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Ghorpade V.S.,YSPMs Yashoda Technical Campus | Yadav A.V.,Gourishankar Institute of Pharmaceutical Education and Research | Dias R.J.,YSPMs Yashoda Technical Campus
Carbohydrate Polymers | Year: 2017

Citric acid crosslinked β-cyclodextrin–carboxymethylcellulose (βCD-CMC) hydrogel films were prepared by esterification-crosslinking method for the controlled release of ketoconazole (model drug). The hydrogel films were evaluated for active βCD content, carboxyl content, swelling ratio, drug loading and release, and hemolytic activity. The structural characterization was carried out using solid state 13C NMR, ATR-FTIR, TGA and DSC analysis. The βCD-CMC hydrogel films showed increase in active βCD content swelling ratio and drug loading with increase in the concentration of βCD in the feed. The βCD helped to minimize the burst effect and retarded the release of ketoconazole. The hydrogel films were found to be biocompatible and capable of controlling the release of ketoconazole for long duration. © 2017 Elsevier Ltd


Yadav A.V.,Gourishankar Institute of Pharmaceutical Education and Research | Murthy M.S.,Vignan Institute of Pharmaceutical Sciences
Drug Development and Industrial Pharmacy | Year: 2013

Objective: The objective of present investigation was to evaluate performance of cocrystals of Mefloquine Hydrochloride (MFL) in tablet dosage form. Our previous investigation showed significant effect of cocrystal formers on improving the solubility and dissolution rate of Mefloquine hydrochloride by cocrystallization method when prepared by solution cocrystallization method. Materials and methods: Prepared cocrystals of MFL with different ratio of cocrystal formers were incorporated in tablet dosage form and evaluated for micrometric properties, drug content, hardness, disintegration test, vitro dissolution studies and stability studies. Performance was compared with laboratory prepared tablet of MFL 250 mg. Results: The considerable improvement in the dissolution rate was observed in case of cocrystals based tablets than pure MFL tablets. Discussion and conclusion: So we can incorporate cocrystals in tablet dosage form to enhance in vitro and in vivo performance. To the best of our knowledge, this is the first report, cocrystals has been evaluated in tablet dosage form. © 2013 Informa Healthcare USA, Inc.


Yadav A.V.,Gourishankar Institute of Pharmaceutical Education and Research
International Journal of Pharmacy and Technology | Year: 2013

Tramadol hydrochloride, highly water soluble drug was chosen as candidate drug for formulation of controlled release drug delivery owing to its undesirable side effects like abdominal pain, anorexia which were likely to happen after administration of conventional drug delivery of tramadol. The objective of present study was to design and investigate the performance of hydrophilic and hydrophobic matrix system in controlling release of tramadol. Moreover the effect of Chitosan and its water soluble form as release retarding agent was investigated as polymeric matrix systems accompany the problem of initial burst release. Polymers such as HPMC and ethyl cellulose were used and controlled release tablets were prepared by direct compression. Further they were subjected to evaluation of flow properties, tablet properties and in vitro dissolution. All the batches depicted improvement in flow property and compressibility. It was observed that all the batches had uniform thickness and reflected uniform behaviour during compression process. In, in-vitro drug release studies, the drug release was found to be completed within 10 hours. Further addition of ethyl cellulose was found to control the drug release to certain extent. All formulations without Chitosan and water soluble Chitosan gave initial burst release followed by steady state release. However incorporation of Chitosan and water soluble Chitosan impaired the initial burst release indicating better and more controlled drug release. Thus Chitosan and water soluble Chitosan could be best suited to modulate HPMC-EC based controlled release Tramadol matrix system with minimal burst and maximal controlled release.


Yadav A.V.,Gourishankar Institute of Pharmaceutical Education and Research
Artificial Cells, Blood Substitutes, and Biotechnology | Year: 2012

To have advantages of reduced dosing frequency, improved bioavailability and effective delivery system of Cefuroxime Axetil, a Chitosan based intragastric sustained release microbead formulation of Cefuroxime Axetil was developed. The drug delivery system was prepared by ionotropic gelation of Chitosan in presence of sodium tripolyphosphate as polyanion and optimized by box-behnken experimental design. Response surface methodology was applied to evaluate various vitro characteristics of prepared mucoadhesive microbeads. Multiple independent variables were optimized to achieve responses of interest, thereby to get the desired sustained release profile of Cefuroxime Axetil in gastric environment. © 2012 Informa Healthcare USA, Inc.


Karekar P.,Gourishankar Institute of Pharmaceutical Education and Research | Salunkhe N.,Gourishankar Institute of Pharmaceutical Education and Research | Yadav A.,Gourishankar Institute of Pharmaceutical Education and Research | Bangar D.,Gourishankar Institute of Pharmaceutical Education and Research
Research Journal of Pharmacy and Technology | Year: 2014

Solid dispersions of terbinafine HCl were prepared with polxamer 188 using melt granulation technique. Three formulations were prepared by using three different ratios of drug and polymer. The prepared formulations were subjected to solubility and dissolution tests. Moreover they were characterized by X-ray powder diffractometry (XRPD) and Fourier Transformation Infra-red Spectroscopy (FTIR). The characterization studies depicted better physical interaction among drug and polymer with no chemical interaction. Further it was clearly observed that there was significant rise in solubility and dissolution properties due to decrease in crystallinity. Thus solid dispersion could be best solution to improve physicochemical properties of terbinafine HCl. © RJPT All right reserved.


Ghorpade V.S.,YSPMs Yashoda Technical Campus | Yadav A.V.,Gourishankar Institute of Pharmaceutical Education and Research | Dias R.J.,YSPMs Yashoda Technical Campus
International Journal of Biological Macromolecules | Year: 2016

The present communication deals with preparation of β-cyclodextrin (βCD) grafted hydroxypropylmethylcellulose (HPMC) hydrogel films using citric acid as crosslinking agent with the aim of improving the loading and achieving controlled release of hydrophobic weak base (ketoconazole). The hydrogel films were characterized by attenuated total reflectance-fourier transform infrared (ATR-FTIR) spectroscopy, solid state 13C-nuclear magnetic resonance (13C NMR) spectroscopy, thermal analysis and scanning electron microscopy (SEM). The films were evaluated for βCD content, carboxyl content, swelling ratio, drug loading, drug release and hemolytic assay. ATR-FTIR spectra indicated crosslinking via ester formation whereas 13C NMR, thermal analysis and SEM confirmed βCD grafting. The βCD grafted hydrogel films with high carboxyl content showed maximum swelling and high drug loading. The presence of grafted βCD helped to retard the release of ketoconazole from the hydrogel films. The hemolytic assay suggested the biocompatible nature of the hydrogel films. Altogether, βCD grafted HPMC hydrogel films were found to be suitable for delivery of poorly soluble weak bases. © 2016 Elsevier B.V.


PubMed | Gourishankar Institute of Pharmaceutical Education and Research and YSPMs Yashoda Technical Campus
Type: Journal Article | Journal: International journal of biological macromolecules | Year: 2016

The present communication deals with preparation of -cyclodextrin (CD) grafted hydroxypropylmethylcellulose (HPMC) hydrogel films using citric acid as crosslinking agent with the aim of improving the loading and achieving controlled release of hydrophobic weak base (ketoconazole). The hydrogel films were characterized by attenuated total reflectance-fourier transform infrared (ATR-FTIR) spectroscopy, solid state


Gujar P.P.,Gourishankar Institute of Pharmaceutical Education and Research | Kokil A.A.,Gourishankar Institute of Pharmaceutical Education and Research | Karekar P.S.,Gourishankar Institute of Pharmaceutical Education and Research | Gurav Y.A.,Gourishankar Institute of Pharmaceutical Education and Research | Yadav A.V.,Gourishankar Institute of Pharmaceutical Education and Research
International Journal of Pharmacy and Technology | Year: 2012

Nevirapine is an antiviral drug, having poor aqueous solubility and dissolution profile. Therefore an attempt was made to improve dissolution behaviour of nevirapine by using co-crystallisation technique. The co-crystals were prepared by using two conformers benzoic acid and oxalic acid. The method used for co-crystal formation was solution crystallization method. Further prepared co-crystals were characterized by Powder X-ray diffractometry (PXRD), Fourier Transformation Infra-red Spectroscopy (FTIR) to evaluate hydrogen bonding interactions. Moreover they are studied for melting point determination, flow property studies and dissolution studies. All the performed study revealed formation of co-crystals, improvement in micromeritic properties and dissolution behaviour of drug. Thus physicochemical properties of nevirapine could be improved via crystal engineering technique.

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