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Dhaka, Bangladesh

The Gono University or Gono Bishwabidyalay is a private university in Savar, Bangladesh which was established on 14 July 1998. It is now operating their academic and administrating activity on their permanent campus at Nalam, Savar, Dhaka. It was approved by University Grants Commission on 1998. It also introduced new academic courses UGC approval along with a number of other private universities. Wikipedia.

Ali N.,TU Dortmund | Ali N.,University of Rajshahi | Blaszkewicz M.,TU Dortmund | Manirujjaman M.,Gono University | Degen G.H.,TU Dortmund
Mycotoxin Research | Year: 2016

Ochratoxin A (OTA) and citrinin (CIT) are both nephrotoxic and teratogenic in animals, and the occurrence of these mycotoxins in food may cause adverse health effects in humans. Data on the combined exposure to these food contaminants are still scarce, especially in pregnancy. Therefore, a biomonitoring study was conducted to determine the presence of urinary biomarkers of exposure to OTA and CIT in pregnant women in Bangladesh. In total, 54 spot urine samples were collected from residents of a rural and a suburban area of the Savar region in Dhaka district for analysis of OTA and CIT urinary biomarkers by previously validated HPLC-FD and LC-MS/MS methods. Most urines were positive for OTA and CIT biomarkers, with OTA being detected in 93 % (range 0.01–0.84 ng/mL) and CIT biomarkers in 87 % (range 0.02–6.93 ng/mL) of all samples. The mean levels of OTA were different between the rural (0.06 ± 0.07 ng/mL) and suburban (0.15 ± 0.19 ng/mL) study participants. CIT and its metabolite dihydrocitrinone (HO-CIT) were more than twofold higher in the rural (0.42 ± 1.20 and 0.55 ± 1.04 ng/mL, respectively) than the suburban (CIT 0.15 ± 0.13 ng/mL; HO-CIT 0.23 ± 0.18 ng/mL) participants. When a provisional daily intake for CIT was calculated, it exceeded the preliminary tolerable value set by European Food Safety Authority (0.2 μg/kg/day) in 9 % of the rural participants but in none of the urban participants. Urinary biomarker levels for OTA and CIT did not show significant association with intake of certain types of food consumed by the pregnant women, although total CIT biomarker levels were considerably higher among participants who consumed more rice in a day. Overall, this study indicates a frequent co-exposure to OTA and CIT among pregnant women in Bangladesh, at levels similar to those determined recently in the general population of this country. © 2016 Society for Mycotoxin Research and Springer-Verlag Berlin Heidelberg

Khan R.,University of Rajshahi | Zerega N.,Chicago Botanic Garden | Zerega N.,Northwestern University | Hossain S.,Gono University | Zuberi M.I.,University of Rajshahi
Economic Botany | Year: 2010

Jackfruit (Artocarpus heterophyllus Lam.) Diversity in Bangladesh: Land Use and Artificial Selection. Bangladesh is often recognized as a secondary center of diversity for jackfruit (Artocarpus heterophyllus Lam.) and is expected to harbor important genetic diversity of this underutilized tree crop. Unfortunately, genetic erosion is occurring before this rich local resource has been documented and utilized for potential crop improvement. The aim of this study was to carry out a village-based survey and make morphological measurements to document and assess jackfruit diversity across trees associated with a gradient of three locations/habitats (homesteads, public lands, and forest or fallow lands). We also tested the hypotheses that cultivated jackfruit found in homesteads exhibited positive selection pressure for characteristics desirable in the market, and that the tree location reflected its history of origin and human selection. This was accomplished using 28 standardized morphological descriptors and represents the first large-scale assessment (900 trees) of jackfruit diversity in multiple locations (nine villages). Among the descriptors studied, those most closely associated with jackfruit marketability showed a trend for selection among the trees located in homesteads. Both fruits and leaves were larger in plants on homesteads compared to plants in forest/fallow lands, and fruit quality was significantly higher in homestead trees compared to the other two location categories. However, 18.7% and 23.7% of the fruits found on public lands and forest/fallow lands, respectively, were still considered to be of excellent fruit quality and tree vigor was significantly higher in jackfruit in forest/fallow lands compared to the other location categories. The combination of high tree vigor and presence of excellent fruit quality among jackfruit in forest/fallow lands suggests that the "wild" Bangladeshi jackfruit germplasm, which is considered inferior for market and is being negatively impacted, has valuable genetic diversity to contribute to jackfruit cultivation. Furthermore, sampling across a gradient of habitats may enable the detection of possible trends resulting from domestication pressures. © 2010 The New York Botanical Garden.

Mahmud M.S.,Gono University
Bangladesh Journal of Medical Science | Year: 2013

Bacground: Untreated disposal of chemical waste poses serious environmental hazard. An attempt was made towards presumptive identification of the major genera of microbial contaminants found in a natural pond that receives waste from a pharmaceutical industry of Gonoshasthaya Antibiotic Ltd. during the period of 2008 to 2009. Methodology: Water sample was collected and physical parameters were determined. Results: A total of 38 bacterial isolates were found from surface water, deep layer water and sediment soil but only five isolates were found to resist up to 0.1 mg/ml of phenol. Microscopic and biochemical test of five isolates presumptively identified them Staphylococcus sp, Sporosarcina sp, Bacillus sp and members of family Enterobacteriaceae. All five isolates were resistant to Amoxycillin (30?g), Erythromycin (15?g), and Penicillin-G (10units). Conclusion: Resistance against common therapeutic antibiotics indicates possible epidemiological risk.

Binte Atique F.,North South University | Rahman Khalil M.M.,Gono University
BioMed Research International | Year: 2014

Present study was carried out for the microbiological evaluation of allogeneic bone processed from femoral heads. A total 60 bacterial isolates comprising five different species including Streptococcus spp., Staphylococcus spp., Klebsiella spp., Bacillus spp., and Pseudomonas spp. were characterized based on their cultural and biochemical characteristics. Average bioburden was ranged from 5.7×101 to 3.9×104 cfu/gm. The majority (81.7%) of the microbial contaminants were detected as Gram positive with the predominant organism being skin commensal coagulase negative Staphylococci (43.3%). Antimicrobial resistance was evaluated by the activities of 14 broad and narrow spectrum antibiotic discs. Comparing the overall pattern, marked resistance was noted against Penicillin and Amoxicillin 100% (60/60). The most effective single antibiotics were Gentamicin, Tobramycin, and Ofloxacin which were bactericidal against 100% (60/60) isolates. Multidrug resistance (MDR) was confirmed in 70% (42/60) of the samples. Among them, the most prevalent antibiotypes were Penicillin, Amoxicillin, Oxacillin, Polymyxin, and Cefpodoxime (80% of total MDR). The study results revealed higher contamination rate on bone allografts and recommend the implementation of good tissue banking practices during tissue procurement, processing, and storage in order to minimize the chances of contamination. © 2014 Fahmida Binte Atique and Md. Masudur Rahman Khalil.

Zhong X.,Johns Hopkins University | Isharwal S.,Johns Hopkins Hospital | Isharwal S.,University of Minnesota | Veltri R.W.,Johns Hopkins Hospital | And 5 more authors.
PLoS ONE | Year: 2013

Purpose: Schistosoma haematobium is associated with chronic bladder damage and may subsequently induce bladder cancer in humans, thus posing a serious threat where the parasite is endemic. Here we evaluated aberrant promoter DNA methylation as a potential biomarker to detect severe bladder damage that is associated with schistosomiasis by analyzing urine specimens. Materials and Methods: A quantitative methylation-specific PCR (QMSP) assay was used to examine the methylation status of seven genes (RASSF1A, RARβ2, RUNX3, TIMP3, MGMT, P16, ARF) in 57 urine samples obtained from volunteers that include infected and uninfected by S. haematobium from an endemic region. The Fishers Exact Test and Logistic Regression analysis were used to evaluate the methylation status with bladder damage (as assessed by ultrasound examination) in subjects with S. haematobium infection. Results: RASSF1A and TIMP3 were significant to predict severe bladder damage both in univariate (p = 0.015 and 0.023 respectively) and in multivariate (p = 0.022 and 0.032 respectively) logistic regression analysis. Area under the receiver operator characteristic curves (AUC-ROC) for RASSF1A and TIMP3 to predict severe bladder damage were 67.84% and 63.73% respectively. The combined model, which used both RASSF1A and TIMP3 promoter methylation, resulted in significant increase in AUC-ROC compared to that of TIMP3 (77.55% vs. 63.73%.29; p = 0.023). Conclusions: In this pilot study, we showed that aberrant promoter methylation of RASSF1A and TIMP3 are present in urine sediments of patients with severe bladder damage associated with S. haematobium infection and that may be used to develop non-invasive biomarker of S. haematobium exposure and early molecular risk assessmentof neoplastic transformation. © 2013 Zhong et al.

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