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Choi J.-S.,Silla University | Kim J.W.,Glucan Corporation and 305 Marine Bio Industry Development Center | Jung G.-W.,Glucan Corporation and 305 Marine Bio Industry Development Center | Moon S.-B.,Glucan Corporation and 305 Marine Bio Industry Development Center | And 6 more authors.
Toxicology and Environmental Health Sciences | Year: 2016

The objective of the present study was to determine if Aureobasidium-originated beta-glucan (beta-glucan) modulated transforming growth factor (TGF)-β1-mediated wound healing. Proliferation of and collagen production by human dermal fibroblast cells were measured during in vitro dermal wound repopulation after treatment with 100, 10, 1, 0.1 and 0.01 mg/mL β-glucan and 1 ng/mL TGF-β1. Control group was treated without β-glucan or 1 ng/mL TGF-β1. TGF-β1 significantly decreased the optical density at A570 (a measure of fibroblast cell number) and increased procollagen production compared with the control. Also, fibroblast migration into wound defects decreased. The reductions in fibroblast proliferation and migration were significantly and dose-dependently inhibited by β-glucan (at 0.1 mg/mL or higher). However, glucan did not affect procollagen production. Thus, β-glucan may aid wound healing mediated by TGF-β1, an important cytokine in this context. © 2016, Korean Society of Environmental Risk Assessment and Health Science and Springer Science+Business Media Dordrecht.


Ku S.-K.,Daegu Haany University | Ku S.-K.,Glucan Corporation and 305 Marine Bio industry Development Center | Ku S.-K.,Silla University | Cho H.-R.,Daegu Haany University | And 8 more authors.
Toxicology and Environmental Health Sciences | Year: 2015

This study evaluated the effects of Polycan, a β-glucan produced by Aureobasidium pullulans SM-2001, on calcium (Ca) bioavailability in an ovariectomy (OVX) model and a thyroparathyroidectomy (TPTX) model of osteoporosis in the SD rat. Polycan (62.5, 125, and 250 mg/kg body weight) was administered daily with an oral gavage for 4 weeks in both the OVX group (beginning 10 weeks following OVX surgery) and the TPTX group (beginning 4 days following TPTX surgery) while a commercial food product containing 1% milk-borne Ca was available ad libitum. After 4 weeks of Polycan administration, all animals were sacrificed and changes in bone mineral density (BMD) in the femur, tibia, and lumbar vertebrae (L6) were analyzed using dual-energy X-ray absorptiometry. Ca intake was calculated based on the amount of food intake during the 24 h period prior to sacrifice and the Ca balance, absorption, and retention ratios were calculated based on Ca intake, urinary and faecal Ca content, and Ca balance. Polycan treatment resulted in a marked increase in the BMD of the femur, tibia, and L6 relative to the OVX and TPTX controls with concomitant increases in Ca bioavailability and decreases in secreted Ca. These findings indicate that Polycan may enhance the absorption and bioavailability of Ca and improve Ca balance. © 2015, Korean Society of Environmental Risk Assessment and Health Science and Springer Science+Business Media Dordrecht.


Choi J.-S.,Silla University | Kim J.-W.,Glucan Corporation and 305 Marine Bio Industry Development Center | Cho H.-R.,Glucan Corporation and 305 Marine Bio Industry Development Center | Kim K.-Y.,Glucan Corporation and 305 Marine Bio Industry Development Center | And 3 more authors.
Toxicology and Environmental Health Sciences | Year: 2014

The present study was performed to evaluate the laxative effects of fermented rice extract (FRe) in normal rats. FRe was orally administered at doses of 100, 200, and 300 mg/kg once per day for 15 days, and the changes in fecal parameters (fecal pellet numbers, weights, and water contents), gastrointestinal transit ratio, fecal mucus contents, colonic mucus-producing cell numbers, and mean colonic mucosa thicknesses were examined in normal rats. The laxative effects of FRe were compared with those of sodium picosulfate. At the three doses administered, FRe treatment resulted in marked increases in fecal pellet numbers and water contents discharged over 24 h, surface mucus thickness in the colonic lumen, intestinal charcoal-transit ratio, and in thickness and mucus-producing goblet cell number of the colonic mucosa with decreases in fecal pellet numbers and mean diameters remaining in the colonic lumen in comparison to the vehicle control. With the exception of intestinal charcoal-transit ratio, the effects of FRe were less marked than those of sodium picosulfate. The results of this study suggest that FRe has a laxative effect without causing diarrhea, as compared with sodium picosulfate, and FRe may be highly effective as a complementary medicine in humans suffering from lifestyle-induced constipation. © 2014, Korean Society of Environmental Risk Assessment and Health Science and Springer Science+Business Media Dordrecht.


Lee J.-K.,JKnutra and 502 | Kim J.W.,Glucan Corporation and 305 Marine Bio Industry Development Center | Kim K.-Y.,Glucan Corporation and 305 Marine Bio Industry Development Center | Ha Y.-M.,Silla University | And 3 more authors.
Toxicology and Environmental Health Sciences | Year: 2014

It was evaluated the synergistic effects of fermented rice extracts (FRe) on the laxative and probiotic effects of yogurt in normal rats. Commercial liquid yogurt (Bulgaris™) containing 0.05%, 0.10%, and 1.0% FRe (BFRe) was administered orally to normal rats daily for 10 days. Compared with the vehicle control, the three BFRe treatments exhibited highly significant increases in fecal pellet numbers, water content, thickness of surface mucous in the colonic lumen, intestinal charcoal transit ratio, thickness of the colonic mucosa, and mucous-producing goblet cells; decreased numbers and mean diameters of fecal pellets remaining in the colonic lumen were detected compared with the vehicle control, and numbers of viable Lactobacilli in cecum contents and feces were dramatically higher than those in vehicle control rats. More favorable probiotic and laxative effects were detected in rats treated with 0.1% and 1.0% BFRe compared with equal doses of liquid yogurt or FRe alone. Therefore, appropriate concentrations of BFRe may be highly effective for alleviating constipation and provide a complementary natural approach to reducing lifestyleinduced constipation. © 2014, Korean Society of Environmental Risk Assessment and Health Science and Springer Science+Business Media Dordrecht.


PubMed | Daegu Haany University, Glucan Corporation and 305 Marine Bio Industry Development Center and Silla University
Type: Journal Article | Journal: Pakistan journal of pharmaceutical sciences | Year: 2013

The aim of present research was to determine the acute oral toxicity of fermented rice extracts (FREs), in female and male ICR mice. To investigate the toxicity and identify target organs, FREs were orally administered once to male and female ICR mice at doses of 0 (vehicle control), 500, 1000, or 2000 mg/kg body weight (BW). Effects on mortality, BW, and clinical signs were monitored over 14 days, including changes in the weights and histopathological characteristics of 14 organs, as described in the Korea Food and Drug Administration (KFDA) Guidelines (2009-116, 2009). No treatment-related mortality was observed during the 14-day observation period in either gender. In addition, no FRE-related change was observed in BW or organ weight (OW), clinical indicators, or histopathological findings in this study. Our results suggest that the FRE is non-toxic in mice and is therefore likely to be safe for clinical use. The approximate LD and LD50 in mice after single oral dose of FRE are greater than 2000 mg/kg in female and male ICR mice. Additionally, no specific target organ or negative clinical indicator was detected in this study.

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