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Busan, South Korea

Lim M.-K.,Kyungpook National University | Ku S.-K.,Daegu Haany University | Choi J.-S.,Silla University | Kim J.-W.,Glucan Corporation
Experimental and Therapeutic Medicine

The aim of the present study was to analyze the effect of polycan, a β-glucan originating from Aureobasidium, on high-fat diet (HFD)-induced hyperlipemia and hepatic damage. A total of 30 hamsters were divided into 6 groups based on their body weight following acclimatization: control, sham, simvastatin (SIMVA) and 3 Polycan groups. In the polycan groups, Polycan, at three concentrations (31.25, 62.5 and 125 mg/kg), was administered orally once a day for 56 days, in addition to the HFD. On the day of sacrifice, changes in the body weight, food consumption, liver weight and serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglyceride and total cholesterol (T-CHOL) were observed, as well as changes to the liver and aorta (thoracic and abdominal) histopathology and histomorphometry. The results from the polycan groups were compared with a SIMVA 10 mg/kg oral treatment group, in addition to the sham and vehicle control groups. After the HFD-induced hyperlipidemic hamsters were administered Polycan, there was no significant change in their body weight and food consumption when compared with the hamsters in the vehicle control group. However, the serum levels of AST, ALT, triglyceride, T-CHOL and LDL were significantly reduced in a dose-dependent manner when compared with the vehicle control group (P<0.05). Furthermore, the levels of liver steatosis and arteriosclerosis in the abdominal and thoracic aorta were significantly decreased in a dose-dependent manner (P<0.01). In the SIMVA-treated group, body weight (P<0.05), the serum level of lipids (triglyceride, T-CHOL and LDL; P<0.01) and the level of arteriosclerosis (P<0.01) were significantly reduced when compared with the vehicle control group. However, liver weight and the serum levels of AST, ALT, and liver steatosis increased when compared with the vehicle control group. Based on these results, it was concluded that polycan exerts a favorable effect in decreasing HFD-induced hyperlipemia and associated atherosclerosis, with relatively good protective effects on liver damage. © 2015, Spandidos Publications. All rights reserved. Source

Ku S.-K.,Daegu Haany University | Chung I.-K.,Daegu Haany University | Cheon W.-H.,Daegu Haany University | Kim J.-W.,Glucan Corporation
Journal of Veterinary Clinics

The antiobese effects of Allium victorialis (AV) leaf methanol extract were evaluated in a high fat diet (HFD) supplied mice. The changes on the body weight, food consumption, leptin and adiponectin levels as well as the periovarian fat weights and histopathology of adipocytes were examined. The effects were compared with those of a group given 250 mg/kg of metformin. After 91 days of a continuous HFD supply, the mice were significantly showed obesity. However, the obesity induced by the HFD was inhibited by the AV extract treatment at the three different doses (62.5, 125 and 250 mg/kg) respectively. The results suggest that the AV methanol extract is beneficial for improving the diet-induced obesity in humans. Source

Glucan Corporation | Date: 2010-05-12

Disclosed is a composition for preventing, treating, or alleviating arthritis, and particularly, a composition effective for preventing, treating, or alleviating arthritis comprising -1,3-1,6-branched D-glucan. The -1,3-1,6-branched D-glucan of the composition is characterized in that glucoses are linked via a beta-1,3 linkage between two glucose molecules and a gluclose is branched via a linkage between 1 and 6 positions of two glucose molecules in every 1-20 of the beta-1,3 linked glucoses, and the branched glucose is bound with an organic acid. Further, an arthritis therapeutic agent and a health supplement food including the composition, and a method of preventing, treating, or alleviating arthritis including administering a pharmaceutically effective amount of the composition, are disclosed.

Choi J.-S.,Silla University | Shin H.-S.,Namyang Dairy Products Co. | Ha Y.-M.,Silla University | Kim K.Y.,Glucan Corporation | And 3 more authors.
Toxicology and Environmental Health Sciences

A mixed composition of purified β-glucan from Aureobasidium pullulans and calcium lactate-gluconate 1: 9(g/g) (polycalcium) was administered orally to female and male Sprague-Dawley (SD) rats once per day for 14 days at doses of 0, 500, 1,000 and 2,000 mg/kg in a volume of 10 mL/kg to investigate the effects of an oral repeated dose. After 14 days of oral polycalcium treatment, no treatment-related mortalities, clinical signs, or body/organ weight changes were detected. In addition, no meaningful polycalcium treatment-related changes were observed in hematological, serum biochemical, gross or histopathological parameters as compared with sex-matched vehicle controls following treatment with doses up to 2,000 mg/kg, the maximum dose limit for rodents. Therefore, polycalcium is non-toxic to rats and is therefore likely to be safe for clinical use. © 2014, Korean Society of Environmental Risk Assessment and Health Science and Springer Science+Business Media Dordrecht. Source

Choi J.-S.,center | Choi J.-S.,Silla University | Kim J.W.,Glucan Corporation | Cho H.-R.,Glucan Corporation | And 5 more authors.
Experimental and Therapeutic Medicine

Constipation is a common problem in males and females. The aim of the present study was to evaluate the laxative effects of fermented rice extract (FRe) on rats with loperamide-induced constipation. FRe (100, 200 and 300 mg/kg) was administered orally once per day for six days following 1 h loperamide treatment. The laxative effects of FRe were compared with those of sodium picosulfate (S. picosulfate). Following the induction of constipation in the rats, a marked decrease was observed in the fecal pellet number and water content discharged over 24 h, the surface mucus thickness in the colonic lumen, intestinal charcoal transit ratio, thickness of the colonic mucosa and the number of mucus-producing cells, while an increase was observed in the number of fecal pellets remaining in the colonic lumen and their mean diameter, as compared with the normal vehicle control rats. These conditions were significantly alleviated following the administration of the three doses of FRe when compared with the loperamide control group. However, the alleviating effects were lower than those of S. picosulfate, with the exception of the intestinal charcoal transit ratio. Similar effects on the intestinal charcoal transit ratio were detected for the three doses of FRe when compared with the S. picosulfate-treated rats. In conclusion, the results indicated that FRe exhibits a laxative effect without causing diarrhea, as compared with sodium picosulfate; thus, FRe may be effective as a complementary medicine in patients suffering from lifestyle-induced constipation. © 2014, Spandidos Publications. All rights reserved. Source

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