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Hyderabad, India

Srinivas P.,Osmania University | Rajanna K.C.,Osmania University | Krishnaiah G.,Osmania University | Kumar M.S.,Osmania University | Reddy J.N.,Government City College
Synthesis and Reactivity in Inorganic, Metal-Organic and Nano-Metal Chemistry | Year: 2014

Prussian blue triggered transesterification of ethylacetoacetate with various alcohols underwent efficiently. The reaction is mild, eco-friendly, and selective with good yields. The proposed reaction pathway depicts the formation of an intermediate by the interaction of β-ketoesters with catalytic site of the Prussian blue, followed by nucleophilic attack of the alcohol at the electrophilic center followed by successive elimination of the proton to give the product. Observed longer reaction times under conventional conditions reduced amazingly under sonication and microwave irradiation followed enhanced yield of products. © 2014 Copyright Taylor & Francis Group, LLC. Source


Latha T.S.,Yogi Vemana University | Panati K.,Government City College | Gowd D.S.K.,Yogi Vemana University | Reddy M.C.,Yogi Vemana University | Lomada D.,Yogi Vemana University
International Reviews of Immunology | Year: 2014

Ovarian cancer is the most lethal malignancy of the female reproductive system and the fifth leading cause of cancer death in women. In the year 2012 alone, United States had 22,280 new ovarian cancer cases and 15,500 deaths were reported. About 7%-10% of ovarian cancers result from an inherited tendency to develop the disease. Ovarian cancer has the ability to escape the immune system because of its pathological interactions between cancer cells and host immune cells in the tumor microenvironment create an immunosuppressive network that promotes tumor growth, protects the tumor from immune system. The levels of immune suppressive elements like regulatory T cells, plasmacytoid dendritic cells and cytokines such as IL-10, IL-6, TNF-α, and TGF-β are elevated in the tumor microenvironment. Vascular endothelial growth factor is known to have an immune suppressing role besides its angiogenic role in the tumor microenvironment. Ovarian cancer is associated with high mortality partly due to difficulties in early diagnosis and development of metastases. These problems may overcome by developing accurate mouse models that should mimic the complexity of human ovarian cancer. Such animal models are better suited to understand pathophysiology, metastases, and also for preclinical testing of targeted molecular therapeutics. Immunotherapy is an area of active investigation and off late many clinical trials is ongoing to prevent disease progression. The main aim of dendritic cells vaccination is to stimulate tumor specific effector T cells that can reduce tumor size and induce immunological memory to prevent tumor relapse. © Informa Healthcare USA, Inc. Source


Sadhana K.,Osmania University | Naina Vinodini S.E.,Government City College | Sandhya R.,Osmania University | Praveena K.,Indian Institute of Science | Praveena K.,Eternal University
Advanced Materials Letters | Year: 2015

Al3Fe5O12 (AIG) nanopowders were synthesized at different pH using aqueous co-precipitation method. The effect of pH on the phase formation of AIG is characterized using XRD, TEM, FTIR and TG/DTA. From the Scherer formula, the particle sizes of the powders were found to be 15, 21, 25 and 30 nm for pH= 9, 10, 11 and 12, respectively. It is found that as the pH of the solution increase the particle size also increases. It is clear from the TG/DTA curves that as the pH is increasing the weight losses were found to be small. The nanopowders were sintered at 900°C/4hrs using conventional sintering method. The phase formation is completed at 800°C/4h which is correlated with TG/DTA. The average grain size of the samples is found to be ~55 nm. As the pH increases the magnetization values are also increasing. The saturation magnetization was found to be 4 emu/g, 6 emu/g, 7 emu/g and 9 emu/g corresponding to pH= 9, 10, 11 and 12, respectively which clearly shows that the magnetization values are dependent on pH. Room temperature magnetization measurements established these compounds to be soft magnetic. The dielectric and magnetic properties (ε′, ε″, μ′ and μ″) of AIG was studied over a wide range of frequency (1GHz-50GHz). With increase of pH both ε′ and μ′ increased. This finding provides a new route for AIG materials that can be used in the gigahertz range. © 2015 VBRI Press. Source


Chinna Babua J.,Government City College | ChandraMoulib V.,Osmania University
Indian Journal of Pure and Applied Physics | Year: 2016

Differential scanning calorimetry (DSC), electron spin resonance (ESR), Raman, infrared (IR) and optical absorption studies on 10Na2 O-xNb2 O5 -(89-x)TeO2 -1CuO glasses (where x =0, 5, 10, 15 and 20 mol%) containing Cu2+ spin probe have been carried out. Glass transition temperature (Tg ) and thermal stability of glass samples have been estimated from the DSC measurements and it has been found that both increase with increasing the Nb2 O5 content. From Raman and IR spectra, it is clear that present glass system consists of structural units of TeO3 (tp) and TeO4 (tbp) and NbO6 octahedra. Also, TeO4 units convert into TeO3 units with change in Nb2 O5 content. The hyperfine splittings in the parallel features of ESR spectra of Cu2+ are recorded for all compositions. ESR results show that ||> g ⊥ indicating that the Cu2+ ion is in tetragonal distorted octahedral site and its ground state is x2-y2. There is considerable variation in Hamiltonian parameters for the different compositions. The observed optical absorption peak of Cu2+ is found to be maximum at 780 nm for 10 mol% of Nb2 O5 content. Bonding parameters and % bonding symmetry are calculated from both optical and ESR data changing with increasing Nb2 O5 content. Source


Rao Y.R.,Government City College | Deshmukh S.S.,Government City College | Deshmukh S.S.,Srtm University
Asian Journal of Chemistry | Year: 2010

Bio-diesel derived from oils and fats by transesterification with alcohols is a renewable, biodegradable and non-toxic fuel for compression ignition engine. As an alternate fuel bio-diesel has attracted considerable attention during the past decades. Commercial production of bio-diesel from vegetable oils is not economically viable and use of unconventional microbial sources particularly micro-algae for the production of bio-diesel is of practical significance. The present work describes conversion of algal oil to bio-diesel by transesterfication with methanol in the presence of metal ion catalysts. The bio-diesel obtained was analyzed for methyl ester components and fuel related physical properties as per ASTM methods. Source

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