Herlev Gentofte University Hospital

Herlev, Denmark

Herlev Gentofte University Hospital

Herlev, Denmark

Time filter

Source Type

Larsen M.N.,University of Southern Denmark | Nielsen C.M.,Copenhagen University | Orntoft C.,University of Southern Denmark | Randers M.B.,University of Southern Denmark | And 7 more authors.
BioMed research international | Year: 2017

We investigated the exercise intensity and fitness effects of frequent school-based low-volume high-intensity training for 10 months in 8-10-year-old children. 239 Danish 3rd-grade school children from four schools were cluster-randomised into a control group (CON, n = 116) or two training groups performing either 5 × 12 min/wk small-sided football plus other ball games (SSG, n = 62) or interval running (IR, n = 61). Whole-body DXA scans, flamingo balance, standing long-jump, 20 m sprint, and Yo-Yo IR1 children's tests (YYIR1C) were performed before and after the intervention. Mean running velocity was higher (p < 0.05) in SSG than in IR (0.88 ± 0.14 versus 0.63 ± 0.20 m/s), while more time (p < 0.05) was spent in the highest player load zone (>2; 5.6 ± 3.4 versus 3.7 ± 3.4%) and highest HR zone (>90% HRmax; 12.4 ± 8.9 versus 8.4 ± 8.0%) in IR compared to SSG. After 10 months, no significant between-group differences were observed for YYIR1C performance and HR after 2 min of YYIR1C (HRsubmax), but median-split analyses showed that HRsubmax was reduced (p < 0.05) in both training groups compared to CON for those with the lowest aerobic fitness (SSG versus CON: 3.2%  HRmax [95% CI: 0.8-5.5]; IR versus CON: 2.6%  HRmax [95% CI: 1.1-5.2]). After 10 months, IR had improved (p < 0.05) 20 m sprint performance (IR versus CON: 154 ms [95% CI: 61-241]). No between-group differences (p > 0.05) were observed for whole-body or leg aBMD, lean mass, postural balance, or jump length. In conclusion, frequent low-volume ball games and interval running can be conducted over a full school year with high intensity rate but has limited positive fitness effects in 8-10-year-old children.


PubMed | University of Aalborg, Herlev Gentofte University Hospital and Copenhagen University
Type: | Journal: The international journal of cardiovascular imaging | Year: 2017

The extra-cardiac work-up in infective endocarditis (IE) comprises a search for primary and secondary infective foci. Whether


Moller-Bisgaard S.,Rigshospitalet | Moller-Bisgaard S.,Slagelse Hospital | Ejbjerg B.,Slagelse Hospital | Eshed I.,Sheba Medical Center | And 23 more authors.
Scandinavian Journal of Rheumatology | Year: 2016

Objectives: To investigate whether a treat-to-target strategy based on methotrexate (MTX) and intra-articular (IA) betamethasone suppresses magnetic resonance imaging (MRI)-determined measures of disease activity and reduces joint destruction in early rheumatoid arthritis (eRA) patients, and to investigate whether concomitant cyclosporin A (CyA) provides an additional effect. Method: In the 2-year randomized, double-blind, treat-to-target trial CIMESTRA, 160 patients with eRA (< 6 months) were randomized to MTX, intra-articular betamethasone and CyA, or placebo CyA. A total of 129 patients participated in the MRI substudy, and had contrast-enhanced MR images of the non-dominant hand at months 0, 6, 12, and 24. MR images were evaluated for osteitis, synovitis, tenosynovitis, bone erosion, and joint space narrowing (JSN), using validated scoring methods. Results: Significant reductions were seen at 6 months in all inflammatory parameters [synovitis, mean change –1.6 (p < 0.001, Wilcoxon), tenosynovitis, –3.5 (p < 0.001), and osteitis, –1.3 (p < 0.05)] and at 12/24 months in synovitis and tenosynovitis [–1.6/–2.2 and –3.6/–3.8, respectively; all p < 0.001]. MRI signs of inflammation were not fully eliminated, and increases in erosion and JSN scores were observed at 6 months [0.4 (p < 0.01)/0.1 (p < 0.05)], 12 months [0.8 (p < 0.001)/0.3 (p < 0.01)], and 24 months [1.0 (p < 0.001)/0.4 (p < 0.001)]. Clinical measures decreased significantly (p < 0.001) at all time points. There were no consistent statistically significant differences between treatment groups. Conclusions: In this eRA treat-to-target trial, MTX and intra-articular glucocorticoids markedly reduced, but did not eliminate, MRI osteitis, synovitis, and tenosynovitis. Accordingly, minimal but statistically significant increases in bone erosion and JSN were observed. No additional effect of CyA was demonstrated. © 2016 Informa Healthcare on license from Scandinavian Rheumatology Research Foundation


PubMed | Hvidovre Hospital, University of Leipzig, Herlev Gentofte University Hospital, Varde Heart Center and 7 more.
Type: | Journal: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology | Year: 2016

Early identification of patients who could benefit from early re-intervention after catheter ablation is highly warranted. Our aim was to investigate the association between post-procedural burden of supraventricular ectopic complexes (SVEC) and the risk of long-term atrial fibrillation (AF) recurrence.A total of 125 patients undergoing catheter ablation for AF were included. Patients underwent 7-day Holter recordings immediately post-procedural. The number of SVEC in post-procedural Holter recordings was categorized into quartiles: 0-72, 73-212, 213-782 and783 SVEC/day. Long-term AF recurrence was defined as a combined endpoint of AF1min during follow-up Holter recordings, cardioversion or hospitalization for AF after a 3-month blanking period and within 24months of follow-up. High post-procedural supraventricular ectopy burden was associated with an increased risk of long-term AF recurrence in a dose-dependent manner (783 SVEC: HR 4.6 [1.9-11.5], P<0.001) irrespective of AF recurrence during the blanking period or other risk factors. In patients with early AF recurrence<90days after catheter ablation ectopy burden was also highly predictive of long-term AF recurrence (SVEC213: HR 3.0 [1.3-6.7], P=0.007). Correspondingly, patients with early AF recurrence but low ectopy burden remained at low risk of long-term AF recurrence after the blanking period.Our results indicate that post-procedural ectopy burden is highly associated with long-term AF recurrence and could be a potent risk marker for selection of patients for early re-ablation. Development of future ablation risk stratification and strategies should include focus on post-procedural ectopy burden.


Larsen M.N.,Copenhagen University | Nielsen C.M.,Copenhagen University | Helge E.W.,Copenhagen University | Madsen M.,Copenhagen University | And 6 more authors.
British Journal of Sports Medicine | Year: 2016

Objectives We investigated whether musculoskeletal fitness of school children aged 8-10 years was affected by frequent intense PE sessions. Design and participants 295 Danish school children aged 8-10 years were cluster randomised to a small-sided ball game group (SSG) (n=96, four schools, five classes), a circuit strength training group (CST) (n=83, four schools, four classes) or a control group (CON, n=116, two schools, five classes). Intervention SSG or CST was performed 3×40 min/week over 10 months. Whole-body dual-energy X-ray absorptiometry (DXA) scans were used to determine areal bone mineral density (aBMD), bone mineral content (BMC) and lean body mass (LBM). Flamingo balance, standing long jump and 20-m sprint tests were used to determine muscular fitness. Results Analysis of baseline-to-10 months change scores showed between-group differences in favour of the interventions in whole-body aBMD (SSG vs CON: 8 mg/ cm2, 95% CI 3 to 13; CST vs CON: 7 mg/cm2, 95% CI 2 to 13, p<0.05) and leg BMC (SSG vs CON: 11 g, 95% CI 4 to 18; CST vs CON: 11 g, 95% CI 3 to 18, p<0.05). SSG had higher change scores in leg aBMD compared with CON and CST (SSG vs CON: 19 mg/cm2, 95% CI 11 to 39, p<0.05; SSG vs CST: 12 mg/cm2, 95%CI 3 to 21, p<0.05), and CST had higher change scores in whole-body BMC compared with CON (CST vs CON: 25 g, 95% CI 10 to 39, p<0.05). Both training types resulted in higher change scores in postural balance (SSG vs CON: 2.4 fewer falls/min, 95% CI 0.3 to 4.5, CST vs CON: 3.6 fewer falls/ min, 95% CI 1.3 to 5.9, p<0.05) and jump length (SSG vs CON: 10%, 95% CI 5 to 16%; CST vs CON: 9%, 95% CI 3 to 15%, p<0.05). No between-group differences were observed for sprint performance or LBM (p>0.05). Conclusions In conclusion, 3×40 min/week with SSG or CST over a full school year improves bone mineralisation and several aspects of muscular fitness of children aged 8- 10 years, suggesting that well-organised intense physical education classes can contribute positively to develop musculoskeletal health in young children. Trial registration number NCT02000492, post results. © 2016 BMJ Publishing Group Ltd & British Association of Sport and Exercise Medicine.


Tolstrup C.K.,Herlev & Gentofte University Hospital | Lose G.,Copenhagen University | Klarskov N.,Copenhagen University
International Urogynecology Journal and Pelvic Floor Dysfunction | Year: 2016

Introduction and hypothesis: Uterine prolapse is a common health problem and the number of surgical procedures is increasing. No consensus regarding the surgical strategy for repair of uterine prolapse exists. Vaginal hysterectomy (VH) is the preferred surgical procedure worldwide, but uterus-preserving alternatives including the Manchester procedure (MP) are available. The objective was to evaluate if VH and the MP are equally efficient treatments for uterine prolapse with regard to anatomical and symptomatic outcome, quality of life score, functional outcome, re-operation and conservative re-intervention rate, complications and operative outcomes. Methods: We systematically searched Embase, PubMed, the Cochrane databases, Clinicaltrials and Clinical trials register using the MeSh terms “uterine prolapse”, “uterus prolapse”, “vaginal prolapse” “pelvic organ prolapse”, “prolapsed uterus”, “Manchester procedure” and “vaginal hysterectomy”. No limitations regarding language, study design or methodology were applied. In total, nine studies published from 1966 to 2014 comparing the MP to VH were included. Results: The anatomical recurrence rate for the middle compartment was 4–7 % after VH, whereas recurrence was very rare after the MP. The re-operation rate because of symptomatic recurrence was higher after VH (9–13.1 %) compared with MP (3.3–9.5 %) and more patients needed conservative re-intervention (14–15 %) than after MP (10–11 %). After VH, postoperative bleeding and blood loss tended to be greater, bladder lesions and infections more frequent and the operating time longer. Conclusions: This review is in favour of the MP, which seems to be an efficient and safe treatment for uterine prolapse. We suggest that the MP might be considered a durable alternative to VH in uterine prolapse repair. © 2016 The International Urogynecological Association


PubMed | University of Exeter, Team Danmark, Frederikssund Municipality, Copenhagen University and Herlev Gentofte University Hospital
Type: | Journal: British journal of sports medicine | Year: 2016

We investigated whether musculoskeletal fitness of school children aged 8-10years was affected by frequent intense PE sessions.295 Danish school children aged 8-10years were cluster randomised to a small-sided ball game group (SSG) (n=96, four schools, five classes), a circuit strength training group (CST) (n=83, four schools, four classes) or a control group (CON, n=116, two schools, five classes).SSG or CST was performed 340 min/week over 10 months. Whole-body dual-energy X-ray absorptiometry (DXA) scans were used to determine areal bone mineral density (aBMD), bone mineral content (BMC) and lean body mass (LBM). Flamingo balance, standing long jump and 20-m sprint tests were used to determine muscular fitness.Analysis of baseline-to-10months change scores showed between-group differences in favour of the interventions in whole-body aBMD (SSG vs CON: 8mg/cmIn conclusion, 340min/week with SSG or CST over a full school year improves bone mineralisation and several aspects of muscular fitness of children aged 8-10years, suggesting that well-organised intense physical education classes can contribute positively to develop musculoskeletal health in young children.NCT02000492, post results.


PubMed | Herlev & Gentofte University Hospital and Copenhagen University
Type: Journal Article | Journal: International urogynecology journal | Year: 2016

Uterine prolapse is a common health problem and the number of surgical procedures is increasing. No consensus regarding the surgical strategy for repair of uterine prolapse exists. Vaginal hysterectomy (VH) is the preferred surgical procedure worldwide, but uterus-preserving alternatives including the Manchester procedure (MP) are available. The objective was to evaluate if VH and the MP are equally efficient treatments for uterine prolapse with regard to anatomical and symptomatic outcome, quality of life score, functional outcome, re-operation and conservative re-intervention rate, complications and operative outcomes.We systematically searched Embase, PubMed, the Cochrane databases, Clinicaltrials and Clinical trials register using the MeSh terms uterine prolapse, uterus prolapse, vaginal prolapse pelvic organ prolapse, prolapsed uterus, Manchester procedure and vaginal hysterectomy. No limitations regarding language, study design or methodology were applied. In total, nine studies published from 1966 to 2014 comparing the MP to VH were included.The anatomical recurrence rate for the middle compartment was 4-7% after VH, whereas recurrence was very rare after the MP. The re-operation rate because of symptomatic recurrence was higher after VH (9-13.1%) compared with MP (3.3-9.5%) and more patients needed conservative re-intervention (14-15%) than after MP (10-11%). After VH, postoperative bleeding and blood loss tended to be greater, bladder lesions and infections more frequent and the operating time longer.This review is in favour of the MP, which seems to be an efficient and safe treatment for uterine prolapse. We suggest that the MP might be considered a durable alternative to VH in uterine prolapse repair.

Loading Herlev Gentofte University Hospital collaborators
Loading Herlev Gentofte University Hospital collaborators