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Priyadarshini S.,Government Ayurveda Medical College | Ashadevi J.S.,University of Mysore | Nagarjun V.,Uppsala University | Prasanna K.S.,Maharanis Science College for Women
Journal of Ayurveda and Integrative Medicine | Year: 2010

We report preliminary results from an ongoing series of experiments on lifespan extension by appropriately modified Ayurvedic rasayanas in animal models. Here data are presented indicating lifespan extensions of 51-55% (up to 70-95% in the pilot experiment) in a standard strain of Drosophila melanogaster (Oregon-K) using a standard rasayana (Ayurvedic herbal formulation for life-extension) suitably adapted for insects. In a first experiment, two groups of 20 unmated D. melanogaster strain Oregon-K kept at 22oC received either rasayana or standard yeast diet; days of death were recorded. Another experiment investigated possible sex differences; equal sized (N = 30) groups of similar males, females, and controls were compared. Life lengths of all controls were in the strain's usual range: in Experiment 1, control life lengths were minimum 40 to maximum 53 days; experimental group figures were 81-91 days; groups were completely separated, experimental group minimum life length being 28 days more than control group maximum life length, i.e., about 2.5 full distribution widths-a sign test for the null hypothesis yields p < 2 -20, i.e., 10-6 as maximum p. Experiment 2 found no differences between life lengths of males and females; but the maximum life length of 30 controls (60 days in males and 66 days in females) was once again far shorter than the minimum life length of the 60 in the two experimental groups, strengthening the findings of Experiment 1. Despite group sizes being relatively small, results are conclusive: the rasayanas in question increase D. melanogaster strain Oregon-K life length. The complexity of the formulation suggests that multiple mechanisms are involved-worth further investigation. Source


Pradeep E.K.,Government Ayurveda Medical College | Umashankar K.S.,Government Ayurveda Medical College | Hegde G.,Government Ayurveda Medical College
International Journal of Research in Ayurveda and Pharmacy | Year: 2013

In the present clinical study the cases of disease 'Vatashteela', which is a type of Mutraghata in terms of Benign Prostate Hypertrophy (BPH), were considered. The objective of the study was to assess the efficacy of Pataladi kashaya in Vatashteela 'vis a vis' BPH. Total 30 patients having signs and symptoms of 'Vatashteela' 'vis a vis' BPH were included according to criteria of AUA-SI (American Urological Association - Symptom Index), and also after diagnosing BPH by Digital Rectal Examination, and Ultrasonography of Abdomen and pelvis. Patients were assigned into a single group consisting of 30 patients for whom Pataladi kashaya 30 ml thrice a day before food with sukhoshna jala for 30 days was administered. Incomplete emptying, Frequency, Urgency, Intermittency, Straining, Weak stream and Nocturia were the Subjective parameters, data of which were collected before (day 0), during (day 15), after (day 30) and follow up (day 60). The objective parameters were residual urine, volume and size of the prostate. These data were collected before (day 0) and after (day 30) of the clinical trial. The analysis was done statistically by using Repeated Measure ANOVA, student't' test and contingency co-efficient table. The statistical values showed significant results in subjective and objective parameters. In lateral lobe enlargement, symptoms were relieved to a greater extent compared to median lobe enlargement. Residual urine, volume of the prostate, obstructive symptoms showed marked improvement in many of the patients, and there was also significant decrease in size of the prostate. Overall assessment showed marked and moderate improvement in many patients. Pataladi kashaya is useful in reducing the signs and symptoms of 'Vatashteela' 'vis a vis' 'BPH' and even residual urine, volume and size of the prostate. Pataladi kashaya is beneficial due to its properties in improving obstructive symptoms and reducing the size of the prostate. Source


Anagha D.N.,Government Ayurveda Medical College | MythreyR.C.,Government Ayurveda Medical College | Hegde G.,Government Ayurveda Medical College
International Journal of Research in Ayurveda and Pharmacy | Year: 2013

Vicharchika is explained as one among Ekadasha Kshudra Kustha. The clinical features of vicharchika like Kandu, Pidaka, Shyavavarnata, Srava, Rookshata, Daha, Raji, and Vedana are very much similar with the features of Eczema. This is an inflammatory response produced by various internal and external factors. To manage such inflammatory condition of the skin, shamana chikitsa, in the form of bahya and abhyantara sneha prayoga was planned in order to have a safe and effective result in treating Vicharchika vis-à-vis Eczema. The objective of this study was, to evaluate the efficacy of Amritadi Ghrita as Shamana sneha along with the external application of Kutaja Sooryapaka Taila in the management of Vicharchika vis-à-vis Eczema. It is an observational clinical study with pre, mid and post test design where 30 patients of Vicharchika vis-à-vis Eczema were randomly selected and subjected to deepana and pachana with Trikatu choorna administered in a dose of 2 g thrice daily before food with ushnodaka, until nirama lakshanas were observed. Shamana snehapana by Amritadi Ghritha was advised in the dose of 30 ml, in empty stomach at annakala for 30 days along with external application of Kutajasooryapaka Taila twice a day after thoroughly cleaning the affected area of the skin with lukewarm water. Pathya ahara and Vihara were advised throughout the course of the study. In the present study, results obtained with respect to all the parameters were statistically highly significant with 'P' value of 0.000. Overall assessment showed marked relief in 20 patients, moderate relief in 6 patients followed by complete relief in 4 patients. Significant results in reduction of all the parameters i.e. Kandu (87.5 %), Pidaka (85.8 %), Srava (60.83 %), Rookshata (60.83 %) and Vaivarnyata (89.16 %) were found. Hence Amritadi Ghrita as Shamana sneha along with the external application of Kutaja Sooryapaka Taila was found to be very effective in the management of Vicharchika vis-à-vis Eczema. Source

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