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Medicine, Iran

Boskabadi H.,Mashhad University of Medical Sciences | Maamouri G.,Mashhad University of Medical Sciences | Mafinejad S.,Fellowship of Neonatology | Rezagholizadeh F.,Ghaem Hospital
Macedonian Journal of Medical Sciences | Year: 2011

Background: Hemolytic jaundice is the most serious cause of hyperbilirubinemia among neonates. It may develop to kernicterus due to misdiagnosis or inappropriate treatment. The aim of this study is to determine the prevalence rate of hemolytic jaundice, predisposing factors and assessment of treatment and complications in hemolytic jaundice. Methods: This prospective descriptive study has been performed on 1568 newborns with jaundice as their chief complaint, in a seven-year period at Ghaem hospital in Mashhad, Iran. 795 neonates were included in our study (237 infants with hemolytic jaundice and 558 infants with idiopathic jaundice). Complete physical examinations and laboratory tests were performed and data were recorded. Statistical analysis was carried out, using SPSS 11.5 statistical package. Results: In the present study, significant differences were determined between two groups of hemolytic and idiopathic jaundice for total serum bilirubin, hematocrit, time of jaundice appearance, age of admission, hospitalization period and incidence of kernicterus (p<0.001). Newborns with ABO incompatibility (17%), Rh disease (7%), G6PD deficiency (6%) and minor blood group immunization (2%) were developed to hyperbilirubinemia, respectively. Among the newborns affected with kernicterus, 12 cases were placed in group with ABO hemolytic disease (9%), 3 cases were in Rh isoimmunization group (5.5%), 4 cases were in G6PD deficiency group (8.9%) and 9 cases were idiopathic (1.6%). Conclusion: Jaundice due to hemolysis is associated with a higher serum bilirubin and more complications like kernicterus. ABO incompatibility was the most common reason of hemolytic jaundice among neonates in north east of Iran. Special attention to ABO incompatibility and G6PD enzyme screening may decrease complications and improve the prognosis. © 2011 Boskabadi H.

Rezvani M.R.,Birjand University | Ghandehari K.,Ghaem Hospital
Journal of Research in Medical Sciences | Year: 2012

Background: The main source of studies about effects of opium consumption on heart and brain attacks originates from Iran Therefore the aim of the present study was to assess opium addiction as a probable influencing factor for ischemic heart disease and ischemic stroke. Materials and Methods: A cross-sectional study was carried out in two Cardiology and Neurology clinics in Eastern Iran in 2011. Diagnosis of Ischemic Heart Disease (IHD) and Ischemic Stroke (IS) was made by Cardiologist and Stroke Neurologist respectively. The influence of gender, hypertension, diabetes, hyperlipidemia, cigarette smoking, oral and inhaled opium consumption on distribution of IHD and IS were evaluated. Results: Five hundred fifty eight patients (307 females, 251 males) with mean age 56.2 years enrolled the study. On adjusted odds ratios of our whole 558 patients, only hypertension and diabetes had a significant influence on occurrence of IHD; (P = 0.000 and P = 0.000) respectively. Oral and inhaled routes of opium addiction did not have a significant effect on occurrence of IHD; [OR = 1.172, 95% CI = 0.624-2.203, P = 0.621] and [OR = 1.820, 95% CI = 0.811-4.085, P = 0.147] respectively. Hypertension and diabetes were significant risk factors of IS in our 558 patients at multivariate analysis; (P = 0.000, P = 0.020). Oral opium addiction was as significant protective factor of IS in our study group; OR = 0.211, 95% CI = 0.079-0.564, P = 0.002, while inhaled opium addiction did not have a significant effect on occurrence of IS in our patients at; OR = 1.760, 95% CI = 0.760-4.076, P = 0.187. Conclusion: Oral opium consumption is a protective factor of IS but not IHD. Inhaled opium addiction does not have a significant influence on occurrence of IS and IHD.

Ajami B.,Harvard University | Ghazvini K.,Ghaem Hospital | Movahhed T.,Harvard University | Ariaee N.,Bu Ali Research Institute | Makarem S.,Mashhad University of Medical Sciences
Iranian Red Crescent Medical Journal | Year: 2012

Background: Dental unit waterline system is considered potential source for contamination with Legionella species. The aim of this study was to determine if contamination of a dental unit water line system by Legionella pneumophila serogroup1 in the Mashhad School of Dentistry occurred in 2009. Methods: A total of 52 dental units were selected from all clinical departments of the Mashhad School of Dentistry. Samples of water were collected from outlets of water/air spray, high-speed dental hand pieces and water cup fillers. Samples were tested via the ELISA method. Results: At the beginning of the work day, a total of 36.1 percent of dental units were contaminated by Le-gionella pneumophila serogroup 1. Conclusion: Infection control of the dental unit water line system regarding legionella in the Mashhad School of Dentistry is a challenge and engineering controls should be used in contaminated clinics. © Iranian Red Crescent Medical Journal.

Hasanzadeh M.,Womens Health Research Center | Sharifi N.,Ghaem Hospital | Esmaieli H.,Mashhad University of Medical Sciences | Daloee M.S.,Nuclear Medicine Research Center | Tabari A.,Nuclear Medicine Research Center
Journal of Obstetrics and Gynaecology Research | Year: 2013

Aim: Considering that Ki-67 is a proliferative marker in molar pregnancies and the possible progression of these kinds of pregnancies to gestational trophoblastic neoplasia (GTN), we decided to evaluate the rate of expression of this marker in patients with uneventful hydatidiform moles and GTN. Moreover, we determined the predictive value of this factor for the progression of molar pregnancies to GTN. Methods: In two groups of patients, including 30 patients with uneventful molar pregnancies and 30 patients with GTN, an immunohistochemical staining technique using the Envision method was performed. To evaluate nuclear immunoreactivity of trophoblastic cells for Ki67 on paraffin sections obtained from molar pregnancy products, the percentage of the stained cells was used. Semi-quantitative evaluation was also performed. Data were analyzed using Mann-Whitney tests and receiver operating characteristic curve analysis. Results: The expression of Ki67 in cytotrophoblastic and syncytiotrophoblastic cells of patients with GTN was significantly more than for patients with an uneventful molar pregnancy (P < 0.05). We considered a 12.5% cut-off value for Ki67 in cytotrophoblastic cells and a sensitivity of 90%, specificity 93%, positive predictive value of 93.1% and negative predictive value of 90.3% were obtained. Similarly, considering a cut-off value of 6% for Ki67 in syncytiotrophoblastic cells, results of 90% were obtained for all diagnostic indices. Conclusion: Our findings suggest that expression of the Ki67 oncogene in trophoblastic cells in patients with GTN are found far more frequently than in patients with an uneventful molar pregnancy, and demonstrate a high predictive value of progression to GTN. © 2012 Japan Society of Obstetrics and Gynecology.

Hasanzadeh N.,Dental Material Research Center | Majidi M.R.,The Surgical Center | Kianifar H.,Ghaem Hospital | Eslami N.,Mashhad University of Medical Sciences
Journal of Craniofacial Surgery | Year: 2014

The purpose of this study was to cephalometrically evaluate the facial soft-tissue characteristics of adolescent patients with bilateral cleft lip and palate (BCLP) and to compare them with a noncleft control group. Lateral cephalometric radiographs obtained from 56 adolescents with nonsyndromic BCLP (29 boys and 27 girls) were analyzed and compared with 67 control subjects (29 boys and 38 girls) who were matched for sex, age, and ethnicity. All patients had been operated on before the age of 2 years for the surgical repair of cleft lip and palate. None had received any orthopedic or orthodontic treatment. Independent-samples t test revealed that patients with BCLP significantly differed from the control group by having a flatter facial profile, thinner and more retruded nasal base, flatter nasal tip (in males), and reduced upper-lip length. Furthermore, thicker lower-lip pit, shallower mentolabial sulcus, and increased inclination angles of the upper and lower lips relative to the horizontal plane were observed in female patients compared with the normal group. The findings of the current study suggested that adolescent patients with BCLP showed several facial soft-tissue deformities when compared with normal individuals with the same age, sex, and ethnic origin. This study provides objective measures that could lead to better treatment planning and prediction of the need for corrective surgeries in patients with BCLP. Copyright © 2014 by Mutaz B. Habal, MD.

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