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News Article | October 6, 2016
Site: news.yahoo.com

There may be a limit to how long humans can live, according to a new study. The oldest known person was Jeanne Calment, a French woman who died in 1997 at age 122. Calment's longevity record is unlikely to be broken, the researchers said. "In contrast to previous suggestions that human longevity can be extended ever further, our data strongly suggest that the duration of life is limited," the researchers wrote in their study, published today (Oct. 5) in the journal Nature. However, the new findings don't mean that researchers know for sure that humans will never live longer than 122 years, said Steven Austad, a professor of biology and aging at the University of Alabama at Birmingham, who was not involved in the study. He said that scientists used to believe that the limit to the human life span was 110 years until somebody lived to be older than that, which shows that it is tough to predict what this limit can be for humans. [Extending Life: 7 Ways to Live Past 100] In the new study, the researchers looked at the Human Mortality Database, an international database with detailed mortality data that's maintained by researchers at the University of California, Berkeley and the Max Plank Institutes in Germany. The database contains information on how long people have lived in recent decades in many countries. The researchers found that, in at least 40 countries and territories, the number of people surviving to age 70 and older has increased since 1900. This suggests that people's life expectancy, or the estimate of how long a person may expect to live, has increased. However, if there is no limit to how long people can live, then the greatest increases in survival rates over time should have occurred among those people who are the oldest, the researchers hypothesized. But the data showed that the greatest increase in survival rates among people in the oldest age groups in most countries peaked around 1980, and has not changed since. This may suggest that, after all, there may be a natural limit to how long people can live, the researchers said. The scientists also looked to see how old the very oldest people were when they died. They focused on deaths between 1968 and 2006, in France, Japan, the United Kingdom and the United States, which are the four countries with the largest numbers of people who have lived longer than 110 years, according to the International Database on Longevity. The researchers also looked at the maximum reported age at death between 1972 and 2015 reported by another source, called the Gerontology Research Group. The researchers found that, though the maximum reported age at death did increase until the 1990s, it has actually plateaued, and even slightly decreased since the time Jeanne Calment died. But Austad said that the human life span could likely still be extended. Experiments on mice have shown that these animals live longer if their calorie intake is restricted or if their genes are manipulated, he said. If researchers found medications or lifestyle factors such as special diets that are better than the ones known today, that could allow humans to live longer, too, he said.


Gierman H.J.,Stanford University | Fortney K.,Stanford University | Roach J.C.,Institute for Systems Biology | Coles N.S.,Gerontology Research Group | And 9 more authors.
PLoS ONE | Year: 2014

Supercentenarians (110 years or older) are the world's oldest people. Seventy four are alive worldwide, with twenty two in the United States. We performed whole-genome sequencing on 17 supercentenarians to explore the genetic basis underlying extreme human longevity. We found no significant evidence of enrichment for a single rare protein-altering variant or for a gene harboring different rare protein altering variants in supercentenarian compared to control genomes. We followed up on the gene most enriched for rare protein-altering variants in our cohort of supercentenarians, TSHZ3, by sequencing it in a second cohort of 99 long-lived individuals but did not find a significant enrichment. The genome of one supercentenarian had a pathogenic mutation in DSC2, known to predispose to arrhythmogenic right ventricular cardiomyopathy, which is recommended to be reported to this individual as an incidental finding according to a recent position statement by the American College of Medical Genetics and Genomics. Even with this pathogenic mutation, the proband lived to over 110 years. The entire list of rare protein-altering variants and DNA sequence of all 17 supercentenarian genomes is available as a resource to assist the discovery of the genetic basis of extreme longevity in future studies. ©- 2014 Gierman et al.


Millan-Calenti J.C.,Gerontology Research Group | Tubio J.,Gerontology Research Group | Pita-Fernandez S.,Complejo Hospitalario Universitario | Gonzalez-Abraldes I.,Gerontology Research Group | And 3 more authors.
Archives of Gerontology and Geriatrics | Year: 2010

The aim of this study is to establish the existing relationship among variables referred to the person, specifically age and gender, and the functional dependence in basic ADL and in IADL, as well as the possible relationship it has with the increase of morbidity and mortality in a random sample of 598 individuals older than 65 years. Of these individuals, 34.6% were categorized as dependent for at least one ADL, and 53.5% if we refer to IADL. Regarding the ADL, the risk of dependence increases (odds ratio = OR = 1.089) per year of age, (OR = 2.48) in women's case; while there is an IADL correlation between age and the score (r = -0.527; p < 0.001). A relationship exists between dependence and the days of hospitalization (for ADL: r = -0.12, p = 0.018 and IADL: r = -0.97, p = 0.003), the number of visits to the doctor (ADL: r = -0.27, p < 0.001; IADL: r = -0.25, p < 0.001) or the presence of concomitant pathologies such as dementia (ADL: p < 0.001; IADL: p < 0.001). There is a significant association between age, gender and dependence, as well as between dependence and morbidity and mortality, so that dependence could be used as a predictor of both. © 2009 Elsevier Ireland Ltd. All rights reserved.


Millan-Calenti J.C.,Gerontology Research Group | Sanchez A.,Gerontology Research Group | Lorenzo-Lopez L.,Gerontology Research Group | Cao R.,Gerontology Research Group | Maseda A.,Gerontology Research Group
International Journal of Aging and Human Development | Year: 2013

The influence of social support dimensions (the extent of contact with others, the satisfaction with contacts, and the availability of help if sick or disabled) in elderly people with cognitive impairment (COG), depressive symptoms (DEP), or the co-occurrence of these symptoms (COG-DEP) was assessed in a cross-sectional analysis of a representative sample of 579 individuals aged 65 years and older. A lower extent of contact was related to COG (OR: 2.26). Fair satisfaction with contacts was related to DEP (OR: 2.88) and COG-DEP (OR: 4.22). A low level of satisfaction with contacts was an important predictor for DEP (OR: 7.99) and COG-DEP (OR: 7.88). Therefore, different dimensions of social support were independently correlated with different aspects of mental health. Quantitative aspects of social support were significantly linked to the presence of cognitive impairment. Satisfaction with social support affected depressive symptoms both alone and when they co-occurred with cognitive impairment. © 2013, Baywood Publishing Co., Inc.


PubMed | Gerontology Research Group
Type: | Journal: Rejuvenation research | Year: 2017

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PubMed | Gerontology Research Group
Type: Journal Article | Journal: Archives of gerontology and geriatrics | Year: 2010

The aim of this study is to establish the existing relationship among variables referred to the person, specifically age and gender, and the functional dependence in basic ADL and in IADL, as well as the possible relationship it has with the increase of morbidity and mortality in a random sample of 598 individuals older than 65 years. Of these individuals, 34.6% were categorized as dependent for at least one ADL, and 53.5% if we refer to IADL. Regarding the ADL, the risk of dependence increases (odds ratio=OR=1.089) per year of age, (OR=2.48) in womens case; while there is an IADL correlation between age and the score (r=-0.527; p<0.001). A relationship exists between dependence and the days of hospitalization (for ADL: r=-0.12, p=0.018 and IADL: r=-0.97, p=0.003), the number of visits to the doctor (ADL: r=-0.27, p<0.001; IADL: r=-0.25, p<0.001) or the presence of concomitant pathologies such as dementia (ADL: p<0.001; IADL: p<0.001). There is a significant association between age, gender and dependence, as well as between dependence and morbidity and mortality, so that dependence could be used as a predictor of both.


News Article | February 28, 2017
Site: www.prnewswire.com

HUNTINGDON, Pa., Feb. 28, 2017 /PRNewswire-USNewswire/ -- Today, Pennsylvania Department of Aging Secretary Teresa Osborne visited Huntingdon County resident Delphine Gibson, who is 113 years old.  The Gerontology Research Group, which validates longevity and tracks supercentenarians, veri...

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