Gh Patel Institute Of Pharmacy

Vallabh Vidyanagar, India

Gh Patel Institute Of Pharmacy

Vallabh Vidyanagar, India
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Panchal H.H.,Gh Patel Institute Of Pharmacy | Lad B.N.,Gh Patel Institute Of Pharmacy
Pharmacognosy Journal | Year: 2010

Flacourtia ramontchi L.'Herit (Family: Flacourtiaceae), commonly called Vikankata in Sanskrit, Governor's Plum or Madaraskara Plum in English, is found in the Sub-Himalayan tract and Outer Himalayas in India. The leaves of this plant have different indications in Ayurveda and are used traditionally for several ailments. Considerable confusion exists regarding the identification of this species. Hence, the present work was undertaken to establish the requisite pharmacognostic standards for evaluating the plant material. Although some pharmacognostic characters were already reported in Ayurvedic Pharmacopoeia of India, present work re-investigates some of them and reports other necessary pharmacognostic parameters of leaves of Flacourtia ramontchi L.'Herit. © 2010

Patel R.B.,Gh Patel Institute Of Pharmacy | Patel B.G.,Sudan University of Science and Technology
Journal of Drug Delivery Science and Technology | Year: 2013

This paper describes the formulation development, physicochemical characterization and ex vivo evaluation of a microemulsion drug delivery system designed for intranasal administration of risperidone. Drug-loaded microemulsions which contained 4 % oleic acid, 30 % surfactant mixture of [Labrasol: Cremophor RH 40(1:1)]:[Transcutol P] (3:1) and 66%(wlw) aqueous were successfully prepared by a water titration method. The microemulsion formulation which displayed an optical transparency of 99.96%, globule size of 21.08 ± 1.35 nm, and a polydispersity index of 0.109 ± 0.017 was selected for the incorporation of polyelectrolytic polymer (polycarbophil) as the mucoadhesive component. The mucoadhesive microemulsion of risperidone containing 0.5% w/w of polycarbophil showed a higher in vitro mucoadhesive potential (17.0 ± 1.5 min) and diffusion coefficient (3.72 × 10-6 ± 0.022 × 106) as compared to microemulsion. All formulations were found to be free from nasal cilio toxicity and were stable for six months.

Patel R.B.,Gh Patel Institute Of Pharmacy | Bhatt K.K.,Gh Patel Institute Of Pharmacy | Patel B.G.,Gujarat University | Gaikwad R.V.,Veterinary Nuclear Medicine Center
Drug Delivery | Year: 2016

Objective: The objective of present study was to develop and evaluate paliperidone (Pali) loaded microemulsion (Pali-ME) for intranasal delivery in the treatment of schizophrenia.Material and methods: The Pali-ME was formulated by the spontaneous microemulsification method and characterized for physicochemical parameters. Pharmacodynamic assessments (apomorphine-induced compulsive behavior and spontaneous motor activity) were performed using mice. All formulations were tagged with 99mTc (technetium). Pharmacokinetic evaluation of Pali in the brain was investigated using Swiss albino rats. Brain scintigraphy imaging was performed in rabbits.Results and discussion: Pali-ME was found stable with average droplet size of 20.01 ± 1.28 nm. In pharmacodynamic studies, significant (p < 0.05) deference in parameters estimated, were found between the treated and control groups. 99mTc-tagged Pali solution (Pali-SOL)/Pali-ME/Pali muco-adhesive ME (Pali-MME) was found to be stable and suitable for in vivo studies. Brain-to-blood ratio at all sampling points up to 8 h following intranasal administration of Pali-MME compared to intravenous Pali-ME was found to be 6-8 times higher signifying greater extent of distribution of the Pali in brain. Rabbit brain scintigraphy demonstrated higher intranasal uptake of the Pali into the brain.Conclusion: This investigation demonstrates a prompt and larger extent of transport of Pali into the brain through intranasal Pali-MME, which may prove beneficial for treatment of schizophrenia. © 2014 Informa Healthcare USA, Inc.

Rokad V.,Gh Patel Institute Of Pharmacy | Nagda D.,Gh Patel Institute Of Pharmacy
Journal of Young Pharmacists | Year: 2014

Background: The work has been undertaken with an objective to prepare a self-emulsifying drug delivery system (SEDDS) of rosuvastatin calcium (ROS) with the least amount of surfactant which could enhance its solubility and oral bioavailability. Materials and Methods: Spectrophotometric method was used to estimate the solubility of the drug in various oils, surfactant and co-surfactant. The phase behavior and most efficient self-emulsifying region were identified by constructing pseudo ternary phase diagram. The solid-SEDDS (S-SEDDS) was prepared using an adsorbent consequently the prepared S-SEDDS were filled up in hard gelatin capsule which were evaluated for various physicochemical parameters. Results: The composition of optimized formulation consisted of 10 mg of ROS, capmul MCM (oil), cremophor ELP (surfactant) and propylene glycol (co-surfactant). The optimized formulation showed negative zeta potential (-22.11 mv), optimal particle size (10.59 nm) and demonstrated excellent self-emulsifying ability with a maximum solubilizing capability. The S-SEDDS formulations were prepared from the optimized liquid SEDDS, which revealed maximum release rate (97.7%) among all the prepared S-SEDDS formulation and marketed formulation. Conclusion: It was concluded that S-SEDDS prepared from liquid SEDDS can be a promising novel approach to enhance the solubility and drug release of ROS, which in turn also develops a stable formulation, least drugs leakage and precipitation than the liquid SEDDS.

Patel K.T.,Torrent Pharmaceuticals Ltd. | Chotai N.P.,GH Patel Institute of Pharmacy
Journal of Young Pharmacists | Year: 2011

'If it's not written down, then it didn't happen!' The basic rules in any good manufacturing practice (GMP) regulations specify that the pharmaceutical manufacturer must maintain proper documentation and records. Documentation helps to build up a detailed picture of what a manufacturing function has done in the past and what it is doing now and, thus, it provides a basis for planning what it is going to do in the future. Regulatory inspectors, during their inspections of manufacturing sites, often spend much time examining a company's documents and records. Effective documentation enhances the visibility of the quality assurance system. In light of above facts, we have made an attempt to harmonize different GMP requirements and prepare comprehensive GMP requirements related to 'documentation and records,' followed by a meticulous review of the most influential and frequently referred regulations.

Galani V.,Gh Patel Institute Of Pharmacy | Patel B.,Gh Patel Institute Of Pharmacy | Patel N.,Gh Patel Institute Of Pharmacy
Pharmacognosy Reviews | Year: 2010

Argyreia speciosa (Linn. f.) Sweet is a popular Indian medicinal plant, which has long been used in traditional Ayurvedic Indian medicine for various diseases. This plant is pharmacologically studied for nootropic, aphrodisiac, immunomodulatory, hepatoprotective, antioxidant, antiinflammatory, antihyperglycemic, antidiarrheal, antimicrobial, antiviral, nematicidal, antiulcer, anticonvulsant, analgesic and central nervous depressant activities. A wide range of phytochemical constituents have been isolated from this plant. A comprehensive account of the morphology, phytochemical constituents and pharmacological activities reported are included in view of the many recent findings of importance on this plant.

Patel A.S.,Gh Patel Institute Of Pharmacy | Saikat P.,Gh Patel Institute Of Pharmacy | Pravinbhai P.R.,Gh Patel Institute Of Pharmacy
Current Drug Delivery | Year: 2014

The spherical microspheres consisting of Furosemide loaded sodium alginate and along with HPMC E50 or sodium CMC as mucoadhesive polymers in different ratios were prepared using ionic gelation technique. Calcium chloride was used as crosslinking, to retard the drug release from the mucoadhesive microspheres. The prepared mucoadhesive microspheres were subjected for evaluation of various parameters like production yield, particle size, encapsulation efficiency, mucoadhesion test and in vitro dissolution profile studies. Formulations were subjected to DSC study and SEM analysis. The in vitro release data were well fit into Higuchi and Korsmeyer-Peppas model and followed non-Fickian diffusion mechanism. © 2014 Bentham Science Publishers.

Prajapati P.,Gujarat Forensic Sciences University | Vaghela V.,Gh Patel Institute Of Pharmacy | Rawtani D.,Gujarat Forensic Sciences University | Patel H.,Gujarat Forensic Sciences University | And 2 more authors.
Journal of Pharmaceutical Analysis | Year: 2012

A novel, safe, economic and sensitive method of spectrophotometric estimation has been developed using Azeoptropic mixture (water:methanol: 60:40, v/v) for the quantitative determination of Lornoxicam, a practically water-insoluble drug. Hence, Lornoxicam stock solution was prepared in Azeoptropic mixture. Lornoxicam showed maximum absorbance at 383 nm. Beers law was obeyed in the concentration range 4-24 μg/mL with regression coefficient of 0.999. The method was validated in terms of linearity (R2=0.999), precision (CV for intra-day and inter-day was 0.28-0.68 and 0.12-0.92, respectively), accuracy (98.03-100.59% w/w) and specificity. This method is simple, precise, accurate, sensitive and reproducible and can be used for the routine quality control testing of the marketed formulations. © 2012 Xi'an Jiaotong University.

Prajesh P.,Gujarat Forensic Sciences University | Vipul V.,Gh Patel Institute Of Pharmacy
Journal of Liquid Chromatography and Related Technologies | Year: 2013

Ciclesonide, 2-[(1S,2S,4 R,8S,9S,11S,12S,13 R)-6-cyclohexyl-11-hydroxy-9, 13-dimethyl-16-oxo-5,7-dioxapentacyclo[,9.04,8.013,18]icosa-14, 17-dien-8-yl]-2-oxoethyl 2-methyl propanoate, persists as a newer anti-asthmatic drug of the glucocorticoid class. A fast, safe, and sensitive method for estimation of Ciclesonide was developed as it is officially in IP-2007 and acquires a longer time for detection. The chromatographic separation employs isocratic elution by utilizing an inertsil ODS-C18, 250 mm × 4.6 mm, 5 μm columns. A mobile phase consisting of solvent [solution containing Methanol:Water (95:05%, v/v)] endowed at a flow rate of 1.0 mL min-1. The analyte was detected and quantified at λmax 242 nm using UV detector. The method was validated according to ICH guidelines, illustrating to be accurate (98.91%-100.59%) and precise (CV = 0.21-1.11 for intra-day and CV = 0.21-1.51 for inter-day) within the corresponding linear range. © 2013 Taylor and Francis Group, LLC.

Prajapati P.,Gujarat Forensic Sciences University | Vaghela V.,Gh Patel Institute Of Pharmacy
Journal of Planar Chromatography - Modern TLC | Year: 2013

A sensitive method based on high-performance thin-layer chromatography (HPTLC) by using principle of densitometry with UV detection at λmax 242 nm for quantitative estimation of major pharmaceutically active compound, ciclesonide, 2-[(1S,2S,4R,8S,9S, 11S,12S,13R)-6-cyclohexyl-11-hydroxy-9,13-dimethyl-16-oxo-5,7- dioxapentacyclo[,9.04,8.013,18]icosa-14,17-dien-8-yl]-2-oxoethyl-2-methylpropanoate, which persists as a newer antiasthmatic drug of glucocorticoid class, is described here. Chromatographic separation was performed by semiautomatic CAMAG HPTLC instrument. The method was validated according to the International Conference on Harmonization (ICH) guidelines, illustrating to be accurate (98.92-100.26%) and precise (CV = 0.43-0.67 for intra-day and CV = 0.58-1.45 for inter-day) within the corresponding linear range. Limit of detection (LOD) and limit of quantification (LOQ) of sample were found to be 100 ng/spot and 303 ng/spot, respectively. © Akadémiai Kiadó, Budapest.

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