Aleshkin A.V.,Gn Gabrichevsky Moscow Research Institute For Epidemiology And Microbiology |
Zeigarnik M.V.,Russian National Research Medical University |
Bochkareva S.S.,Gn Gabrichevsky Moscow Research Institute For Epidemiology And Microbiology
Voprosy Prakticheskoi Pediatrii | Year: 2016
The review presents data about the history and present-day of using bacteriophage preparations in treatment and prevention of various infectious diseases in pediatrics. It sums up the results of numerous Russian studies of the efficacy and safety of the employed phages in treatment of acute intestinal infections and decompensated forms of dysbacteriosis in children from birth. The development of new ideas in molecular biology, ecological interrelations between bacteriophages and their hosts, along with the growing concern about antibiotic-resistant strains of microorganisms necessitate a more thorough research of the possibilities of using phages in clinical practice. In this context, phages have been used to prevent and/or treat infectious diseases of bacterial etiology (including in newborns and young children) for almost a century. Given the ability of lytic phages to kill bacteria that cannot be killed by commonly available antibiotics, it seems prudent that this approach is rigorously evaluated in carefully designed clinical trials.