Zhai J.-H.,GI Medicine |
Gu W.-C.,Shanghai Pudong New Area People s Hospital |
Xu X.-L.,Fudan University |
Wu J.,GI Medicine |
And 2 more authors.
Tumor Biology | Year: 2015
Many studies evaluated the correlations of CD133 expression with the clinical outcomes in patients treated with chemoradiotherapy (CRT) but yielded controversial results. This meta-analysis was performed to identify the impacts of CD133 expression on the prognosis of cancer patients treated with CRT. Electronic databases updated up to March 2014 were searched to find relevant studies. Relevant literatures without any language restrictions were searched via electronic databases as follows: Web of Science (1945 ~ 2013), the Cochrane Library Database (Issue 12, 2013), PubMed (1966 ~ 2013), EMBASE (1980 ~ 2013), CINAHL (1982 ~ 2013), and the Chinese Biomedical Database (CBM) (1982 ~ 2013). STATA software was used for the current meta-analysis. Hazard ratios (HR) and its corresponding 95 % confidence interval (95 % CI) were calculated. Six studies were identified with a total of 470 cancer patients treated with CRT. The meta-analysis results showed that CD133-positive patients had poorer overall survival (OS) than that of CD133-negative patients (HR = 2.13, 95 % CI = 1.20 ~ 3.07, P < 0.001). Furthermore, CD133-positive patients displayed shorter disease-free survival (DFS) than that of CD133-negative patients (HR = 1.74, 95 % CI = 0.08 ~ 3.40, P = 0.039). Ethnicity-stratified analysis indicated that CD133 expression positively correlated with shorter OS among the Japanese, Chinese, and Spanish populations (all P < 0.05). In conclusion, our findings suggest that CD133 expression may be positively correlated with poorer prognosis in cancer patients treated with CRT. © 2014, International Society of Oncology and BioMarkers (ISOBM).
Liu S.-P.,GI Medicine |
Dong Y.-Y.,Peoples Hospital of Handan City |
Kong W.-P.,Handan City Maternal and Child Health Hospital |
Shi Y.-Q.,GI Medicine |
And 5 more authors.
Journal of Dalian Medical University | Year: 2015
Objective: To determine the expression of MIF, MMP - 9 and VEGF in the esophageal squamous cell carcinoma and its significance. Methods: Of all the 58 cases of esophageal squamous cell carcinoma, 40 cases of normal endometrial tissue were detected in MIF and VEGF by microwave EliVision™. Results: The expression of MIF, MMP - 9 and VEGF were higher than the normal tissue (P <0. 05). MIF, MMP-9 and VEGF were related with differentiation degree and lymph nodemetastasis and pathological staging(P < 0. 05). It was positive correlation between MIF and MMP - 9 (P < 0.05), It was also positive correlation between MIF and VEGF(P <0.05), the correlation between MMP-9 and VEGF was positive, too(P<0.05). Conclusion: The positive expression of MIF, MMP-9 and VEGF may play an important role during tumor, invasion and metastasis. Detection on expression of VEGF, MMP-9 and MIF may be valuable to further understand the squamous carcinoma.