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Madhanraj K.,Pondichery Institute of Medical Science | Singh N.,GMCH | Singh M.P.,PGIMER | Ratho R.K.,PGIMER
Indian Pediatrics | Year: 2014

Objective: To investigate an outbreak of fever with rash in an urbanized village in Chandigarh, India.Methods: Active case search was performed by house-to-house survey. The etiological agent of the outbreak was confirmed by serology. Spot map was done using Geographical Information System (GIS) technology.Results: Out of 7742 persons screened, 12 were serologically confirmed rubella cases and 83 were epidemiologically linked cases. Overall attack rate was 1.1, more among the age group 1–4 years (4.9).Conclusion: An outbreak mimicking measles was investigated only to be confirmed as rubella. © 2014, Indian Academy of Pediatrics.

Jindal V.,GMCH | Gupta S.,GMCH | Das R.,GMCH
Molecular Neurobiology | Year: 2013

Meditation is a complex process involving change in cognition, memory, and social and emotional control, and causes improvement in various cardiovascular, neurological, autoimmune, and renal pathologies. Meditation also become widely used in medical and psychological treatment therapies for stress-related physical and mental disorders. But still, biological mechanisms in terms of effect on brain and body are poorly understood. This paper explains the basic changes due to meditation in cerebral cortex, prefrontal area, cingulate gyrus, neurotransmitters, white matter, autonomic nervous system, limbic system, cytokines, endorphins, hormones, etc. The following is a review of the current literature regarding the various neurophysiological mechanisms, neuro-endocrine mechanisms, neurochemical substrates, etc. that underlies the complex processes of meditation. © 2013 Springer Science+Business Media New York.

Deswal J.,GMCH | Arya S.K.,GMCH
Journal of Clinical and Diagnostic Research | Year: 2017

Ocular candidiasis is one of the opportunistic infection occurring in human body. Pathogenesis wise, Candida is very virulent and slow growing organism. We report a case of 76-year-old female with left eye candidal stromal abscess, not responding to topical and oral antifungal drugs. Patient was administered intrastromal amphotetericin B injection in the affected eye. Four midstromal injections were given in the areas surrounding the corneal abscess. A total of approximately 0.05 mL of amphotericin B, 5 μg per 0.1 mL, was administered. Within next four weeks, the eye became completely quiet with healed epithelial defect and corneal scarring. Intracorneal injection of amphotericin B is a safe and effective treatment option for recurrent and recalcitrant fungal infections. © 2017, Journal of Clinical and Diagnostic Research. All rights reserved.

Singh D.,GMCH | Gombar K.K.,Inscol Hospital | Bhatia N.,PGIMER | Gombar S.,GMCH | Garg S.,GMCH
Journal of Anaesthesiology Clinical Pharmacology | Year: 2013

Background and Objective: Pain is a complex process influenced by both physiological and psychological factors. In spite of an armamentarium of analgesic drugs and techniques available to combat post-operative pain, appropriate selection, and effective management for relief of post-operative pain still poses unique challenges. The discovery of peripheral opioid receptors has led to growing interest in the use of locally applied opioids (intra-articular, intra-pleural, intra-peritoneal, and perineural) for managing acute pain. As bone graft harvesting is associated with significant post-operative pain and there is a paucity of literature on the use of peripheral opioids at the iliac crest bone harvesting site, the present study was planned to evaluate the analgesic efficacy of local administration of morphine after iliac crest bone graft harvesting. Materials and Methods: A total of 60 patients, 20-50 years of age scheduled to undergo elective surgery for delayed and non-union fracture both bone leg with bone grafting under general anaesthesia (GA) were randomly assigned to one of the four groups of 15 patients each: group 1: 2.5 ml normal saline (NS) +2.5 ml NS infiltrated into the harvest site at 2 sites + 1 ml NS intramuscularly (i/m); Group 2: 2.5 ml NS + 2.5 ml NS infiltrated into the harvest site at 2 sites + 5 mg morphine in 1 ml i/m.; Group 3: 2.5 mg (2.5 ml) morphine + 2.5 mg (2.5 ml) morphine infiltrated into the harvest site at 2 sites + 1 ml NS i/m; Group 4: 0.5 mg naloxone (2.5 ml) +5 mg (2.5 ml) morphine infiltrated into the harvest site at 2 sites + 1 ml NS i/m. Pain from the bone graft site and operative site was assessed for 24 h post-operatively. Results: The patients who had received morphine infiltration (Group 3) had significantly less pain scores at the graft site at 4, 6, and 10 post-operative hours. They also had significantly less morphine consumption and overall better pain relief as compared to the other groups. Conclusions: Morphine administered peripherally provided better analgesia as compared to that given systemically and this effect was noticeable after 4 h post-operatively.

Kaur B.,Punjabi University | Garg N.,Punjabi University | Sachdev A.,GMCH
Asian Journal of Pharmaceutical and Clinical Research | Year: 2013

To enhance production of pediocin BA28, produced by Pediococcus acidilactici, cultivation conditions and medium composition were optimized using response surface methodology (RSM). The Plackett Burman experimental design was effective in searching for the significant variables that influence bacteriocin production. From PB Design, three factors peptone, beef extract and initial pH were found to be significant factors and had positive effect on bacteriocin production. The effects of three main factors on bacteriocin production were further investigated by central composite design (CCD). RSM revealed that the maximum bacteriocin production was achieved at peptone concentration of 5% w/v, beef extract concentration of 5% w/v and an initial pH of 6.0. After RSM, the titer of bacteriocin was all most same as obtained in MRS medium which is much costlier than the designed media. Bacteriocin production in a cost effective medium might facilitate industrial scale production of lactic acid bacteriocin and their use as a natural food biopreservative.

Barua C.C.,Assam Agricultural University | Begum S.A.,Assam Agricultural University | Barua A.G.,Assam Agricultural University | Borah R.S.,Assam Agricultural University | Lahkar M.,GMCH
Indian Journal of Experimental Biology | Year: 2013

Anxiety related disorders are the most common mental illnesses and major cause of disability in man. Anxiolytic activity of methanol extract of leaves of A. brasiliana (L.) Kuntze (MEAB) was evaluated using hole board (HB), open field (OF), elevated plus maze (EPM) and light/dark exploration test (LDE) in mice. Its locomotor activity was studied using actophotometer and anticonvulsant effect was studied using maximal electroshock-induced seizures and pentylenetetrazoleinduced seizures in mice. Single oral administration of MEAB at different doses (100, 300 and 600 mg/kg, ip) significantly increased the number and duration of head poking in the HB test; rearing, assisted rearing and number of square traveled in the OF test; entries and time spent in open arm in the EPM test; time spent in lighted box, and numbers of crossings and transfer latency time in the LDE test. There was significant reduction in the time spent in close arm in the EPM test and time spent in dark box in LDE test. In the actophotometer, the activity count was reduced in MEAB and diazepam treated group than control group. All the three doses of the extract significantly reduced the duration of seizures induced by pentylenetetrazole (chemoshock convulsion). However, the extract did not show any appreciable effect in electroshock convulsion model. The results of the present study suggest promising anxiolytic and anticonvulsant activity of MEAB which might be accredited to different phytoconstituents like alkaloids, steroids and triterpenes present in the methanol extract of A. brasiliana.

Vashishtha K.,GMCH
Journal of the Anatomical Society of India | Year: 2011

Aim of the study was to study the variations in the branching pattern of median nerve in the carpal tunnel and hand, which would form useful data for hand surgeons doing open/endoscopic carpal tunnel release. Median nerve and its branches were explored by dissection in fifty hands of twenty-five formalin fixed adult human cadavers over a period of three years. We found variations in 35 out of 50 hands. Based upon Lanz classification, frequency of variations in present series was variation in the course of thenar branch (58%), accessory branches at the distal portion of the carpal tunnel (34%), high divisions of the median nerve (8%) and accessory branches proximal to the carpal tunnel (nil). Rare variations including transligamentous median nerve and multiple thenar branches were also observed. Medial take off of thenar branch as observed in this series has special clinical significance in carpal tunnel release. Knowledge of the variable anatomy of median nerve would help to avoid incomplete decompression at operations for nerve entrapment and injury to thenar branch.

Non puerperal uterine inversions resulting from mixed mullerian uterine sarcoma are rare. We present a case of a postmenopausal woman with a large mixed mullerian tumour presenting as a huge abdominopelvic mass. It required a challenging surgical procedure to remove the tumour which is also described along with the review of literature.

Kaur R.,GMCH | Chauhan D.,GMCH | Dalal U.,GMCH | Khurana U.,GMCH
Abdominal Imaging | Year: 2012

Abdominal cocoon is a rare condition that results in an intestinal obstruction due to total or partial encapsulation of the small bowel by a fibrocollagenous membrane. Treatment is surgical resection of the membrane and free the bowel. Preoperative diagnosis is possible with combination of sonography and CT scan. We report two cases where the diagnosis of abdominal cocoon was suggested preoperatively based on the sonography and CT scan of abdomen. © Springer Science+Business Media, LLC 2011.

PubMed | Fortis Hospital, GMCH and PGIMER
Type: Journal Article | Journal: Journal of mid-life health | Year: 2017

The level of awareness about osteoporosis in postmenopausal women who are the common sufferers.This study aims to evaluate the level of awareness in postmenopausal women using the Osteoporosis Health Belief Scale (OHBS).Osteoporosis has emerged as a common health problem in geriatric population. A proactive role needs to be played for preventing its consequences. Before initiating any preventive measures, an evaluation of awareness level of the target population is necessary. The questionnaire-based study design was used for this study.A questionnaire (OHBS)-based study in 100 postmenopausal women in Chandigarh was conducted. The bone mineral density (BMD) was measured in each case by dual energy X-ray absorptiometry. Height, weight, and body mass index (BMI) of the participants were noted.Statistical analysis was conducted to evaluate any correlation between the various components of the OHBS and the BMD.No statistically significant difference was noted in the seven component parameters of OHBS among the normal, osteopenic, and osteoporotic women suggesting that the health belief regarding susceptibility is not much different between the three groups of the study population. A statistically significant difference between the mean BMI of normal and osteoporotic population was noted.The results show that there is a great deficit in the awareness level of postmenopausal Indian women regarding osteoporosis. Most of the women were unaware of the condition and the means to prevent it. The study emphasizes that health care professionals have lot of ground to cover to decrease the incidence of osteoporosis and its associated health problem.

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