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Eslami N.,Dental Research Center | Majidi M.R.,Ghaem Hospital | Aliakbarian M.,Mashhad University of Medical Sciences | Hasanzadeh N.,Mashhad University of Medical Sciences
Journal of Craniofacial Surgery | Year: 2013

Considering the essential need for oral health-related quality-of-life measures for patients with craniofacial malformations, the current study aimed to investigate the oral health-related quality of life of Iranian patients with cleft lip and palate. Fifty children referred to Cleft lip/Palate Research Center of Mashhad Dental School (Iran) were recruited. Participants were asked to complete the Child Oral Health Impact Profile questionnaire. The questionnaire comprised 38 items and was divided over 5 subscales. The scores on all subscales were compared with regard to patients' age, sex, and type of cleft. A significant difference between boys and girls was found on the subscale emotional well-being (P = 0.027). There was no significant difference between 8-to 12-year-old patients and those older than 12 years. Also, no significant difference was found between bilateral and unilateral cleft lip and palate patients regarding mean score of Child Oral Health Impact Profile questionnaire and its subscales. Oral health-related quality of life of cleft lip and palate patients did not change with patients' age. Also, the impact of unilateral and bilateral clefts on OHRQoL was similar. Quality of life of girls was more affected by oral health. © 2013 by Mutaz B. Habal, MD.


Eslami N.,Dental Research Center | Majidi M.R.,Ghaem Hospital | Aliakbarian M.,Sheikh Hospital | Hasanzadeh N.,Mashhad University of Medical Sciences
Journal of Craniofacial Surgery | Year: 2013

The aim of the present study was to investigate the prevalence of dental anomalies in a group of patients with cleft lip and palate (CL/P) in the northeast of Iran. Ninety-one patients referring to the Cleft Lip and Palate Clinic of Mashhad Dental School were enrolled and classified into right CL/P, left CL/P, and bilateral CL/P groups. Photographs, dental casts, and panoramic and periapical radiographs were retrieved, and dental anomalies were recorded. χ test was used to analyze the frequency of dental anomalies according to type of cleft and sex. Missing maxillary lateral incisors was the most frequent dental anomaly, which was slightly higher in the bilateral group (61.1%). There were significantly more cases of missing lateral incisors outside the cleft area in right CL/P (P = 0.015). Peg lateral incisors were observed in 33.3% of bilateral CL/P compared with 28% of right and 23.3% of left unilateral cases. The sample presented rotations of central incisors in the cleft area in 33.3% of bilateral clefts. In unilateral clefts, it occurred more frequently in the right side (48%). Sexual dimorphism appeared only for maxillary central incisor rotation in the cleft area, which showed significantly greater frequency in females (P = 0.025). Transposition of maxillary canine and first premolars was found in 5.5% of bilateral, 8% of right, and 3.3% of left unilateral clefts. The prevalence of dental anomalies in the studied sample seems to be higher than that reported in the normal population. More anomalies were observed at the cleft side. The frequency of most anomalies was not significantly different between the 2 sexes. Copyright © 2013 by Mutaz B. Habal, MD.


Hasanzadeh N.,Dental Material Research Center | Majidi M.R.,The Surgical Center | Kianifar H.,Ghaem Hospital | Eslami N.,Mashhad University of Medical Sciences
Journal of Craniofacial Surgery | Year: 2014

The purpose of this study was to cephalometrically evaluate the facial soft-tissue characteristics of adolescent patients with bilateral cleft lip and palate (BCLP) and to compare them with a noncleft control group. Lateral cephalometric radiographs obtained from 56 adolescents with nonsyndromic BCLP (29 boys and 27 girls) were analyzed and compared with 67 control subjects (29 boys and 38 girls) who were matched for sex, age, and ethnicity. All patients had been operated on before the age of 2 years for the surgical repair of cleft lip and palate. None had received any orthopedic or orthodontic treatment. Independent-samples t test revealed that patients with BCLP significantly differed from the control group by having a flatter facial profile, thinner and more retruded nasal base, flatter nasal tip (in males), and reduced upper-lip length. Furthermore, thicker lower-lip pit, shallower mentolabial sulcus, and increased inclination angles of the upper and lower lips relative to the horizontal plane were observed in female patients compared with the normal group. The findings of the current study suggested that adolescent patients with BCLP showed several facial soft-tissue deformities when compared with normal individuals with the same age, sex, and ethnic origin. This study provides objective measures that could lead to better treatment planning and prediction of the need for corrective surgeries in patients with BCLP. Copyright © 2014 by Mutaz B. Habal, MD.


Ghandehari K.,Mashhad University of Medical Sciences | Ghandehari K.,Ghaem Hospital | Gerami Sarabi M.R.,Ghaem Hospital | Maarufi P.,Tabriz University of Medical Sciences
Stroke Research and Treatment | Year: 2010

Background. Spinal Cord Infarction (SCI) is a rare and disabling disease. This hospital-based study was conducted for clinical evaluation of SCI patients in east of Iran. Methods. Consecutive SCI patients admitted in Ghaem hospital,Mashhad during 20062010 were enrolled in a prospective clinical study. Diagnosis of SCI was made by neurologists and radiologists. Demographic features, clinical syndrome, and Magnetic Resonance Imaging (MRI) findings were recorded. All of the patients underwent a standard battery of diagnostic investigations. All of the patients suspected to SCI had MRI of spinal cord at the symptomatic level of cord with a 0.5 Tesla generation, Philips NT Intra, Netherland equipment. An equal number of patients with Brain Infarction (BI) were randomly selected from our stroke registry data bank. Etiology and degree of disability were compared between these groups of patients. Results. Fourteen SCI patients (9 females, 5 males) with mean age 38.8±SD: 19.9 years were evaluated. Miscellaneous causes consisted 50 of etiologies in patients with SCI. Uncertain etiology, atherosclerosis, and cardioembolisms consisted 35.7, 7.1, and 7.1 of SCI causes, respectively. Distribution of etiologies was significantly different between SCI and BI patients, X 2 =12.94, df=3, P=.003. Difference in mean disability score at acute phase of stroke was not significant between two studied groups, z=1.54, P=.057. Difference in mean changes of disability score at 90 days postevent was significant in two groups of patients, z=2.65, P=.019. Conclusion. SCI is a rare disease with poor recovery. Distribution of etiologies of SCI patients is quite different than of BI patients. Copyright 2010 Kavian Ghandehari et al.


Boskabadi H.,Mashhad University of Medical Sciences | Maamouri G.,Mashhad University of Medical Sciences | Mafinejad S.,Fellowship of Neonatology | Rezagholizadeh F.,Ghaem Hospital
Macedonian Journal of Medical Sciences | Year: 2011

Background: Hemolytic jaundice is the most serious cause of hyperbilirubinemia among neonates. It may develop to kernicterus due to misdiagnosis or inappropriate treatment. The aim of this study is to determine the prevalence rate of hemolytic jaundice, predisposing factors and assessment of treatment and complications in hemolytic jaundice. Methods: This prospective descriptive study has been performed on 1568 newborns with jaundice as their chief complaint, in a seven-year period at Ghaem hospital in Mashhad, Iran. 795 neonates were included in our study (237 infants with hemolytic jaundice and 558 infants with idiopathic jaundice). Complete physical examinations and laboratory tests were performed and data were recorded. Statistical analysis was carried out, using SPSS 11.5 statistical package. Results: In the present study, significant differences were determined between two groups of hemolytic and idiopathic jaundice for total serum bilirubin, hematocrit, time of jaundice appearance, age of admission, hospitalization period and incidence of kernicterus (p<0.001). Newborns with ABO incompatibility (17%), Rh disease (7%), G6PD deficiency (6%) and minor blood group immunization (2%) were developed to hyperbilirubinemia, respectively. Among the newborns affected with kernicterus, 12 cases were placed in group with ABO hemolytic disease (9%), 3 cases were in Rh isoimmunization group (5.5%), 4 cases were in G6PD deficiency group (8.9%) and 9 cases were idiopathic (1.6%). Conclusion: Jaundice due to hemolysis is associated with a higher serum bilirubin and more complications like kernicterus. ABO incompatibility was the most common reason of hemolytic jaundice among neonates in north east of Iran. Special attention to ABO incompatibility and G6PD enzyme screening may decrease complications and improve the prognosis. © 2011 Boskabadi H.


Dastgheib S.S.,Shefa Neuroscience Research Center | Layegh P.,Mashhad University of Medical Sciences | Sadeghi R.,Mashhad University of Medical Sciences | Foroughipur M.,Mashhad University of Medical Sciences | And 4 more authors.
Current Neurology and Neuroscience Reports | Year: 2014

Mozart's music has been shown to have promising effects on nervous system functions. In this study, the effects of Mozart's work on epilepsy were reviewed. Articles were obtained from a variety of sources. The results of 12 studies were extracted. Three different meta-analyses were performed to examine (i) the percentage of patients who had changes in their interictal epileptic discharges (IEDs) by music therapy; and the changes of IEDs (ii) during and (iii) after exposure to Mozart's music. Data analysis indicated that 84 % of patients listening to Mozart's music showed a significant decrease in IEDs. In addition, IEDs were decreased during (31.24 %) and after (23.74 %) listening to Mozart's compositions. A noteworthy response to music therapy in patients with a higher intelligence quotient, generalized or central discharges, and idiopathic epilepsy was demonstrated. The effect of Mozart's music on epilepsy seems to be significant. However, more randomized control studies are needed to determine its clinical efficacy. © 2013 Springer Science+Business Media New York.


Rezvani M.R.,Birjand University | Ghandehari K.,Ghaem Hospital
Journal of Research in Medical Sciences | Year: 2012

Background: The main source of studies about effects of opium consumption on heart and brain attacks originates from Iran Therefore the aim of the present study was to assess opium addiction as a probable influencing factor for ischemic heart disease and ischemic stroke. Materials and Methods: A cross-sectional study was carried out in two Cardiology and Neurology clinics in Eastern Iran in 2011. Diagnosis of Ischemic Heart Disease (IHD) and Ischemic Stroke (IS) was made by Cardiologist and Stroke Neurologist respectively. The influence of gender, hypertension, diabetes, hyperlipidemia, cigarette smoking, oral and inhaled opium consumption on distribution of IHD and IS were evaluated. Results: Five hundred fifty eight patients (307 females, 251 males) with mean age 56.2 years enrolled the study. On adjusted odds ratios of our whole 558 patients, only hypertension and diabetes had a significant influence on occurrence of IHD; (P = 0.000 and P = 0.000) respectively. Oral and inhaled routes of opium addiction did not have a significant effect on occurrence of IHD; [OR = 1.172, 95% CI = 0.624-2.203, P = 0.621] and [OR = 1.820, 95% CI = 0.811-4.085, P = 0.147] respectively. Hypertension and diabetes were significant risk factors of IS in our 558 patients at multivariate analysis; (P = 0.000, P = 0.020). Oral opium addiction was as significant protective factor of IS in our study group; OR = 0.211, 95% CI = 0.079-0.564, P = 0.002, while inhaled opium addiction did not have a significant effect on occurrence of IS in our patients at; OR = 1.760, 95% CI = 0.760-4.076, P = 0.187. Conclusion: Oral opium consumption is a protective factor of IS but not IHD. Inhaled opium addiction does not have a significant influence on occurrence of IS and IHD.


Saghafi N.,Ghaem Hospital
The journal of obstetrics and gynaecology research | Year: 2011

Preterm delivery is defined as a birth before 37 weeks' gestation and is the cause of two-thirds of perinatal mortality and thus one of the major problems in obstetrics. Its etiology is unknown, but hormonal factors have been reported to play a part. Progesterone is a placental hormone and effective in maintaining pregnancy. The aim of this study is to evaluate the efficacy of 17α-hydroxyprogesterone caproate in the prevention of preterm delivery. This interventional study was performed with 100 pregnant women who had been referred to the Obstetrics Clinic of Ghaem Hospital (related to Mashhad University of Medical Sciences) during 2007 to 2008. They were randomly divided into two groups of 50 cases and 50 controls. The case group received 250 mg of intramuscular 17α-hydroxyprogesterone caproate weekly from 16 weeks' gestation up to a maximum of 37 weeks' gestation. In the control group, routine perinatal care was performed and the pregnancy outcomes were compared in both groups. The mean gestational age was 36 weeks in the case group and 34 weeks in the control group. The mean birth weight was 2695 g in the case group and 2399 g in the control group. A significant difference was observed between the two groups in terms of gestational age and birth weight (P < 0.05). Weekly administration of 17α-hydroxyprogesterone caproate to pregnant women with a history of preterm delivery was associated with a decrease in preterm delivery and improvement in birth weight. © 2011 The Authors. Journal of Obstetrics and Gynaecology Research © 2011 Japan Society of Obstetrics and Gynecology.


Sasannejad P.,Mashhad University of Medical Sciences | Saeedi M.,Mashhad University of Medical Sciences | Shoeibi A.,Mashhad University of Medical Sciences | Shoeibi A.,Ghaem Hospital | And 3 more authors.
European Neurology | Year: 2012

Lavender essential oil has been used as an anxiolytic drug, a mood stabilizer, a sedative, spasmolytic, antihypertensive, antimicrobial, analgesic agent as well as a wound healing accelerator. We have studied for the first time the efficacy of lavender essential oil inhalation for the treatment of migraine in a placebo-controlled clinical trial. Methods: Forty-seven patients with definite diagnosis of migraine headache were divided into cases and controls. Cases inhaled lavender essential oil for 15 min, whereas the control group used liquid paraffin for the same time period. Patients were asked to record their headache severity and associated symptoms in 30-min intervals for a total of 2 h. We matched the two groups for key confounding factors. Results: The mean reduction of headache severity in cases was 3.6 ± 2.8 based on Visual Analogue Scale score. The reduction was 1.6 ± 1.6 in controls. This difference between the controls and cases was statistically significant with p < 0.0001. From 129 headache attacks in cases, 92 responded entirely or partially to lavender. In the control group, 32 out of 68 recorded headache attacks responded to placebo. The percentage of responders was significantly higher in the lavender group than the placebo group (p = 0.001). Conclusion: The present study suggests that inhalation of lavender essential oil may be an effective and safe treatment modality in acute management of migraine headaches. Copyright © 2012 S. Karger AG, Basel.


Objective: asthma is a chronic inflammatory airway disease. The development of asthma and allergy appears to be the results of gene-environment interaction. Potential environmental risk factors such as allergens and life style pattern may trigger respiratory symptoms. Evidence of increased asthma and allergic response among urban versus rural children has been reported. The aim of this study was to investigate the association between household characteristics in childhood asthma, who have positive skin prick test (SPT) to mite and to compare the results with those of the patients who have negative SPT. Method: The study population consist 150 asthmatic children aged 1-14 years attended to Dr Sheikh hospital in Mashhad, between Januay 2008 and December 2009. Results: Out of 150 children with asthma, 28 (18.7%) had positive SPT to mites. All of the patients with positive SPT to mites lived in urban areas. Conclusion: We found significant relationship between mite skin test positivity and living in urban area (P=0.043), which suggests living in urban areas as a potential risk factor for mite sensitivity in childhood asthma.

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