Soubrier F.,GH La Pitie Salpetriere |
Soubrier F.,University Pierre and Marie Curie |
Colas C.,GH La Pitie Salpetriere |
Boucher C.,GH La Pitie Salpetriere |
And 5 more authors.
Medecine Therapeutique Medecine de la Reproduction, Gynecologie et Endocrinologie | Year: 2010
The BRCA1 and 2 genes are the two major predisposing genes for breast and ovarian cancer both by the frequency of the mutations of these genes in the population and by the risk associated with these mutations. This review discusses the frequency of BRCA1/2 mutations according to age of onset of cancers, and their type. It is essential, for elaborating the follow-up program of the patient, to take into account the risk of cancer, which depends on the mutated gene and the age of the patient, the possible parental project and the genital life-stage of the patient. The different options of care are analyzed, based on their results, in this review.