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Puglisi M.A.,GI and Liver Stem Cell Research Group GILSteR | Tesori V.,GI and Liver Stem Cell Research Group GILSteR | Lattanzi W.,Catholic University of the Sacred Heart | Piscaglia A.C.,GI and Liver Stem Cell Research Group GILSteR | And 3 more authors.
Journal of Biomedicine and Biotechnology | Year: 2011

Mesenchymal stem cells (MSCs), represent an attractive tool for the establishment of a successful stem-cell-based therapy of liver diseases. A number of different mechanisms contribute to the therapeutic effects exerted by MSCs, since these cells can differentiate into functional hepatic cells and can also produce a series of growth factors and cytokines able to suppress inflammatory responses, reduce hepatocyte apoptosis, regress liver fibrosis, and enhance hepatocyte functionality. To date, the infusion of MSCs or MSC-conditioned medium has shown encouraging results in the treatment of fulminant hepatic failure and in end-stage liver disease in experimental settings. However, some issues under debate hamper the use of MSCs in clinical trials. This paper summarizes the biological relevance of MSCs and the potential benefits and risks that can result from translating the MSC research to the treatment of liver diseases. © 2011 Maria Ausiliatrice Puglisi et al. Source


Puglisi M.A.,GI and Liver Stem Cell Research Group GILSteR | Saulnier N.,GI and Liver Stem Cell Research Group GILSteR | Piscaglia A.C.,GI and Liver Stem Cell Research Group GILSteR | Agnes S.,Catholic University of the Sacred Heart | Gasbarrini A.,GI and Liver Stem Cell Research Group GILSteR
European Review for Medical and Pharmacological Sciences | Year: 2011

Mesenchymal Stem Cells (MSCs) are multipotent cells, able to differentiate into elements of the mesodermal lineage. Bone marrow and adipose tissue represent the main sources for MSC isolation. In the last decade, several studies have reported the plasticity of MSCs toward a hepatocyte-like phenotype. The use of MSCs to generate hepatocyte-like cells holds great promises to overcome the scarcity of available organs for transplantation. However, little is known about the molecular pathways involved in lineage cross-differentiation and several issues remain to be answered before MSC application in clinical settings. Aim of this review is to critically analyze the possible sources of MSCs suitable for liver repopulation and the molecular mechanisms underlying MSC hepatic differentiation. Source

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