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Kagoshima-shi, Japan

Shibata M.,Hokkaido University | Shibata M.,MC Food Specialties Inc. | Onodera K.,Hokkaido University | Onodera K.,Glico Dairy Products Co. | And 7 more authors.
Food Science and Technology Research | Year: 2014

The potential of supercritical carbon dioxide (SC-CO2) extraction of "koku" enhancing compounds from dried herring fillet ("Migaki-nishin" in Japanese) and sturgeon liver was explored. "Koku" enhancing compounds from a water-soluble extract and a mixed water miscible SC-CO2 extract were isolated and evaluated for their effects on sensory perception. Results showed that only select compounds were found in the mixed water miscible SC-CO2 extract compared to the complicated composition of the water-soluble extract. A notable feature was that the mixed water miscible SC-CO2 extract contained "koku" enhancing compounds, e.g., nicotinamide, glycerol and creatine. This study revealed for the first time that these compounds were extracted by SC-CO2 extraction and that nicotinamide enhances "koku". We also extracted "koku" enhancing compounds from sturgeon liver using the SC-CO2 extraction technique. Instrumental analysis revealed that the sturgeon liver contained relatively large amounts of nicotinamide and glycerol. Thus, it is suggested that this technique might be applicable to the extraction of select compounds from fish and fishery by-products. Copyright © 2014, Japanese Society for Food Science and Technology Source


Ishizuka A.,Glico Dairy Products Co. | Tomizuka K.,Fuji Womens University | Aoki R.,Glico Dairy Products Co. | Nishijima T.,Glico Dairy Products Co. | And 5 more authors.
Journal of Bioscience and Bioengineering | Year: 2012

The aim of this study was to evaluate the changes in endogenous bifidobacteria and administered . Bifidobacterium animalis subsp. . lactis (. B. lactis) GCL2505 (GCL2505) in the intestine after administration of GCL2505 by means of a randomized, placebo-controlled double-blind, cross-over study. An increase in the number of total bifidobacteria (the sum of . B. bifidum, . B. breve, . B. longum subsp. . longum, . B. adolescentis, . B. anglatum, . B. catenulatum, . B. pseudocatenulatum, . B. dentium, . B. longum subsp. . infantis and . B. lactis) in the feces were observed after administration of GCL2505 using species- and subspecies-specific real-time polymerase chain reaction analysis. However, the number of endogenous bifidobacteria species (excluding . B. lactis) remained unchanged. . B. lactis also became the predominant bifidobacterial species. Taking into account the number of GCL2505 administered, the findings further suggested that GCL2505 proliferated in the intestine. In addition, the defecation frequency increased during GCL2505 administration compared with the placebo. Moreover, a single administration study (n. =. 17) clearly demonstrated that GCL2505 successfully reached the intestine before proliferating at least 10-fold. This is the first report to show an increase in intestinal bifidobacteria, with no changes to the endogenous species, and improvements in constipation following proliferation of administered bifidobacteria. © 2012 The Society for Biotechnology, Japan. Source


Takii H.,Glico Dairy Products Co. | Nishijima T.,Glico Dairy Products Co. | Takami K.,Glico Dairy Products Co. | Tanaka Y.,Glico Dairy Products Co. | And 4 more authors.
Japanese Pharmacology and Therapeutics | Year: 2012

The aim of this study was to evaluate the changes in intestinal bifidobacteria and the effect on fecal properties in healthy subjects with mild constipation after administration of a fermented milk containing Bifidobacterium animalis subsp. lactis (B. lactis) GCL2505. Volunteers (n=62 ; 15 male, 47 female ; 42.5±10.2 years [mean±SD]) were randomly divided into two groups and given 100 g of fermented milk containing B. lactis GCL2505 (>1×10 7cfu/g) or a placebo daily for 2 weeks in a double-blind crossover study. An increase in the number of total bifidobacteria (sum of B. bifidum, B. breve, B. longum subsp. longum, B. adolescente, B. angulatum, B. catenulatum, B. pseudocatenulatum, B. dentium, B. longum subsp. infantis, and B. lactis) was detected in feces after administration of the B. lactis GCL2505 fermented milk by species- and subspecies-specific real-time polymerase chain reaction analysis. The number of endogenous bifidobacteria species, excluding B. lactis, remained unchanged, and B. lactis became the predominant bifidobacterial species. Defecation frequency and stool quantity increased significantly (p < 0.05) during the B. lactis GCL2505 fermented milk ingesting period compared with placebo. These results indicate that GCL2505-fermented milk contributes to an increase in intestinal bifidobacteria by proliferating itself and to improvements in mild constipation without affecting endogenous bifidobacteria. Source

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