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Gonbad-e Qābūs, Iran

Nobari K.,Ferdowsi University of Mashhad | Ghazanfari S.,University of Tehran | Nassiry M.R.,Ferdowsi University of Mashhad | Tahmoorespur M.,Ferdowsi University of Mashhad | Jorjani E.,Gonbad Institute of Higher Education
Journal of Animal and Veterinary Advances | Year: 2010

The aim of this study was to investigate leptin gene polymorphism in Sistani cows and brown swiss cows and relationship between it's polymorphism with economical traits in them. Blood samples were collected from Sistani cows and Brown Swiss cows. DNA was extracted from the blood samples and then it was amplified by Polymerase Chain Reaction (PCR) technique to amplify a 422 bp DNA fragment. Digestion of amplicons with BstMBl was done on PCR product. Genotype frequencies were 0.77, 0.22, 0.01 for AA, AB andBB, respectively in Sistani cows and 0.64, 0.35 and 0.01 for AA, AB and BB, respectively in Brown Swiss cows. The populations were in Hardy-Weinberg equilibrium with respect to Leptin gene. The AB genotype had a significant effect on growth traits including weight at 9 and 12 months and age at successful insemination than the other genotypes in Sistani cows. AB genotype also had a significant effect on milk production, days open and milking days compared with other genotypes in Brown Swiss cows. © Medwell Journals, 2010.


Nobari K.,Ferdowsi University of Mashhad | Tahmoorespur M.,Ferdowsi University of Mashhad | Ghazanfari S.,University of Tehran | Nassiry M.R.,Ferdowsi University of Mashhad | Jorjani E.,Gonbad Institute of Higher Education
Journal of Animal and Veterinary Advances | Year: 2011

The aim of this study was to investigate leptin gene polymorphism in Sistani cows and Brown Swiss cows and relationship between it's polymorphism with economical traits in them. Blood samples were collected from Sistani cows and Brown Swiss cows. DNA was extracted from the blood samples and then it was amplified by Polym erase Chain Reaction (PCR) technique to amplify a 422 bp DNA fragment. Digestion of amplicons with BstMBl was done on PCR product. Genotype frequencies were 0.77, 0.22, 0.01 for AA, AB andBB, respectively in Sistani cows and 0.64, 0.35 and 0.01 for AA, AB and BB, respectively in Brown Swiss cows. The populations were in Hardy-Weinberg equilibrium with respect to Leptin gene. The AB genotype had a significant effect on growth traits including weight at 9 and 12 months and age at successful insemination than the other genotypes in Sistani cows. AB genotype also had a significant effect on milk production, days open and milking days compared with other genotypes in Brown Swiss cows. © Medwell Journals, 2011.


Honary S.,Mazandaran University of Medical Sciences | Ebrahimi P.,Gonbad Institute of Higher Education | Emrani N.,Mazandaran University of Medical Sciences
International Journal of Pharma and Bio Sciences | Year: 2010

Plasticizers are added to improve the mechanical and conditional quality of film coating. However, other properties of coating solutions such as viscosity, droplet size and water vapor permeability (WVP) of free films be affected by incorporation of plasticizers. In this study, films of various viscosity grades of hydroxypropyl methylcellulose (HPMC) without and with different molecular weights (MWs) of polyethylene glycol (PEG) as plasticizer were prepared by a casting/solvent evaporation process and their water vapor permeability coefficient (R wvp) were calculated. The results showed that, addition of 10% w/w PEG 200 caused a decrease in Rwvp of all grades of HPMC (E5, E15 and E50) free films and Rwvp increased by increasing the concentration of PEG 200 from 10% to 30% w/w. The R wvp of HPMC E5 and E50 free films increased by increasing the PEG MW from 200 to 1500, but using higher MWs of PEG (4000 and 6000) caused to reduction of R wvp. The conclusion could be drown that, as regards permeability, the addition of low MW of PEG as plasticizer at low concentration (10%) could be resulted to decrease of Rwvp of HPMC free films.


Sadray S.,Tehran University of Medical Sciences | Honary S.,Mazandaran University of Medical Sciences | Ebrahimi P.,Gonbad Institute of Higher Education | Jafari P.,Mazandaran University of Medical Sciences | Rezaee S.,Tehran University of Medical Sciences
International Journal of Pharma and Bio Sciences | Year: 2010

Similarity in Dissolution behavior of drugs has long been sought from the percpective of both bioavailability and quality control considrations. The objective of this study was to apply several profile comparison to dissolution data of three different batches of Indomethacin (SR) which two of them were German products as the refernce batches. Dissolution was performed using the United States Pharmacopiea (USP) monograph method on tablets and capsules. Two general approaches to compare dissolution profiles were examined: Model-independent approaches and Model-dependent approaches. The model-independent methods included dissolution efficiency (DE) and the fit factors (F 1 and F 2). The model-dependent approaches included Weibull and Exponential models. It is concluded that according to the fit factors and model-dependend approaches, the dissolution of test batches are significantly different with one of the reference batches and is almost similar to the other one.


Eftekhari M.,Gorgan University of Agricultural Sciences and Natural Resources | Alizadeh M.,Gorgan University of Agricultural Sciences and Natural Resources | Ebrahimi P.,Gonbad Institute of Higher Education
Industrial Crops and Products | Year: 2012

Secondary phenolic metabolites play an important role in plant defense mechanisms and most of them are known to be valuable in human health. There are only few studies related to the significant role of various mycorrhizal fungi on changes taking place in their host secondary metabolites. Furthermore, grapevine pruning wastes were known as a potential source of high-value phytochemicals with respect to medicinal and antimicrobial properties. Total phenols and quercetin content of four Iranian grape (Vitis vinifera L.) varieties (Asgari, Khalili, Keshmeshi and Shahroodi) were investigated following inoculation with four arbuscular mycorrhizal fungi (AMF) strains (Glomus mosseae, Glomus fasciculatum and Glomus intraradices and a mixture of three species). Moreover, quercetin content of vegetative parts (leaf and stem tissues) was studied using a simple extraction and isocratic HPLC method. Additionally the effect of a common postharvest processing treatment (oven-drying) on the quercetin content of these grape varieties were also investigated. Higher levels of quercetin were consistently found in Keshmeshi (70.8 μg/g FW) and Shahroodi (100.6 μg/g FW) varieties following inoculation with G. mosseae. The non inoculated plants of the same varieties were found to produce only 35.7 and 16.3 μg/g FW quercetin, respectively. Oven-drying did not affect the leaf quercetin content in none of samples except in Keshmeshi variety in which drying resulted to higher quercetin yield in comparison with fresh leaf tissues (72.4 vs. 37.0 μg/g FW, respectively). The present study suggests that grapevine wastes are valuable sources for extraction of flavonoid quercetin which can also be further increased following inoculation with arbuscular mycorrhizal fungi. © 2012 Elsevier B.V.

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