Background:High-fat diets (HFDs) induce systemic inflammation, gut microbial derangements and disturb metabolic homeostasis, resulting in weight gain, insulin resistance and nonalcoholic fatty liver (NAFL). Numerous antioxidants and prebiotic/probiotics per se may prevent HFD-associated comorbidities, but there are no reports related to their combination.Objective:In the present study, we aim to evaluate a cobiotic combination of lycopene (antioxidant) and isomalto-oligosaccharides (IMOs, a prebiotic) for prevention of HFD-induced alterations.Design:Male Swiss albino mice were fed either normal pellet diet (NPD) or HFD and lycopene (5 and 10 mg kg -1), IMOs (0.5 and 1 g kg -1) or their combination for 12 weeks. Systemic adiposity, glucose tolerance, insulin sensitivity, feeding regulators in hypothalamus, hepatosteatosis and liver inflammation, cecal short chain fatty acids (SCFAs), serum inflammatory cytokines, gut morphology and alterations in selected gut microbes were studied.Results:Lycopene, IMOs and their combination prevented weight gain, adiposity, improved adipose tissue fat mobilization and reduced insulin resistance. Hypothalamic orexigenic and anorectic genes have also been modulated by these treatments. Dietary interventions prevented NAFL-like symptoms and improved glucose homeostasis. Improvement in selected gut microbial abundance and SCFA concentration along with reduced systemic inflammation, metabolic endotoxemia and improved ileal and colonic health were observed in mice supplemented with lycopene, IMOs and their combination. Interestingly, cobiotic combination synergistically improved many of the HFD-induced alterations.Conclusion:The present work provide evidence that new approach based on cobiotic combination (antioxidant plus prebiotic) can be employed to develop novel class of functional foods for their application against HFD-associated pathological complications. © 2016 Macmillan Publishers Limited.


Saini G.S.S.,Panjab University | Dogra S.D.,Panjab University | Singh G.,Panjab University | Tripathi S.K.,Panjab University | And 3 more authors.
Vibrational Spectroscopy | Year: 2012

We report the effects of methanol, pyridine, diethylamine, dichloromethane, acetonitrile, bromine and NO 2 vapours on the Raman and infrared absorption spectra of zinc tetraphenylporphine thin films by recording their spectra before and after exposure with chemical vapours. Positions of some vibrational bands show detectable change on exposure. Changes in the intensity of some vibrational bands of the thin films have also been observed on exposure. Coordination of vapours molecules at the zinc ion and subsequent charge transfer are responsible for the shift in the vibrational bands. Density functional theory calculations have been carried out to determine the probable geometric structures of the porphyrin-vapour complexes. Calculated geometric structures show in-plane and out-of-plane distortions in the porphyrin macrocycle. Calculations also result in charge transfer between vapour and porphyrin molecules. © 2012 Elsevier B.V.


Chand K.,HP University | Kumar R.,Government College for Girls | Sharma S.,HP University
Turkish Journal of Engineering and Environmental Sciences | Year: 2013

An investigation of the combined influence of rarefaction and Darcy effects on the flow of oscillatory MHD viscous, incompressible, chemically reacting, and electrically conducting fluid in a vertical channel is carried out. The fluid is assumed to be gray and absorbing and emitting radiation but to be a nonscattering medium. The flow is assumed to be laminar and hydrodynamically and thermally fully developed. The Navier-Stokes, energy, and concentration equations, which are accompanied by appropriate velocity-slip and temperature-jump boundary conditions, are analytically solved. It is found that rarefaction effects significantly influence the flow and thermal fields such that mass flow and heat transfer rates are increased as compared to the continuum regime.


Singh R.,Guru Nanak Institutions | Sathe V.,University Campus | Kaur S.,Government College for Girls | Saini G.S.S.,Panjab University
Journal of Molecular Structure | Year: 2016

Effect of solvation on coumarin6 dye has been studied with density functional theory (DFT). Optimized structure of the dye has been obtained in various solvents and frequencies of various vibrational bands have been calculated in these solvents. Calculations predict shift in the frequency of certain bands in the solvents. Similar shifts have been observed experimentally in the vibrational spectra of the dye in solvents. In order to ascertain the origin of these shifts, the interactions of solvent molecules with the coumarin6 molecule have been studied using various tools of DFT like donor-acceptor interactions, Molecular Electrostatic potential (MEP) and HOMO-LUMO analysis etc. © 2015 Elsevier B.V. All rights reserved.


PubMed | Panjab University, Government College for Girls, SAS Institute and BioNeutra North America Incorporation
Type: Journal Article | Journal: International journal of obesity (2005) | Year: 2016

High-fat diets (HFDs) induce systemic inflammation, gut microbial derangements and disturb metabolic homeostasis, resulting in weight gain, insulin resistance and nonalcoholic fatty liver (NAFL). Numerous antioxidants and prebiotic/probiotics per se may prevent HFD-associated comorbidities, but there are no reports related to their combination.In the present study, we aim to evaluate a cobiotic combination of lycopene (antioxidant) and isomalto-oligosaccharides (IMOs, a prebiotic) for prevention of HFD-induced alterations.Male Swiss albino mice were fed either normal pellet diet (NPD) or HFD and lycopene (5 and 10mgkg(-1)), IMOs (0.5 and 1gkg(-1)) or their combination for 12 weeks. Systemic adiposity, glucose tolerance, insulin sensitivity, feeding regulators in hypothalamus, hepatosteatosis and liver inflammation, cecal short chain fatty acids (SCFAs), serum inflammatory cytokines, gut morphology and alterations in selected gut microbes were studied.Lycopene, IMOs and their combination prevented weight gain, adiposity, improved adipose tissue fat mobilization and reduced insulin resistance. Hypothalamic orexigenic and anorectic genes have also been modulated by these treatments. Dietary interventions prevented NAFL-like symptoms and improved glucose homeostasis. Improvement in selected gut microbial abundance and SCFA concentration along with reduced systemic inflammation, metabolic endotoxemia and improved ileal and colonic health were observed in mice supplemented with lycopene, IMOs and their combination. Interestingly, cobiotic combination synergistically improved many of the HFD-induced alterations.The present work provide evidence that new approach based on cobiotic combination (antioxidant plus prebiotic) can be employed to develop novel class of functional foods for their application against HFD-associated pathological complications.


Dogra S.D.,Panjab University | Singh S.,Government College for Women | Kaur S.,Government College for Girls | Tripathi S.K.,Panjab University | Saini G.S.S.,Panjab University
Vibrational Spectroscopy | Year: 2011

Abstract: In the present work, we have studied the effect of pyridine on the zinc phthalocyanine by recording the infrared absorption and X-ray diffraction spectra with and without pyridine. In the presence of pyridine phase of the crystalline zinc phthalocyanine changes from β to α. Some infrared bands show changes in their positions and/or intensities. These changes have been interpreted on the basis of coordination of the pyridine molecule with the central zinc ion. Coordinated pyridine transfers some of its charge to the π electron system of the phthalocyanine ring through zinc ion. Pyridine molecule also distorts the phthalocyanine molecule by pulling zinc ion out of the phthalocyanine plane. Density functional theory also confirms the ligation of pyridine molecule at the fifth coordination site of the central metal ion. © 2010 Elsevier B.V. All rights reserved.


Singh G.,University of Punjab | Kaur S.,Government College for Girls | Saini G.S.S.,University of Punjab
AIP Conference Proceedings | Year: 2011

Vibrational study of Melatonin (N-acetyl 5-methoxytrypatamin) was done using FTIR and Raman spectroscopy. DFT calculations were employed to the structural analysis of melatonin and to the end products. The theoretical calculations confirmed the different observed vibrational modes. The optimized structure energy calculations of the different end products confirmed the most probable site of the hydroxyl radical attack is the hydrogen attached to nitrogen present in the indole ring. © 2011 American Institute of Physics.


Sharma R.,Government College for Girls
Molecular and cellular biochemistry | Year: 2012

The effect of alloxan-induced gestational diabetes on the postnatal development of brush border disaccharidases and D-glucose transport in rat intestine was studied. Pups born to diabetic mothers showed 92-22% increase in blood sugar levels compared with the controls. Western blot and RT-PCR analyses revealed that the activities of brush border sucrase, lactase and Sodium Glucose Co-transporter 1 (SGLT1) correlates with protein and mRNA levels in intestine of pups born to diabetic rat mothers after 5-45 days of birth. Intestinal histology in pups born to diabetic mothers at day 10 and 45 after birth showed distorted cellular organization of mucosa with a decrease in the number of secretary goblet cells and regression of tubular mass. These findings suggest that the genetic switch in utero regulates the postnatal expression of enzyme and transport functions in intestine of pups born to diabetic rat mothers. This may influence the growth and development of offsprings later in life.


Singh S.,Government College for Girls | Saini G.S.S.,Panjab University | Tripathi S.K.,Panjab University
Sensors and Actuators, B: Chemical | Year: 2014

The vacuum evaporated thin films of zinc phthalocyanine (ZnPc) were prepared at room temperature and structurally investigated using X-ray diffraction and scanning electron microscope (SEM). The temperature dependence of dark and photoconductivity of as-deposited (i.e. unexposed) and exposed ZnPc films were measured in the temperature range 305-389 K. Some of the optical absorption such as molar extinction coefficient, the oscillator strength, the electrical dipole strength have been evaluated. The optical band gaps of the ZnPc thin films have been determined from α2 versus hν graph. These films have been studied as chemical sensors such as methanol and ammonia. © 2014 Elsevier B.V.


Saini G.S.S.,Panjab University | Kaur S.,Government College for Girls | Tripathi S.K.,Panjab University | Dogra S.D.,Panjab University | And 2 more authors.
Vibrational Spectroscopy | Year: 2011

The present work reports vibrational spectra and density functional theory calculations for chloranil, imidazole and their complexes. The experimentally observed infrared and Raman bands have been assigned with the help of calculated vibrational frequencies and potential energy distribution analysis. Some bands of chloranil and imidazole have been found to shift on the complex formation due to partial electronic charge transfer from imidazole to chloranil. The charge transfer between these molecules is also corroborated by the electronic absorption spectroscopy and calculations. The theoretical values of the interaction energy of various possible chloranil-imidazole interactions suggest that the two molecules interact preferably via N and H atoms of imidazole and CO group of chloranil with their molecular planes almost perpendicular to each other. © 2010 Elsevier B.V. All rights reserved.

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