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Banweer J.,Barkatullah University | Pandey S.,Glenmark Pharmaceuticals Ltd andheri E | Pathak A.K.,Barkatullah University
Iranian Journal of Pharmaceutical Sciences | Year: 2010

Lisinopril dihydrate (angiotensin converting enzyme inhibitor) is a lysine derivative of enalaprilat and does not require hydrolysis to exert pharmacological activity. It has an extensive hepatic first pass metabolism resulting in a bioavailability of 6-60%. To overcome the poor bioavailability of the drug, transdermal patches have been prepared. The present study also aims at optimization of the formulation by incorporating the penetration enhancers in different concentration and ratios. The patches were prepared employing hydroxy propyl methyl cellulose (HPMC) and polyvinyl alcohol (PVA) in a 1:1 ratio as polymeric matrix using glycerol as plasticizer in 6% concentration. Binary solvent system (water-methanol) in a ratio of 70:30 was taken for the study. The transdermal devices were fabricated on glass substrate using solvent casting technique. Dimethylsulfoxide (DMSO) and propylene glycol (PG) were added as the penetration enhancers individually and in blends in different concentrations and ratios. Various physico-chemical evaluation parameters were carried over prepared patches to ascertain their integrity and physical stability at normal and accelerated temperature conditions. Optimization of the penetration enhancer's concentration and ratio was done by performing in vitro diffusion rate studies using Keshary-Chein diffusion cell on Goatskin. The patch containing DMSO:PG in the ratio of 70:30, at 10% showed the best in vitro drug flux and possesses excellent physico-chemical properties at normal and accelerated temperature conditions. It could be concluded that all patches prepared increased the drug flux through skin but optimization of the formulation yields highest drug flux through patch containing DMSO and PG in 10 % concentration.

Chauhan H.,Sterling | Patil S.,Glenmark Pharmaceuticals Ltd andheri E | Hajare A.,Glenmark Pharmaceuticals Ltd andheri E | Krishnaprasad K.,Glenmark Pharmaceuticals Ltd andheri E | Bhargava A.,Glenmark Pharmaceuticals Ltd andheri E
Journal of Clinical and Diagnostic Research | Year: 2015

Necrotizing fasciitis (NF) is an aggressive and life-threatening infection of skin and soft tissue characterized by widespread fascial necrosis, leads to gross morbidity and mortality if left untreated. Although MRSA has become a common isolate associated with skin and soft tissue infections globally over the past few years, monomicrobial MRSA NF has been reported only in a few studies. Our case represents the development of NF followed by trivial trauma salvaged with daptomycin and amputation of the affected limb. Prompt diagnosis and surgical management with empiric MRSA cover in areas where community acquired MRSA (CA-MRSA) is endemic for suspected cases of necrotizing fasciitis can prevent the dreaded consequences. © 2015, Journal of Clinical and Diagnostic Research. All right reserved.

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