Puglisi M.A.,GI and Liver Stem Cell Research Group GILSteR |
Saulnier N.,GI and Liver Stem Cell Research Group GILSteR |
Piscaglia A.C.,GI and Liver Stem Cell Research Group GILSteR |
Agnes S.,Catholic University of the Sacred Heart |
Gasbarrini A.,GI and Liver Stem Cell Research Group GILSteR
European Review for Medical and Pharmacological Sciences | Year: 2011
Mesenchymal Stem Cells (MSCs) are multipotent cells, able to differentiate into elements of the mesodermal lineage. Bone marrow and adipose tissue represent the main sources for MSC isolation. In the last decade, several studies have reported the plasticity of MSCs toward a hepatocyte-like phenotype. The use of MSCs to generate hepatocyte-like cells holds great promises to overcome the scarcity of available organs for transplantation. However, little is known about the molecular pathways involved in lineage cross-differentiation and several issues remain to be answered before MSC application in clinical settings. Aim of this review is to critically analyze the possible sources of MSCs suitable for liver repopulation and the molecular mechanisms underlying MSC hepatic differentiation.