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Homyel', Belarus

Gomel State Medical University is public teaching ] based in Gomel, Belarus. Wikipedia.


Novikova I.,Gomel State Medical University
Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia | Year: 2011

Research interest in ceruloplasmin (CP) has significantly increased in recent years owing to new discoveries of its properties including anti-inflammatory and anti-oxidant effects. Data on CP blood plasma level in patients with herpetic infection caused by herpes simplex virus are scarce and often contradictory. Most point to a reduction of CP in the blood plasma of patients during the exacerbation of the disease with gradually return to normal values after treatment. There is evidence of an increase in CP levels during the acute period of CRHI (chronic recurrent herpes infection) and decrease in remission. The content of ceruloplasmin in blood plasma was determined by immunoturbidimetry using the test-systems "Spinreact" (Spain) and biochemical analyzer "Architect C8000". We found that in patients with severe forms of chronic recurrent herpes infection in the exacerbation period, CP levels were increased by approximately 35% relative to the control values. However in the remission period in 80% of patients, CP concentrations remained elevated and in some patients the CP level was even increased in comparison with values in the exacerbation. Such dynamics of CP were not caused by the exacerbation of concomitant diseases. The increased CP levels in the remission period in patients with severe forms of chronic recurrent herpes infection may have been caused by its effect as an endogenous antioxidant. No correlations of CP levels with other laboratory signs of acute inflammation were found but identified was a relation to free radical activity. Source


Kazlouskaya V.,Gomel State Medical University | Wittmann C.,New Hill | Tsikhanouskaya I.,Vitebsk State Medical University
International Journal of Dermatology | Year: 2014

Background: Pustular syphilis is an extremely rare manifestation of secondary syphilis. Failure to recognize the disease can have devastating consequences. Methods: We present three patients with pustular syphilis as the primary manifestation of secondary syphilis. Results: Patient 1 was initially diagnosed by Venereal Disease Research Laboratory (VDRL) test (titers 1 : 32) and confirmed by enzyme immunoassay (EIA) for Treponema pallidum. Patient 2 was screened for syphilis by VDRL (titers 1 : 64), yielding a positive result, and tested negative for HIV. Secondary syphilis was confirmed by EIA. In Patient 3, a diagnosis of secondary syphilis was established by VDRL (titers 1 : 128) and EIA. Treponema pallidum was detected by dark field microscopy in three patients. Testing for HIV infection was negative in all patients. Conclusions: Diagnosis in secondary syphilis remains challenging because of the diversity of clinical presentations. The most commonly observed cutaneous presentation is a generalized, non-pruritic, papulosquamous eruption varying from pink to violaceous to brown, with mucous membrane involvement. The diagnostic methods used to identify secondary syphilis are the same as those used to diagnose other stages of syphilitic infection. The persistence of syphilis in both developed and underdeveloped regions highlights the importance of considering syphilitic infection in the setting of a cutaneous pustular eruption, especially one that fails to respond to standard therapy. Testing for other sexually transmitted diseases, including HIV, should be performed in all patients diagnosed with syphilis. © 2014 The International Society of Dermatology. Source


Edelstein M.V.,Smolensk State Medical Academy | Skleenova E.N.,Smolensk State Medical Academy | Shevchenko O.V.,Smolensk State Medical Academy | D'souza J.W.,Smolensk State Medical Academy | And 7 more authors.
The Lancet Infectious Diseases | Year: 2013

Background: Multidrug-resistant and extensively-drug-resistant Pseudomonas aeruginosa are increasing therapeutic challenges worldwide. We did a longitudinal epidemiological and clinical study of extensively-drug-resistant P aeruginosa in Belarus, Kazakhstan, and Russia. Methods: The study was done in three prospectively defined phases: Jan 1, 2002-Dec 31, 2004; Jan 1, 2006-Dec 31, 2007; and Jan 1, 2008-Dec 31, 2010. The first two phases were in Russia only. All consecutive, non-duplicate, nosocomial isolates and case report forms were sent to the coordinating centre (Institute of Antimicrobial Chemotherapy, Smolensk, Russia), where species reidentification, susceptibility testing, and molecular typing of isolates were done. We did susceptibility testing by agar dilution. The presence of metallo-β-lactamase (MBL) genes was established by PCR and sequencing, and class 1 integrons containing MBL gene cassettes were analysed by the PCR restriction fragment length polymorphism approach. Strain relatedness was analysed by multiple loci variable-number tandem-repeat (VNTR) analysis (at six VNTR loci) and multilocus sequence typing. Results: In 2002-04, 628 of 1053 P aeruginosa isolates were insusceptible to carbapenems and 47 (4·5%) possessed MBLs. In 2006-07, 584 of 787 isolates were insusceptible to carbapenems and 160 (20·3%) possessed MBLs. In 2008-10, 1238 of 1643 Russian P aeruginosa isolates were insusceptible to carbapenems and 471 (28·7%) possessed MBLs. Additionally, the 32 P aeruginosa isolates from Belarus and Kazakhstan were all carbapenem insusceptible and all possessed MBLs. More than 96% of MBL-positive P aeruginosa isolates were resistant to all antibiotics except colistin (ie, extensively drug resistant), and, in 2010, 5·9% were resistant to colistin. 685 (96·5%) of 710 MBL-positive P aeruginosa belonged to ST235. blaVIM-2 genes were detected in 707 (99·6%) of 710 MBL-positive isolates. Interpretation: Extensively-drug-resistant ST235 P aeruginosa has rapidly spread throughout Russia and into Belarus and Kazakhstan via clonal dissemination. Increases in the use of colistin will probably result in further spread of ST235 P aeruginosa resistant to all drugs. Funding: HEFC, Ministry of Health of the Russian Federation, Government of the Republic of Belarus, Government of the Republic of Kazakhstan, European Union, Medical Research Council UK-Canada partnership. © 2013 Elsevier Ltd. Source


Grint D.,HIV Epidemiology and Biostatistics Group | Peters L.,Copenhagen University | Rockstroh J.K.,University of Bonn | De Wit S.,Saint Pierre Hospital | And 6 more authors.
AIDS | Year: 2014

BACKGROUND:: Most antiretroviral drugs are metabolized by the liver; hepatic disease or liver damage as a result of hepatitis C virus (HCV) could impair this metabolism leading to an increased risk of drug toxicity. This study aimed to determine the risk of antiretroviral drug discontinuation among HCV/HIV coinfected patients. METHODS:: EuroSIDA patients taking combination antiretroviral therapy were included. Poisson regression identified factors associated with antiretroviral treatment discontinuation. RESULTS:: A total of 9535 HIV-positive patients with known HCV status were included (6939 HCVAb-negative; 2596 HCVAb-positive at baseline). Viremic HCV infection was associated with a 44% increased risk of antiretroviral drug discontinuation compared with aviremic infection [adjusted incidence rate ratio, aIRR: 1.44 (95% confidence interval, CI 1.22-1.69)]; this relationship was largest among nonnucleoside reverse transcriptase inhibitors [aIRR: 1.59 (95% CI 1.18-2.14)]. In the subset of 935 HIV-positive patients also HCV-positive or HBV-positive with plasma hyaluronic acid measured, hyaluronic acid more than 100Sng/ml was associated with a 37% increased risk of antiretroviral drug discontinuation [aIRR: 1.37 (95% CI 1.08-1.73) vs. hyaluronic acid ≤100Sng/ml] and the effect of HCV viremia became nonsignificant; the largest drug association was seen for protease inhibitors [aIRR: 1.40 (95% CI 1.04-1.89)]. CONCLUSION:: HCV viremia and high levels of hyaluronic acid predict antiretroviral drug discontinuation. Evidence was also found to suggest a link between impaired liver function and protease inhibitor toxicity. © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins. Source


Kramoreva L.I.,Gomel State Medical University | Rozhko Y.I.,The Republican Research Center for Radiation Medicine and Human Ecology
Journal of Applied Spectroscopy | Year: 2010

The basic principles and possibilities of optical coherence tomography (OCT) as a method for the investigation of pathologies in medical diagnostics are outlined. We discuss the OCT method limitations and issues related to the need for improving the resolution of optical tomographs. The prospects are considered for developing the OCT methods based on probing with diffraction-free light beams. © 2010 Springer Science+Business Media, Inc. Source

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