GHG Khalsa College

Ludhiāna, India

GHG Khalsa College

Ludhiāna, India

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Bharti S.,Panjab University | Kaur G.,Ghg Khalsa College | Gupta S.,Goswami Ganesh Dutta Sanatan Dharma College | Tripathi S.K.,Panjab University
Journal of Luminescence | Year: 2017

Surface modification of CdSe quantum dots (QDs) plays a significant role for their use in biomedical field due to their cytotoxicity effects. CdSe QDs and CdSe/ZnS nanoparticles (NPs) have been prepared by chemical route and their functionalization has been done using Polyethylene glycol diamine (PEGdiamine) polymer. Absorption in the ultra-violet-visible and infra red region confirms the encapsulation of PEGdiamine over CdSe/ZnS NPs. TEM micrographs also show the growth of ZnS over CdSe QDs and PEGylation over CdSe/ZnS NPs. The photoluminescence (PL) spectra in different pH environments ranging pH 2–10 have been deeply investigated to know the stability of NPs. CdSe QDs, CdSe/ZnS NPs and PEGylated CdSe/ZnS NPs agglomerate with complete disappearance of fluorescence peak at low pH (below pH 4) however no shift in the fluorescence emission peak is observed for the pH range 4–10. Therefore NPs can be used as the fluorescence tags for biomedical field in this specific range 6–8 pH. PEGylation leads to increase in the PL intensity as well as shows better stability of CdSe/ZnS NPs. CdSe/ZnS NPs and PEGylated CdSe/ZnS NPs are more luminescent in the weak acidic environment than uncoated CdSe QDs. © 2016


PubMed | Punjabi University, Panjab University and GHG Khalsa College
Type: Review | Journal: Future science OA | Year: 2016

The desirable physical and physiochemical properties of clay minerals have led them to play a substantial role in pharmaceutical formulations. Clay minerals like kaolin, smectite and palygorskite-sepiolite are among the worlds most valuable industrial minerals and of considerable importance. The elemental features of clay minerals which caused them to be used in pharmaceutical formulations are high specific area, sorption capacity, favorable rheological properties, chemical inertness, swelling capacity, reactivity to acids and inconsiderable toxicity. Of course, these are highly cost effectual. This special report on clay minerals provides a birds eye view of the chemical composition and structure of these minerals and their influence on the release properties of active medicinal agents. Endeavor has been made to rope in myriad applications depicting the wide acceptability of these clay minerals.


Dhir V.,Ghg Khalsa College | Dhir V.,University of Punjab | Dhand P.,Punjab Agricultural University
Toxicology International | Year: 2010

Lead being a toxic cumulative poison and an environmental pollutant, experiments were conducted at an oral chronic dose of (60 mg/kg/day) for 90 days on adult female rats (Rattus Norvegicus) and its effect on the reproductive functions in relation to the biochemical effects was studied. It was observed that the chronic dose of lead caused an elevation in the level of proteins, acid phosphatase, alkaline phosphatase, alanine aminotransferase, and aspartate aminotransferase in all the soft tissues studied indicating tissue damage. It also inhibited the level of acetylcholinesterase in all the tissues. Fertility tests by pairing treated females with males showed that lead-treated female showed irregular estrous cycle and the fertility rate dropped to 40% as female pups of lead-treated mothers showed loss in weight, high mortality rate, poor growth rate, and late vaginal opening. Histological studies of ovary showed atresia in all the stages of folliculogenesis sustaining the poor fertility observations. The present study revealed that lead caused great tissue damage and affected reproductive performance of female rats at a chronic dose.


Heavy metal toxicity is a serious worldwide problem which adversely affects the growth, health, reproductive performance and life span of all living organisms. In my previous work1-2 I (Dhir) worked on the physicochemical interactions in between the biomolecules (eccrine) with series of cations and also studied the importance of hydrophobic character of big biomolecules. Therefore; in this project I studied the effect of toxic cations like Cu2+, Pb2+ & Cd2+ on the various biological aspects. Copper (copper sulphate), Leads (lead acetate) and cadmium(cadmium sulphate) being a toxic cumulative poison and an environmental pollutant, experiments were conducted at an oral chronic dose of (60 mg/kg/day) for 90 days on adult female rats (Rattus Norvegicus) and its effect on the reproductive functions in relation to the biochemical effects was studied. It was observed that the chronic dose of copper, lead & cadmium caused an elevation in the level of proteins, acid phosphatase, alkaline phosphatase, alanine aminotransferase and aspartate aminotransferase in all the soft tissues studied indicating tissue damage, whereas it was observed be me the effects were received in the following order: Cu2+ > Pb2+ > Cd2+ (in terms of toxicity) However no literature was available so far as to compare the toxicity level of copper, cadmium with lead (because the cadmium ions or compounds are available in trace amount but I cannot rule out the possibility of cadmium pollution). Therefore it is necessary to compare copper and lead with cadmium. But the effect of lead is more important as compared to cadmium and copper because lead is released in our environment as the major pollutant. Like lead, copper and cadmium also inhibited the level of acetylcholinesterase in all the tissues. Fertility tests by pairing treated females with males showed that lead and cadmium treated female showed irregular oestrous cycle and the fertility rate dropped to 35% (in case of copper), 40%(in case of lead) and 50% (in case of cadmium) as female pups of lead treated mothers showed loss in weight, high mortality rate, poor growth rate and late vaginal opening. Histological studies of ovary showed atresia (figures 1-4) in all the stages of folliculogenesis sustaining the poor fertility observations. Since the absorption of lead indicated toxicity in humans is great due to the intake through food, air, and water, it became imperative to carry out a systematic study on the effect of chronic oral dose of lead on female reproductive functions and also to record the various enzymatic changes in rats. These findings would be useful in understanding the various effects on sensitive species and also extrapolating, with care the results for humans.


Puri J.K.,Panjab University | Singh R.,Panjab University | Chahal V.K.,Ghg Khalsa College | Sharma R.P.,Panjab University | And 2 more authors.
Journal of Organometallic Chemistry | Year: 2011

The present work aims at the synthesis of various novel silatranes bearing substituted urea functionality. Nucleophilic addition of various amines (morpholine, aniline, ethylenediamine and 3-aminopropyltriethoxysilane) to 3-isocyanatopropyltriethoxysilane resulted in the four triethoxysilanes; N-[3-(triethoxysilyl)propyl]morpholine-4-carboxylic acid amide (1), 1-[3-(triethoxysilyl)propyl]-3-phenylurea (2), 1,2-bis{N′-[3- (triethoxysilyl)propyl]ureido}-ethane (3) and N-[3-(triethoxysilyl)propyl]- N′-[3-(triethoxysilyl)propyl]urea (4), respectively. In the presence of a base the resulting silanes undergo transesterification reaction with triethanolamine, thus forming the corresponding silatranes, N-(3- silatranylpropyl)morpholine-4-carboxylic acid amide (5), 1-(3-silatranylpropyl)- 3-phenylurea (6), 1,2-Bis[N′-(3-silatranylpropyl)ureido]-ethane (7) and N-(3-silatranylpropyl)-N′-(3-silatranylpropyl)urea (8), respectively. Among these are four novel compounds (5-8), which were characterized by elemental analysis, IR, multinuclear (1H, 13C and 29Si) NMR and mass spectroscopy. Structures of compounds 5 and 6 were deduced by X-ray crystallography. Single crystal X-ray studies revealed distorted trigonal bipyramidal coordination about Si in 5 and 6 with Si-N bond distance of 2.121(1)Å and 2.189(2)Å, respectively. © 2011 Elsevier B.V. All rights reserved.

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