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Patiāla, India

Garg A.,Gian Sagar Medical College | Goyal N.,GMC | Gorea R.K.,Forensic Medicine
Journal of Indian Academy of Forensic Medicine | Year: 2011

Age determination is very important. The perfect way to store the age related data is still lacking in developing countries. For age determination, different parts of the skeleton are more useful at different age ranges. The different age ranges include fetal, children, teen age, young adult, and older adult. Age determination is required in both civil as well as criminal cases. So for these cases, forensic experts are entrusted duty to determine the age. Forensic experts rely on radiographs of various bones and joints to determine age. Most of the age determination data available in middle and old adult is from autopsies and not from living population radiographs. Due to lack of this living person radiograph database, Xiphisternal joint is studied to determine the age in middle and old people. Lateral view radiograph of this joint was done in people whose exact date of birth was known and who had a valid proof of date of birth.

Sehgal V.,Commonwealth Medical College | Bajwa S.J.S.,Gian Sagar Medical College | Bajaj A.,Wright Center
Annals of Cardiac Anaesthesia | Year: 2013

With the adoption of dabigatran, rivaroxaban, and apixaban into clinical practice, a new era has arrived in the practice of oral anticoagulants. Venous thromboembolism (VTE) has traditionally been underdiagnosed and under treated in Asia. With increasing longevity, the diagnosis and the need for management of atrial fibrillation (AF) and VTE is likely to increase significantly. The new orally active anticoagulants (NOACs) have reasonably filled the lacunae that clinicians traditionally faced when treating patients with vitamin K antagonist (VKA). Unlike VKA, NOACs do not need frequent monitoring. Therefore, more patients are likely to get therapeutic effects of anticoagulation and thus reduce morbidity and mortality associated with VTE and AF. However, the clinicians need to be circumspect and exercise caution in use of these medications. In particular (in geriatric population), the clinicians should look out for drug-drug interactions and underlying renal insufficiency. This would ensure therapeutic efficacy and minimize bleeding complications. Here, it is important to note that the antidote for NOACs is not available and is a major concern if emergency surgical procedure is required in their presence.

Gupta S.,Gian Sagar Medical College | Baweja P.,Government of Punjab | Mittal S.,Government of Punjab | Kumar A.,Government of Punjab | And 2 more authors.
North American Journal of Medical Sciences | Year: 2013

Background: Diabetes mellitus represents a syndrome complex in which multiple organ systems, including the central nervous system, are affected. Aim: The study was conducted to determine the changes in the brainstem auditory evoked potentials in type 2 diabetes mellitus. Materials and Methods: A cross sectional study was conducted on 126 diabetic males, aged 35-50 years, and 106 age-matched, healthy male volunteers. Brainstem auditory evoked potentials were recorded and the results were analyzed statistically using student's unpaired t-test. The data consisted of wave latencies I, II, III, IV, V and interpeak latencies I-III, III-V and I-V, separately for both ears. Results: The latency of wave IV was significantly delayed only in the right ear, while the latency of waves III, V and interpeak latencies III-V, I-V showed a significant delay bilaterally in diabetic males. However, no significant difference was found between diabetic and control subjects as regards to the latency of wave IV unilaterally in the left ear and the latencies of waves I, II and interpeak latency I-III bilaterally. Conclusion: Diabetes patients have an early involvement of central auditory pathway, which can be detected with fair accuracy with auditory evoked potential studies.

Gupta M.,Gian Sagar Medical College | Joshi K.,Jawaharlal Institute of Postgraduate Medical Education & Research | Nagi O.N.,Shri Ganga Ram Hospital
Journal of Molecular Histology | Year: 2010

Articular cartilage degeneration seen in osteoarthritis is primarily the consequence of events within the articular cartilage that leads to the production of proteases by chondrocytes. 22 osteoarthritic cartilage specimens were obtained from patients with primary osteoarthritis (46-81 years) undergoing total knee replacement. 12 age-matched (41-86 years) and 16 young (16-40 years) non-osteoarthritic control cartilage specimens were obtained from the cadavers in the department of Anatomy and from patients undergoing lower limb amputation in Trauma center of PGIMER, Chandigarh. 5 μ thick paraffin sections were stained for osteocalcin, osteopontin, osteonectin and alkaline phosphatase to analyze their expression in hypertrophied chondrocytes and osteoarthritic cartilage matrix and to compare the staining intensity with that of normal ageing articular cartilage. Immunohistochemical staining of tissue sections revealed moderate to strong cytoplasmic staining for all four stains in all the specimens of the osteoarthritic group compared to age-matched control. The immunohistochemical scores were significantly higher in the osteoarthritic group for all four stains. The features of the osteoarthritic articular cartilage were markedly different from the non-osteoarthritic age-matched articular cartilage suggesting that osteoarthritis is not an inevitable feature of aging. © 2010 Springer Science+Business Media B.V.

Mittal S.,Government Medical College | Gupta S.,Gian Sagar Medical College | Kumar A.,Government Medical College | Singh K.D.,Government Medical College
Lung India | Year: 2013

Background: Measurement of peak expiratory flow (PEF) is imperative for management and evaluation of asthmatic children. It is well-known that lung function parameters show wide variations with respect to regional, racial, and genetic factors. Aim: This study was conducted to measure PEF in healthy Punjabi children aged 7-14 years as only a few studies have evaluated the lung functions in North Indian children. Materials and Methods: A cross-sectional study was conducted in which PEF was measured in 366 healthy schoolchildren (186 boys and 180 girls) of Patiala district, using the Mini Wright Peak Flow Meter. Best of the three trials was recorded. All the subjects were tested in standing position after recording their age, height, and weight. SPSS v. 13 was used for the statistical analysis. Results: The present study showed that all the three independent variables (age, height, and weight) had a significant positive correlation with PEF, in both genders. Furthermore, height was maximally correlated with PEF in both boys (r = 0.970) and girls (r = 0.964). The mean PEF value in boys (249.34 ± 81.36 L/min) was significantly higher than girls (233.31 ± 67.06 L/min). Regression equations for PEF were also determined using age, height, and weight, separately for the genders. Conclusion: Equations derived from this study for estimation of expected PEF values would help the clinicians in assessing the airway obstruction in this population subset.

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