Enugu State, Nigeria

Godfrey Okoye University

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Eze A.C.,Godfrey Okoye University | Eze A.C.,University of Nigeria | Eze R.N.C.,University of Nigeria | Eze R.N.C.,Japan Aerospace Exploration Agency | Esaenwi S.,Center for Basic Space Science
Turkish Journal of Physics | Year: 2017

We carried out spectroscopic analysis of the extracted stellar flare of the Algol binary system observed using the Suzaku satellite (OBSID: 401093010), and resolved a strong 6.7 keV line emission. The 6.7 keV line emission of the Algol binary system is similar to the 6.7 keV line of the galactic ridge X-ray emission (GRXE). The equivalent width (EW) compared favorably with the EW of the 6.7 keV emission line obtained from different galactic ridge regions. In the galaxy, we have a reasonable number of Algol binary systems and many other stars as strong coronal X-ray emitters characterized by frequent quiescent and super flaring phases as observed by Suzaku, and these systems could contribute to the 6.7 keV emission line from the galactic ridge. © TÜBİTAK.


Nwozor K.K.,University of Aberdeen | Nwozor K.K.,University of Nigeria | Onuorah L.O.,Godfrey Okoye University | Onyekuru S.O.,Federal University of Technology Owerri | Egbuachor C.J.,University of Nigeria
Journal of Petroleum Exploration and Production Technology | Year: 2017

The relationships between density and velocity are important in many geological analyses that involve rock property parameters. However, the accuracy of the results is often limited when there is a verbatim application of generalized rock property relationships. Many studies in the Niger Delta Basin suffer from this limitation. As a way forward, well logs in the Niger Delta were used to derive lithology-specific coefficients that can be applied in density–velocity transforms that make use of the Gardner equation. Whereas the default coefficient (α) and exponent (β) in the original Gardner equation are 0.31 and 0.25, respectively, fitting the Gardner curve to local data results in a coefficient value of 0.33 and 0.29 for shales and sands, respectively, when the exponent is kept at the default value. Comparing measured density data with estimates obtained from sonic velocities using the original Gardner equation gives a regional mean absolute deviation of 0.13 g/cc while those of the newly derived local coefficients do not exceed 0.05 g/cc giving an improvement of over 60% in the accuracy of estimated rock properties. © 2017, The Author(s).


Engwa A.G.,Godfrey Okoye University | Unaegbu M.,Godfrey Okoye University | Francis O.H.,Godfrey Okoye University | Obiudu I.K.,Godfrey Okoye University | And 2 more authors.
International Journal of Pharmacognosy and Phytochemical Research | Year: 2016

Reactive oxygen species generated from certain cellular processes cause tissue and cell damage and may alter the structure and functioning of proteins and nucleic acids. Endogenous antioxidant defence mechanisms involving certain enzymes as well as exogenous antioxidant from plants are capable of preventing such complications. This study investigated the in vitro and in vivo antioxidant activity of Murraya koenigii (curry leaf) extracts. Water and ethanol extracts of the leaf were obtained by soxhlet extraction. In vitro antioxidant activity was by the ferric reducing power and hydrogen peroxide scavenging assays and the total flavonoid and flavonol levels determined. The in vivo activity was assessed using albino wistar rats which were treated with 100mg/kg of aqueous and ethanol leaf extracts and ascorbic acid as positive control for six consecutive days after which a single dose (2.5mL/kg body) of CCl4was administered except for the normal control group 24hrs later. The animals were sacrificed and the liver homogenate was used to assess the catalase activity and lipidic peroxidation. Aqueous and ethanol extracts showed ferric reducing activity and were concentration dependent. The hydrogen peroxide scavenging potential was very high at various concentrations for both extracts (between 81.2 to 99.9%) comparable to ascorbic acid. Molondialdehyde (MDA) level (lipidic peroxidation) was significantly lower (p<0.05) in group 2 animals which received aqueous extract compared to group 1 (normal control) and group 4 (negative control). There was a significant difference (p<0.05) in the catalase activity of group 2 animals which received aqueous extract compared to the normal control. Acute toxicity was observed in group 5 animals administered ethanol extract. Flavonoid and flavonol were greater in the ethanol extract (625.33 and 835.04 g/g of rutin) than in the aqueous extract (449.33 and 100.33 g/g of rutin) respectively. These results suggest that Murraya koenigii (curry leaf) aqueous and ethanol extracts possess antioxidant activity due to high amounts of flavonoid and flavonol. This property may partly be responsible for the medicinal application of the plant. © 2016, International Journal of Pharmacognosy and Phytochemical Research. All Rights reserved.


Oguanya C.E.,University of Nigeria | Chiaghanam O.I.,University of Nigeria | Nwokeabia C.N.,Nnamdi Azikiwe University | Chiadikobi K.C.,University of Nigeria | Ikegwuonu N.O.,Godfrey Okoye University
Petroleum and Coal | Year: 2017

Source rock geochemistry of the paleogene (Imo and Ameki Formations) strata in Bende- Umuahia and its environs, Niger Delta Basin, southern eastern Nigeria was assessed for its hydrocarbon play using walkley black wet oxidation and rock-eval pyrolysis techniques. The total organic carbon (TOC) average values for Imo and Ameki Formation are 0.86wt% and 0.74 wt%, this indicates a fair petroleum potential and organic matter concentration. The generative potential (GP) average value of 0.38mg Hc/g for the two formations studies indicates that the organic matter quality is poor. The result of hydrogen index (HI) shows a studied area that is basically type IV Kerogen. The average Tmax value for Imo Formation was 408.8°C ad 410.8°C for Ameki Formation, which suggest that the studied area is thermally immature. The average vitrinite reflectance (RO) values for Imo and Ameki Formation, which are 0.59R° and 0.32R° respectively also suggests that the area studied is thermally immature.Theplots of Rock-Eval s2 versus Toc and hydrogen index versus oxygen index indicates that the studied area is basically type IV Kerogen, while the plots of production Index versus Tmax and Hydrogen index versus Tmax indicates thermally immature for the area. Source rock geochemistry of type IV Kerogen, Thermally immature and fair petroleum potential can be assigned to the area studied.


Nwozor K.K.,University of Aberdeen | Nwozor K.K.,University of Nigeria | Onuorah L.O.,Godfrey Okoye University
Petroleum and Coal | Year: 2014

Significant discrepancies often exist between measured and predicted pore pressures especially in deep-seated reservoirs in the Niger Delta Basin. The associated risks when not properly considered contribute to drilling challenges and some exploration downturns. At the background to these challenges is the vague understanding of the subtle complexities that may characterize the geopressure system. Key to this is the growing need to account for additional mechanisms of overpressure generation beyond the routinely believed undercompaction during pressure prognosis and well planning. Data from a deep well in the Central Swamp Depobelt depict the occurrence of two vertical effective stress regimes. The corresponding two pressure settings by massive succession of shales at an approximate depth of 14500ft(4421m) to wards the base of the Agbada Formation. Cross-plots of density and velocity as well as velocity and vertical effective stress indicate that undercompaction dominates pressure generation above the massive shale while late geopressure processes, especially hydrocarbon generation could be responsible for deep-seated extreme overpressures. The intervening massive shale acts as an effective regional seal with the result that there is no pressure communication between the reservoirs above and beneath it. Calculated overpressures in the water-saturated section of the reservoir that lies above the seal typically were below 150 psi (1.03MPa). On the contrary, overpressure beneath the seal is as much as 4490psi (30.96MPa). Pressure estimation based on standard Eaton method failed to produce matching profile with measured data in the deep reservoir. Modified Eaton and Bowers methods were then used to obtain a geopressure profile consistent with wireline measurements.


Onuorah L.O.,Godfrey Okoye University | Nwozor K.K.,University of Aberdeen | Nwozor K.K.,University of Nigeria
Petroleum and Coal | Year: 2014

Rocks as natural materials are inhomogeneous and anisotropic with the implication that their physical properties are never the same but rather vary in depth, time and space. A good understanding of rock parameters at deep and challenging settings helps improve the interpretation of essential explo-ration data. Vital to this improved knowledge is the need to establish a threshold of normal and standard rock property behaviours in target areas in order to detect abnormal trends that could be critical to exploration success. Analyses of rock property trends in a normally pressured reservoir in Offshore Niger Delta have been carried out using wireline log data such as sonic, density, resistivity and gamma ray logs. The petrophysical workflow involved the generation and interpretation of cross-plots of density - Vp, and Poisson's ratio - Vp; and depth trends of Vp, Vs, density, acoustic impedance and Poisson's ratio for sands and shales. A predictable linear relationship exist in these plots; it is normal for velocity, density and acoustic impedance trends to increase with depth due to progressive mechanical compaction while Poisson's ratio decreases with depth.


Ezeonu C.S.,Godfrey Okoye University | Egbuna P.A.C.,University of Nigeria | Ezeanyika L.U.S.,University of Nigeria | Nkwonta C.G.,University of Nigeria | Idoko N.D.,University of Nigeria
Research Journal of Medical Sciences | Year: 2011

The antihepatotoxic effect of ethanolic extract of ginger (Zingiber officinale) against CCL (10 mL kg-1 body weight) were investigated. Total 7 groups of rats were used in the investigation with alternative methods of administration of ginger extract and CC14 both at 24 h intervals as well as simultaneous administrations. All the administration methods involved injection of the substances intraperitoneally. Serum Glutamate Pyruvate Transaminase (SGPT) and Serum Glutamate Oxaloacetate Transaminase (SGOT) decreased significantly (p<0.05) when ginger ethanolic extract was administered first (1000 mg kg-1 body weight) followed by CC14 24 h later. Injection of CC14 followed by ethanolic ginger extract 24 h later gave a reduction in the serum enzyme but not as much as when ginger extract was first administered. The same result above was also obtained for lipid peroxidation production. Protein synthesis was not affected by the various groups although, CC14 and ethanolic extract of ginger caused increase in serum protein which did not show any significant increase (p>0.05). Inorganic phosphate was increased by both CC14 and ethanolic extract administration. Fraction D was shown to have more hepatoprotective effect than even the ethanolic extract itself. Administration of ginger extract and CC14 simultaneously had the least hepatoprotective effect. Thus, preventive intraperitoneal administration of ginger ethanolic extract before liver injury had the highest efficacy against hepatotoxic induction using CC14. © Medwell Journals, 2011.


Engwa G.A.,Godfrey Okoye University | Ayuk E.L.,Godfrey Okoye University | Igbojekwe B.U.,Godfrey Okoye University | Unaegbu M.,Godfrey Okoye University
Biochemistry Research International | Year: 2016

The global increase in oxidative stress related diseases such as cancer, cardiovascular, and inflammatory diseases caused by overwhelming level of free radicals in the body has encouraged the search for new antioxidant agents. Based on the ability of newly synthesized phenothiazine derivatives (6-chloro-11-azabenzo[a]phenothiazine-5-one and 6-[4-bromophenyl]-10-methyl-11-azabenzo[a]phenothiazine-5-one) to oxidize H2O2, a known free radical to sulfoxide, this study assessed the in vitro and in vivo antioxidant activity. The synthesized phenothiazine derivatives exhibited reducing power potential to convert Fe3+ to Fe2+ and high ability to scavenge H2O2 free radical in vitro. These activities were comparable to ascorbic acid, a standard antioxidant. The catalase activity significantly increased (p<0.05) in groups 1 and 2 animals that received the phenothiazine derivatives compared to the controls (groups 3 and 4) suggesting the ability of the phenothiazine derivatives to scavenge H2O2 in vivo. The malondialdehyde level in groups 1 and 2 animals was lower than that in group 3 that received the reference compound (ascorbic acid) and group 4 that received the solvent suggesting the ability of the phenothiazine derivatives to prevent lipid membrane damage. AST and bilirubin levels were higher in group 2 animals which received 6-[4-bromophenyl]-10-methyl-11-azabenzo[a]phenothiazine-5-one compared to group 3, the positive control. The results suggest that phenothiazine derivatives, especially 6-chloro-11-azabenzo[a]phenothiazine-5-one, possess antioxidant activity though 6-[4-bromophenyl]-10-methyl-11-azabenzo[a]phenothiazine-5-one was slightly toxic. This activity may be due to the presence of electron donors such as sulfur as well as the richness of hydrogen in the additional benzene rings for substitution. Further study is needed to identify tolerable doses for possible therapeutic purposes. © 2016 Godwill Azeh Engwa et al.


Njoku M.G.C.,Godfrey Okoye University
International Journal of Mobile Learning and Organisation | Year: 2016

This study examined the trend in articles published on mobile and ubiquitous learning from 2014 to 2015. Articles were drawn from Computers & Education, Computers in Human Behavior, Educational Technology and Society, Journal of Computer Assisted Learning, Innovations in Education and Teaching International, British Journal of Educational Technology and Turkish Journal of Educational Technology. A total of 135 articles related to mobile and ubiquitous learning were published in the journals indicated above for the 2014/2015 period. The most frequently studied learning domain was science; empirical research method was used most often and majority of the studies were conducted in the USA. This study indicates that interest in mobile and ubiquitous learning has increased. The implication is that course instructors and designers should continue to integrate mobile and ubiquitous learning into their course delivery and design. © 2016 Inderscience Enterprises Ltd.


PubMed | Godfrey Okoye University
Type: | Journal: Biochemistry research international | Year: 2016

The global increase in oxidative stress related diseases such as cancer, cardiovascular, and inflammatory diseases caused by overwhelming level of free radicals in the body has encouraged the search for new antioxidant agents. Based on the ability of newly synthesized phenothiazine derivatives (6-chloro-11-azabenzo[a]phenothiazine-5-one and 6-[4-bromophenyl]-10-methyl-11-azabenzo[a]phenothiazine-5-one) to oxidize H2O2, a known free radical to sulfoxide, this study assessed the in vitro and in vivo antioxidant activity. The synthesized phenothiazine derivatives exhibited reducing power potential to convert Fe(3+) to Fe(2+) and high ability to scavenge H2O2 free radical in vitro. These activities were comparable to ascorbic acid, a standard antioxidant. The catalase activity significantly increased (p < 0.05) in groups 1 and 2 animals that received the phenothiazine derivatives compared to the controls (groups 3 and 4) suggesting the ability of the phenothiazine derivatives to scavenge H2O2 in vivo. The malondialdehyde level in groups 1 and 2 animals was lower than that in group 3 that received the reference compound (ascorbic acid) and group 4 that received the solvent suggesting the ability of the phenothiazine derivatives to prevent lipid membrane damage. AST and bilirubin levels were higher in group 2 animals which received 6-[4-bromophenyl]-10-methyl-11-azabenzo[a]phenothiazine-5-one compared to group 3, the positive control. The results suggest that phenothiazine derivatives, especially 6-chloro-11-azabenzo[a]phenothiazine-5-one, possess antioxidant activity though 6-[4-bromophenyl]-10-methyl-11-azabenzo[a]phenothiazine-5-one was slightly toxic. This activity may be due to the presence of electron donors such as sulfur as well as the richness of hydrogen in the additional benzene rings for substitution. Further study is needed to identify tolerable doses for possible therapeutic purposes.

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