Government Ayurveda Medical College

Mysore, India

Government Ayurveda Medical College

Mysore, India

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PubMed | Government Ayurveda Medical College and Hospital and Research Center
Type: Journal Article | Journal: Ayu | Year: 2014

Rajata Sindura (RS) is a mercurial preparation, known for its properties like Rasayana (rejuvinating), Balya (strengthening), Vrushya (aphrodisiac), Medhya (increasing intellect) and can cure various diseases when used with appropriate adjuvant. It is prepared with Hingulottha Parada (purified mercury), Shuddha Gandhaka (purified sulfur) and Shuddha Rajata (purified silver) in a proportion of 1:1:4. Process standardization and characterization of RS are not reported until date.Pharmaceutical standardization and characterization of Rajata Sindura.Purified mercury and silver were triturated to form amalgam, followed by the addition of purified sulfur to prepare Kajjali and lavigated with Vatankura (leaf buds of Ficus benghalensis Linn.) swarasa (juice). This Kajjali was processed by Kupipakwa method.RS was prepared in 33 h with 20.25% yield. Scanning electron microscope coupled with energy dispersive spectroscopy analysis has shown Mercury 86.21%, sulfur 13.27% as major elements; iron, calcium, potassium, magnesium and silver were other detected minor elements. X-ray diffraction report revealed the chemical nature of RS as HgS compound, having cubic crystal structure.


Priyadarshini S.,Government Ayurveda Medical College | Ashadevi J.S.,University of Mysore | Nagarjun V.,Uppsala University | Prasanna K.S.,Maharanis Science College for Women
Journal of Ayurveda and Integrative Medicine | Year: 2010

We report preliminary results from an ongoing series of experiments on lifespan extension by appropriately modified Ayurvedic rasayanas in animal models. Here data are presented indicating lifespan extensions of 51-55% (up to 70-95% in the pilot experiment) in a standard strain of Drosophila melanogaster (Oregon-K) using a standard rasayana (Ayurvedic herbal formulation for life-extension) suitably adapted for insects. In a first experiment, two groups of 20 unmated D. melanogaster strain Oregon-K kept at 22oC received either rasayana or standard yeast diet; days of death were recorded. Another experiment investigated possible sex differences; equal sized (N = 30) groups of similar males, females, and controls were compared. Life lengths of all controls were in the strain's usual range: in Experiment 1, control life lengths were minimum 40 to maximum 53 days; experimental group figures were 81-91 days; groups were completely separated, experimental group minimum life length being 28 days more than control group maximum life length, i.e., about 2.5 full distribution widths-a sign test for the null hypothesis yields p < 2 -20, i.e., 10-6 as maximum p. Experiment 2 found no differences between life lengths of males and females; but the maximum life length of 30 controls (60 days in males and 66 days in females) was once again far shorter than the minimum life length of the 60 in the two experimental groups, strengthening the findings of Experiment 1. Despite group sizes being relatively small, results are conclusive: the rasayanas in question increase D. melanogaster strain Oregon-K life length. The complexity of the formulation suggests that multiple mechanisms are involved-worth further investigation.


Anagha D.N.,Government Ayurveda Medical College | MythreyR.C.,Government Ayurveda Medical College | Hegde G.,Government Ayurveda Medical College
International Journal of Research in Ayurveda and Pharmacy | Year: 2013

Vicharchika is explained as one among Ekadasha Kshudra Kustha. The clinical features of vicharchika like Kandu, Pidaka, Shyavavarnata, Srava, Rookshata, Daha, Raji, and Vedana are very much similar with the features of Eczema. This is an inflammatory response produced by various internal and external factors. To manage such inflammatory condition of the skin, shamana chikitsa, in the form of bahya and abhyantara sneha prayoga was planned in order to have a safe and effective result in treating Vicharchika vis-à-vis Eczema. The objective of this study was, to evaluate the efficacy of Amritadi Ghrita as Shamana sneha along with the external application of Kutaja Sooryapaka Taila in the management of Vicharchika vis-à-vis Eczema. It is an observational clinical study with pre, mid and post test design where 30 patients of Vicharchika vis-à-vis Eczema were randomly selected and subjected to deepana and pachana with Trikatu choorna administered in a dose of 2 g thrice daily before food with ushnodaka, until nirama lakshanas were observed. Shamana snehapana by Amritadi Ghritha was advised in the dose of 30 ml, in empty stomach at annakala for 30 days along with external application of Kutajasooryapaka Taila twice a day after thoroughly cleaning the affected area of the skin with lukewarm water. Pathya ahara and Vihara were advised throughout the course of the study. In the present study, results obtained with respect to all the parameters were statistically highly significant with 'P' value of 0.000. Overall assessment showed marked relief in 20 patients, moderate relief in 6 patients followed by complete relief in 4 patients. Significant results in reduction of all the parameters i.e. Kandu (87.5 %), Pidaka (85.8 %), Srava (60.83 %), Rookshata (60.83 %) and Vaivarnyata (89.16 %) were found. Hence Amritadi Ghrita as Shamana sneha along with the external application of Kutaja Sooryapaka Taila was found to be very effective in the management of Vicharchika vis-à-vis Eczema.


Pradeep E.K.,Government Ayurveda Medical College | Umashankar K.S.,Government Ayurveda Medical College | Hegde G.,Government Ayurveda Medical College
International Journal of Research in Ayurveda and Pharmacy | Year: 2013

In the present clinical study the cases of disease 'Vatashteela', which is a type of Mutraghata in terms of Benign Prostate Hypertrophy (BPH), were considered. The objective of the study was to assess the efficacy of Pataladi kashaya in Vatashteela 'vis a vis' BPH. Total 30 patients having signs and symptoms of 'Vatashteela' 'vis a vis' BPH were included according to criteria of AUA-SI (American Urological Association - Symptom Index), and also after diagnosing BPH by Digital Rectal Examination, and Ultrasonography of Abdomen and pelvis. Patients were assigned into a single group consisting of 30 patients for whom Pataladi kashaya 30 ml thrice a day before food with sukhoshna jala for 30 days was administered. Incomplete emptying, Frequency, Urgency, Intermittency, Straining, Weak stream and Nocturia were the Subjective parameters, data of which were collected before (day 0), during (day 15), after (day 30) and follow up (day 60). The objective parameters were residual urine, volume and size of the prostate. These data were collected before (day 0) and after (day 30) of the clinical trial. The analysis was done statistically by using Repeated Measure ANOVA, student't' test and contingency co-efficient table. The statistical values showed significant results in subjective and objective parameters. In lateral lobe enlargement, symptoms were relieved to a greater extent compared to median lobe enlargement. Residual urine, volume of the prostate, obstructive symptoms showed marked improvement in many of the patients, and there was also significant decrease in size of the prostate. Overall assessment showed marked and moderate improvement in many patients. Pataladi kashaya is useful in reducing the signs and symptoms of 'Vatashteela' 'vis a vis' 'BPH' and even residual urine, volume and size of the prostate. Pataladi kashaya is beneficial due to its properties in improving obstructive symptoms and reducing the size of the prostate.


PubMed | Government Ayurveda Medical College
Type: Journal Article | Journal: Journal of Ayurveda and integrative medicine | Year: 2011

We report preliminary results from an ongoing series of experiments on lifespan extension by appropriately modified Ayurvedic rasayanas in animal models. Here data are presented indicating lifespan extensions of 51-55% (up to 70-95% in the pilot experiment) in a standard strain of Drosophila melanogaster (Oregon-K) using a standard rasayana (Ayurvedic herbal formulation for life-extension) suitably adapted for insects. In a first experiment, two groups of 20 unmated D. melanogaster strain Oregon-K kept at 22C received either rasayana or standard yeast diet; days of death were recorded. Another experiment investigated possible sex differences; equal sized (N = 30) groups of similar males, females, and controls were compared. Life lengths of all controls were in the strains usual range: in Experiment 1, control life lengths were minimum 40 to maximum 53 days; experimental group figures were 81-91 days; groups were completely separated, experimental group minimum life length being 28 days more than control group maximum life length, i.e., about 2.5 full distribution widths - a sign test for the null hypothesis yields p < 2(-20), i.e., 10(-6) as maximum p. Experiment 2 found no differences between life lengths of males and females; but the maximum life length of 30 controls (60 days in males and 66 days in females) was once again far shorter than the minimum life length of the 60 in the two experimental groups, strengthening the findings of Experiment 1. Despite group sizes being relatively small, results are conclusive: the rasayanas in question increase D. melanogaster strain Oregon-K life length. The complexity of the formulation suggests that multiple mechanisms are involved - worth further investigation.


PubMed | Government Ayurveda Medical College
Type: Journal Article | Journal: Ayu | Year: 2013

Depression is a psychiatric condition in which there is loss of interest in all pleasurable outlets, viz. food, sex, work, friends, hobbies and entertainment. The prevalence rate of the disease is 6-8% in women and 3-5% in men. Ayurveda, the science of life, provides systematic management principles for depression. Mamsyadi Kwatha is one such formulation stated by Yadavji Trikamji Acharya in Siddha Yoga Sangraha and Bheshaja Samhita, which is said to be effective in psychiatric conditions. The ingredients are Jatamansi (Nardostachys jatamansi), Ashwagandh (Withania somnifera) and Parasika Yavani (Hyocymus niger) in an 8:4:1 ratio, respectively. The test drug was subjected for antidepressant activity in experimental models. The models selected for anti depressant activity were behavioral despair test, anti-reserpine test and Chronic Fatigue Syndrome (CFS) test in albino mice. The test formulation showed significant inhibition of behavioural despair (P < 0.05), weak to moderate anti-reserpine activity - ptosis (P < 0.001), catatonia (P < 0.01), sedation (P < 0.01) and moderate effect in CFS test (P < 0.050). These effects clearly show that Mamsyadi Kwatha has an anti-depressant activity.


Leptadenia reticulata (Retz) Wight & arn is mentioned in the ancient ayurvedic literature as an immune booster and rejuvenator.To investigate, the effects of different forms of the extract of Leptadenia reticulata [Aqueous extract (JAE), Padavashesha kashaya (JPK) and Tarpana kashaya (JTK)] to alleviate the experimental immunosuppression induced by the immunotoxicant chromate (VI) in vitro.Standard cell proliferation and cytotoxicity assays like MTT assay, trypan blue dye exclusion test, neutral red dye uptake test, NBT reduction test, determination of percentage cell survival and estimation of markers of oxidative stress were performed in the study. The study was conducted on primary cultures of mouse splenic lymphocytes and bone marrow derived macrophages.Treatment with all the three forms of the extract used in the study offered protection against chromate (VI)-induced immunosuppression and the overall protective effect was found to be superior in the case of the aqueous extract of Leptadenia reticulata (JAE). These results confirm that Leptadenia reticulata acts as a modulator and alleviates the immunosuppressive conditions induced by chromate (VI).

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