Gilan University of Medical Sciences
Rasht, Iran

Gilan University of Medical science , is a medical school in Gilan Province of Iran.Located in the city of Rasht, the university fell under the Ministry of Health and Medical Education in 1986, the same year it was established.The university consists of four schools of Medicine, Dental, Nursing, and Allied Health science, and administers seven hospitals and several research centers in the city of Rasht.The University president was Dr.Hasan Behboudi until Jan.2014 and then Dr.Barzeger have got the responsibility.Affiliated hospitals include: Razi hospital, Poursina hospital, Heshmat Hospital, Amiralmomenin Hospital, Azzahra Hospital, Shafa Hospital Wikipedia.

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Jadidi M.S.,Gilan University of Medical Sciences | Ranjbar M.M.,Gilan University of Medical Sciences
International Journal of Engineering and Technology(UAE) | Year: 2016

In this paper, to verify the effect of zeolite on the strength of concrete and the effect of high temperatures on this type of concrete 5 com-position, containing different percentages zeolite (5%, 10%, 15% and 20%) with fixed water to cement ratio for perception of optimized percent of zeolite is made and influence of heat on compressive strength and ultrasonic speed waves was checked. According to tests, it is concluded that the replacement of 10% cement with zeolite at ratio water to cement 0.45 at ages 7, 28 and 90 days, is the optimized replacement level to zeolite. © 2016, Mahdi Sharif Jadidi, Malek Mohammad Ranjbar.

Zendedel A.,RWTH Aachen | Zendedel A.,Gilan University of Medical Sciences | Johann S.,RWTH Aachen | Mehrabi S.,Tehran University of Medical Sciences | And 5 more authors.
Molecular Neurobiology | Year: 2016

Stromal cell-derived factor-1 alpha (SDF-1a) or CXCL12 is an important cytokine with multiple functions in the brain during development and in adulthood. The inflammatory response initiated by spinal cord injury (SCI) involves the processing of interleukin-1beta (IL-1ß) and IL-18 mediated by caspase-1 which is under the control of an intracellular multiprotein complex termed inflammasome. Using an SCI rat model, we found improved functional long-term recovery which is paralleled by a reduction of apoptosis after intrathecal treatment with SDF-1a. An intriguing aspect is that SDF-1a changed the number of neuroinflammatory cells in the damaged area. We further examined the cellular localization and sequential expression of several inflammasomes during SCI at 6 h, 24 h, 3 days, and 7 days as well as the role of SDF-1a as a regulatory factor for inflammasomes. Using 14-week old male Wistar rats, spinal cord contusion was applied at the thoracic segment 9, and animals were subsequently treated with SDF-1a via intrathecal application through an osmotic pump. SCI temporally increased the expression of the inflammasomes NLRP3, ASC, the inflammatory marker tumor necrosis factor-a (TNF-a), interleukin-1ß (IL-1β) and IL-18. SDF-1a significantly reduced the levels of IL-18, IL-1b, TNF-a, NLRP3, ASC, and caspase-1. Immunofluorescence double-labeling demonstrated that microglia and neurons are major sources of the ASC and NLRP3 respectivley. Our data provide clear evidence that SCI stimulates a complex scenario of inflammasome activation at the injured site and that SDF-1a-mediated neuroprotection presumably depends on the attenuation of the inflammasome complex. © 2015, Springer Science+Business Media New York.

Ghavimi H.,Tabriz University of Medical Sciences | Charkhpour M.,Tabriz University of Medical Sciences | Ghasemi S.,Gilan University of Medical Sciences | Mesgari M.,Tabriz University of Medical Sciences | And 3 more authors.
Pharmacological Reports | Year: 2015

Background Opioid induced neuroinflammation is shown to be implicated in opioid analgesic tolerance development. In the present study the effect of pioglitazone on morphine-induced tolerance and neuroinflammation in the cerebral cortex of the rat was investigated. Materials and methods Various groups of rats received morphine (10 mg/kg; ip) and vehicle (po), or morphine (10 mg/kg) and pioglitazone (20 or 40 mg/kg; po) once a day for 17 days. In order to determine the possible involvement of PPAR-γ in the pioglitazone effect, one group of rats received PPAR-γ antagonist, GW-9662 (2 mg/kg; sc), and pioglitazone (40 mg/kg) and morphine once daily for 17 days. Nociception was assessed using a tail flick apparatus and the percentage of the maximal possible effect was calculated as well. On 18th day, 2 h after the last morphine injection, the cerebral cortex of the animals were harvested and the tissue levels of tumour necrosis factor alpha, interleukin-1beta, interleukin-6, interleukin-10 and nuclear factor-kappa B activity were determined. Results Co-administration of pioglitazone (40 mg/kg) with morphine not only attenuated morphine-induced tolerance, but also prevented the up-regulation of pro-inflammatory cytokines (tumour necrosis factor alpha, interleukin-1beta, interleukin-6) and nuclear factor-kappa B activity in the rat cerebral cortex. Moreover, GW-9662 (2 mg/kg) administration 30 min before pioglitazone, antagonized the above mentioned pioglitazone-induced effects. Conclusion It is concluded that oral administration of pioglitazone attenuates morphine-induced tolerance. This effect of pioglitazone may be, at least in part, due to its anti-inflammatory property which suppressed the cortical pro-inflammatory cytokine and inhibited of nuclear factor-kappa B activity. © © 2014 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Urban and Partner Sp.z o.o. All rights reserved.

Sabri M.,Amirkabir University of Technology | Sarabi A.A.,Amirkabir University of Technology | Naseri Kondelo S.M.,Gilan University of Medical Sciences
Materials Chemistry and Physics | Year: 2012

Nickel-alumina nano-composite coatings were obtained from nickel sulphamate solution containing nano-α-alumina particles by direct current (DC) plating. Nano-alumina particles were dispersed in the solution with the aid of different concentrations (50-300 mg l -1) of the anionic surfactant sodium dodecyl sulfate (SDS) by ultrasonic method. The microhardness variation of the coatings in different concentrations of SDS was investigated. Furthermore, the corrosion behavior of composite coatings was studied by polarization measurements in 3.5% w/v NaCl solution. The results revealed that increasing the surfactant concentration, up to an optimum value (125 mg l -1), led to more uniform distribution of nano-particles in the coatings, improved corrosion potential (E corr) to the most positive value (-0.209 V) and corrosion current density (i corr) to the lowest value (1.141 × -7 A cm -2), and enhanced the microhardness of composite coatings to 492 HV. However, beyond this optimum level, these properties were attenuated. © 2012 Elsevier B.V. All rights reserved.

Moussavi G.,Tarbiat Modares University | Talebi S.,Tarbiat Modares University | Farrokhi M.,Gilan University of Medical Sciences | Sabouti R.M.,Gilan Rural Water and Wastewater Co.
Chemical Engineering Journal | Year: 2011

This study examined the applicability of the natural zeolite for simultaneous removal of ammonia and humic acid, two of the most encountered concurrent contaminants in the surface waters. The influence of various operating parameters including pH (2-10), concentrations of zeolite (1-10. g/L), initial concentration of ammonia (10-100. mg/L) and/or humic acid (2-20. mg/L), contact time (5-90. min), and temperature (20-50 °C) was investigated on the removal of target contaminants from water through different experimental runs. The results indicated that zeolite had best performance for simultaneous removal of ammonia and humic acid at the pH close to that of natural waters. The adsorption of humic acid was found to be improved in the presence of ammonia. The removal of ammonia and humic acid as single or binary components using natural zeolite was indicated to be a rapid process, following the pseudo-second-order kinetic model. The temperature positively influenced the removal of target contaminant both as single and binary components, although with greater influence for lower concentrations of zeolite. Equilibrium adsorption of ammonia and humic acid onto natural zeolite had best fitness with the Freundlich isotherm at all temperatures ranging from 20 to 50 °C. The maximum experimental adsorption capacities of ammonia and humic acid as binary components were 49.7 and 10.5. mg/g, respectively. It was understood from the results of this study that adsorption onto natural zeolite is an efficient in performance, simple to operate, and economical process and thereby affordable technology for simultaneous removal of ammonia and humic acid from the contaminated water source. © 2011 Elsevier B.V.

Nejad Ebrahimi S.,Shahid Beheshti University | Hadian J.,Shahid Beheshti University | Ranjbar H.,Gilan University of Medical Sciences
Natural Product Research | Year: 2010

Coriander (Coriandrum sativum L.) has been cultivated for a many years in different parts of Iran. The chemical profiles of different accessions were analysed by means of GC-MS. The essential oil content of the dried seeds varied from 0.1% to 0.36%. Thirty-four different compounds were identified in the essential oil of all accessions. Linalool (40.9-79.9%), neryl acetate (2.3-14.2%), γ-terpinene (0.1-13.6%) and α-pinene (1.2-7.1%) were identified as main components in the oil of the coriander accessions. Almost all of the studied accessions contained more that 60% linalool, showing the high quality of coriander seeds produced in Iran and the suitability of the accessions as initial genetic materials for the breeding of homogenous and talented Coriander cultivars. © 2010 Taylor & Francis.

Hadi N.,Shiraz University of Medical Sciences | Soltanipour S.,Gilan University of Medical Sciences | Talei A.,Shiraz University of Medical Sciences
Archives of Iranian Medicine | Year: 2012

Background: Systematic reviews favor a better body image and sexual activity in patients who have undergone conservative breast surgery (BCS) compared to modified radical mastectomy (MRM). In those patients with the same survival, MRM remains the surgical choice among both surgeons and patients in Iran as well as in many other countries. This cross-sectional study focuses on health-related quality of life in early stage breast cancer patients following BCS and MRM. Methods: From all post-op patients who referred to the Motahari Clinic, Shiraz, Iran, we used a convenient sampling method to select 160 MRM patients and 127 who underwent BCS. Translated copies of the EORTC QLQ-C30 (version 3) and the EORTC QLQ-BR23 questionnaires, in addition to a third questionnaire which was customized and prepared for this study, were completed by the patients under our supervision Results: The two groups were compared by a multivariate method (Hotelling's trace test) after controlling for variables with unequal values such as disease stage, hormonal and radiotherapy treatments, and patients' role in the choice of surgery. We noted a significant difference (P < 0.001) attributed to a significantly better BI in the BCS group (average: 78.49 ± 23.14) compared to the MRM group (average: 60.71 ± 23.14). Discussion: We concluded that in terms of body image, BCS has a better impact on health-related quality of life.

Badeli H.,Gilan University of Medical Sciences
Arab journal of nephrology and transplantation | Year: 2013

Vesicoureteral reflux (VUR) is a risk factor for kidney scarring, hypertension and declining renal function. Standard diagnostic methods are invasive and can cause exposure to radiation and urinary tract infections (UTIs). We aimed to investigate urine albumin and interleukin-8 levels as markers of ongoing VUR and renal damage in children without UTIs. Random urine samples were collected from 51 children, including 16 children with VUR (group A), 17 children with resolved VUR (group B) and 18 normal children (group C). The diagnosis of VUR or resolved VUR was confirmed by voiding cystourethrogram (VCUG) or direct radionuclide cystography (DRNC). All children had normal kidney function and had no evidence of UTI in the preceding three months. Random urine specimens were assayed for albumin (Alb), creatinine (Cr) and interleukin-8 (IL-8) and mean values were compared by one way ANOVA. In groups A and B, the mean age at first UTI was 31.7 ± 2.4 and 27 ± 2.0 months respectively. In group A, the mean duration between VUR diagnosis and study entrance was 30 ± 9.1 months. In group B, the mean duration between VUR diagnosis and recovery was 19.9 ± 1.3 months. Overall, 76.4% of affected children had bilateral VUR and 41.2% had severe VUR. There were no significant differences in urinary Alb, IL-8, Alb/Cr and IL-8/Cr between the three groups. The current study does not support the hypothesis that microalbuminuria or urinary IL-8 are good indicators of ongoing VUR and renal injury in children.

Shahalami S.H.,Gilan University of Medical Sciences
PEDSTC 2010 - 1st Power Electronics and Drive Systems and Technologies Conference | Year: 2010

This paper presents a novel control approach of a current source inverter drive system using an induction motor. A variant of hysteresis-band current control adapted to the current source inverter circuit topology is proposed. The current control strategy is based on the correction of the two out of three larger errors of the instantaneous real currents of motor with respect to their references. The well known GTO current source inverter in which an auxiliary branch of inverter is added in order to ensure the continuity of DC link current in special conditions The indirect rotor flux-orientated vector control of induction motor gives the reference motor's currents. In order to suppress the inherent instability of current fed induction motor, a coefficient of derivative of real motor's currents is added to the reference ones. The simulation results of steady state and dynamic operations of the novel control asynchronous drive are shown and the advantages of this technique are discussed. © 2010 IEEE.

Seyednoori T.,Gilan University of Medical Sciences | Pakseresht S.,Gilan University of Medical Sciences | Roushan Z.,Gilan University of Medical Sciences
Women and Health | Year: 2012

The Gail model has been widely used to quantify an individual woman's risk of developing breast cancer by using important clinical parameters, usually for clinical counselling purposes or to determine eligibility for mammography and genetic tests. The aim of the present study was to estimate the five-year and lifetime breast cancer risk among women in Rasht, Iran. In this cross-sectional study, 314 women were evaluated at Alzahra Women Hospital in 2007. Participants were ≥35 years of age without a history of breast cancer. Risk estimation was performed using the computerized Gail model. A five-year risk &1.66% was considered high-risk; 5.1% of women were high-risk. The mean five-year breast cancer risk was 0.8% (SD±1). Mean breast cancer risk up to the age of 90 years (lifetime risk) was 9.0% (SD±3.9%); 16.2% of the participants had a five-year risk higher than the average woman of the same age, and 18.2% had the same risk. Also for the lifetime risk, 11.1% of the women had higher risk and 1.6% had the same risk as the average woman. Routine use of the Gail model is recommended for identifying women at high average risk for increasing the survival of women from breast cancer. © 2012 Taylor and Francis Group, LLC.

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