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Ezeonu C.S.,Godfrey Okoye University | Egbuna P.A.C.,University of Nigeria | Ezeanyika L.U.S.,University of Nigeria | Nkwonta C.G.,University of Nigeria | Idoko N.D.,University of Nigeria
Research Journal of Medical Sciences | Year: 2011

The antihepatotoxic effect of ethanolic extract of ginger (Zingiber officinale) against CCL (10 mL kg-1 body weight) were investigated. Total 7 groups of rats were used in the investigation with alternative methods of administration of ginger extract and CC14 both at 24 h intervals as well as simultaneous administrations. All the administration methods involved injection of the substances intraperitoneally. Serum Glutamate Pyruvate Transaminase (SGPT) and Serum Glutamate Oxaloacetate Transaminase (SGOT) decreased significantly (p<0.05) when ginger ethanolic extract was administered first (1000 mg kg-1 body weight) followed by CC14 24 h later. Injection of CC14 followed by ethanolic ginger extract 24 h later gave a reduction in the serum enzyme but not as much as when ginger extract was first administered. The same result above was also obtained for lipid peroxidation production. Protein synthesis was not affected by the various groups although, CC14 and ethanolic extract of ginger caused increase in serum protein which did not show any significant increase (p>0.05). Inorganic phosphate was increased by both CC14 and ethanolic extract administration. Fraction D was shown to have more hepatoprotective effect than even the ethanolic extract itself. Administration of ginger extract and CC14 simultaneously had the least hepatoprotective effect. Thus, preventive intraperitoneal administration of ginger ethanolic extract before liver injury had the highest efficacy against hepatotoxic induction using CC14. © Medwell Journals, 2011. Source


Nwozor K.K.,University of Aberdeen | Nwozor K.K.,University of Nigeria | Onuorah L.O.,Godfrey Okoye University
Petroleum and Coal | Year: 2014

Significant discrepancies often exist between measured and predicted pore pressures especially in deep-seated reservoirs in the Niger Delta Basin. The associated risks when not properly considered contribute to drilling challenges and some exploration downturns. At the background to these challenges is the vague understanding of the subtle complexities that may characterize the geopressure system. Key to this is the growing need to account for additional mechanisms of overpressure generation beyond the routinely believed undercompaction during pressure prognosis and well planning. Data from a deep well in the Central Swamp Depobelt depict the occurrence of two vertical effective stress regimes. The corresponding two pressure settings by massive succession of shales at an approximate depth of 14500ft(4421m) to wards the base of the Agbada Formation. Cross-plots of density and velocity as well as velocity and vertical effective stress indicate that undercompaction dominates pressure generation above the massive shale while late geopressure processes, especially hydrocarbon generation could be responsible for deep-seated extreme overpressures. The intervening massive shale acts as an effective regional seal with the result that there is no pressure communication between the reservoirs above and beneath it. Calculated overpressures in the water-saturated section of the reservoir that lies above the seal typically were below 150 psi (1.03MPa). On the contrary, overpressure beneath the seal is as much as 4490psi (30.96MPa). Pressure estimation based on standard Eaton method failed to produce matching profile with measured data in the deep reservoir. Modified Eaton and Bowers methods were then used to obtain a geopressure profile consistent with wireline measurements. Source


Onuorah L.O.,Godfrey Okoye University | Nwozor K.K.,University of Aberdeen | Nwozor K.K.,University of Nigeria
Petroleum and Coal | Year: 2014

Rocks as natural materials are inhomogeneous and anisotropic with the implication that their physical properties are never the same but rather vary in depth, time and space. A good understanding of rock parameters at deep and challenging settings helps improve the interpretation of essential explo-ration data. Vital to this improved knowledge is the need to establish a threshold of normal and standard rock property behaviours in target areas in order to detect abnormal trends that could be critical to exploration success. Analyses of rock property trends in a normally pressured reservoir in Offshore Niger Delta have been carried out using wireline log data such as sonic, density, resistivity and gamma ray logs. The petrophysical workflow involved the generation and interpretation of cross-plots of density - Vp, and Poisson's ratio - Vp; and depth trends of Vp, Vs, density, acoustic impedance and Poisson's ratio for sands and shales. A predictable linear relationship exist in these plots; it is normal for velocity, density and acoustic impedance trends to increase with depth due to progressive mechanical compaction while Poisson's ratio decreases with depth. Source


Godfrey Okoye University | Entity website

Thursday, June 23rd 2016 in News & Events by Peter Gbuji Godfrey Okoye University in conjunction with the African Biosafety Network of Expertise (ABNE), an Agency of the New Partnership for African Development (NEPAD, will hold a training programme for African policy and decision-makers on Biosafety, in collaboration with the National Biosafety Management Agency (NBMA) and the Michigan State University, East Lansing, USA. For more information visit http://www ...


Ogbuchi I.F.,Godfrey Okoye University | Ude C.M.,Enugu State University of Science and Technology | Ezeonu C.S.,Godfrey Okoye University | Oje O.A.,University of Nigeria
Electronic Journal of Environmental, Agricultural and Food Chemistry | Year: 2011

The effect of storage at 0°C, 4°C and ambient temperature on the vitamin c (ascorbic acid) and sugar content of five fruits; pawpaw (Carica papaya), pineapple (Anana comosus), apple (Pirus malus), watermelon (Citrullus lanatus) and orange (Citrus sinensus) was determined titrimetrically by the use of 2,6-dichlorophenol indophenol and spectrometrically using the Nelson's colorimetric methods respectively. It was discovered that at both the ambient (room) temperature and 0°C, there was much loss of vitamin c and sugar in the stored fruits compared to those stored at 4°C. Thus, 4°C (refrigeration temperature) is the best temperature for the storage of fruit when the ascorbic acid and sugar contents must be retained. Source

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