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Terakura M.,Goushi Hospital | Ikebe T.,Goushi Hospital | Nishioka T.,Goushi Hospital | Horiike M.,Goushi Hospital | Kaneko M.,Goushi Hospital
Japanese Journal of Cancer and Chemotherapy | Year: 2010

The patient is a 75-year-old woman who received 2 courses of neoadjuvant chemotherapy (NAC) with S-1/CDDP for advanced gastric cancer and para-aortic lymph node metastasis. After completion of the second course, both the primary tumor and lymph node metastases practically disappeared. Later, total gastrectomy was performed. Histopathological examination revealed cancer cells remaining in just one part of subserosa (ss), and no lymph node metastases were detected. The postoperative course was favorable, and the patient is currently attending the outpatient clinic.


PubMed | Goushi Hospital
Type: Journal Article | Journal: Gan to kagaku ryoho. Cancer & chemotherapy | Year: 2016

We administered multi-line chemotherapy(ie, more than fifth-line chemotherapy)to 5 patients with metastatic colorectal cancer(age range, 62to 78 years; median age, 68years). Four of the five patients died because of cancer progression; however, the mean overall survival(OS)was 39 months. In our experience, re-challenging with key drugs was associated with clinical benefits. A case that could be thrown until ninth-line treatment was also experienced. A strategy based on rechallenging and changes in the combination of key drugs[5-FU-based chemotherapy, oxaliplatin, irinotecan(CPT-11), bevacizumab(Bmab)and panitumumab(Pmab)]may prolong life and offer new hope for these patients.

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