Sathiyamoorthi K.,Government Arts College C Mutlur |
Mala V.,Government Arts College C Mutlur |
Suresh R.,Government Arts College C Mutlur |
Sakthinathan S.P.,Government Arts College C Mutlur |
And 7 more authors.
Der Pharma Chemica | Year: 2014
A series of some substituted (E)-1-(1-hydroxynaphthalen-2-yl)-3-phenylprop-2-en-1-oneshave been synthesized by microwave assisted Silica-H3PO4catalyzed green Crossed-Aldol condensation of 1-hydroxy-2-acetylenaphthone and substituted benzaldehydes. These chalcones were characterized by their physical constants and spectral data. From IR and NMR spectra, the spectral frequencies of vCOs-cis and s-trans, deformation modes of vCHip, vCHop, vCH=CHop and vC=Cop(cm-1), δH and δC of α, β and CO (ppm) of synthesized chalcones were correlated with Hammett substituent constants, F and R parameters. From the results of statistical analyses the effects of substituents on the group frequencies have been discussed. The antimicrobial activities of all chalcones have been studied using Bauer-Kirby method.