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Xiang L.,Zhejiang University | Cao X.-L.,Zhejiang University | Xing T.-Y.,Hangzhou Napochi Pharmaceutical Co. | Mori D.,Gifu Shellac Manufacturing Co. | And 4 more authors.
Nutrients | Year: 2016

Long-term use of fish oil (FO) is known to induce oxidative stress and increase the risk of Alzheimer’s disease in humans. In the present study, peanut skin extract (PSE), which has strong antioxidant capacity, was mixed with FO to reduce its side effects while maintaining its beneficial properties. Twelve-week Institute of Cancer Research (ICR) mice were used to conduct animal behavior tests in order to evaluate the memory-enhancing ability of the mixture of peanut skin extract and fish oil (MPF). MPF significantly increased alternations in the Y-maze and cognitive index in the novel object recognition test. MPF also improved performance in the water maze test. We further sought to understand the mechanisms underlying these effects. A significant decrease in superoxide dismutase (SOD) activity and an increase in malonyldialdehyde (MDA) in plasma were observed in the FO group. The MPF group showed reduced MDA level and increased SOD activity in the plasma, cortex and hippocampus. Furthermore, the gene expression levels of brain-derived neurotrophic factor (BDNF) and cAMP responsive element-binding protein (CREB) in the hippocampus were increased in the MPF group, while phosphorylation of protein kinase B (AKT), extracellular signal-regulated kinase (ERK) and CREB in the hippocampus were enhanced. MPF improves memory in mice via modulation of anti-oxidative stress and activation of BDNF/ERK/CREB signaling pathways. © 2016 by the authors; licensee MDPI, Basel, Switzerland.


PubMed | Hangzhou Napochi Pharmaceutical Co., Gifu Shellac Manufacturing Co. and Zhejiang University
Type: Journal Article | Journal: Nutrients | Year: 2016

Long-term use of fish oil (FO) is known to induce oxidative stress and increase the risk of Alzheimers disease in humans. In the present study, peanut skin extract (PSE), which has strong antioxidant capacity, was mixed with FO to reduce its side effects while maintaining its beneficial properties. Twelve-week Institute of Cancer Research (ICR) mice were used to conduct animal behavior tests in order to evaluate the memory-enhancing ability of the mixture of peanut skin extract and fish oil (MPF). MPF significantly increased alternations in the Y-maze and cognitive index in the novel object recognition test. MPF also improved performance in the water maze test. We further sought to understand the mechanisms underlying these effects. A significant decrease in superoxide dismutase (SOD) activity and an increase in malonyldialdehyde (MDA) in plasma were observed in the FO group. The MPF group showed reduced MDA level and increased SOD activity in the plasma, cortex and hippocampus. Furthermore, the gene expression levels of brain-derived neurotrophic factor (BDNF) and cAMP responsive element-binding protein (CREB) in the hippocampus were increased in the MPF group, while phosphorylation of protein kinase B (AKT), extracellular signal-regulated kinase (ERK) and CREB in the hippocampus were enhanced. MPF improves memory in mice via modulation of anti-oxidative stress and activation of BDNF/ERK/CREB signaling pathways.


Yao S.,Fukuoka University | Sakurai M.,Fukuoka University | Sekiguchi H.,Fukuoka University | Otsubo H.,Fukuoka University | And 5 more authors.
Nihon Reoroji Gakkaishi | Year: 2012

We recently discovered that a block co-polymer constructed with side chain crystalline monomer and solvent compatible monomer (Side Chain Crystalline Block Co-Polymer: SCCBC) have an ability to decrease viscosity of concentrated polyethylene (PE) particle suspension system incredibly. This suspension system shows the Thermal Rheological (TR) Fluid effect, which is reversible temperature dependence of viscosity, with increasing temperature and the viscosity increases to almost the original value of the suspension without the SCCBC. In this time, we have investigated the SCCBC as a surface modifier of PE porous membrane. We investigated a permeation rate of this membrane by measuring the conductivity of Li ion and of their temperature dependence. In this investigation we found a transition temperature that the conductivity changed discontinuity. This function is able to applicable to a Li ion battery. © 2012 The Society of Rheology, Japan.


Ichikawa S.,Gifu Shellac Manufacturing Co. | Yao S.,Fukuoka University
Nihon Reoroji Gakkaishi | Year: 2012

In a previous paper, we reported that a block co-polymer constructed with side chain crystalline monomer and monomer having solvent affinity (Side Chain Crystalline Block Co-Polymer: SCCBC) decreased the viscosity of polyethylene particle dispersion incredibly. The dispersion system also showed the Thermal Rheological (TR) phenomenon that was with increasing the temperature the viscosity increased to the almost original viscosity of the dispersion system without SCCBC and with decreasing temperature the viscosity decreased reversibly. In this study, we considered the effect of the sequence distribution of SCCBC, species of side chain crystalline monomer, and species of solvent. We found that with using random copolymer, the TR behavior decreased. By changing the length of the side chain we could change the dispersant effect and also could control the transition temperature of TR phenomenon. We also found a specific SCCBC structure which could apply to the Teflon particle dispersion system. Moreover, we found that the dispersant effect depended on the species of the solvent and the dependence could arrange by the interfacial tension between solvent and solvent affinity monomer. © 2012 The Society of Rheology, Japan.


Yao S.,Fukuoka University | Sakurai M.,Fukuoka University | Sekiguchi H.,Fukuoka University | Otsubo H.,Fukuoka University | And 5 more authors.
Nihon Reoroji Gakkaishi | Year: 2013

We recently developed a new dispersant which can decrease the viscosity of concentrated polyethylene (PE) particle dispersions significantly. This dispersant is a block copolymer constructed with side chain crystalline monomers and solvent compatible monomers (Side Chain Crystalline Block Copolymer: SCCBC). Also the viscosity of this dispersion shows reversible temperature dependence that the viscosity increases with increasing temperature up to almost the original value of the dispersion without the dispersant. This phenomenon is named as "Thermal Rheology" and the fuid is named as "Thermal Rheological (TR) Fluid". In the previous report, we found this TR Fluid effect depends on the randomness of the copolymer and solvent species qualitatively. In this investigation we researched about copolymer molecular composition and weight dependence on the TR Fluid effects. We also researched about deformation mode dependence. From this research, the TR Fluid effects strongly depend on the molecular weight, especially on the molecular weight of side chain crystalline composition. Also the TR Fluid effects are signifcant in low shear rate region and dynamic deformation mode. © 2013 The Society of Rheology, Japan.


Yao S.,Fukuoka University | Okuma T.,Fukuoka University | Kumamaru C.,Fukuoka University | Sekiguchi H.,Fukuoka University | And 2 more authors.
Materials Transactions | Year: 2013

Recently, we polymerized a block copolymer that was constructed of side-chain crystalline monomer and a solvent-compatible monomer, which we referred to as a side-chain crystalline block copolymer (SCCBC). This SCCBC has a specific melting point. We found that this SCCBC was adsorbed onto polyethylene (PE) crystal by via supramolecular interaction. In addition, through this supramolecular interaction, the SCCBC acts as a dispersant for a concentrated PE particle dispersion, and this dispersion can be considered a Thermal Rheological Fluid. By using this novel supramolecular interaction, we can easily modify the surface properties of high crystalline polymers (PE, polytetrafluoroethylene (PTFE), etc.), which have been thought to be inert. Especially, we can modify the inner surface properties of porous membranes without using physical methods (such as UV irradiation or plasma irradiation). Furthermore, these modified surface properties can revert to those in the non-modified state under changes in temperature. It may possible to develop intelligent materials with use of this supramolecular interaction in the near future. © 2013 The Japan Institute of Metals and Materials.

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