Selvakumar K.,Global BioLim |
Madhan R.,Global BioLim |
Srinivasan G.,Global BioLim |
Baskar V.,Global BioLim
Pharmaceutical Reviews | Year: 2011
Proteins undergo intra-molecular self-assembly processes to form a stable conformation in order to perform diverse and most essential processes in living organisms. This regular process can be disturbed with mis-folding phenomenon which leads to the formation of insoluble amyloid fibrils resulting production of a wide range of amyloidogenic diseases. These diseases are both inherited as well as acquired. They are localized and also systemic. Most of these diseases are chronic and degenerative. Currently diagnosis is carried out by both invasive and non-invasive methods, whereas treatment is given in the form of chemotherapy, organ transplantation and surgical treatments. However diagnosis and treatment of amyloidosis is more challenging and hence more knowledge and research is needed in this criteria with molecular and medicinal approach to reveal the mystery of folding and mis-folding events and also to find a more suitable and lifesaving therapy for different kinds of amyloidosis to save the mankind.