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Buntzel J.,Head & Neck Surgery | Buntzel J.,German Working Group Trace Elements and Electrolytes in Oncology AKTE | Knolle U.,Sudharz Krankenhaus Nordhausen | Knolle U.,German Working Group Trace Elements and Electrolytes in Oncology AKTE | And 8 more authors.
Trace Elements and Electrolytes | Year: 2011

Objective: Is there a relation between tumor volume and SCC/CEA/CYFRA 21-1 and/or trace element status (selenium, zinc) in patients with advanced head and neck cancer? Material and methods: Before starting the treatment we performed magnetic resonance imaging (MRI) based tumor volumetry in 21 patients (3 female, 18 male) suffering from advanced head and neck cancer. The following tumor localizations were included - oropharynx 6 patients (pts), cavum oris 5 pts, hypopharynx 6 pts, others 4 pts. At the time of diagnosis classical tumor markers SCC, CEA, CYFRA 21-1 were measured as well as the serum-concentrations of selenium and zinc (atom absorption spectrometry). Relations between tumor volume and laboratory data were calculated with MS Excel. Results: The median tumor volume of the primary tumor was 16.45 cm3 (range 1.14-209.87 cm3). We have seen reduced zinc in 6/21 patients (28.6%) and selenium 16/21 patients (76.1%). Increased values were observed in 14/21 cases for SCC (66.7%), 1/21 cases for CEA (4.8%), and 4/21 cases for CYFRA21-1 (19%). These sensitivities were increased to 50% for Zn, 83.3% for Se, 75% for SCC, 8.3% for CEA, and 16.7% for CYFRA 21-1 if the tumor volume was > 10 cm3 (n = 12). Conclusion: SCC and serum selenium seem to be effective tumor markers in head neck cancer patients with primary tumor volumes > 10 cm3. ©2011 Dustri-Verlag Dr. K. Feistle. Source

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