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Lakhtin V.,Gn Gabrichevsky Research Institute For Epidemiology And Microbiology | Lakhtin M.,Gn Gabrichevsky Research Institute For Epidemiology And Microbiology | Alyoshkin V.,Gn Gabrichevsky Research Institute For Epidemiology And Microbiology
Anaerobe | Year: 2011

Occurrence, organization, and functioning of lectins as well as their current classifications are under investigation. Results indicate importance of symbiotic lectins for clinical microecology. Lectins and lectin-based approaches have wide perspectives for medical biotechnology. Lectin terms, relationships between lectins and enzymes are discussed. © 2011 Elsevier Ltd.


Lakhtin M.,Gn Gabrichevsky Research Institute For Epidemiology And Microbiology | Lakhtin V.,Gn Gabrichevsky Research Institute For Epidemiology And Microbiology | Alyoshkin V.,Gn Gabrichevsky Research Institute For Epidemiology And Microbiology | Afanasyev S.,Gn Gabrichevsky Research Institute For Epidemiology And Microbiology
Beneficial Microbes | Year: 2011

In this review our last results and proposals with respect to general aspects of lectin studies are summarised and compared. System presence, organisation and functioning of lectins are proposed, and accents on beneficial symbiotic microbial lectins studies are presented. The proposed general principles of lectin functioning allows for a comparison of lectins with other carbohydrate-recognition systems. A new structure-functional superfamily of symbiotic microbial lectins is proposed and its main properties are described. The proposed superfamily allows for extended searches of the biological activities of any microbial member. Prospects of lectins of beneficial symbiotic microorganisms are discussed. © 2011 Wageningen Academic Publishers.


Lakhtin M.,Gn Gabrichevsky Research Institute For Epidemiology And Microbiology | Alyoshkin V.,Gn Gabrichevsky Research Institute For Epidemiology And Microbiology | Lakhtin V.,Gn Gabrichevsky Research Institute For Epidemiology And Microbiology | Afanasyev S.,Gn Gabrichevsky Research Institute For Epidemiology And Microbiology | And 2 more authors.
Probiotics and Antimicrobial Proteins | Year: 2010

Preparations of probiotic bifidobacterial and lactobacillus lectins possessed system affinity to mannan and mucin-type polymers. It was shown that these lectins possess fungistatic and fungicidal activities against nystatin-resistant Candida albicans clinical strains. Lectins revealed destructive properties with respect to C. albicans and Staphylococcus aureus biofilms, depending on clinical strain origin and lectin preparation type. Synergistic antipathogen activities between lectins and between lectins and nystatin were observed. In the presence of lectins, pathogen biofilm degradation occurred in sequential steps, including biofilm refinement, appearance of edge cavities, segmentation, detachment of fragments and their lysis. Fungal response to lectins was more complex compared to that of staphylococci. Cold stress improved pictures of lectin antipathogen action. The data indicate that probiotic bacterial lectins are members of a new class of antimicrobials-destructors of pathogen biofilms. © 2010 Springer Science + Business Media, LLC.

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