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Barua C.C.,Assam Agricultural University | Begum S.A.,Assam Agricultural University | Barua A.G.,Assam Agricultural University | Borah R.S.,Assam Agricultural University | Lahkar M.,GMCH
Indian Journal of Experimental Biology | Year: 2013

Anxiety related disorders are the most common mental illnesses and major cause of disability in man. Anxiolytic activity of methanol extract of leaves of A. brasiliana (L.) Kuntze (MEAB) was evaluated using hole board (HB), open field (OF), elevated plus maze (EPM) and light/dark exploration test (LDE) in mice. Its locomotor activity was studied using actophotometer and anticonvulsant effect was studied using maximal electroshock-induced seizures and pentylenetetrazoleinduced seizures in mice. Single oral administration of MEAB at different doses (100, 300 and 600 mg/kg, ip) significantly increased the number and duration of head poking in the HB test; rearing, assisted rearing and number of square traveled in the OF test; entries and time spent in open arm in the EPM test; time spent in lighted box, and numbers of crossings and transfer latency time in the LDE test. There was significant reduction in the time spent in close arm in the EPM test and time spent in dark box in LDE test. In the actophotometer, the activity count was reduced in MEAB and diazepam treated group than control group. All the three doses of the extract significantly reduced the duration of seizures induced by pentylenetetrazole (chemoshock convulsion). However, the extract did not show any appreciable effect in electroshock convulsion model. The results of the present study suggest promising anxiolytic and anticonvulsant activity of MEAB which might be accredited to different phytoconstituents like alkaloids, steroids and triterpenes present in the methanol extract of A. brasiliana. Source


Non puerperal uterine inversions resulting from mixed mullerian uterine sarcoma are rare. We present a case of a postmenopausal woman with a large mixed mullerian tumour presenting as a huge abdominopelvic mass. It required a challenging surgical procedure to remove the tumour which is also described along with the review of literature. Source


Kaur B.,Punjabi University | Garg N.,Punjabi University | Sachdev A.,GMCH
Asian Journal of Pharmaceutical and Clinical Research | Year: 2013

To enhance production of pediocin BA28, produced by Pediococcus acidilactici, cultivation conditions and medium composition were optimized using response surface methodology (RSM). The Plackett Burman experimental design was effective in searching for the significant variables that influence bacteriocin production. From PB Design, three factors peptone, beef extract and initial pH were found to be significant factors and had positive effect on bacteriocin production. The effects of three main factors on bacteriocin production were further investigated by central composite design (CCD). RSM revealed that the maximum bacteriocin production was achieved at peptone concentration of 5% w/v, beef extract concentration of 5% w/v and an initial pH of 6.0. After RSM, the titer of bacteriocin was all most same as obtained in MRS medium which is much costlier than the designed media. Bacteriocin production in a cost effective medium might facilitate industrial scale production of lactic acid bacteriocin and their use as a natural food biopreservative. Source


Bardale R.,Government Medical College and Hospital | Ambade V.,GMCH | Dixit P.,Government Medical College and Hospital
Journal of Indian Academy of Forensic Medicine | Year: 2012

Exhumation is done for number of reason and includes establishment of identity, to know cause and manner of death, belated suspicion of an unnatural death or for medical insurance problems. It is infrequently done in India and due to cultural practice of cremation by burning to ashes the data are lacking. Compared with conventional autopsy done immediately after death, exhumation poses many problems. The present study was aimed to collect data regarding exhumation, to collect morphological findings in comparison with maximum postmortem interval and to analyze them in an attempt to formulate "catalogue of expectation" to supplement the published literature. Total 24 forensic exhumations performed at three centers of this region from 1999 to 2008 were evaluated retrospectively. Total 24 cases were analyzed and amongst them 12 were men and 12 were women and their age ranged from 3 years to 75 years (mean age 26.95). In the present series, the cause of death at exhumation could be clearly determined in 16 cases (66.6%). Amongst others, the burial practice and postmortem interval are major determining factors for possible outcome at exhumation. Source


Siddharth V.,AIIMS | Goyal V.,State Institute of Mental Health | Koushal V.,GMCH
Indian Journal of Community Medicine | Year: 2012

Introduction: Influenza virus is a common human pathogen that has caused serious respiratory illness and death over the past century. In April 2009, a new strain of Influenza virus A H1N1, commonly referred to as "swine flu," began to spread in several countries around the world, and India confirmed its first case on 16 May 16 2009. Aim: To study the clinical and epidemiological profile of Influenza A H1N1 cases at the Government Medical College and Hospital, Chandigarh. Materials and Methods: Clinical epidemiological characteristics of Influenza A H1N1 cases from May 2009 to April 2010 were retrospectively, descriptively analyzed using data from the Influenza A H1N1 screening center and isolation ward at the Government Medical College and Hospital, Chandigarh. Data were Analyzed using MS Excel software. Results: At GMCH, till April 2010, a total of 4379 patients were screened for Influenza A H1N1, of which 365 patients were tested. The most common symptoms were fever (87.6%), cough (49.77%), sore throat (27%) and breathlessness (23.9%). The most common presentation (42.30%) of Influenza A H1N1 cases was fever and cold-like features, not cough. 29.58% (108) of the tested patients were found to be positive for the disease. Maximum cases were detected in the month of December, and the patients less than 40 years of age accounted for 81.4% (44 cases) of the cases. Influenza A H1N1 resulted in death of 54.9% (28) of the admitted cases, of which 46% (12) deaths occurred within 48 h of admission. Conclusion: On the basis of these findings, it can be safely hypothesized that prevalence of Influenza A H1N1 is high in the younger population, and fever, cough and sore throat are the most common symptoms with which the patients usually present. Source

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