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Mohod P.S.,Rajiv Gandhi Ayurved College | Jangde C.R.,Nagpur Veterinary College | Narnaware S.D.,National Research Center on Camel | Raut S.,Government Ayurved College
Journal of Applied Pharmaceutical Science | Year: 2014

The aqueous and alcoholic extracts of bark skin of Saraca indica (Ashoka) and Shorea robusta (Shal) were evaluated for their analgesic activity in Swiss albino rats by making use of different pain models such as, tail immersion test, tail clip method and writhing induced by 4% NaCl solution. The aqueous and alcoholic extract of Saraca indica and Shorea robusta showed significant analgesic activity at 300 mg/ Kg body weight in Swiss albino rats as compared with control rats from physical, thermal and chemical stimulus of evaluation techniques. The analgesic activity might have been attributed to the presence of alkaloids, steroids in these plants as revealed from phytochemical analysis. On the basis of these observations it was concluded that Ashoka and Shal has got analgesic property, however further experimental as well as clinical evaluations are necessary. © 2014 Poonam S. Mohod et al.

Yedke S.,Yashwant Ayurved College | Raut S.,Government Ayurved College | Jangde C.,Nagpur Veterinary College
Journal of Ayurveda and Integrative Medicine | Year: 2013

Background: Success of surgery depends on wound closure and healing. Ancients had coated many suture materials from plant and animal origin. As the quest for natural nonabsorbable, monofilament surgical suture continues, horsehair has been taken for study, which is mentioned in ancient literature. Objectives: Aim of the study was to evaluate detail mechanical and biophysical properties of horsehair. Materials and Methods: Physical properties, that are diameter, straight pull and knot pull tensile strength, bioburden, sterility tests were performed. Visual and histological wound healing parameters were studied in experimental Wistar rat incision wound model. Two experimental wounds about 5 cm long were created on each side of dorsal midline. Each animal received two sutures-Horsehair 4-0 and Ethilon 4-0. The sutured areas were grossly examined on 3 rd and 7 th days for visual observations like congestion, edema, infection, wound disruption, and impression of suture material on healed wound and then subjected for histological study. Results: Revealed that horsehair has got diameter of 0.19 mm which complies with the 4-0 size USP standard. Straight pull tensile strength was found 0.5851 ± 0.122 kg and knot pull tensile strength was 0.3998 ± 0.078 kg, which complies with the standards of United State Pharmacopia for class II nonabsorbable suture materials. In vivo study revealed that there was no evidence of edema, congestion, and discharge in both the groups. Wounds healed with minimum impressions of suture material with minimum scar mark. Mean histological scoring shows very mild tissue reaction. Conclusion: Horsehair has got properties of standard suture material except low tensile strength and hence can be used in reconstructive, plastic surgeries, and ophthalmic surgeries.

Ukhalkar V.P.,Government Ayurved College | Rathi G.,Government Ayurved College | Jadav R.,Government Ayurved College | Tamoli S.,Target Institute of Medical Education and Research
International Journal of Pharma and Bio Sciences | Year: 2015

Hemorrhoid is abnormal dilatation of venous plexus of anus, which causes bleeding per rectum, pain and itching at anus. 'ARWL12' capsule is a polyherbal formulation has been evaluated for efficacy and safety in patients of internal hemorrhoids. Thirty two patients received one 'ARWL12 capsule', twice daily orally after meals for 60 days. On day 60, reduction in proportion of patients showing bleeding per rectum was observed. The episodes and quantity of bleeding per rectum and piles mass decreased at the end of the study. The quality of life of patient also improved significantly. Global evaluation by physician and patient showed excellent improvement in reducing the symptoms of hemorrhoids. Almost all patients of the study showed excellent tolerability to study drug. No significant changes, in most of the safety laboratory parameters were observed. The study provided good evidence for potential efficacy and safety of 'ARWL12' capsule in patients with internal hemorrhoids.

Tumram A.C.,Government Ayurved College | Chawre S.V.,Government Ayurved College | Suryavanshi S.S.,Government Ayurved College | Kamble M.R.,Government Ayurved College | Shinde V.S.,Panchkarma Vaidya
International Journal of Research in Ayurveda and Pharmacy | Year: 2014

Every creature wants diet for survival in this world. Specific diet is suitable for specific creature and everyone has to follow the nature's rule. But sometimes it is taken for granted only for taste which is injurious to health. In ancient era it has been described in Ayurveda that, there are some dietary combinations which are really injurious to health. So with the help of study of Virudha Aahar, the first aim of Ayurveda that is prevention, can be achieved. The knowledge of Virudha Aahara may prevent certain diseases. In Ayurved, Acharya Charak also stated that the diet is the life of an individual's only if it is taken with Yukti. The Yuktiyukta diet produce effects like Rasayana but without Yukti it can be like Visha (poison) which may be leading to Prannasha (death). The substances which are contrary to dehadhatus (seven fundamental elements in the body) behave with Virudha (antagonism). This antagonism may be in terms of properties, combination, processing, place, time and dose, etc. or natural composition.

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